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| 1 | Review of risk factors for human echinococcosis prevalence on the Qinghai-Tibet Plateau, China: a prospective for control options显示文摘Objective: Echinococcosis is a major parasitic zoonosis of public health importance in western China. In 2004, the Chinese Ministry of Health estimated that 380,000 people had the disease in the region. The Qinghai-Tibet Plateau is highly co-endemic with both alveolar echinococcosis (AE) and cystic echinococcosis (CE). In the past years, the Chinese government has been increasing the financial support to control the diseases in this region. Therefore, it is very important to identify the significant risk factors of the diseases by reviewing studies done in the region in the past decade to help policymakers design appropriate control strategies. Review: Selection criteria for which literature to review were firstly defined. Medline, CNKI (China National Knowledge Infrastructure), and Google Scholar were systematically searched for literature published between January 2000 and July 2011. Significant risk factors found by single factor and/or multiple factors analysis were listed, counted, and summarized. Literature was examined to check the comparability of the data;age and sex specific prevalence with same data structures were merged and used for further analysis. A variety of assumed social, economical, behavioral, and ecological risk factors were studied on the Plateau. Those most at risk were Tibetan herdsmen, the old and female in particular. By analyzing merged comparable data, it was found that females had a significant higher prevalence, and a positive linearity relationship existed between echinococcosis prevalence and increasing age. In terms of behavioral risk factors, playing with dogs was mostly correlated with CE and/or AE prevalence. In terms of hygiene, employing ground water as the drinking water source was significantly correlated with CE and AE prevalence. For definitive hosts, dog related factors were most frequently identified with prevalence of CE or/and AE;fox was a potential risk factor for AE prevalence only. Overgrazing and deforestation were significant for AE prevalence only. Conclusion: Tibetan herdsmen communities were at the highest risk of echinococcosis prevalence and should be the focus of echinococcosis control. Deworming both owned and stray dogs should be a major measure for controlling echinococcosis;treatment of wild definitive hosts should also be considered for AE endemic areas. Health education activities should be in concert with the local people's education backgrounds and languages in order to be able to improve behaviors. Further researches are needed to clarify the importance of wild hosts for AE/CE prevalence, the extent and range of the impacts of ecologic changes (overgrazing and deforestation) on the AE prevalence, and risk factors in Tibet. | Qian Wang Yan Huang Liang Huang Wenjie Yu Wei He Bo Zhong Wei Li Xiangman Zeng Dominique A Vuitton Patrick Giraudoux Philip S Craig Weiping Wu | 2014 | Infectious Diseases of Poverty2014，3，1： | 35 |
| 2 | Impact of overgrazing on the transmission of Echinococcus multilocularis in Tibetan pastoral communities of Sichuan Province,China显示文摘背景过度放牧被假定增加是包虫 multilocularis 的中间的主人的小哺乳动物的人口密度,在 Qinghai 西藏高原的牙槽的包虫病的病原体。这研究测试了过度放牧可能支持的假设通过增加小哺乳动物的人口的包虫 multilocularis 传播,在擦伤惯例的西藏的牧剧 communities.Methods 的中间的主人,小哺乳动物索引和狗包虫 rnultilocularis 感染数据被收集分析在用的 nonpararnetric 测试和多重逐步的逻辑 regression.Results 过度放牧和包虫 rnultilocularis 传播之间的关系调查一公社的牧场存在,可得到的牧草为放牧是缺乏的。开(普通) 牧场被过度放牧并且与附近的 fenced 相比有小哺乳动物的更高的洞穴密度(私人) 牧场;由附近的 fenced 区域测量的开的牧场上的这个高过度放牧压力在开的牧场导致了小哺乳动物的更高的洞穴密度。在开的牧场的小哺乳动物的中部的洞穴密度独立地与附近犬的包虫 multilocularis 感染被联系(P=0.003, OR=1.048 ) 过度放牧的 .Conclusion 可以通过增加小哺乳动物的人口密度支持包虫 multilocularis 的传播。 | WANG Qian XIAO Yong-fu Dominique A Vuitton Peter M Schantz Francis Raoul Christine Budke Maiza Campos-Ponce Philip S Craig Patrick Giraudoux | 2007 | Chinese Medical Journal2007，，3： | 20 |
| 3 | 青海省果洛州人与动物棘球蚴病调查显示文摘目的 通过对青海省果洛州人群与动物棘球蚴病的调查与分析,了解当地棘球蚴病在人群和动物中的流行与分布状况。方法 应用B超对人群进行患病率调查;囊液抗原间接血凝试验(IHA)法筛查人群棘球蚴抗体的阳性率;并分别用重组Em18(rEm18)、重组抗原B(rAgB)和Eg囊液抗原(EgcF),对随机选取的B超检查和IHA检测阳性者进行ELISA试验,与B超诊断结果进行符合率比较,评价泡型棘球蚴病(AE)、囊型棘球蚴病(CE)的分布情况;应用ELISA检测家犬和藏狐粪抗原阳性率;现场检查牛、羊胸腹腔,确定牛、羊感染率。结果 人群调查:①B超检查2826人,总患病率为9.45%。血清IHA法检查1113人,阳性率25.79%。女性人群的患病率和血清阳性率均显著高于男性;②血清囊液抗原IHA检测阳性者(108)与ELISA法检测EgcF,阳性符合率为66.94%:3种重组抗原检测,ELISA法与IHA法阳性符合率为75.00%。③B 超法诊断棘球蚴病(88人)与ELISA法检测,符合率EgcF为94.32%,rAgB为68.18%,rEm18为51-4%。EgcF阳性率符合率为69.44%:3种抗原检测与IHA检测总体阳性符合率为75.00%。61例CE患者中,血清ELISA法检测,EgcF阳性率为96.72%,rAgB为68.85%,rEm18为33.33%;26例AE患者中,EgcF和rEm18阳性率均为92-31%,rAgB为65.39%。动物调查:①高原鼠兔棘球蚴感染率21.74%。经cytb基因分析,证实有多房棘球绦虫(E.muhilocularis)和石渠棘球绦虫(Eshiquicus)感染。绵羊棘球蚴感染率82.61%,牦牛棘球蚴感染率78.52%。②野犬、藏狐、猞猁均有不同程度的棘球绦虫感染。结论 青海省果洛州人群与动物中存在棘球蚴病的高度流行。E.shiquicus种的幼虫和成虫分别在高原鼠兔和藏狐体内寄生已得到证实,提示果洛州为3种棘球蚴的混合流行区。 | 王虎 马俊英 韩秀敏 吴献洪 肖宁 Akira Ito Philips Craig | 2007 | 中国地方病学杂志2007，26，5： | 20 |
| 4 | Grass height and transmission ecology of Echinococcus multilocularis in Tibetan communities, China显示文摘背景牙槽的包虫病是在西方的中国的公共健康意义的主要动物病。过度放牧最近为牙槽的包虫病的传播作为一个潜在的风险因素被假定。研究被设计进一步由调查过度放牧怎么影响了中间的主人的洞穴密度测试过度放牧的假设小哺乳动物并且小哺乳动物的洞穴密度怎么与狗包虫 multilocularis infection.Methods 被联系学习地点被发现了牙槽的包虫病是流行的区域的以前的研究选择。数据包括草高度,挖中间的主人的密度烘便的样品以及全球放系统(GPS ) 放的小哺乳动物,狗和狐狸,在 Shiqu 县从领域调查被收集,四川省,中国。烘便的样品用 copro-PCR 被分析。在烘便的样品的蠕虫,牙齿,骨头和头发视觉上被检验。包括 chi 平方和概括线性模型的单个因素和 multifactor 分析工具被把草高度用作在同质的牧场擦伤压力的一个代理用于这些 data.Results ,在导致的牧场发现那棵更高的草的这研究降低小哺乳动物的洞穴密度 X^2=A.67O , P=0.031 , coefficient=-1.570 )。在狗的包虫 multilocularis 蠕虫负担是显著地统计上与中介的最大的密度有关招待 Ochotona spp。(X^2=5.250, P=0.022, coefficient=0.028 ) 。在拥有的狗的流行断然被相关到在 200 米半径以内看见的迷路的狗的数字(Wald X^2=8.375, P=0.004,机会 ratio=1.198 ) 。结论我们的调查结果支持过度放牧支持的假设牙槽的包虫病的传播并且在牙槽的包虫病的传播证实迷路的狗的角色。 | WANG Qian Francis Raoul Christine Budke Philip S. Craig XIAO Yong-fu, Dominique A. Vuitton,Maiza Campos-Ponce, QIU Dong-chuan, David Pleydell and Patrick Giraudoux XIAO Yong-fu Dominique A. Vuitton Maiza Campos-Ponce QIU Dong-chuan David Pleydell Patrick Giraudoux | 2010 | Chinese Medical Journal2010，，1： | 12 |
| 5 | 包虫病手术患者1312例流行病学资料分析显示文摘目的了解青藏高原包虫病的分布特点。方法对1992-2006年的1312例包虫病手术患者的相关资料进行分析。结果囊型和泡型包虫病均有分布。患者主要集中于21~50岁,20岁以下的患者相对较少,以藏族为主。囊型包虫病分布于四川省甘孜州和阿坝州的17个县以及青海省果洛州的5个县,而泡型包虫病同时分布于其中的大部分地区。结论囊型和泡型包虫病同时流行于四川省的西北部和青海省的东南部。 | 仁真 李调英 廖万明 陈兴旺 赵晓东 肖宁 喻晓慧 张西春 Akira Ito 邱加闽 Patrick Giraudoux Philip S Craig | 2008 | 寄生虫病与感染性疾病2008，6，3： | 8 |
| 6 | 南瓜子-槟榔法治疗藏区疑似带绦虫病效果观察显示文摘目的通过采用南瓜子-槟榔法治疗四川省甘孜藏族自治州雅江县绦虫病患者,了解南瓜子-槟榔法的驱绦效果,为控制绦虫病/囊尾蚴病提供安全、有效的药物治疗。方法于2007-05/2009-11,在四川省雅江县7个乡镇18个村寨,对部分村民进行问卷调查,对近年内有排绦虫节片史且自愿接受治疗的患者采用南瓜子-槟榔法进行驱绦。对驱绦后获得的绦虫标本用mu ltip lex PCR作进一步虫种鉴定。结果共治疗175例,完成治疗后5h内共计112例排出绦虫,获虫率为64.0%。在排出虫体的112例中,83.0%(93例)排出全虫(可见头节),其余19例仅排出绦虫节片。药物常见不良反应是头昏和胃肠不适,排虫后均自行消失。结论南瓜子-槟榔法是安全、有效的治疗带绦虫病方法。 | 龙昌平 李调英 陈兴旺 肖宁 Akira Ito 谭勇 阿斗塔 Philip Simon Craig | 2010 | 寄生虫病与感染性疾病2010，8，4： | 6 |
| 7 | Priorities for research and control of cestode zoonoses in Asia显示文摘Globally,cestode zoonoses cause serious public health problems,particularly in Asia.Among all neglected zoonotic diseases,cestode zoonoses account for over 75%of global disability adjusted life years(DALYs)lost.An international symposium on cestode zoonoses research and control was held in Shanghai,China between 28th and 30th October 2012 in order to establish joint efforts to study and research effective approaches to control these zoonoses.It brought together 96 scientists from the Asian region and beyond to exchange ideas,report on progress,make a gap analysis,and distill prioritizing settings with a focus on the Asian region.Key objectives of this international symposium were to agree on solutions to accelerate progress towards decreasing transmission,and human mortality and morbidity caused by the three major cestode zoonoses(cystic echinococcosis,alveolar echinococcosis,and cysticercosis);to critically assess the potential to control these diseases;to establish a research and validation agenda on existing and new approaches;and to report on novel tools for the study and control of cestode zoonoses. | Ning Xiao Jia-Wen Yao Wei Ding Patrick Giraudoux Philip S Craig Akira Ito | 2013 | Infectious Diseases of Poverty2013，2，1： | 6 |
| 8 | Microbial communities biostimulated by ethanol during uranium (VI) bioremediation in contaminated sediment as shown by stable isotope probing显示文摘(啜) 稳定的同位素探查被用来识别乙醇增加在包含在 US 能源部橡树理兹地点从 bioremediation 测试地区收集的二沉积的缩影刺激的微生物, TN,美国。一件样品是高度有乙醇的 bioreduced 当另外一个少些被减少时。有各自的沉积的缩影与标记乙醇并且为啜为 7 孵化了天的 13C 被修改。乙醇很快在伴有硝酸盐和硫酸盐的减小的 24 h 以内被变换成醋酸盐。醋酸盐的累积在远处坚持了 7 d 时期。水的 U 没由于 U 的解吸附作用与减少的沉积在缩影衰退,但是连续地在少些减少的样品衰退。微生物引起的生长和伴随物 < 啜 class= “ a-plus-plus ” > 13 C-DNA 生产被检测乙醇是否是精疲力尽的,丰富的醋酸盐在两个缩影积累了。这在少些减少的样品与 U (VI ) 减小与一致。< 啜 class= “ a-plus-plus ” > 13 从乙醇发源的 C 最终为生长被利用,直接或间接地,由在 7 天孵化以内的主导的微生物引起的社区成员。微生物引起的社区由包括 Desulfovibrio, Sphingomonas, Ferribacterium, Rhodanobacter, Geothrix, Thiobacillus 和其它减少细菌的已知的 denitrifiers,减少硫酸盐的细菌和铁(III ) 主要组成,包括减少细菌 Acidovorax, Anaeromyxobacter, Desulfovibrio, Geobacter 和 Desulfosporosinus 的已知的 U (VI ) 。调查结果建议那乙醇 biostimulates 由首先为硝酸盐,硫酸盐,铁( III )和 U ( VI )用作一个电子施主减少微生物引起的社区的 U ( VI )减小,并且然后为微生物引起的生长为 U ( VI )减小和碳来源作为电子施主工作的醋酸盐。 | Mary Beth LEIGH Wei-Min WU Erick CARDENAS Ondrej UHLIK Sue CARROLL Terry GENTRY Terence L. MARSH Jizhong ZHOU Philip JARDINE Craig S. CRIDDLE James M. TIEDJE | 2015 | Frontiers of Environmental Science & Engineering2015，9，3： | 5 |
| 9 | 细粒棘球蚴抗原B酵母表达载体的克隆与序列分析(英文)显示文摘目的 获得重组细粒棘球蚴抗原 B(Eg B)的真核表达蛋白 ,构建 Eg B酵母表达重组体 ,并对构建的重组体进行序列分析。方法 以原核重组体 JM10 9- p Mal2 x Eg B作为模板 ,采用聚合酶链式反应 (PCR)扩增 Eg B片断。目的基因 Eg B片断插入酵母表达载体 p YES2 / NT B,再将酵母表达重组体转化 DH5 a菌 ,并对转化筛选的重组体进行序列分析。 结果 共筛选得到 16个重组克隆 ,其中 7个克隆证实为 Eg B正确序列 ,并与酵母表达载体的开放阅读框 (ORF)相一致。 结论 成功地将细粒棘球蚴抗原 B基因构建入酵母表达载体 p YES2 / NT B的开放阅读框。此重组体可在酵母中进一步表达特异性蛋白。 | 卢晓梅 张利华 张文宝 林仁勇 Philip Craig McManus Don 温浩 | 2003 | 中国寄生虫病防治杂志2003，16，3： | 4 |
| 10 | HLA-DRB1 allele in 35 patients with alveolar echinococcosis in Gansu Province of China显示文摘Objective To investigate the association between histocompatibility leukocyte antigen (HLA)-DRB1 alleles and alveolar echinococcosis (AE).Methods Thirty-five patients with AE in high prevalence areas in Gansu Province of China were tested for the HLA-DRB1 gene using the polymerase chain reaction with sequence-specific primer (PCR-SSP) technique. The results were compared with those of 104 healthy individuals.Results The frequency of the HLA-DRB1*040x gene was 26% in the patient group,which was significantly higher than that in the control group (9.62%) with a relative risk (RR) of 4.45 (χ 2 =13.67, P <0.01),and an etiological fraction (EF) of 0.20. The frequency of the HLA-DRB1 *0701 allele was significantly lower in the patient group (2.86%) as compared to the control group (13.94%; χ 2=6.67,P <0.05) with a preventable fraction (PF) of 0.30. The frequencies of other DRB1 alleles were not significantly different.Conclusion Susceptibility to AE is significantly associated with the HLA-DRB1*040x. HLA-DRB1 *0701 gene might confer protection against AE in humans. | 李富荣 石佑恩 史大中 Dominique Angele Vuitton Philip Simon Craig | 2003 | Chinese Medical Journal2003，，10： | 4 |
| 11 | A tandem colonoscopy study of adenoma miss rates during endoscopic training: a venture into uncharted territory显示文摘 | Craig A. Munroe Philip Lee Andrew Copland Kuan K. Wu Tonya Kaltenbach Roy M. Soetikno Shai Friedland | 2012 | Gastrointestinal Endoscopy2012，，3： | 3 |
| 12 | Echinococcus shiquicus n. sp., a taeniid cestode from Tibetan fox and plateau pika in China显示文摘 | Ning Xiao Jiamin Qiu Minoru Nakao Tiaoying Li Wen Yang Xingwang Chen Peter M. Schantz Philip S. Craig Akira Ito | 2005 | International Journal for Parasitology2005，，6： | 2 |
| 13 | 中国中部寄生虫病的景观控制(英文)显示文摘多房棘球绦虫(Echinococcus multilocularis)的幼虫期导致罕见而致命的肝病即人类的泡型包虫病(HAE)。绦虫在狐狸(或狗类)与一些小型哺乳类动物之间以寄生虫-寄主的方式进行循环传播。中国中部一些地区的人类泡型包虫病属于地方流行病,在部分乡村的发生概率达到15%。本文研究如何利用遥感数据并基于地区景观特性获取该流行病清晰地空间危害分布图。遥感数据分析的结果显示,人类居住地附近的草地或灌木是HAE传播的一个主要危险区域,从空间分布上看,这些区域是小型哺乳动物等中间寄主的聚集处。 | F. Mark Danson Patrick Giraudoux David Pleydell Philip S. Craig | 2007 | 遥感学报2007，11，5： | 2 |
| 14 | Molecular identification of Echinococcus species from eastern and southern Qinghai, China, based on the mitochondrial cox1 gene显示文摘 | Junying Ma Hu Wang Gonghua Lin Philip S. Craig Akira Ito Zhenyuan Cai Tongzuo Zhang Xiumin Han Xiao Ma Jingxiao Zhang Yufang Liu Yanmei Zhao Yongshun Wang | 2012 | Parasitology Research2012，，1： | 2 |
| 15 | Echinococcus shiquicus n. sp., a taeniid cestode from Tibetan fox and plateau pika in China显示文摘 | Ning Xiao Jiamin Qiu Minoru Nakao Tiaoying Li Wen Yang Xingwang Chen Peter M. Schantz Philip S. Craig Akira Ito | 2005 | International Journal for Parasitology2005，，6： | 2 |
| 16 | Wisconsin Ginseng (Panax quinquefolius) to Improve Cancer-Related Fatigue: A Randomized, Double-Blind Trial, N07C2显示文摘 | Debra L. Barton Heshan Liu Shaker R. Dakhil Breanna Linquist Jeff A. Sloan Craig R. Nichols Travis W. McGinn Philip J. Stella Grant R. Seeger Amit Sood Charles L. Loprinzi | 2013 | JNCI Journal of the National Cancer Institute2013，，16： | 1 |
| 17 | Epidemiology of human alveolar echinococcosis in China显示文摘 | Philip S. Craig | 2005 | Parasitology International2005，，： | 1 |
| 18 | Effect of nutritional interventions and resistance exercise on aging muscle mass and strength显示文摘 | Darren Candow Scott Forbes Jonathan Little Stephen Cornish Craig Pinkoski Philip Chilibeck | 2012 | Biogerontology2012，，4： | 1 |
| 19 | A tandem colonoscopy study of adenoma miss rates during endoscopic training: a venture into uncharted territory显示文摘 | Craig A. Munroe Philip Lee Andrew Copland Kuan K. Wu Tonya Kaltenbach Roy M. Soetikno Shai Friedland | 2012 | Gastrointestinal Endoscopy2012，，3： | 1 |
| 20 | Modeling in-situ uranium(VI) bioreduction by sulfate-reducing bacteria显示文摘 | Jian Luo Frank-Andreas Weber Olaf A. Cirpka Wei-Min Wu Jennifer L. Nyman Jack Carley Philip M. Jardine Craig S. Criddle Peter K. Kitanidis | 2007 | Journal of Contaminant Hydrology2007，，1： | 1 |
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