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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | 反流性食管炎中埃索美拉唑比奥美拉唑更能促进病变愈合和症状缓解显示文摘 | Kahrilas PJ Falk GW Johnson DA Schmitt C Collins DW Whipple J D’Amino D Hamelin B Joelsson B 钟捷 | 2002 | 中华消化杂志2002，22，11： | 19 |
| 3 | 脂质组学改善传统危险因素预测的2型糖尿病患者的心血管事件显示文摘临床脂质测定并未显示出糖尿病或心血管病相关的脂质代谢改变的复杂性。脂质组学则能够评估可作为疾病风险潜在标志物的数百种脂质种类。方法:纳入来自糖尿病治疗和血管保护行动。 | 刘莉 叶鹏 Alshehry ZH Mundra PA Barlow CK Mellett NA Wong G McConville MJ Simes J Tonkin AM Sullivan DR Barnes EH Nestel PJ Kingwell BA Marre M Neal B Poulter NR Rodgers A Williams B Zoungas S Hillis GS Chalmers J Woodward M Meikle PJ | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 4 | Laryngeal and oropharyngeal cancer, and alcohol dehydrogenase 3 and glutathione S-transferase M1 polymorphisms显示文摘 | Coutelle C Ward PJ Fleury B Quattrocchi P Chambrin H Iron A | 1997 | Hum Genet1997，99，3： | 3 |
| 5 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 6 | Mechanisms underlying nonsteroidal anti inflammatory drug-mediated apoptosis显示文摘 | Chan TA Morin PJ Vogelstein B | | 0，，： | 2 |
| 7 | Leptin inhibits insulin secretion induced by cellular cAMP in a pancreatic B cell line ( INS - 1 cell) 显示文摘 | Ahren B Havel PJ | 1999 | AM J Physiol1999，277，42： | 1 |
| 8 | Down-regulation of cell surface CXCR4 by HIV-1 显示文摘 | Choi B Gatti PJ Fermin CD | 2008 | Virol J2008，5，： | 1 |
| 9 | Cryotherapy for breast cancer:a feasibility study without excision显示文摘 | Littrup PJ Jallad B Chandiwala PM | 2009 | J Vasc Interv Radiol2009，20，： | 1 |
| 10 | Mutational analysis of the APC/β-catenin/TCF pathway in colorectal cancer显示文摘 | Sparks AB Morin PJ Vogestein B | 1998 | Cancer Res1998，58，： | 1 |
| 11 | Prevalence of age, genderand body weight on the frequency of hypertension and diabetes mel-litus in patients hospitalized in cardiology department 显示文摘 | Stryjewski PJ Janu A B Krupa E | 2011 | PrzeglLek2011，68，9： | 1 |
| 12 | Apolipoprotein A-I and B levels and the risk of ischemic heart disease during a five-year follow-up of men in the Quebec Cardiovascular Study显示文摘 | Lamarche B Moorjani S Lupien PJ | 1996 | Circulation1996，94，3： | 1 |
| 13 | Where have all the Helicobacter gone? Etiologic factors in patients with duodenal ulcers presenting to a University Hospital显示文摘 | Gislason GT Emu B Okolo Ⅲ P Pasricha PJ Kalloo AM | | 0，，： | 1 |
| 14 | Massive genomic re- arrangement acquired in a single catastrophic event during cancer development显示文摘 | Stephens PJ Greenman CD Fu B | 2011 | Cell2011，144，1： | 1 |
| 15 | Obstructive sleep apnea therapy显示文摘 | H~kema A Stegenga B Wijkstra PJ | 2008 | J Dent Res2008，87，9： | 1 |
| 16 | Effect of air pollutants on the pulmonary surfactant system 显示文摘 | Muller B Seifart C Barth PJ | 1998 | European Journal of Clinical Investigation1998，28，9： | 1 |
| 17 | Survey of Patients' Knowledge of Nosocomial Infections显示文摘 | Miller PJ Farr B M | 1989 | Am J Infect Control1989，17，1： | 1 |
| 18 | Organic anion transporting polypeptides of the OATPPSLC21 family : phylogenetic classificationas OATP/ SLCO superfamily, new nomenclature and molecular/functional properties显示文摘 | FIagenbuch B Meier PJ | 2004 | Pflugers Arch2004，447，5： | 1 |
| 19 | Measles virus exploits den-dritic cells to suppress CD4+T-cell proliferation via expression ofsurface viral lycoproteins independently of T-cell trans-infection显示文摘 | Dubois B Lamy PJ Chemin K | 2001 | Cell Immunol2001，214，2： | 1 |
| 20 | Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching显示文摘 | Adams EL Rice PJ Graves B | 2008 | J Pharmacol Exp Ther2008，325，： | 1 |
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