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| 1 | Immunotherapy and immunoescape in colorectal cancer显示文摘Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma. | Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero | 2007 | World Journal of Gastroenterology2007，13，44： | 4 |
| 2 | 3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration显示文摘Bone infections following open bone fracture or implant surgery remain a challenge in the orthopedics field.In order to avoid high doses of systemic drug administration,optimized local antibiotic release from scaffolds is required.3D additive manufactured(AM)scaffolds made with biodegradable polymers are ideal to support bone healing in non-union scenarios and can be given antimicrobial properties by the incorporation of antibiotics.In this study,ciprofloxacin and gentamicin intercalated in the interlamellar spaces of magnesium aluminum layered double hydroxides(MgAl)andα-zirconium phosphates(ZrP),respectively,are dispersed within a thermoplastic polymer by melt compounding and subsequently processed via high temperature melt extrusion AM(~190◦C)into 3D scaffolds.The inorganic fillers enable a sustained antibiotics release through the polymer matrix,controlled by antibiotics counterions exchange or pH conditions.Importantly,both antibiotics retain their functionality after the manufacturing process at high temperatures,as verified by their activity against both Gram+and Gram-bacterial strains.Moreover,scaffolds loaded with filler-antibiotic do not impair human mesenchymal stromal cells osteogenic differentiation,allowing matrix mineralization and the expression of relevant osteogenic markers.Overall,these results suggest the possibility of fabricating dual functionality 3D scaffolds via high temperature melt extrusion for bone regeneration and infection prevention. | María C´amara-Torres Stacy Duarte Ravi Sinha Ainhoa Egizabal Noelia´Alvarez Maria Bastianini Michele Sisani Paolo Scopece Marco Scatto Alessandro Bonetto Antonio Marcomini Alberto Sanchez Alessandro Patelli Carlos Mota Lorenzo Moroni | 2021 | Bioactive Materials2021，6，4： | 2 |
| 3 | Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice显示文摘 | Maria Lauda Tomasi Minjung Ryoo Heping Yang Ainhoa Iglesias Ara Kwang Suk Ko Shelly C. Lu | 2014 | Free Radical Biology and Medicine2014，，： | 2 |
| 4 | Potential of video games for the promotion of neuroadaptation to multifocal intraocular lenses: a narrative review显示文摘Multifocal intraocular lenses(IOLs) are currently usually implanted for the treatment of cataracts because they have been proved to be superior to monofocal IOLs with respect to spectacle independence. In turn, they are associated with a higher prevalence of dysphotopsia symptoms that is one of the most common causes of patient dissatisfaction. Neuroadaptation seems to play a major role in the optimal adaptation to multifocal IOLs. In this context, the development of strategies that facilitate the neuroadaptation process to multifocality might be an effective strategy to reduce patients' dissatisfaction. Video games have been proved to be effective for the improvement of visual acuity and for the promotion of neuroplasticity in elderly subjects and other populations with cortical-related visual impairment. This narrative review highlights the physiological potential of video games as a perceptual strategy to improve visual acuity and promote neuroplasticity in patients using multifocalIOLs, although research is still needed to confirm these benefits in this specific population, with only one comparative study to this date providing evidence of them. | Maria Begona Coco-Martin Pedro LValenzuela Miguel JMaldonado-López Alejandro Santos-Lozano Ainhoa Molina-Martin David P Pinero | 2019 | International Journal of Ophthalmology(English edition)2019，12，11： | 2 |
| 5 | Iron deficiency in chronic heart failure: An international pooled analysis显示文摘 | IJsbrand T. Klip Josep Comin-Colet Adriaan A. Voors Piotr Ponikowski Cristina Enjuanes Waldemar Banasiak Dirk J. Lok Piotr Rosentryt Ainhoa Torrens Lech Polonski Dirk J. van Veldhuisen Peter van der Meer Ewa A. Jankowska | 2013 | American Heart Journal2013，，： | 2 |
| 6 | Hotel Location In Tourism Cities Madrid 1936-1998 显示文摘 | Ainhoa Urtasun Isabel Gutorrez | 2006 | Annals of Tourism Researeh2006，33，2： | 1 |
| 7 | Gastric versus transpyloric feeding in severe traumatic brain injury: a prospective, randomized trial显示文摘 | Jose Acosta-Escribano Miguel Fernández-Vivas Teodoro Grau Carmona Juan Caturla-Such Miguel Garcia-Martinez Ainhoa Menendez-Mainer Manuel Solera-Suarez José Sanchez-Payá | 2010 | Intensive Care Medicine2010，，9： | 1 |
| 8 | High-sensitivity temperature sensor based on overlay on side-polished fibers 显示文摘 | Javier Senosiain Idoya Diaz Ainhoa Gaston | 2000 | IEEE Photonics Technology Letter2000，12，： | 1 |
| 9 | Endoglin modulates cellular responses to TGF-β1显示文摘 | Pedro L Ainhoa L Zhang H W | 1996 | Cell Biol1996，133，： | 1 |
| 10 | HOTEL LOCATIONIN TOURISM CITIES Madrid 1936-1998显示文摘 | AINHOA URTASUN ISABEL GUTIE' RREZ | 2006 | Annals of Tourism Research2006，33，2： | 1 |
| 11 | Hotel location in tourism cities,Madrid 1936-1998显示文摘 | Ainhoa Utrasun Isabel Gutlerrez | | 0，，02： | 1 |
| 12 | Neurologic Outcome of Posttraumatic Refractory Intracranial Hypertension Treated With External Lumbar Drainage显示文摘 | Josep M. Abadal-Centellas Juan A. Llompart-Pou Javier Homar-Ramírez Jon Pérez-Bárcena Ainhoa Rosselló-Ferrer Jordi Ibá?ez-Juvé | 2007 | The Journal of Trauma: Injury Infection and Critical Care2007，，2： | 1 |
| 13 | The effect of temperature and pH on the growth and physiological response of juvenile yellowtail kingfish Seriola lalandi in recirculating aquaculture systems 显示文摘 | WOUT A AINHOA B G JONATHAN A C R | 2012 | Aquaculture2012，，： | 1 |
| 14 | Mycorrhiza - induced resistance and priming of plant defenses 显示文摘 | Sabine CJung Ainhoa Martinez - Medina Juan A Lopez - Raez | 2012 | Journal of Chemical Ecology2012，38，： | 1 |
| 15 | The effect of temperature and pH on the growth and physiological response of juvenile yellowtail kingfish Seriolalalandi in recirculating aquaculture system显示文摘 | Wout A Ainhoa B G Jonathan A C R | 2011 | Aquaculture2011，，： | 1 |
| 16 | Tourism agglomeration and its impact on social welfare: An empirical approach to the Spanish case 显示文摘 | Ainhoa Urtasun Isabel Gutierrez | 2006 | Tourism Management2006，27，4： | 1 |
| 17 | Cell microencapsulation technology:Towards clinical application显示文摘 | Ainhoa M Aitziber P Gorka O Rosa M H Maria DC José Luis P | 2008 | Journal of controlled release2008，132，： | 1 |
| 18 | 显示文摘 | Ainhoa Morata-Orrantia Susana Garci'a-Marti'n Emilio Mora'n | 2002 | Chem Mater2002，14，： | 1 |
| 19 | Hydrothermal stability of HZSM-5 catalysts modified with Ni for the transformation of bioethanol into hydrocarbons显示文摘 | Ana G. Gayubo Ainhoa Alonso Beatriz Valle Andrés T. Aguayo Martín Olazar Javier Bilbao | 2010 | Fuel2010，，11： | 1 |
| 20 | Influence of superficial organic modification of MCM-41 matrices on drug delivery rate显示文摘 | PATRICIA H AINHOA R GERARD F | 2006 | SolidState Sci2006，8，10： | 1 |
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