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| 1 | Current global trends in the incidence of pediatric-onset inflammatory bowel disease显示文摘AIM To perform a comprehensive review and provide an up-to-date synopsis of the incidence and trends of inflammatory bowel disease(IBD). METHODS We systematically searched the MEDLINE(source Pub Med), EMBASE and Cochrane Library databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines(period: 1985-2018) to identify studies reporting population-based data on the incidence of pediatriconset(< 19 years at diagnosis) IBD in full manuscripts. Two authors carried out screening and data extraction. Choropleth interactive maps and temporal trends were used to illustrate the international differences and incidences of and changes in IBD and subtypes.RESULTS In total, one hundred forty studies reporting data from 38 countries were considered in this review. The highest annual pediatric incidences of IBD were 23/100000 person-years in Europe, 15.2/100000 in North America, and 11.4/100000 in Asia/the Middle East and Oceania. The highest annual incidences of Crohn's disease(CD) were 13.9/100000 in North America and 12.3/100000 in Europe. The highest annual incidences of ulcerative colitis(UC) were 15.0/100000 in Europe and 10.6/100000 in North America. The highest annual incidences of IBD-unclassified(IBD-U) were 3.6/100000 in Europe and 2.1/100000 in North America. In the time-trend analyses, 67% of CD, 46% of UC and 11% of IBD-U studies reported an increasing incidence(P < 0.05). The risk of IBD is increasing among firstgeneration of migrant populations.CONCLUSION Globally, the incidence of IBD varies greatly by geographical areas. The steadily increasing incidence of pediatric IBD over time indicates its emergence as a global disease, suggesting that studies should investigate the environmental risk factors among pediatric cohorts. | Josef Sykora Renta Pomahacov Marcela Kreslová Dominika Cvalínová Premysl Stych Jan Schwarz | 2018 | World Journal of Gastroenterology2018，24，25： | 27 |
| 2 | Colorectal cancer screening:20 years of development and recent progress显示文摘Colorectal cancer(CRC)is the second most common cancer in Europe and its incidence is steadily increasing.This trend could be reversed through timely secondary prevention(screening).In the last twenty years,CRC screening programs across Europe have experienced considerable improvements(fecal occult blood testing;transition from opportunistic to population based program settings).The Czech Republic is a typical example of a country with a long history of nationwide CRC screening programs in the face of very high CRC incidence and mortality rates.Each year,approximately 8000 people are diagnosed with CRC and some 4000 die from this malignancy.Twenty years ago,the first pilot studies on CRC screening led to the introduction of the opportunistic Czech National Colorectal Cancer Screening Program in 2000.Originally,this program was based on the guaiac fecal occult blood test(FOBT)offered by general practitioners,followed by colonoscopy in cases of FOBT positivity.The program has continuously evolved,namely with the implementation of immunochemical FOBTs and screening colonoscopy,as well as the involvement of gynecologists.Since the establishment of the Czech CRC Screening Registry in 2006,2405850 FOBTs have been performed and 104565 preventive colonoscopies recorded within the screening program.The overall program expanded to cover 25.0%of the target population by 2011.However,stagnation in the annual number of performed FOBTs lately has led to switching to the option of a population-based program with personal invitation,which is currently being prepared. | Miroslav Zavoral Stepan Suchanek Ondrej Majek Premysl Fric Petra Minarikova Marek Minarik Bohumil Seifert Ladislav Dusek | 2014 | World Journal of Gastroenterology2014，20，14： | 16 |
| 3 | Plant Phosphatidylcholine-Hydrolyzing Phospholipases C NPC3 and NPC4 with Roles in Root Development and Brassinolide Signaling in Arabidopsis thaliana显示文摘水解 Phosphatidylcholine phospholipase C (PC-PLC ) 催化 phosphatidylcholine (PC ) 的水解作用产生 phosphocholine 和 diacylglycerol (DAG ) 。PC-PLC 有在动物信号 transduction 的长传统除切开 phospholipase C (PI-PLC ) 的古典 phosphatidylinositol 以外作为第二个送信人产生 DAG。基于氨基酸顺序类似到细菌的 PC-PLC,六通常认为的 PC-PLC 基因(到 NPC6 的 NPC1 ) 在 Arabidopsis 染色体被识别。RTPCR 分析在根,茎,叶,花,和 silique 揭示了 NPC 基因的重叠表示模式。在对待植物生长素的 PNPC3 : GUS 和 PNPC4 : GUS 幼苗, GUS 活动的猛烈增加在根,叶子,和射击并且,是可见的到更弱的程度,在里面对待 brassinolide (BL ) 幼苗。PNPC4 : GUS 幼苗也在年轻叶子与增加的 GUS 活动对细胞激动素作出回应。比作野类型, T-DNA insertional 大美人 npc3 和 npc4 在低 BL 集中显示出更短的主要的根和更低的侧面的根密度,但是增加了侧面的根密度响应外长 0.051.0 ? M BL。TCH4 和 LRX2 的导致 BL 的表示,涉及房间扩大,在 CPD 的压抑被损害然而并非损害, BL 生合成基因,在对待 BL 的 npc3 和 npc4。这些观察建议 NPC3 和 NPC4 在在根生长的调停 BL 的发信号是重要的。当与 0.1 对待时 ? M BL, DAG 累积在用标记的烟草 BY-2 房间文化被观察荧光灯象 15 一样早的 PC ? 在申请以后的 min。我们假设那至少一 PC-PLC 是在 BL 信号 transduction 表明酶的植物并且更早出现在 elicitor 信号 transduction。 | Rinukshi Wimalasekera Premysl Pejchar Andre Holka Jan Martinec Gunther RE. Scherer | 2010 | Molecular Plant2010，3，3： | 13 |
| 4 | Colorectal cancer screening in Europe显示文摘Colorectal cancer(CRC)is the second most frequent malignant disease in Europe.Every year,412 000people are diagnosed with this condition,and 207 000patients die of it.In 2003,recommendations forscreening programs were issued by the Council of the European Union(EU),and these currently serve as thebasis for the preparation of European guidelines forCRC screening.The manner in which CRC screening iscarried out varies significantly from country to countrywithin the EU,both in terms of organization and thescreening test chosen.A screening program of onesort or another has been implemented in 19 of 27 EUcountries.The most frequently applied method is testing stool for occult bleeding(fecal occult blood test,FOBT).In recent years,a screening colonoscopy hasbeen introduced,either as the only method(Poland)orthe method of choice(Germany,Czech Republic). | Miroslav Zavoral Stepan Suchanek Filip Zavada Ladislav Dusek Jan Muzik Bohumil Seifert Premysl Fric | 2009 | World Journal of Gastroenterology2009，15，47： | 8 |
| 5 | The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice显示文摘 | Premysl Bercik Emmanuel Denou Josh Collins Wendy Jackson Jun Lu Jennifer Jury Yikang Deng Patricia Blennerhassett Joseph Macri Kathy D. McCoy Elena F. Verdu Stephen M. Collins | 2011 | Gastroenterology2011，，2： | 2 |
| 6 | Evidence to suggest adoption of water exchange deservesbroader consideration:Its pain alleviating impact occurs in90%of investigators显示文摘AIM: To determine variations in colonoscopy real-time insertion pain among investigators using three different insertion techniques.METHODS: From March 2013 through June 2014, 18-85-year-old diagnostic and 50-70-year-old screening patients were enrolled at each center to on-demand sedation colonoscopy with water exchange(WE), water immersion(WI) and insufflation with air or CO2 for insertion and withdrawal [air or carbon dioxide(AICD)]. Data were aggregated for analysis. Primary outcome: Variations in real-time maximum insertion pain(0 = none, 1-2 = discomfort, 10 = worst).RESULTS: One thousand and ninety-one cases analyzed: WE(n = 371); WI(n = 338); AICD(n = 382). Demographics and indications were comparable. The WE group had the lowest real-time maximum insertion pain score, mean(95%CI): WE 2.8(2.6-3.0), WI 3.8(3.5-4.1) and AICD 4.4(4.1-4.7), P < 0.0005. Ninety percent of the colonoscopists were able to use water exchange to significantly decrease maximum insertion pain scores. One investigator had high insertion pain in all groups, nonetheless WE achieved the lowest real-time maximum insertion pain score. WE had the highest proportions of patients with painless unsedated colonoscopy(vs WI, P = 0.013; vs AICD, P < 0.0005); unsedated colonoscopy with only minor discomfort(vs AICD, P < 0.0005), and completion without sedation(vs AICD, P < 0.0005).CONCLUSION: Aggregate data confirm superiority of WE in lowering colonoscopy real-time maximum insertion pain and need for sedation. Ninety percent of investigators were able to use water exchange to significantly decrease maximum insertion pain scores. Our results suggest that the technique deserves consideration in a broader scale. | Sergio Cadoni Mauro Liggi Premysl Falt Stefano Sanna Mariangela Argiolas Viviana Fanari Paolo Gallittu Donatella Mura Maria L Porcedda Vit Smajstrla Matteo Erriu Felix W Leung | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 2 |
| 7 | Proton Pump Inhibitors Exacerbate NSAID-Induced Small Intestinal Injury by Inducing Dysbiosis显示文摘 | John L. Wallace Stephanie Syer Emmanuel Denou Giada de Palma Linda Vong Webb McKnight Jennifer Jury Manlio Bolla Premysl Bercik Stephen M. Collins Elena Verdu Ennio Ongini | 2011 | Gastroenterology2011，，： | 2 |
| 8 | A Case Study of Modelling Concave Globoidal Cam 显示文摘 | NGUYEN Van Tuong PREMYSL Pokorny | 2009 | International Journal of Computer Intergrated Manufacturing2009，22，10： | 1 |
| 9 | Nanoparticle-specific changes in Arabidopsis thaliana gene expression after exposure to ZnO, TiO 2 , and fullerene soot显示文摘 | Premysl Landa Radomira Vankova Jana Andrlova Jan Hodek Petr Marsik Helena Storchova Jason C. White Tomas Vanek | 2012 | Journal of Hazardous Materials2012，，： | 1 |
| 10 | Chronic Gastrointestinal Inflammation Induces Anxiety-Like Behavior and Alters Central Nervous System Biochemistry in Mice显示文摘 | Premysl Bercik Elena F. Verdu Jane A. Foster Joseph Macri Murray Potter Xiaxing Huang Paul Malinowski Wendy Jackson Patricia Blennerhassett Karen A. Neufeld Jun Lu Waliul I. Khan Irene Corthesy–Theulaz Christine Cherbut Gabriela E. Bergonzelli Stephen M. | 2010 | Gastroenterology2010，，6： | 1 |
| 11 | Lactobacillus paracasei normalizes muscle hypercontractility in a murine model of postinfective gut dysfunction显示文摘 | Elena FV Premysl B Gabriela EB | 2004 | Gastroenterology2004，127，3： | 1 |
| 12 | Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gut dysfunction 显示文摘 | Premysl B Lu W Elena FV | 2004 | Gastroenterology2004，127，1： | 1 |
| 13 | Unusual and very long-chain fatty acid produced by basidimycetes 显示文摘 | Tomas R Premysl M | 1987 | J Chromatogr1987，409，： | 1 |
| 14 | The adoptive transfer of behavioral phenotype via the intestinal microbiota: experimental evidence and clinical implications显示文摘 | Stephen M Collins Zain Kassam Premysl Bercik | 2013 | Current Opinion in Microbiology2013，，： | 1 |
| 15 | The Rome III Criteria for the Diagnosis of Functional Dyspepsia in Secondary Care Are Not Superior to Previous Definitions显示文摘 | Alexander C. Ford Premysl Bercik David G. Morgan Carolina Bolino Maria Ines Pintos–Sanchez Paul Moayyedi | 2014 | Gastroenterology2014，，4： | 1 |
| 16 | Sulvanite in the quartz-carbonate veins of the Pai-Khoi range显示文摘 | Smirnov F L Premysler K M | 1967 | Zapiski Vsesoyuznogo Mineralogicheskogo Obshehestva (Proceedings of the All-Union Mineralogical Society)1967，96，1： | 1 |
| 17 | In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E2 biosynthesisb显示文摘 | Premysl Landa Ladislav Kokoska Marie Pribylova Tomas Vanek Petr Marsik | 2009 | Archives of Pharmacal Research2009，，1： | 1 |
| 18 | Interstitial Cells of Cajal and Inflammation-Induced Motor Dysfunction in the Mouse Small Intestine显示文摘 | Tara Der Premysl Bercik Graeme Donnelly Tim Jackson Irene Berezin Stephen M. Collins Jan D. Huizinga | 2000 | Gastroenterology2000，，6： | 1 |
| 19 | Motor correlates of models of secondary bilateral synchrony and multiple epileptic foci 显示文摘 | Premysl J Jan P Jakub O | 2007 | Seizure2007，16，7： | 1 |
| 20 | High- Frequency Oscillations as a New Biomarker in Epilepsy显示文摘 | Maeike ZijImans Premysl Jimska Rina Zelinarm | 2012 | Ann Neurol2012，71，： | 1 |
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