|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | IPA1 functions as a downstream transcription factor repressed by D53 in strigolactone signaling in rice显示文摘Strigolactones (SL ) ,一组类胡萝卜素导出 terpenoid 内酯,是压制射击由禁止腋的芽的长出分叉的 root-to-shoot 植物激素。矮子 53 (D53 ) ,表明小径的 SL 的关键抑压者,被推测调整 SL 反应的下游的 transcriptional 网络。然而, D53 指向的下游的抄写因素还都没被报导。这里,我们报导那理想的植物体系结构 1 (IPA1 ) ,在米饭的植物体系结构的一个关键管理者,在调整 tiller 数字和导致 SL 的基因表示作为 D53 的一个直接下游的部件工作。我们证明 D53 在 vivo 并且在 vitro 与 IPA1 交往并且压制 IPA1 的 transcriptional 激活活动。我们进一步证明 IPA1 能直接绑在 D53 倡导者并且在导致 SL 的 D53 表示的反馈规定起一个关键作用。这些调查结果表明 IPA1 是可能的与 D53 行动到的长推测的抄写因素之一调停在米饭的调整 SL 的 tiller 发展。 | Xiaoguang Song Zefu Lu Hong Yu Gaoneng Shao Jinsong Xiong Xiangbing Meng Yanhui Jing Guifu Liu Guosheng Xiong Jingbo Duan Xue-Feng Yao Chun-Ming Liu Hongqing Li Yonghong Wang Jiayang Li | 2017 | Cell Research2017，27，9： | 48 |
| 2 | Tiller Bud Formation Regulators MOC1 and MOC3 Cooperatively Promote Tiller Bud Outgrowth by Activating F0N1 Expression in Rice显示文摘Tillering in rice is one of the most important agronomic traits.Rice tiller development can be divided into two main processes: the formation of the axillary bud and its subsequent outgrowth.Several genes critical for bud formation in rice have been identified by genetic studies;however,their molecular functions and relationships are still largely unknown.Here,we report that MONOCULM 1 (MOC1) and MONOCULM 3/ TILLERS ABSENT 1/STERILE AND REDUCED TILLERING 1 (MOC3/TAB1/SRT1),two vital regulators for tiller formation in rice,physically interact to regulate tiller bud outgrowth through upregulating the expression of FLORAL ORGAN NUMBER 1 (FON1),the homolog of CLAVATA1 in rice.We found that M0C3 is able to directly bind the promoter ofFONI and subsequently activate FON1 expression.MOC1 functions as a coactivator of MOC3,whereas it could not directly bind the FON1 promoter,and further activated FON1 expression in the presence of MOC3.Accordingly,FON1 is highly expressed at axillary meristems and shows remarkably decreased expression levels in mod and moc3 mutants.Loss-of-function mutants of FON1 exhibit normal bud formation but defective bud outgrowth and reduced tiller number.Collectively,these results shed light on a joint transcriptional regulatory mechanim by MOC1 and MOC3,and establish a new framework for the control of tiller bud formation and outgrowth. | Gaoneng Shao Zefu Lu Jinsong Xiong Bing Wang Yanhui Jing Xiangbing Meng Guifu Liu Haiyan Ma Yan Liang Fan Chen Yonghong Wang Jiayang Li Hong Yu | 2019 | Molecular Plant2019，12，8： | 15 |
| 3 | Changing Forestry Policy by Integrating Water Aspects into Forest/Vegetation Restoration in Dryland Areas in China显示文摘Restoration forestry (forest rehabilitation) or re-vegetation is one effective measure to solve environmental problems, notably soil erosion. It may be further stimulated by the Clean Development Mechanism for carbon sequestration. However, there is an intensive and on-going debate about the adverse effects arising from afforestation in dryland areas, such as soil drying up which may cause further damage to the success of forest restoration, and the water yield reduction from watershed which may harm the regional development. On other hand, some preliminary studies showed a possibility that these adverse effects may be diminished more or less by properly designing the system structure and spatial distribution of forest/vegetation in a watershed. However, it is urgent to develop an evidence-based and sustainable new forestry policy for harmonizing forest-water interrelation. As a leading country in afforestation, China is beginning to develop a more trans-disciplinary and cross-sectoral forestry policy for harmonizing forestry development with water management. The main points of the changing new forestry policy should include: (1) Establishing a regional development strategy focusing on harmonized forest-water relations; (2) Taking forest-water interactions as an important part of evaluation; (3) Reducing the 'eco-water' quota of forests through technical advancement; (4) Developing and extending water-adaptive forest management practices; (5) Strengthening forest ecohydrological research and decision support ability. | WANG Yanhui Mike Bonell Karl-Heinz Feger YU Pengtao XIONG Wei XU Lihong | 2012 | Bulletin of the Chinese Academy of Sciences2012，26，1： | 9 |
| 4 | Boosting electrocatalytic water splitting via metal-metalloid combined modulation in quaternary Ni-Fe-P-B amorphous compound显示文摘Design and synthesis of highly efficient and cost-effective bifunctional catalysts for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)remain a big challenge.Herein,a quaternary amorphous nanocompound Ni-Fe-P-B has been synthesized by a facile,scalable co-reduction method.The Ni-Fe-P-B exhibits high electrocatalytic activity and outstanding durability for both HER and OER,delivering a current density of 10 mA·cm^-2 at overpotentials of 220 and 269 mV,respectively.When loaded on carbon fiber paper(CFP)as a bifunctional catalyst,the Ni-Fe-P-B@CFP electrode requires a low cell voltage of 1.58 V to obtain 10 mA·cm^-2 for overall water splitting with negligible recession over 60 h.The excellent catalytic performances of Ni-Fe-P-B mainly benefit from the metal-metalloid combined composition modulation and the unique amorphous structure.This work provides new insights into the design of robust bifunctional catalysts for water splitting,and may promote the development of multicomponent amorphous catalysts. | Wukui Tang Xiaofang Liu Ya Li Yanhui Pu Yao Lu Zhiming Song Qiang Wang Ronghai Yu Jianglan Shui | 2020 | Nano Research2020，13，2： | 8 |
| 5 | Up-regulation of breast cancer resistance protein plays a role in HER2-mediated chemoresistance through PI3K/Akt and nuclear factor-kappa B signaling pathways in MCF7 breast cancer cells显示文摘人的表皮的生长因素受体 2 (HER2/neu,也作为 ErbB2 知道) overexpression 在癌症与差的预后和 chemoresistance 被相关。乳癌抵抗蛋白质(BCRP 和 ABCG2 ) 在许多癌症房间是为 multidrug 抵抗(MDR ) 负责的药流出泵。HER2 和 BCRP 在乳癌病人与差的治疗反应被联系,尽管在 HER2 和 BCRP 表示之间的关系不是清楚的。这里,我们证明进 MCF7 乳癌房间(MCF7/HER2 ) 的 HER2 的 transfection 经由 phosphatidylinositol 3-kinase (PI3K ) 导致了 BCRP 的一条起来规定 /Akt 和发信号的原子 factor-kappa B (NF-B ) 。有 PI3K 禁止者 LY294002, IB phosphorylation 禁止者 Bay11-7082,和 IB 的主导的否定异种的 MCF/HER2 房间的治疗禁止了导致 HER2 的 BCRP 倡导者活动。而且,我们发现 HER2 overexpression 导致了 MCF7 房间的一个增加的电阻到多重 antitumor 药象 paclitaxel (Taxol ) 那样, cisplatin (DDP ) , etoposide (VP-16 ) , adriamycin (ADM ) , mitoxantrone (MX ) ,和 5 氟尿嘧啶(5-FU ) 。而且, silencing BCRP 或有选择地的表示禁止 Akt 或 NF-B 的活动部分地至少敏化 MCF7/HER2 房间到这些化疗代理人。一起拿,通过表明小径的 PI3K/AKT/NF-B 的 BCRP 的起来规定在 MCF7 的调停 HER2 的 chemoresistance 起了一个重要作用房间,和 AKT, NF-B,和 BCRP 小径可能为治疗学的干预用作潜在的目标。 | Weijia Zhang Wei Ding Ye Chen Meilin Feng Yongmei Ouyang Yanhui Yu Zhimin He | 2011 | Acta Biochimica et Biophysica Sinica2011，43，8： | 8 |
| 6 | Water yield reduction due to forestation in arid mountainous regions, northwest China显示文摘Forestation has been encouraged worldwide due to increasing demand for forest products, and for its ecological benefits such as soil erosion control and sediment reduction. However, forestation reduces runoff, thus potentially aggravating water shortages in arid regions. In order to quantitatively estimate the possible water yield reductions caused by forestation in an arid region, a small watershed (the Pailugou watershed) in the Qilian Mountains of northwest China was chosen as a study area. The responses of hydrological dynamics to different forestation scenarios in the study area were simulated using the TOPOG model. The results showed that forestation could lead to a complete loss of runoff at the site scale. At the watershed scale, a 10% increase in forest coverage led to a runoff reduction of 25.6 mm, equivalent to 13% of the runoffin the un-forested watershed. However, due to climatological and topographical constraints, the potential forest distribution occupied only 46.3% of the watershed area, and runoff reduction was estimated to reach a maximum of 60% when the forest cover ratio increased from 0.41% to 46.1%. Actual forest coverage is 36% in the study area, thus the water yield will be reduced with any further increase in forest area. Our study suggested that a trade-off between the numerous benefits of forest coverage increase and its negative impact on water yield should be carefully addressed in arid regions with inherently severe water-shortage. | Pengtao YU Yanhui WANG Xudong WU Xiaohong DONG Wei XIONG Gaowa BU Shunli WANG Jinye WANG Xiande LIU Lihong XU | 2010 | International Journal of Sediment Research2010，25，4： | 7 |
| 7 | Meso-Cenozoic Evolution of Earth Surface System under the East Asian Tectonic Superconvergence显示文摘The East Asian geological setting has a long duration related to the superconvergence of the Paleo-Asian, Tethyan and Paleo-Pacific tectonic domains. The Triassic Indosinian Movement contributed to an unified passive continental margin in East Asia. The later ophiolites and I-type granites associated with subduction of the Paleo-Pacific Plate in the Late Triassic, suggest a transition from passive to active continental margins. With the presence of the ongoing westward migration of the Paleo-Pacific Subduction Zone, the sinistral transpressional stress field could play an important role in the intraplate deformation in East Asia during the Late Triassic to Middle Jurassic, being characterized by the transition from the E-W-trending structural system controlled by the Tethys and Paleo-Asian oceans to the NE-trending structural system caused by the Paleo-Pacific Ocean subduction. The continuously westward migration of the subduction zones resulted in the transpressional stress field in East Asia marked by the emergence of the Eastern North China Plateau and the formation of the Andean-type active continental margin from late Late Jurassic to Early Cretaceous(160-135 Ma), accompanied by the development of a small amount of adakites. In the Late Cretaceous(135-90 Ma), due to the eastward retreat of the Paleo-Pacific Subduction Zone, the regional stress field was replaced from sinistral transpression to transtension. Since a large amount of late-stage adakites and metamorphic core complexes developed, the Andean-type active continental margin was destroyed and the Eastern North China Plateau started to collapse. In the Late Cretaceous, the extension in East Asia gradually decreased the eastward retreat of the Paleo-Pacific subduction zones. Futhermore, a significant topographic inversion had taken place during the Cenozoic that resulted from a rapid uplift of the Tibet Plateau resulting from the India-Eurasian collision and the formation of the Bohai Bay Basin and other basins in the East Asian continental margin. The inversion caused a remarkable eastward migration of deformation, basin formation and magmatism. Meanwhile, the basins that mainly developed in the Paleogene resulted in a three-step topography which typically appears to drop eastward in altitude. In the Neogene, the basins underwent a rapid subsidence in some depressions after basin-controlled faulting, as well as the intracontinental extensional events in East Asia, and are likely to be a contribution to the uplift of the Tibetan Plateau. | DMITRIENKO Liudmila V. WANG Pengcheng LI Sanzhong CAO Xianzhi Ian SOMERVILLE ZHOU Zaizheng HU Mengying SUO Yanhui GUO Lingli WANG Yongming LI Xiyao LIU Xin YU Shengyao ZHU Junjiang | 2018 | Acta Geologica Sinica(English Edition)2018，92，2： | 6 |
| 8 | Numerical analysis of applying special pavements to solve the frost heave diseases of high-speed railway roadbeds in seasonally frozen ground regions显示文摘The Haerbin-Dalian Passenger Dedicated Line is the first high-speed railway constructed in the seasonally frozen ground regions of northeastern China. Frost heave diseases occurred in the first winter of its operation(between October 2012 and January 2013), and frost heave was observed mainly in the roadbed fills that were considered not susceptible to frost heave. This paper proposes applying two special pavements — black pavement and insulation-black pavement — to improve the thermal regime of the roadbed. Three numerical models of the roadbed temperature field were built based on the field conditions of the Changchun section(D3K692+840 to D3K692+860). The results show that:(1) Compared with cement pavement, black pavement and insulation-black pavement could reduce the freezing index at the roadbed surface by 37% and 64%, respectively, which could influence the maximum frozen depth;(2) the maximum frozen depths under the black pavement and insulation-black pavement were respectively 1.3–1.4 m and 1 m. Compared with cement pavement, they could reduce the maximum frozen depth by 0.4 m and 0.7–0.8 m, respectively, which would reduce the permitted amount of frost heave by 4 mm and 7–8 mm, which would meet the deformation limit established by the Code for Design on Special Subgrade of Railway;(3) the freezing periods of the black pavement and the insulation-black pavement were, respectively, approximately four months and two months. Compared with cement pavement, they could reduce the freezing period by approximately 19 days and 40 days, respectively, and delay the initial freezing time by 9 days and 18 days; and(4) compared with cement pavement, black pavement and black-insulation pavement could reduce the frozen areas of roadbeds in the cold season, which suggests that these two special pavements could provide better thermal stability for roadbeds. | Chang Yuan FuJun Niu QiHao Yu XinBin Wang Lei Guo YanHui You | 2015 | Research in Cold and Arid Regions2015，7，4： | 5 |
| 9 | Aerodynamic configuration integration design of hypersonic cruise aircraft with inward-turning inlets显示文摘In this work, a novel airframe/propulsion integration design method of the wing-body configuration for hypersonic cruise aircraft is proposed, where the configuration is integrated with inward-turning inlets. With the help of this method, the major design concern of balancing the aerodynamic performance against the requirements for efficient propulsion can be well addressed. A novel geometric parametrically modelling method based on a combination of patched class and shape transition(CST) and COONs surface is proposed to represent the configuration, especially a complex configuration with an irregular inlet lip shape. The modelling method enlarges the design space of components on the premise of guaranteeing the configuration integrity via special constraints imposed on the interface across adjacent surfaces. A basic flow inside a cone shaped by a dual-inflection-point generatrix is optimized to generate the inward-turning inlet with improvements of both compression efficiency and flow uniformity. The performance improvement mechanism of this basic flow is the compression velocity variation induced by the variation of the generatrix slope along the flow path. At the design point, numerical simulation results show that the lift-to-drag ratio of the configuration is as high as 5.2 and the inlet works well with a high level of compression efficiency and flow uniformity. The design result also has a good performance on off-design conditions. The achievement of all the design targets turns out that the integration design method proposed in this paper is efficient and practical. | Jifei WANG Jinsheng CAI Chuanzhen LIU Yanhui DUAN Yaojie YU | 2017 | Chinese Journal of Aeronautics2017，30，4： | 5 |
| 10 | Synergy between metallic components of MoNi alloy for catalyzing highly efficient hydrogen storage of MgH2显示文摘Catalysts play a critical role in improving the hydrogen storage kinetics in Mg/MgH2 system.Exploring highly efficient catalysts and catalyst design principles are hot topics but challenging.The catalytic activity of metallic elements on dehydrogenation kinetics generally follows a sequence of Ti>Nb>Ni>V>Co>Mo.Herein,we report a highly efficient alloy catalyst composed of low-active elements of Mo and Ni(i.e.MoNi alloy)for MgH2 particles.MoNi alloy nanoparticles show excellent catalytic effect,even outperforming most advanced Ti-based catalysts.The synergy between Mo and Ni elements can promote the break of Mg-H bonds and the dissociation of hydrogen molecules,thus significantly improves the kinetics of Mg/MgH2 system.The MoNi-catalyzed Mg/MgH2 system can absorb and release 6.7 wt.%hydrogen within 60 s and 10 min at 300℃,respectively,and exhibits excellent cycling stability and low-temperature hydrogen storage performance.This study provides a strategy for designing efficient catalysts for hydrogen storage materials using the synergy of metal elements. | Meng Chen Yanhui Pu Zhenyang Li Gang Huang Xiaofang Liu Yao Lu Wukui Tang Li Xu Shuangyu Liu Ronghai Yu Jianglan Shui | 2020 | Nano Research2020，13，8： | 5 |
| 11 | Engineering Ruthenium-Based Electrocatalysts for Effective Hydrogen Evolution Reaction显示文摘The investigation of highly effective,durable,and cost-effective electrocatalysts for the hydrogen evolution reaction(HER)is a prerequisite for the upcoming hydrogen energy society.To establish a new hydrogen energy system and gradually replace the traditional fossil-based energy,electrochemical water-splitting is considered the most promising,environmentally friendly,and efficient way to produce pure hydrogen.Compared with the commonly used platinum(Pt)-based catalysts,ruthenium(Ru)is expected to be a good alternative because of its similar hydrogen bonding energy,lower water decomposition barrier,and considerably lower price.Analyzing and revealing the HER mechanisms,as well as identifying a rational design of Ru-based HER catalysts with desirable activity and stability is indispensable.In this review,the research progress on HER electrocatalysts and the relevant describing parameters for HER performance are briefly introduced.Moreover,four major strategies to improve the performance of Ru-based electrocatalysts,including electronic effect modulation,support engineering,structure design,and maximum utilization(single atom)are discussed.Finally,the challenges,solutions and prospects are highlighted to prompt the practical applications of Rubased electrocatalysts for HER. | Yingjie Yang Yanhui Yu Jing Li Qingrong Chen Yanlian Du Peng Rao Ruisong Li Chunman Jia Zhenye Kang Peilin Deng Yijun Shen Xinlong Tian | 2021 | Nano-Micro Letters2021，13，10： | 5 |
| 12 | Deep origin of Cenozoic volcanoes in Northeast China revealed by 3-D electrical structure显示文摘The three-dimensional(3-D)electrical structure of the upper-mantle was used to examine the deep origins of and relationship among the Cenozoic volcanoes located in Northeast China(NEC).High-quality,long-period magnetotelluric(LMT)full-impedance tensor data were collected in NEC and subjected to 3-D Gauss-Newton inversion in order to construct a resistivity model.The resulting model reveals the presence of multiple localized low-resistivity anomalies(LRAs)within the high resistivity lithosphere beneath NEC.These LRAs partially coincide with Cenozoic volcanoes on the surface.Three LRAs that form a larger,annular LRA were observed in the deep upper mantle beneath the Songliao Basin,whereas vein-like LRAs were found in the asthenosphere that connect the lithosphere and deep upper mantle.Petrophysical analyses suggest that the LRAs may have been caused by fluid-induced melting.Based on our electrical model,we propose that,following dehydration of the subducted Western Pacific slab into the mantle transition zone(MTZ)beneath NEC,the released water migrated upward and caused partial melting at the top of the MTZ beneath the Songliao Basin.Under the effect of buoyancy,the melted mantle formed a thermal upwelling that caused melting of asthenosphere before diapiring at the base of the dry lithosphere.The magma then penetrated structural boundaries(such as thinner,weaker,or activated suture zones)and finally reached the Earth's surface.This melting and upwelling of hot mantle materials may have resulted in large-scale volcanism in the region throughout the Cenozoic,including the eruption of Changbai Mountain and Halaha Volcanoes.Our results suggest that the Cenozoic NEC volcanoes may all share a similar mode of genesis,and probably originated from the annular LRA in the deep upper mantle. | Shiwen LI Aihua WENG Jianping LI Xuanlong SHAN Jiangtao HAN Yu TANG Yanhui ZHANG Xueqiu WANG | 2020 | Science China Earth Sciences2020，63，4： | 4 |
| 13 | Origins and pathways of the subsurface and intermediate water masses of the Indonesian Throughflow derived from historical and Argo data显示文摘On the basis of Argo data and historic temperature/salinity data from the World Ocean Database 2001(WOD01),origins and spreading pathways of the subsurface and intermediate water masses in the Indonesian Throughflow(ITF)region were discussed by analyzing distributions of salinity on representative isopycnal layers.Results were shown that,subsurface water mostly comes from the North Pacific Ocean while the intermediate water originates from both the North and South Pacific Ocean,even possibly from the Indian Ocean.Spreading through the Sulawesi Sea,the Makassar Strait,and the Flores Sea,the North Pacific subsurface water and the North Pacific Intermediate water dominate the western part of the Indonesian Archipelago.Furthermore as the depth increases,the features of the North Pacific sourced water masses become more obvious.In the eastern part of the waters,high salinity South Pacific subsurface water is blocked by a strong salinity front between Halmahera and New Guinea.Intermediate water in the eastern interior region owns salinity higher than the North Pacific intermediate water and the antarctic intermediate water(AAIW),possibly coming from the vertical mixing between subsurface water and the AAIW from the Pacific Ocean,and possibly coming from the northward extending of the AAIW from the Indian Ocean as well. | ZHANG Yanhui YU Xiaolin WANG Fan | 2008 | Acta Oceanologica Sinica2008，27，4： | 4 |
| 14 | USP47-mediated deubiquitination and stabilization of YAP contributes to the progression of colorectal cancer显示文摘Dear Editor,The Hippo tumor suppressor pathway plays an important role in development and tumorigenesis.Yes-associated protein(YAP)is a major effector of the Hippo pathway regulating the expression of genes involved in cell proliferation,cell death,and cell differentiation(Pan,2010;Johnson and Haider,2014;Piccolo etal.,2014;Yu etal.,2015).In intestine,YAP is mainly expressed in leucine rich repeat containing G protein-coupled receptor 5(LGR5)marked stem cells,and is required for regeneration following tissue damage and the development of colon cancer in mice(Cai etal.,2010;Barry etal.,2013;Wang etal.,2017).Moreover,in colorectal cancer(CRC)specimens,elevated YAP expression and activity is frequently observed(Steinhardt et al.,2008).It has been shown that high YAP expression is associated with cancer metastasis,poor prognosis,resistance to chemotherapy,and greater possibility of relapse(Johnson and Haider,2014;Yu etal.,2015). | Beiqing Pan Yi Yang Jian Li Yu Wang Chuantao Fang Fa-Xing Yu Yanhui Xu | 2020 | Protein & Cell2020，11，2： | 4 |
| 15 | Scorpion venom heat-resistant protein decreases immunoreactivity of OX-42-positive microglia cells in MPTP-treated mice显示文摘BACKGROUND:Microglia function as the immune surveyors of the brain under normal physiological conditions.However,microglia become activated in response to brain injuries and immunological stimula-tion.OBJECTIVE:To explore the influence of scorpion venom(SV) heat-resistant protein on frontal cortex and hippocampal microglia cells in a mice model of Parkinson's disease.DESIGN,TIME AND SETTING:Randomized,controlled,cellular immunity study.The experiment was performed at the Physiology Department Laboratory in Dalian Medical University between June 2005 and July 2008.MATERIALS:Ninety-six healthy,C57Bl/6 mice;1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) from Sigma,USA;SV heat-resistant protein(Experimental Base Institute in Dalian Medical University).The mice were randomly divided into four groups(n = 24):normal control,negative control,model,and SV heat-resistant protein.METHODS:Mice in the model and SV heat-resistant protein groups were subcutaneously injected with MPTP(20 mg/kg) to model Parkinson's disease,while the normal control and negative control groups were injected with physiological saline in the neck for 8 successive days.In addition,mice in the model and nor-mal control groups were intraperitoneally injected with physiological saline 2 hours following administration,while SV heat-resistant protein and negative control groups were injected SV heat-resistant protein(0.01 mg/kg).MAIN OUTCOME MEASURES:Immunoreactivity of microglia cells in MPTP-treated mice.RESULTS:Compared with normal control mice,MPTP-treated mice displayed increased OX-42 expression in the brain.However,in the SV heat-resistant protein-treated mice,OX-42 expression was decreased,com-pared to the model group.In the model mouse group,the number of OX-42-positive microglia was increased in the frontal cortex,caudatum,and hippocampal hilus,compared to the normal control mice(P < 0.01).However,in the SV heat-resistant protein-treated mice,the number of OX-42-positive microglia significantly decreased in the frontal cortex,caudatum,and hippocampal hilus,compared to the model group(P < 0.01).CONCLUSION:SV heat-resistant protein inhibited MPTP-induced microglial activation in the mouse fron-tal cortex and hippocampus,resulting in reduced microglial activation in the brain. | Shengming Yin Deqin YU Xi Gao Yan Peng Yanhui Feng Jie Zhao Yiyuan Tang Wanqin Zhang | 2008 | Neural Regeneration Research2008，3，9： | 4 |
| 16 | Fargeted elimination of mutant mitochondria DNA in MELAS-iPSCs by mitoTALENs显示文摘 | Yi Yang Han Wu Xiangjin Kang Yanhui Liang Ting Lan Tianjie Li Tao Tan Jiangyun Peng Quanjun Zhang Geng An Yali Liu Qian Yu Zhenglai Ma Ying Lian Boon Seng Soh Qingfeng Chen Ping Liu Yaoyong Chen Xiaofang Sun Rong Li Xiumei Zhen Yang Yu Xiaoping Li Yong Fan | 2018 | Protein & Cell2018，9，3： | 4 |
| 17 | Lacrimal sac diverticulum presenting as a lower eyelid mass with a secreting fistula显示文摘 | Zhang Chengyue Wu Qian Yu Jifeng Cui Yanhui Cao Wenhong Fan Yunwei Yu Gang | 2014 | Chinese Medical Journal2014，，18： | 4 |
| 18 | Estimate of NO_X production in the lightning channel based on three-dimensional lightning locating system显示文摘Based on the VHF lightning locating system,a three-dimensional-space cell-gridded approach is used to extract the lighting channel and calculate the length of the channel.Through clustering of the located radiation sources and then extracting the lightning channel,it can accurately obtain the length of the channel.To validate the feasibility of the approach,a simulation experiment is designed,and it shows the length error is no more than 10%.The relationship between the NO production of per unit arc length and atmospheric pressure obtained in laboratory is applied to the NOX production of per unit flash length at different altitudes in this paper.The channel length and the NOX production of 11 negative cloud-to-ground flashes and 59 intracloud flashes in an isolated thunderstorm in the northeastern Qinghai-Tibet Plateau are calculated.The results show that the average channel lengths of per cloud-to-ground and intracloud flash are 28.9 and 22.3 km respectively;the average NOX productions of per cloud-to-ground and intracloud flash are 1.89×1025 and 0.42×1025 molecules,respectively. | ZHANG Rong ZHANG GuangShu LI YaJun WANG YanHui WU Bin YU Hai LIU YanXiu | 2014 | Science China Earth Sciences2014，57，7： | 4 |
| 19 | Whole-genome sequencing of monozygotic twins discordant for schizophrenia indicates multiple genetic risk factors for schizophrenia显示文摘Schizophrenia is a common disorder with a high heritability, but its genetic architecture is still elusive.We implemented whole-genome sequencing(WGS) analysis of 8 families with monozygotic(MZ) twin pairs discordant for schizophrenia to assess potential association of de novo mutations(DNMs) or inherited variants with susceptibility to schizophrenia. Eight non-synonymous DNMs(including one splicing site) were identified and shared by twins, which were either located in previously reported schizophrenia risk genes(p.V24689 I mutation in TTN, p.S2506 T mutation in GCN1L1, IVS3+1G > T in DOCK1) or had a benign to damaging effect according to in silico prediction analysis. By searching the inherited rare damaging or loss-of-function(LOF) variants and common susceptible alleles from three classes of schizophrenia candidate genes, we were able to distill genetic alterations in several schizophrenia risk genes, including GAD1, PLXNA2, RELN and FEZ1. Four inherited copy number variations(CNVs; including a large deletion at 16p13.11) implicated for schizophrenia were identified in four families, respectively. Most of families carried both missense DNMs and inherited risk variants, which might suggest that DNMs, inherited rare damaging variants and common risk alleles together conferred to schizophrenia susceptibility. Our results support that schizophrenia is caused by a combination of multiple genetic factors, with each DNM/variant showing a relatively small effect size. | Jinsong Tang Yu Fan Hong Li Qun Xiang Deng-Feng Zhang Zongchang Li Ying He Yanhui Liao Ya Wang Fan He Fengyu Zhang Yin Yao Shugart Chunyu Liu Yanqing Tang Raymond C.K.Chan Chuan-Yue Wang Yong-Gang Yao Xiaogang Chen | 2017 | Journal of Genetics and Genomics2017，44，6： | 4 |
| 20 | Efficacy and brain mechanism of transcutaneous auricular vagus nerve stimulation for adolescents with mild to moderate depression:Study protocol for a randomized controlled trial显示文摘Background Depression is a common mental illness in childhood and adolescence,with an incidence of 4%–5%;it can lead to impairments in learning and social functioning.Transcutaneous auricular vagus nerve stimulation(taVNS)is a commonly used method of auricular acupuncture point stimulation,which is regarded as an effective treatment for adults with depression.The aim of this study was to investigate the efficacy and mechanism of taVNS for adolescents with mild to moderate depression.Methods This randomized controlled clinical trial will include 120 patients aged 12–16 years,all of whom are diagnosed with mild to moderate depression.Patients will be randomly assigned to a taVNS group and a drug control group(sertraline hydrochloride)at a ratio of 1:1.Patients will be evaluated using the 17‐item Hamilton Depression Scale,Hamilton Anxiety Rating Scale,Self‐Rating Depression Scale,Self‐Rating Anxiety Scale,and Pittsburgh Sleep Quality Index scores at baseline,as well as at the 2nd,4th,6th,8th,and 12th weeks.To investigate the underlying neural mechanisms of taVNS treatment from the perspective of the default mode network,multimodal magnetic resonance imaging(MRI;i.e.,structural MRI[sMRI],resting state MRI[rsMRI],and pseudocontinuous arterial spin‐labeled[pcASL]MRI)will be used to compare cerebral images among groups.MRI data will also be collected from 40 healthy volunteers to assess whether the participants exhibit normal development of structural and functional components.Discussion Depression is the most common mental disorder in adolescence.Drug treatment can improve depression symptoms;however,the side effects of drug treatments are often severe.This study proposes a simple physiotherapy that aims to treat adolescents with mild to moderate depression.The mechanism of taVNS in the treatment of depression will also be investigated.The results of this study will provide evidence to guide the application of taVNS in adolescents with depression. | Xue Xiao Xiaobing Hou Zhangjing Zhang Ying Li Xue Yu Yanhui Wang Jing Tian Ke Xu | 2020 | Pediatric Investigation2020，4，2： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员