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| 1 | Dissecting the role of AMP-activated protein kinase in human diseases显示文摘AMP-activated protein kinase(AMPK), known as a sensor and a master of cellular energy balance, integrates various regulatory signals including anabolic and catabolic metabolic processes.Accompanying the application of genetic methods and a plethora of AMPK agonists, rapid progress has identified AMPK as an attractive therapeutic target for several human diseases, such as cancer, type2 diabetes, atherosclerosis, myocardial ischemia/reperfusion injury and neurodegenerative disease. The role of AMPK in metabolic and energetic modulation both at the intracellular and whole body levels has been reviewed elsewhere. In the present review, we summarize and update the paradoxical role of AMPK implicated in the diseases mentioned above and put forward the challenge encountered. Thus it will be expected to provide important clues for exploring rational methods of intervention in human diseases. | Jin Li Liping Zhong Fengzhong Wang Haibo Zhu | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 18 |
| 2 | nterferon alpha (IFNα)-induced TRIM22 interrupts HCV 'eplication by ubiquitinating NS5A显示文摘 | Chen Yang Xinhao Zhao Dakang Sun Leilei Yang Chang Chong Yu Pan Xiumei Chi Yanhang Gao Moli Wang Xiaodong Shi Haibo Sun Juan Lv Yuanda Gao Jin Zhong Junqi Niu Bing Sun | 2016 | Cellular & Molecular Immunology2016，13，1： | 13 |
| 3 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 4 | CFD simulation of gas–liquid flow in a high-pressure bubble column with a modified population balance model显示文摘In this study,based on the Luo bubble coalescence model,a model correction factor C_e for pressures according to the literature experimental results was introduced in the bubble coalescence efficiency term.Then,a coupled modified population balance model(PBM) with computational fluid dynamics(CFD) was used to simulate a high-pressure bubble column.The simulation results with and without C_e were compared with the experimental data.The modified CFD-PBM coupled model was used to investigate its applicability to broader experimental conditions.These results showed that the modified CFD-PBM coupled model can predict the hydrodynamic behaviors under various operating conditions. | Bo Zhang Lingtong Kong Haibo Jin Guangxiang He Suohe Yang Xiaoyan Guo | 2018 | Chinese Journal of Chemical Engineering2018，26，6： | 5 |
| 5 | Effect of Preparation Process on Compressive Strength and Hydrogenation Performance of Raney-Ni/Al2O3 Catalyst显示文摘In this study, Raney-Ni/Al_2O_3 catalysts were prepared from precursors which were calcined in different atmosphere(argon and air) and leached for different time. XRD, SEM, H_2-TPR and BET techniques were introduced to characterize the catalysts, and hydrogenation of unsaturated hydrocarbons, including vinyltoluene, dicyclopentadiene and indene, was used as probe reaction to evaluate the catalytic hydrogenation performance of the catalysts. The results demonstrated that the calcination atmosphere had noticeable effects on the compressive strength and hydrogenation performance of Raney-Ni/Al_2O_3. The catalyst calcined in argon exhibited better compressive strength and catalytic performance than the one calcined in air. The compressive strength and activity stability of catalyst were also determined by the leaching time. A too longer leaching time was not conducive to improving the compressive strength and catalytic performance of catalysts. When the precursor calcined in argon was treated in a 15%(by wt.) sodium hydroxide solution at 343 K for 5 h, a catalyst with higher compressive strength(at 26.10 N/mm) was obtained and the conversion of vinyltoluene, dicyclopentadiene(DCPD), and indene could amount to more than 87.5%, 99% and even 100%, respectively, under the reaction conditions covering a temperature of 493 K, a hydrogen pressure of 2.0 MPa, a LSHV of 3.0 h^(-1), and a hydrogen/oil ratio of 200:1. | Luo Guohua Wang Yanli Sun Daming Xu Xin Jin Haibo | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，2： | 5 |
| 6 | A Layout Optimization Method of Composite Wing Structures Based on Carrying Efficiency Criterion显示文摘二水平的布局优化策略为大规模合成翅膀结构在这份报纸被建议。设计要求根据结构的变丑在系统水平被调整,当布局在从系统水平满足限制的分系统水平被优化时。各种各样的失败的来临的度在翅膀面板的批评负担被采用估计结构正在带效率。由作为一个目的优化效率,这个问题的连续性能被保证。使硬的翅膀面板被相等的 orthotropic 盘子建模,并且全球弄弯负担被精力方法预言。stringer 皮肤本地人扣环抵抗上的支持弹性的非线性的效果被神经网络(NN ) 调查并且接近代理人模型。这些失败预言基于分析答案,它能有效地节省计算资源。最后,大规模翅膀结构的不可分的优化作为一个例子被完成。结果完成设计要求并且显示出这个方法的可行性。 | ZHAO Qun DING Yunliang JIN Haibo | 2011 | Chinese Journal of Aeronautics2011，24，4： | 4 |
| 7 | The effect of operating conditions on acylation of 2-methylnaphthalene in a microchannel reactor显示文摘Acylation of 2-methylnaphthalene(2-MN) is a very important reaction in organic synthesis,and the effiency of the continuous reactor is more than one of the batch reactor.Considering that the Friedel–Crafts acylation is a rapid exothermic reaction,in this study,we perform the acylation of 2-MN in a stainless steel microchannel flow reactor,which is characterized by high mass and heat transfer rates.The effect of reactant ratio,mixing temperature,reaction temperature,and reaction time on product yield and selectivity were investigated.Under the optimal conditions,2-methyl-6-propionylnaphthalene(2,6-MPN) was obtained in 85.8% yield with 87.5% selectivity.Compared with the conventional batch system,the continuous flow microchannel reactor provides a more efficient method for the synthesis of 2,6-MPN. | Wenpeng Li Suohe Yang Xiaoyan Guo Guangxiang He Haibo Jin | 2018 | Chinese Journal of Chemical Engineering2018，26，6： | 3 |
| 8 | PtNi-W/C with Atomically Dispersed Tungsten Sites Toward Boosted ORR in Proton Exchange Membrane Fuel Cell Devices显示文摘The performance of proton exchange membrane fuel cells is heavily dependent on the microstructure of electrode catalyst especially at low catalyst loadings.This work shows a hybrid electrocatalyst consisting of PtNi-W alloy nanocrystals loaded on carbon surface with atomically dispersed W sites by a two-step straightforward method.Single-atomic W can be found on the carbon surface,which can form protonic acid sites and establish an extended proton transport network at the catalyst surface.When implemented in membrane electrode assembly as cathode at ultra-low loading of 0.05 mgPt cm^(−2),the peak power density of the cell is enhanced by 64.4%compared to that with the commercial Pt/C catalyst.The theoretical calculation suggests that the single-atomic W possesses a favorable energetics toward the formation of*OOH whereby the intermediates can be efficiently converted and further reduced to water,revealing a interfacial cascade catalysis facilitated by the single-atomic W.This work highlights a novel functional hybrid electrocatalyst design from the atomic level that enables to solve the bottle-neck issues at device level. | Huawei Wang Jialong Gao Changli Chen Wei Zhao Zihou Zhang Dong Li Ying Chen Chenyue Wang Cheng Zhu Xiaoxing Ke Jiajing Pei Juncai Dong Qi Chen Haibo Jin Maorong Chai Yujing Li | 2023 | Nano-Micro Letters2023，15，9： | 3 |
| 9 | Essential training steps to achieving competency in the basic intraoperative transesophageal echocardiography examination for Chinese anesthesiologists显示文摘为检查定义的 intraoperative transesophageal echocardiography (T ) 的指南为医药专业人员的一个详细标准,特别地麻醉学者, T 考试怎么应该继续。多年以来, T 获得了实质的流行并且作为一种比较喜欢的监视形式出现了在血液动力学的不稳定性状况或批评照顾背景期间帮助 perioperative 管理和决策。T 训练小径和惯例指南很好在西方的国家和世界的许多区域被建立了。然而, T 为麻醉学者训练和实践信息缺乏中国。当创新技术发展,另外的教育模型出现了帮助在基本 T 考试获得才能。因此,在在中国为麻醉学者训练途径的理想的 T 上建立一致着急地被需要。开发能被合并到居民外套训练也是的麻醉学的有效课程对必要在基本 T 考试向才能提供知识和技巧。与演变,医药系统改革,增加为 intraoperative 要求提供外科的革新的血液动力学的监视,麻醉学专业人员逐渐地被强迫在他们的现在和将来的惯例执行 intraoperative T 考试。克服障碍并且在使用 TEE 形式在 intraoperative 管理和外科的决策帮助获得重要进步,出版为瓷器麻醉学者训练指南的基本 T 是一个重要努力。 | Yong G. Peng Haibo Song E. Wang Weipeng Wang Jin Liu | 2015 | Frontiers of Medicine2015，9，1： | 2 |
| 10 | Graphene Oxide Assemblies for Sustainable Clean-Water Harvesting and Green-Electricity Generation显示文摘CONSPECTUS:The urgent problems of water scarcity and the energy crisis have given rise to the development of a range of sustainable technologies with the great advancement of nanotechnologies and advent of attractive nanomaterials.Graphene oxides(GO),a derivative of graphene with an atom-thin thickness and abundant oxygen-containing functional groups(such as−OH,−COOH),are water-soluble and can be assembled into a variety of structures(such as fiber,membrane,and foam)with great potential in environmental and energy-related fields.As a typical precursor of graphene,GO can be easily reduced to graphene by chemical or thermal treatments to demonstrate excellent photothermal properties as well as tunable thermal conduction,which is highly desirable for efficient solar-driven water evaporation.The intrinsic large specific area of GO nanosheets can provide enough sites for ions adsorption and its porous assemblies facilitate the transport of water.In addition,the abundant functional groups allow the spontaneous adsorption of water molecules from the ambient environment and give birth to movable ions(usually protons)under the solvation effect.Once a chemical gradient is formed on the component,a remarkable electricity is generated from the directional transport of protons.Thanks to the excellent chemical properties of GO nanosheets,a wide range of assemblies with 1D aligned fibers,2D layered membranes and 3D porous foam can be easily fabricated by wet-spinning,solution-filtration,and freezingdrying methods.The various GO assemblies are able to exhibit abundant functions with remarkable weaving capability for GO fibers,superior flexibility for GO membranes,and exceptional adsorption capacity for GO foams.In light of all the advantages,GO and its assemblies are remarkably promising in the fields of sustainable development to meet the pressing challenges of water and energy crisis.In this Account,we will discuss the progress of clean-water production and green-electricity generation technologies based on GO assemblies.The fundamental working mechanism,optimization strategies,and promising applications are explored with an emphasis on the materials development.We also discuss the functions of GO assemblies in the water and electricity generation process and present their limitations and possible solutions.Current challenges and promising directions for the development of clean-water production and green-electricity generation are also demonstrated for their realistic implementations.We anticipate that this Account would promote more efforts toward fundamental research on graphene functionalization and encourage a broad exploration on the application of graphene assemblies in clean-water production and electric power generation systems. | Yaxin Huang Chengzhi Wang Changxiang Shao Boyu Wang Nan Chen Haibo Jin Huhu Cheng Liangti Qu | 2021 | Accounts of Materials Research2021，2，2： | 2 |
| 11 | Involvement of the crebellum in sequential finger movement learning:Evidence from functional magnetic resonance imaging显示文摘Whether the cerebellum is involved in volun-tary motor learning or motor performance is the subject of a new debate. Using functional magnetic resonance imaging (fMRI), we examined cerebellar activation in eight volun-teers before and after an extended period of training. Activa-tion volume on both sides of cerebellum after learning was significantly reduced compared to that before learning even under the same motor frequency. Remarkably, while motor frequency for the training sequence was significantly higher than the control sequence after 41 d of learning, activation in the cerebellum for both sequences, with respect to activation loci and volumes, was very similar. These results suggest that the cerebellum was involved in motor learning but not motor performance. Changes of cerebellar activation from training thus appear to be associated with learning but not with im-provement on task performance. | ZHU Yihong DI Haibo YUAN Yi REN Jin'ge YU Wei ZHANG Zhaoqi GAO Jiahong WENG Xuchu CHEN Yizhang | 2005 | Chinese Science Bulletin2005，50，17： | 2 |
| 12 | Fabrication, annealing, and electrocatalytic properties of platinum nanoparticles supported on self-organized TiO_2 nanotubes显示文摘The platinum nanoparticles supported on self-organized TiO2 nanotubes (Pt-TiO2/Ti) were prepared using electrochemical anodic oxidation followed by cathodic reduction. The structure and chemical nature of the Pt-TiO2/Ti electrocatalyst were investigated by X-ray diffraction (XRD) and scanning electron microscopy (SEM). Both XRD and SEM results indicate the presence of platinum on nanotubular TiO2. The stability of the Pt deposits was also investigated in 0.5 mol/L H2SO4 solution by cyclic voltammetry. The electrocatalytic activity of the Pt-TiO2/Ti catalyst exhibits enhancement effect during electro-oxidation of methanol when annealed to anatase. Successive cyclic voltammograms of methanol oxidation on the Pt-TiO2/Ti electrocatalyst shows unique electrocatalytic characteristics when compared to methanol oxidation on the bulk Pt catalyst. This is because of further quick oxidation of adsorbed CO by Pt (111) facets of Pt particles on self-organized TiO2 nanotubes when the formation of an electroactive film onto the working catalyst surface occurs. | LEI Bin XUE Jianjun JIN Danping NIShougao SUN Haibo | 2008 | Rare Metals2008，27，5： | 2 |
| 13 | Kinetic and Thermodynamic Studies on Raney Ni/Al2O3 Adsorption for Deep Desulfurization of Benzene Stream显示文摘How to remove trace amount of sulfur in benzene is of significance,and deep desulfurization by Ni-containing absorbents is an efficient and promising method.In this paper,The Raney Ni/Al2 O3 adsorbent was prepared and its kinetic and thermodynamic characteristics on adsorptive desulfurization of benzene were studied.The results showed that Raney Ni/Al2 O3 adsorbent exhibited good adsorption performance.The equilibrium isotherms indicated that the adsorption of thiophene over the Raney Ni/Al2 O3 adsorbent complied with the Freundlich model.The results of adsorption kinetics studies showed that the pseudo-second-order kinetics equation was more advantageous than the pseudo-first-order kinetics equation in describing the adsorption kinetics of thiophene on Raney Ni/Al2 O3.The rate constant value(kp)was positively correlated with the temperature whereas the adsorption mass transfer process was mainly determined by the intraparticle and film diffusion.The adsorption thermodynamic analysis proved that△G^0<0,△H^0>0,and△S^0>0,implying that the adsorption was a spontaneous,entropy-increasing and endothermic process. | Cao Yongzheng Luo Guohua Zhang Lanxi Xu Xin Jin Haibo Dong Sen Guo Xuehua | 2020 | China Petroleum Processing & Petrochemical Technology2020，22，2： | 2 |
| 14 | The Active Sites and Corresponding Stability Challenges of the M-N-C Catalysts for Proton Exchange Membrane Fuel Cell显示文摘Proton exchange membrane fuel cells(PEMFCs)as promising alternatives to traditional internal combustion engines have attracted massive concerns to promote their wide application in society.However,the biggest challenge to the commercialization of PEMFCs remains the high cost due to the adoption of the platinum group metal(PGM)catalysts in the cathode. | Ruolin Peng Zhongkun Zhao Hongmin Sun Yongping Yang Tinglu Song Yao Yang Jiankun Shao Haibo Jin Hongtao Sun Zipeng Zhao | 2023 | Chinese Journal of Chemistry2023，41，6： | 1 |
| 15 | Aqueous mineralization process to synthesize uniform shuttle-like BaMoO4 microcrystals at room temperature显示文摘 | Wu Xueying Du Jin Li Haibo | 2007 | Journal of Solid State Chemistry2007，180，： | 1 |
| 16 | Parameters measurement of hydrodynamics and CFD simulation in multi-stage bubble columns显示文摘 | Jin Haibo Lian Yichen Qin Ling | 2014 | The Canadian Journal of Chemical Engineering2014，92，8： | 1 |
| 17 | Analysis and con- trol of multiphase permanent-magnet bearingless motor with a sin- gle set of Half-coiled winding显示文摘 | HUANG Jin LI Bingnan JIANG Haibo | 2014 | IEEE Transactions on Industri- al Electronics2014，61，7： | 1 |
| 18 | Petri net based test case generation for evolved specification显示文摘Model-based testing can use a model to test a concrete program's implementation. When the model is changed due to the evolution of the specification, it is important to maintain the test suites up to date, such that it can be used for regression testing. A complete regeneration of the whole test suite from the new model,although inefficient, is still frequently used in practice. To address this problem effectively, we propose a test case reusability analysis technique to identify reusable test cases of the original test suite based on graph analysis,such that we can generate new test cases to cover only the change-related parts of the new model. The Market Information System(MIS) is employed to demonstrate the feasibility and effectiveness of the proposed method.Our experimental results show that the use of our method saves about 31.5% test case generation cost. | Zuohua DING Mingyue JIANG Haibo CHEN Zhi JIN Mengchu ZHOU | 2016 | Science China(Information Sciences)2016，59，8： | 1 |
| 19 | Guaranteed control performance robust LQG regulator for discrete-time Markovian jump systems with uncertain noise显示文摘Robust LQG problems of discrete-time Markovian jump systems with uncertain noises are investigated. The problem addressed is the construction of perturbation upper bounds on the uncertain noise covariances so as to guarantee that the deviation of the control performance remains within the precision prescribed in actual problems. Furthermore, this regulator is capable of minimizing the worst performance in an uncertain case. A numerical example is exploited to show the validity of the method. | Zhu Jin Xi Hongsheng Xiao Xiaobo Ji Haibo | 2007 | Journal of Systems Engineering and Electronics2007，18，4： | 1 |
| 20 | Instability of parasitic capacitance in T-shape-gate enhancementmode AlGaN/GaN MIS-HEMTs显示文摘Parasitic capacitances associated with overhangs of the T-shape-gate enhancement-mode(E-mode)GaN-based power device,were investigated by frequency/voltage-dependent capacitance-voltage and inductive-load switching measurements.The overhang capacitances induce a pinch-off voltage distinguished from that of the E-mode channel capacitance in the gate capacitance and the gatedrain capacitance characteristic curves.Frequency-and voltage-dependent tests confirm the instability caused by the trapping of interface/bulk states in the LPCVD-SiNx passivation dielectric.Circuit-level double pulse measurement also reveals its impact on switching transition for power switching applications. | Lan Bi Yixu Yao Qimeng Jiang Sen Huang Xinhua Wang Hao Jin Xinyue Dai Zhengyuan Xu Jie Fan Haibo Yin Ke Wei Xinyu Liu | 2022 | Journal of Semiconductors2022，43，3： | 1 |
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