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| 1 | Cerebral processing of auditory stimuli in patients with irritable bowel syndrome显示文摘瞄准:用大脑决定功能的磁性的回声成像(fMRI ) 非内脏的刺激的服的处理是否在急躁的肠症候群(IBS ) 被改变病人与健康题目相比。围绕针的内脏躯体集中机制,并且识别心理因素的可能的影响,我们使用了听觉的刺激刺激在他们的感情的质量不同。方法:在 8 个 IBS 病人和 8 控制, fMRI 大小用不同感情的质量(钟声,讨厌的偷看(2000 Hz ) ,中立的词,和感情的词的愉快的声音) 的 4 听觉的刺激的一个块图案被执行。坡度回响 T2 * 加权的顺序被用于功能的扫描。统计地图用一般线性模型被构造。结果:到感情的听觉的刺激,,相对控制的 IBS 病人在感情的处理区域的一个更大的变化与更强壮的释放反应了反应模式,在控制不同,没在令人烦恼或愉快的声音之间区分。到中立听觉的刺激,由对比,仅仅 IBS 病人与大重要激活反应了。结论:到在感情的处理刺激的区域的听觉的刺激的改变的服的反应模式建议在 IBS 的改变的感觉处理不能为内脏的感觉是特定的,但是可能在感情的敏感和感情方面的反应反映概括变化,可能与经常在 IBS 病人发现的心理 comorbidity 联系了。 | Viola Andresen Alexander Poellinger Chedwa Tsrouya Dominik Bach Albrecht Stroh Annette Foerschler Petra Georgiewa Marco Schmidtmann Ivo R van der Voort Peter Kobelt Claus Zimmer Bertram Wiedenmann Burghard F Klapp Hubert Monnikes | 2006 | World Journal of Gastroenterology2006，12，11： | 8 |
| 2 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 3 | 热年代学年龄温度法和年龄高程法的应用条件:对采样策略及年龄表达的启示显示文摘热年代学的年龄温度法和年龄高程法是研究造山带长期构造演化过程的常用方法。相对于年龄温度法而言,年龄高程法在计算岩石剥露速率上的优势在于回避了地温梯度的假设,但前提条件中最重要的方面则要求地温梯度达到稳定状态。然而,地温场通常会受到地形变化、地表剥露速率、断层活动及岩浆侵入等作用的干扰,导致地温梯度处于非稳定状态。此时,针对造山带长期演化过程中的具体问题采取合理的热年代学采样策略以及对年龄信息的有效提取方法是十分必要的。 | 曹凯 王国灿 Peter van der Beek | 2011 | 地学前缘2011，18，6： | 5 |
| 4 | Megacolon in adulthood after surgical treatment of Hirschsprung's disease in early childhood显示文摘Hirschsprung's disease (HD) is a disorder associated with congenital malformation of the enteric nervous system with segmental aganglionosis. Prevailing therapy includes a resection of the affected part of the bowel. However, patients often do not obtain complete functional improvement after surgical treatment. We present the case of a 25-year-old woman who had surgical treatment of HD in early childhood. After that procedure she had clinical features of constipation for years in the end,passing of stool once a week, requiring laxatives and enemas. We diagnosed an incomplete resection of the aganglionic bowel via rectal biopsy and resected the remaining aganglionic segment. Two months after surgery the patient's bowel function improved to a frequency of 1-4 stools per day. We conclude that regular follow-up is required to identify HD patients with persistent alterations of bowel function after surgery. In patients presenting with constipation, recognition of a remaining aganglionic segment or other alterations of the enteric nervous system should be aimed at in an early stage. | Christoph R.Werner Gisela Stoltenburg-Didinger Henning Weidemann Christoph Benckert Marco Schmidtmann Ivo R.van der Voort Viola Andresen Burghard F.Klapp Peter Neuhaus Bertram Wiedenmann Hubert Mnnikes | 2005 | World Journal of Gastroenterology2005，11，36： | 3 |
| 5 | Value of a comprehensive geriatric assessment for predicting one-year outcomes in patients undergoing transcatheter aortic valve implantation: results from the CGA-TAVI multicentre registry显示文摘Background In a three-month report from the CGA-TAVI registry, we found the Multidimensional Prognostic Index (MPI) and Short Physical Performance Battery (SPPB) to be of value for predicting short-term outcomes in elderly patients undergoing transcatheter aortic valve implantation (TAVI). In the present analysis, we examined the association of these tools with outcomes up to one year post-TAVI. Methods CGA-TAVI is an international, observational registry of geriatric patients undergoing TAVI. Patients were assessed using the MPI and SPPB. Efficacy of baseline values and any postoperative change for predicting outcome were established using logistic regression. Kaplan- Meier analysis was carried out for each comprehensive geriatric assessment tool, with survival stratified by risk category. Results One year after TAVI, 14.1% of patients deceased, while 17.4% met the combined endpoint of death and/or non-fatal stroke, and 37.7% the combined endpoint of death and/or hospitalisation and/or non-fatal stroke. A high-risk MPI score was associated with an increased risk of all-cause mortality (aOR = 36.13, 95% CI: 2.77–470.78, P = 0.006) and death and/or non-fatal stroke (aOR = 10.10, 95% CI: 1.48–68.75, P = 0.018). No significant associations were found between a high-risk SPPB score and mortality or two main combined endpoints. In contrast to a worsening SPPB, an aggravating MPI score at three months post-TAVI was associated with an increased risk of death and/or non-fatal stoke at one year (aOR = 95.16, 95% CI: 3.41–2657.01). Conclusions The MPI showed value for predicting the likelihood of death and a combination of death and/or non-fatal stroke by one year after TAVI in elderly patients. | Martijn S.van Mourik Nathalie van der Velde Giulio Mannarino Marie-Pierre Thibodeau Jean-Bernard Masson Gennaro Santoro Jan Baan Sofie Jansen Jana Kurucova Martin Thoenes Cornelia Deutsch ANDreas W.Schoenenberger ANDrea Ungar Peter Bramlage M Marije Vis | 2019 | Journal of Geriatric Cardiology2019，16，6： | 3 |
| 6 | Better to be alone than in bad company:The antagonistic effect of cisplatin and crizotinib combination therapy in non-small cell lung cancer显示文摘AIM To investigate the potential benefit of combining the cMET inhibitor crizotinib and cisplatin we performed in vitro combination studies.METHODS We tested three different treatment schemes in four non-small cell lung cancer(NSCLC) cell lines with a different cMET/epidermal growth factor receptor genetic background by means of the sulforhodamine B assay and performed analysis with Calcusyn.RESULTS All treatment schemes showed an antagonistic effect in all cell lines,independent of the cMET status.Despite their different genetic backgrounds,all cell lines(EBC-1,HCC827,H1975 and LUDLU-1) showed antagonistic combination indexes ranging from 1.3-2.7.These results were independent of the treatment schedule.CONCLUSION These results discourage further efforts to combine cMET inhibition with cisplatin chemotherapy in NSCLC. | Nele Van Der Steen Christophe Deben Vanessa Deschoolmeester An Wouters Filip Lardon Christian Rolfo Paul Germonpré Elisa Giovannetti Godefridus J Peters Patrick Pauwels | 2016 | World Journal of Clinical Oncology2016，7，6： | 2 |
| 7 | Modification of DAISY SVAT model for potential use of remotely sensed data显示文摘 | VAN DER KEUR PETER | 2001 | Agricultural and Forest Meteorology2001，，2： | 2 |
| 8 | Toward Carbon-Neutral Water Systems:Insights from Global Cities显示文摘Many cities have pledged to achieve carbon neutrality.The urban water industry can also contribute its share to a carbon-neutral future.Using a multi-city time-series analysis approach,this study aims to assess the progress and lessons learned from the greenhouse gas(GHG)emissions management of urban water systems in four global cities:Amsterdam,Melbourne,New York City,and Tokyo.These cities are advanced in setting GHG emissions reduction targets and reporting GHG emissions in their water industries.All four cities have reduced the GHG emissions in their water industries,compared with those from more than a decade ago(i.e.,the latest three-year moving averages are 13%–32%lower),although the emissions have“rebounded”multiple times over the years.The emissions reductions were mainly due to various engineering opportunities such as solar and mini-hydro power generation,biogas valorization,sludge digestion and incineration optimization,and aeration system optimization.These cities have recognized the many challenges in reaching carbon-neutrality goals,which include fluctuating water demand and rainfall,more carbon-intensive flood-prevention and water-supply strategies,meeting new air and water quality standards,and revising GHG emissions accounting methods.This study has also shown that it is difficult for the water industry to achieve carbon neutrality on its own.A collaborative approach with other sectors is needed when aiming toward the city’s carbon-neutrality goal.Such an approach involves expanding the usual system boundary of the water industry to externally tap into both engineering and non-engineering opportunities. | Ka Leung Lam Gang Liu Anne Marieke Motelica-Wagenaar Jan Peter van der Hoek | 2022 | Engineering2022，8，7： | 2 |
| 9 | A test of genetic association among male nuptial coloration, female mating preference, and male aggression bias within a polymorphic population of cichlid fish显示文摘 | Inke van der SLUIJS Peter D. DIJKSTRA Charlotte M. LINDEYER BertanneVISSER Alan M. SMITH Ton G. G. GROOTHUIS Jacques J. M. van ALPHEN Ole SEEHAUSEN | 2013 | Current Zoology2013，59，2： | 2 |
| 10 | Transjugular Intrahepatic Portosystemic Shunt in Patients With Chronic Portal Vein Occlusion and Cavernous Transformation显示文摘 | Alexandra Wils Edwin van der Linden Bart van Hoek Peter M.T. Pattynama | 2009 | Journal of Clinical Gastroenterology2009，，10： | 2 |
| 11 | ACE inhibition attenuates radiation-induced cardiopulmonary damage显示文摘 | Sonja J. van der Veen Ghazaleh Ghobadi Rudolf A. de Boer Hette Faber Megan V. Cannon Peter W. Nagle Sytze Brandenburg Johannes A. Langendijk Peter van Luijk Robert P. Coppes | 2014 | Radiotherapy and Oncology2014，，： | 2 |
| 12 | Iron deficiency in chronic heart failure: An international pooled analysis显示文摘 | IJsbrand T. Klip Josep Comin-Colet Adriaan A. Voors Piotr Ponikowski Cristina Enjuanes Waldemar Banasiak Dirk J. Lok Piotr Rosentryt Ainhoa Torrens Lech Polonski Dirk J. van Veldhuisen Peter van der Meer Ewa A. Jankowska | 2013 | American Heart Journal2013，，： | 2 |
| 13 | Lipoprotein-Associated Phospholipase A2 Activity Is Associated With Risk of Coronary Heart Disease and Ischemic Stroke: The Rotterdam Study显示文摘 | Hok-Hay S. Oei Irene M. van der Meer Albert Hofman Peter J. Koudstaal Theo Stijnen Monique M.B. Breteler Jacqueline C.M. Witteman | 2005 | Circulation2005，，5： | 2 |
| 14 | ROLE OF TOLL-LIKE RECEPTORS 2 AND 4, AND THE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS IN HIGH-MOBILITY GROUP BOX 1-INDUCED INFLAMMATION IN VIVO显示文摘 | Marieke A.D. van Zoelen Huan Yang Sandrine Florquin Joost C.M. Meijers Shizuo Akira Bernd Arnold Peter P. Nawroth Angelika Bierhaus Kevin J. Tracey Tom van der Poll | 2009 | Shock2009，，3： | 2 |
| 15 | Effects of interpolation and data resolution on methane emission estimates from rice paddies显示文摘 | Peter M. Van Bodegom Peter H. Verburg Alfred Stein Sri Adiningsih Hugo A.C. Denier Van Der Gon | 2002 | Environmental and Ecological Statistics2002，，1： | 1 |
| 16 | Thirty-day incidence and six-month clinical outcome of thrombotic stent occlusion after bare-metal, sirolimus, or paclitaxel stent implantation显示文摘 | Andrew T.L. Ong Angela Hoye Jiro Aoki Carlos A.G. van Mieghem Gaston A. Rodriguez Granillo Karel Sonnenschein Evelyn Regar Eugene P. McFadden Georgios Sianos Willem J. van der Giessen Peter P.T. de Jaegere Pim de Feyter Ron T. van Domburg Patrick W. Serru | 2005 | Journal of the American College of Cardiology2005，，6： | 1 |
| 17 | Coronary collateral circulation: The effects of smoking and alcohol显示文摘 | Jeroen Koerselman Peter P.Th. de Jaegere Marianne C. Verhaar Diederick E. Grobbee Yolanda van der Graaf | 2006 | Atherosclerosis2006，，1： | 1 |
| 18 | Emissions of persistent organic pollutants and eight candidate POPs from UNECE–Europe in 2000, 2010 and 2020 and the emission reduction resulting from the implementation of the UNECE POP protocol显示文摘 | Hugo Denier van der Gon Maarten van het Bolscher Antoon Visschedijk Peter Zandveld | 2007 | Atmospheric Environment2007，，40： | 1 |
| 19 | A least squares algorithm for a mixture model for compositional data显示文摘 | MOOIJAART A B PETER G M Van der Heijdenb ANDRIES L Van der Arkb | 1999 | Computational Statistics & Data Analysis1999，30，： | 1 |
| 20 | Environmental Pollution显示文摘 | de Boer Jacob Wester Peter G van der Horst Aschwin Leonard Pim E G | 2003 | 122 : 632003，122，： | 1 |
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