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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | A Chromosome-Scale Genome Assembly of Paper Mulberry(Bmussonetia papyrifera)Provides New Insights into Its Forage and Papermaking Usage显示文摘Paper mulberry(Broussonetia papyrifera)is a well-known woody tree historically used for Cai Lun papermaking,one of the four great inventions of ancient China.More recently,Paper mulberry has also been used as forage to address the shortage of feedstuff because of its digestible crude fiber and high protein contents.In this study,we obtained a chromosome-scale genome assembly for Paper mulberry using integrated approaches,including Illumina and PacBio sequencing platform as well as Hi-C,optical,and genetic maps.The assembled Paper mulberry genome consists of 386.83 Mb,which is close to the estimated size,and 99.25%(383.93 Mb)of the assembly was assigned to 13 pseudochromosomes.Comparative genomic analysis revealed the expansion and contraction in the flavonoid and lignin biosynthetic gene families,respectively,accounting for the enhanced flavonoid and decreased lignin biosynthesis in Paper mulberry.Moreover,the increased ratio of syringyl-lignin to guaiacyl-lignin in Paper mulberry underscores its suitability for use in medicine,forage,papermaking,and barkcloth making.We also identified the rootassociated microbiota of Paper mulberry and found that Pseudomonas and Rhizobia were enriched in its roots and may provide the source of nitrogen for its stems and leaves via symbiotic nitrogen fixation.Collectively,these results suggest that Paper mulberry might have undergone adaptive evolution and recruited nitrogen-fixing microbes to promote growth by enhancing flavonoid production and altering lignin monomer composition.Our study provides significant insights into genetic basis of the usefulness of Paper mulberry in papermaking and barkcloth making,and as forage.These insights will facilitate further domestication and selection as well as industrial utilization of Paper mulberry worldwide. | Xianjun Peng Hui Liu Peilin Chen Feng Tang Yanmin Hu Fenfen Wang Zhi Pi Meiling Zhao Naizhi Chen Hui Chen Xiaokang Zhang Xueqing Yan Min Liu Xiaojun Fu Guofeng Zhao Pu Yao Lili Wang He Dai Xuming Li Wei Xiong Wencai Xu Hongkun Zheng Haiyan Yu Shihua Shen | 2019 | Molecular Plant2019，12，5： | 18 |
| 3 | Multiple stochastic paths scheme on partially-trusted relay quantum key distribution network显示文摘Quantum key distribution (QKD) technology provides proven unconditional point-to-point security based on fundamental quantum physics. A QKD network also holds promise for secure multi-user communications over long distances at high-speed transmission rates. Although many schemes have been proposed so far, the trusted relay QKD network is still the most practical and flexible scenario. In reality, the insecurity of certain relay sections cannot be ignored, so to solve the fatal security problems of partially-trusted relay networks we suggest a multiple stochastic paths scheme. Its features are: (i) a safe probability model that may be more practical for real applications; (ii) a multi-path scheme with an upper bound for the overall safe probability; (iii) an adaptive stochastic routing algorithm to generate sufficient different paths and hidden routes. Simulation results for a typical partially-trusted relay QKD network show that this generalized scheme is effective. | WEN Hao HAN ZhengFu ZHAO YiBo GUO GuangCan HONG PeiLin | 2009 | Science in China(Series F)2009，52，1： | 17 |
| 4 | Improvement and performance of parallel multilevel fast multipole algorithm显示文摘The method of establishing data structures plays an important role in the efficiency of parallel multilevel fast multipole algorithm(PMLFMA).Considering the main complements of multilevel fast multipole algorithm(MLFMA) memory,a new parallelization strategy and a modified data octree construction scheme are proposed to further reduce communication in order to improve parallel efficiency.For far interaction,a new scheme called dynamic memory allocation is developed.To analyze the workload balancing performance of a parallel implementation,the original concept of workload balancing factor is introduced and verified by numerical examples.Numerical results show that the above measures improve the parallel efficiency and are suitable for the analysis of electrical large-scale scattering objects. | Zhanhe Liu Peilin Huang Zhe Wu Xu Gao | 2011 | Journal of Systems Engineering and Electronics2011，22，1： | 15 |
| 5 | Inhibition of PI3K/Akt/m TOR signaling pathway enhances the sensitivity of the SKOV3/DDP ovarian cancer cell line to cisplatin in vitro显示文摘The activation of the PI3K/AKT/m TOR pathway plays a key role in ovarian cancer tumorigenesis, progression and chemotherapy resistance. This study aimed to explore the possible mechanism that PI-103, a dual inhibitor of phosphatidylinositide 3-kinase and m TOR, enhances the sensitivity of SKOV3/DDP ovarian cancer cell line to cisplatin chemotherapy. The results showed that PI-103 could significantly increase the sensitivity of SKVO3/DDP cells to cisplatin through inhibiting the activation of PI3K/Akt/m TOR signaling pathway and inducing cell cycle arrest and apoptosis. | Yunlang Cai Xiaoqiang Tan Jun Liu Yang Shen Di Wu Mulan Ren Peilin Huang Dandan Yu | 2014 | Chinese Journal of Cancer Research2014，26，5： | 11 |
| 6 | Initial Rotor Position Detection of 12/10 Flux-switching Permanent Magnet Motors显示文摘电机转子初始位置检测的精度直接决定其启动运行时的性能。针对12/10极永磁磁通切换型电机,在验证其凸极性的基础上,采用注入脉振高频信号实现转子初始位置估计。通过对传统高频脉振正弦电压信号注入的分析,研究了基于高频方波或三角波的注入方法,再利用电流差值调制或直接信号调制方法得到位置误差信号,同时根据磁路的饱和效应,通过对d轴电流过零点时间差值的累加,实现了磁极方向辨识。分析了位置误差信号的系数与初始位置检测收敛性的关系。通过实验验证了所提方法的正确性和可行性。 | XU Peilin DENG Zhiquan WANG Yu SONG Lucheng | 2013 | 中国电机工程学报2013，33，9： | 10 |
| 7 | Microbial production of natural poly amino acid显示文摘Three kinds of poly amino acids, poly-γ-glutamic acid, poly(ε-L-lysine) and multi-L-arginyl-poly (L-aspartic acid) can be synthesized by enzymatic process independently from ribosomal protein biosynthesis pathways in microorganism. These biosynthesized polymers have attracted more and more attentions because of their unique properties and various applications. In this review, the current knowledge on the biosynthesis, biodegradations and applications of these three poly amino acids are summarized. | SHI Feng XU ZhiNan CEN PeiLin | 2007 | Science China Chemistry2007，50，3： | 9 |
| 8 | Series expansion feasibility of singular integral in method of moments显示文摘When calculating electromagnetic scattering using method of moments(MoM), integral of the singular term has a significant influence on the results. This paper transforms the singular surface integral to the contour integral. The integrand is expanded to Taylor series and the integral results in a closed form. The cut-off error is analyzed to show that the series converges fast and only about 2 terms can agree well with the accurate result. The comparison of the perfect electric conductive(PEC) sphere's bi-static radar cross section(RCS) using MoM and the accurate method validates the feasibility in manipulating the singularity. The error due to the facet size and the cut-off terms of the series are analyzed in examples. | Jinzu Ji Peilin Huang | 2014 | Journal of Systems Engineering and Electronics2014，25，3： | 9 |
| 9 | Maximal capacity nonorthogonal pulse shape modulation显示文摘To improve spectral utilization of communication system, a novel nonorthogonal pulse shape modulation(NPSM) based on prolate spheroidal wave function(PSWF) is proposed. The modulation employs nonorthogonal PSWF pulses to transmit information and it shows a higher capacity than traditional orthogonal modulations. The NPSM capacity under the constraint of finite input alphabet, which is determined by parameters of PSWF pulse, is derived. An optimization model for maximal capacity of NPSM is constructed and an exhaustive self-adapting gradient search algorithm for the model is proposed. A practical NPSM scheme with the maximal capacity is obtained by this search algorithm and it is proved to be superior to orthogonal signaling in the capacity. Our theoretical analysis is validated by numerical simulations and practical tests, and the results show that NPSM outperforms orthogonal modulations in the capacity and has a lower Peak-to-Average Power Ratio. | Chen Zhaonan Wang Hongxing Liu Xiguo Zhong Peilin | 2015 | Chinese Journal of Aeronautics2015，28，6： | 8 |
| 10 | Speech Magnitude Spectrum Reconstruction from MFCCs Using Deep Neural Network显示文摘This work proposes a Deep neural network(DNN) based method for reconstructing speech magnitude spectrum from Mel-frequency cepstral coefficients(MFCCs). We train a DNN using MFCC vectors as input and the corresponding speech magnitude spectrum as desired output. Exploiting the strong inference power of DNN, the proposed method has the capability to accurately estimate the speech magnitude spectrum even from truncated MFCC vectors. Experiments on TIMIT corpus demonstrate that the proposed method achieves significantly better performance compared with traditional methods. | JIANG Wenbin LIU Peilin WEN Fei | 2018 | Chinese Journal of Electronics2018，27，2： | 8 |
| 11 | Effects of Single and Repeated Exposure to a 50-Hz 2-mT Electromagnetic Field on Primary Cultured Hippocampal Neurons显示文摘The prevalence of domestic and industrial electrical appliances has raised concerns about the health risk of extremely low-frequency magnetic fields(ELF-MFs). At present, the effects of ELF-MFs on the central nervous system are still highly controversial, and few studies have investigated its effects on cultured neurons. Here, we evaluated the biological effects of different patterns of ELF-MF exposure on primary cultured hippocampal neurons in terms of viability, apoptosis, genomic instability,and oxidative stress. The results showed that repeated exposure to 50-Hz 2-mT ELF-MF for 8 h per day after different times in culture decreased the viability and increased the production of intracellular reactive oxidative species in hippocampal neurons. The mechanism was potentially related to the up-regulation of Nox2 expression.Moreover, none of the repeated exposure patterns had significant effects on DNA damage, apoptosis, or autophagy, which suggested that ELF-MF exposure has no severe biological consequences in cultured hippocampal neurons. | Ying Zeng Yunyun Shen Ling Hong Yanfeng Chen Xiaofang Shi Qunli Zeng Peilin Yu | 2017 | Neuroscience Bulletin2017，33，3： | 6 |
| 12 | Cramer-Rao bound and signal-to-noise ratio gain in distributed coherent aperture radar显示文摘This paper studies the estimation performance of the coherent processing parameter(CPP), including time delay differences and phase synchronization errors among different apertures of the distributed coherent aperture radar(DCAR). Firstly,three architectures of signal processing in the DCAR are introduced. Secondly, the closed-form Cramer-Rao bound(CRB) of the CPP estimation is derived and compared. Then, the closed-form CRB is verified by numerical simulations. Finally, when the next generation radar works in a fully coherent mode, the closed-form signal-to-noise ratio(SNR) gain of the three architectures is presented. | Peilin Sun Jun Tang Xiaowei Tang | 2014 | Journal of Systems Engineering and Electronics2014，25，2： | 6 |
| 13 | Mutation analyses of integrated HBV genome in hepatitis B patients显示文摘Little has been learnt in the last 30 years about detection of HBV genome as well as its mutation analysis between hepatitis B fathers (HBF) and their children. In this study, we used nest polymerase chain reaction (PCR), fluorescence in situ hybridization (FISH), and DNA sequencing analysis, to examine the integrated HBV genome in paraffin-embedded testis tissues, which were taken as samples from HBF, and in peripheral blood mononuclear cells (PBMC) from 74 cases of HBFs and their children who were born after their fathers’ HBV infection (caHBF). We found that HBV DNA existed in testis tissues, mainly in the basilar parts of the seminiferous tubules, and also in PBMC of HBF. It was also documented that there were point mutations of poly-loci, insertions and deletions of nucleotides in integrated HBV genomes, and the types of gene mutations in the HBFs were similar to those in caHBF. This study addresses the major types of gene mutations in integrated HBV genome in human patients and also presents reliable evidence of possible genetic transmission of hepatitis B. | Peilin Wang Xiuhai Wang Shuying Cong Hongming Ma Xuecheng Zhang | 2008 | Journal of Genetics and Genomics2008，35，2： | 6 |
| 14 | Research advances in unsupported Pt-based catalysts for electrochemical methanol oxidation显示文摘Direct methanol fuel cells are one of the most promising alternative energy technologies in the foreseeable future, but its successful commercialization in large scale is still heavily hindered by several technical shortfalls, especially the undesirable activity and durability issues of electrocatalysts toward methanol oxidation reaction. In light of these challenges, the inherent advantages of unsupported Pt based nanostructures demonstrate their great potentials as durable and efficient electrocatalysts for direct methanol fuel cells. This review will summarize recent achievements of unsupported Pt-based electrocatalysts toward methanol oxidation, with highlighting the interactions between the performance and structure tailoring and composition modulating. At last, a perspective is proposed for the upcoming challenges and possible opportunities to further prompt the practical application of unsupported Pt-based electrocatalysts for direct methanol fuel cells. | Xin Long Tian Lijuan Wang Peilin Deng Yu Chen Bao Yu Xia | 2017 | Journal of Energy Chemistry2017，26，6： | 5 |
| 15 | Engineering Ruthenium-Based Electrocatalysts for Effective Hydrogen Evolution Reaction显示文摘The investigation of highly effective,durable,and cost-effective electrocatalysts for the hydrogen evolution reaction(HER)is a prerequisite for the upcoming hydrogen energy society.To establish a new hydrogen energy system and gradually replace the traditional fossil-based energy,electrochemical water-splitting is considered the most promising,environmentally friendly,and efficient way to produce pure hydrogen.Compared with the commonly used platinum(Pt)-based catalysts,ruthenium(Ru)is expected to be a good alternative because of its similar hydrogen bonding energy,lower water decomposition barrier,and considerably lower price.Analyzing and revealing the HER mechanisms,as well as identifying a rational design of Ru-based HER catalysts with desirable activity and stability is indispensable.In this review,the research progress on HER electrocatalysts and the relevant describing parameters for HER performance are briefly introduced.Moreover,four major strategies to improve the performance of Ru-based electrocatalysts,including electronic effect modulation,support engineering,structure design,and maximum utilization(single atom)are discussed.Finally,the challenges,solutions and prospects are highlighted to prompt the practical applications of Rubased electrocatalysts for HER. | Yingjie Yang Yanhui Yu Jing Li Qingrong Chen Yanlian Du Peng Rao Ruisong Li Chunman Jia Zhenye Kang Peilin Deng Yijun Shen Xinlong Tian | 2021 | Nano-Micro Letters2021，13，10： | 5 |
| 16 | Coronary heart disease: incidence, risk factors and interventions in Jiaozhou of Shandong province显示文摘 | Yu Hua Li Dan Chu Xianming An Yi Song Tongxun Feng Huixin Lin Peilin Wang Tao Jiang Shaoyan Guo Linlin Xu Fengqiang Liu Zhengke Yang Bin | 2014 | Chinese Medical Journal2014，，12： | 5 |
| 17 | Expression of a New hemA Gene from Agrobacterium radiobacter in Escherichia coli for 5-Aminolevulinate Production显示文摘A new hemA gene encoding 5-aminolevulinate (ALA) synthase was cloned from Agrobacterium ra- diobacter zju-0121. The ALA synthase catalyzes the pyridoxal phosphate-dependent condensation of succinyl coen- zyme A (succinyl-CoA) and glycine to produce ALA. Four plasmids carrying the A, radiobacter hemA gene were transformed into different E. coli strains. The effects of both genetic and physiological factors on the expression of ALA synthase and ALA production were studied. The results indicated that the final intracellular activity of ALA synthase and the production of ALA in different expression systems varied largely. Among them, the recombinant E. coli BL21 (DE3) harboring the expression plasmid pET28-A. R-hemA was the most suitable one. The effects of isopropyl-β-D-thiogalactopyranoside (IPTG) addition time, IPTG concentration, culture temperature and the initial concentration of precursors and glucose on the ALA production were also evaluated. The expressed ALA synthase accounted for about 23.7% of the intracellular soluble protein. The highest specific activity of ALA syn- thase was 13.8nmol·min-1·mg-1 of intracellular soluble protein. In the batch culture of the recombinant E. coli, the extracellular ALA concentration reached 0.9 g·L-1. | LIU Xiaoxia(刘晓侠) LIN Jianping(林建平) QIN Gang(秦钢) CEN Peilin(岑沛霖) | 2005 | Chinese Journal of Chemical Engineering2005，13，4： | 4 |
| 18 | 数字减影脑血管造影术对伴发眩晕的后循环缺血患者血管异常病因分析显示文摘目的通过数字减影脑血管造影术(DSA)对伴发眩晕的后循环缺血(PCI)患者的头颈部血管进行检查,分析其血管异常病因,掌握其发病规律。方法对138例伴发眩晕的PCI患者入院后给予详细的影像学检查,包括MRI、DSA,分析患者血管异常与PCI的因果关系。结果 138例患者,诊断为椎基底动脉系统短暂性缺血发作者89例、椎基底动脉系统脑梗死49例,综合所有的影像学检查结果分析,椎基底动脉血管异常者86例,考虑与PCI病因有关,有12例患者明确有心脏病心房颤动,考虑与后循环脑梗死病因有关,其余40例患者病因不明确。结论伴发眩晕的PCI患者的血管异常病因为:①椎基底动脉系统血管变异;②椎基底动脉系统血管狭窄或闭塞导致的后循环出现低灌注状态或脑梗死。 | 胡沛霖 陈树波 王文胜 李喜朋 周建峰 胡岩芳 HU Peilin CHEN Shubo,WANG Wensheng LI Xipeng,ZHOU Jian feng HU Yanfang | 2012 | 临床荟萃2012，27，6： | 4 |
| 19 | Dietary energy intake affects fetal survival and development during early and middle pregnancy in Large White and Meishan gilts显示文摘This experiment was designed to determine the effects of variations in dietary energy intake on reproductive performance and gene expression of luteal and endometrium tissues in Large White(LW)and Meishan(MS) gilts during early and middle pregnancy. After insemination, 32 LW gilts were assigned to high and low(HE_Land LE_L, 14.23 and 12.56 MJ DE/kg, respectively) diet treatment groups,while 32 MS gilts were allocated to HE_M and LE_M(12.56 and 10.88 MJ DE/kg) groups. Gilts were slaughtered on days 35, 55 and 90 of gestation. The fetal survival and luteal progesterone(P_4) concentration in the HE_Lgroup were higher on day 35 but lower on day 90 of gestation compared with the LE_L group(P < 0.05) for LW gilts. However, fetal survival and luteal P_4 concentration on day 35 of gestation were greater(P < 0.05) in the LE_M group than in the HE_M group for MS gilts, but no significant difference in mid-gestation was showed. The fetal weights of both breeds were higher for the high energy diets compared with the respective control group on day 90 of gestation(P < 0.05). In addition,the m RNA levels of P_4 synthesis-related proteins had correlated with luteal P_4 concentration in both breeds. Further, endometrial levels of uteroferrin(ACP5), retinol-binding protein 4(RBP_4) and secreted phosphoprotein 1(SPP1) m RNA were upregulated in the HE_Lgroup on day 35 of gestation but ACP5 and SPP1 were downregulated on day 55 of gestation compared with the LE_Lgroup(P < 0.05) for LW gilts. In MS gilts, diet only affected the expression of SPP1(P < 0.05). Our results revealed the differential sensitivity of LW and MS breeds to variations in dietary energy intake. For LW gilts, the HE_Lgroup improved fetal survival on day 35 but a sustained high energy diet decreased fetal survival on day 90 of gestation. The differences in dietary energy intake did not influence fetal survival on day 90 of gestation but the higher energy diet did increase fetal weight in the MS breed compared with the lower energy intake diet. These results may be due to differential luteal secretion activity and endometrium gene expression in these two breeds. | Long Che Zhenguo Yang Mengmeng Xu Ziyun Zhang Peilin Liu Shengyu Xu Lianqiang Che Yan Lin Zhengfeng Fang Bin Feng Jian Li De Wu | 2015 | Animal Nutrition2015，，3： | 4 |
| 20 | Regulating electrolytic Fe_(0.5)CoNiCuZn_(x) high entropy alloy electrodes for oxygen evolution reactions in alkaline solution显示文摘The properties of high entropy alloys(HEAs)depend on their phase structures and compositions.However,it is difficult to control the composition of the HEAs that contain highly volatile metals by the conventional arc melting method.In this paper,homogeneous powdery face centered cubic(FCC)phase Fe_(0.5)CoNiCuZn_(x) HEAs were prepared by the electrolysis of metal oxides in molten Na_(2)CO_(3)-K_(2)CO_(3) using a stable Ni11Fe10Cu inert oxygen-evolution anode.The use of oxide precursors and relatively low synthetic temperature are beneficial to efficiently preparing HEAs that contain highly volatile elements such as Zn.Moreover,the microstructures and compositions of the electrolytic HEAs can be easily tailored by adjusting the components of oxide precursors,then further regulating its properties.Thus,the electrocatalytic activity of Fe_(0.5)Co NiCuZn_(x) HEAs towards oxygen evolution reactions(OER)was investigated in 1 M KOH.The results show that Zn promotes the OER activity of Fe_(0.5)CoNiCuZn_(x) HEAs,i.e.,the HEA(Zn_(0.8))shows the best OER activity exhibiting a low overpotential of 340 m V at 10 m A/cm^(2) and excellent stability of 24 h.Hence,molten salt electrolysis not only provides a green approach to prepare Fe_(0.5)CoNiCuZn_(x) HEAs but also offers an effective way to regulate the structure of the alloys and thereby optimizes the electrocatalytic activities for water electrolysis. | Jian Huang Peilin Wang Peng Li Huayi Yin Dihua Wang | 2021 | Journal of Materials Science & Technology2021，，34： | 4 |
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