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| 1 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 2 | Characterization of humic substances in bio-treated municipal solid waste landfill leachate显示文摘 | Guangxia QI Dongbei YUE Yongfeng NIE | 2012 | Frontiers of Environmental Science & Engineering2012，6，5： | 6 |
| 3 | Genome-Wide Identification of Zn_(2)Cys_(6 ) Class Fungal-Specific Transcription Factors(ZnFTFs)and Functional Analysis of UvZnFTFI in Ustilaginoidea virens显示文摘Transcription factors(TFs)orchestrate the regulation of cellular gene expression and thereby determine cell functionality.In this study,we analyzed the distribution of TFs containing domains,which named as ZnFTFs,both in ascomycete and basidiomycete fungi.We found that ZnFTFs were widely distributed in these fungal species,but there was more expansion of the ZnFTF class in Ascomycota than Basidiomycota.We identified 40 ZnFTFs in Ustilaginoidea virens,and demonstrated the involvement of UvZnFTF1 in vegetative growth,conidiation,pigment biosynthesis and pathogenicity.RNA-Seq analysis suggested that UvZnFTF1 may regulate different nutrient metabolism pathways,the production of secondary metabolites,and the expression of pathogen-host interaction genes and secreted protein-encodi ng genes.Analysis of the distributi on of differe nt fungal TFs in U.virens further dem on strated that UvZnFTFs make up a large TF family and may play essential biological roles in U.virens. | SONG Tianqiao ZHANG Xiong ZHANG You LIANG Dong YAN Jiaoling YU Junjie YU Mina CAO Huijuan YONG Mingli PAN Xiayan QI Zhongqiang DU Yan ZHANG Rongsheng LIU Yongfeng | 2021 | Rice science2021，28，6： | 4 |
| 4 | Enabling Efficient Batch Updating Verification for Multi-versioned Data in Cloud Storage显示文摘Existing dynamic data possession verification schemes not only suffer from low efficiency of rebalancing its Merkle Hash tree(MHT) when executing data updating, but also lack effective mechanism to verify multi-version files. Aiming at these problems, this paper propose a new data structure called Rank-based multi-version Merkle AVL tree(RBMV-MAT) to achieve efficient batch updating verification for multi-version data.RBMV-MAT uses a special lock and relaxed balance to decrease the frequency of rebalacing operations. The experimental results show that our efficient scheme has better efficiency than those of existing methods. | QI Yining TANG Xin HUANG Yongfeng | 2019 | Chinese Journal of Electronics2019，28，2： | 3 |
| 5 | Observations of upper layer turbulent mixing in the southern South China Sea显示文摘A turbulent microstructure experiment was undertaken at a low latitude of 10°N in the South China Sea in late August 2012. The characteristics of the eddy diffusivity above 650 m were analyzed, which is one order of magnitude larger than that in the open ocean at that low latitude. Enhanced eddy diffusivities by strong shears and sharp changes in topography were observed. The strongest eddy diffusivity occurred in the mixed layer, and it reached O(10–2 m2/s). Strong stratification in the thermocline inhibited the penetration of surface eddy diffusivities through the thermocline, where the mixing was weakest. Below the thermocline, where the background eddy diffusivity was approximately O(10–6 m2/s), the eddy diffusivity increased with depth, and its largest value was O(10–3 m2/s). | SHANG Xiaodong QI Yongfeng CHEN Guiying LIANG Changrong | 2015 | Acta Oceanologica Sinica2015，34，11： | 3 |
| 6 | Performance of common buckwheat(Fagopyrum esculentum M.) supplied with selenite or selenate for selenium biofortification in northeastern China显示文摘Selenium(Se)deficiency commonly occurs in soils of northeastern China and leads to insufficient Se intake by humans.A two-year field study of Se biofortification of common buckwheat supplied with 40 g Se ha^(-1)as selenite(Se(IV)),selenate(Se(VI)),or a combination(1/2 Se(IV+VI))was performed to investigate Se accumulation and translocation in plants and determine the effects of different forms of Se on the grain yield,biomass production,and Se use efficiency of plants and seeds.Se application increased seed Se concentrations to 47.1–265.1μg kg^(-1).Seed Se concentrations following Se(VI)or 1/2 Se(IV+VI)treatment exceeded 100μg kg^(-1),an amount suitable for crop Se biofortification.Se concentration in shoots and roots decreased with plant development,and Se translocation from root to shoot in Se(IV)-treated plants was lower than that in plants treated with 1/2 Se(IV+VI)and Se(VI).Both grain yield and biomass production increased under 1/2 Se(IV+VI)treatment,with grain yields reaching 1663.8 and 1558.5 kg ha^(-1)in 2015 and 2016,respectively,reflecting increases of 11.0% and 10.3% over those without Se application.The Se use efficiency of seeds and plants under Se(VI)treatment was significantly higher than those under 1/2 Se(IV+VI)and Se(IV)treatments.Thus,application of selenate could result in higher Se accumulation in buckwheat seeds than application of the other Se sources,but the combined application of selenate and selenite might be an alternative approach for improving buckwheat grain yield by Se biofortification in northeastern China. | Ying Jiang Xiaomin Feng Yadong Yang Xiangxue Qi Yongfeng Ren Youhui Gao Weidong Liu Yuegao Hu Zhaohai Zeng | 2018 | The Crop Journal2018，6，4： | 3 |
| 7 | Spatial structure of turbulent mixing of an anticyclonic mesoscale eddy in the northern South China Sea显示文摘Upper turbulent mixing in the interior and surrounding areas of an anticyclonic eddy in the northern South China Sea(SCS)was estimated from underwater glider data(May 2015)in the present study,using the Gregg-HenyeyPolzin parameterization and the Thorpe-scale method.The observations revealed a clear asymmetrical spatial pattern of turbulent mixing in the anticyclonic eddy area.Enhanced diffusivity(in the order of 10–3 m2/s)was found at the posterior edge of the anticyclonic mesoscale eddy;on the anterior side,diffusivity was one order of magnitude lower on average.This asymmetrical pattern was highly correlated with the eddy kinetic energy.Higher shear variance on the posterior side,which is conducive to the triggering of shear instability,may be the main mechanism for the elevated diffusivity.In addition,the generation and growth of sub-mesoscale motions that are fed by mesoscale eddies on their posterior side may also promote the occurrence of strong mixing in the studied region.The results of this study help improve our knowledge regarding turbulent mixing in the northern SCS. | Yongfeng Qi Chenjing Shang Huabin Mao Chunhua Qiu Changrong Liang Linghui Yu Jiancheng Yu Xiaodong Shang | 2020 | Acta Oceanologica Sinica2020，39，11： | 2 |
| 8 | DIRA: Enabling decentralized data integrity and reputation audit via blockchain显示文摘Nowadays more data are being generated than ever before and cloud computing has undoubtedly become one of the most important platforms for dealing with their huge demand.However,there are still a series of concerns that obstructs the migration to clouds,such as security,cost control or data sovereignty. | QI YiNing HUANG YongFeng | 2019 | Science China(Technological Sciences)2019，62，4： | 2 |
| 9 | (2D) 2 PCALDA: An efficient approach for faee reeognition显示文摘 | QI YONGFENG ZHANG JIASHU | 2009 | Applied Mathematics and Computation2009，213，1： | 1 |
| 10 | Distinct lung microbial community states in patients with pulmonary tuberculosis显示文摘An improved understanding of the lung microbiome may lead to better strategies to diagnose, treat, and prevent pulmonary tuberculosis (PTB). However, the characteristics of the lung microbiomes of patients with TB remain largely undefined. In this study, 163 bronchoalveolar lavage (BAL) samples were collected from 163 sputum-negative suspected PTB patients. Furthermore, 12 paired BAL samples were obtained from 12 Mycobacterium tuberculosis-positive (MTB+) patients before and after negative conversion following a two-month anti-TB treatment. The V3–V4 region of the 16S ribosomal RNA (rRNA) gene was used to characterize the microbial composition of the lungs. The results showed that the prevalence of MTB in the BAL samples was 42.9% (70/163) among the sputum-negative patients. The α-diversity of lung microbiota was significantly less diverse in MTB+ patients compared with Mycobacterium tuberculosis-negative (MTB–) patients. There was a significant difference in β-diversity between MTB+ and MTB– patients. MTB+ patients were enriched with Anoxybacillus, while MTB– patients were enriched with Prevotella, Alloprevotella, Veillonella, and Gemella. There was no significant difference between the Anoxybacillus detection rates of MTB+ and MTB– patients. The paired comparison between the BAL samples from MTB+ patients and their negative conversion showed that BAL negative-conversion microbiota had a higher α-diversity. In conclusion, distinct features of airway microbiota could be identified between samples from patients with and without MTB. Our results imply links between lung microbiota and different clinical groups of active PTB. | Yongfeng Hu Ying Kang Xi Liu Min Cheng Jie Dong Lilian Sun Yafang Zhu Xianwen Ren Qianting Yang Xinchun Chen Qi Jin Fan Yang | 2020 | Science China(Life Sciences)2020，63，10： | 1 |
| 11 | A facile preparation of hausmannite as a high-performance catalyst for toluene combustion显示文摘Mesoporous transition metal oxide catalysts are well-used in the elimination of volatile organic compounds.In this study,we developed an efficient method for the preparation of mesoporous-Mn_(3)O_(4)(mMn_(3)O_(4))without the use of templates or surfactants.In this method,KCl protects oxygen defects on the surface of fresh Mn_(3)O_(4) crystallites.m-Mn_(3)O_(4) shows higher ameliorative catalytic activity than bulk-Mn_(3)O_(4)(b-Mn_(3)O_(4)) and calcined-Mn_(3)O_(4)(c-Mn_(3)O_(4)),achieving toluene catalytic oxidation of T_(10) and T_(90)(the temperature at a conversion rate of about 10%and 90%)at 191℃and 230℃,respectively(WHSV=40,000 ml·g^(-1)·h^(-1)).Based on various characterizations,the prepared m-Mn_(3)O_(4)has large specific surface area and abundant oxygen defects,and thus can provide more surface active sites,which give it superior toluene combustion activity. | Qi Liu Gao Cheng Ming Sun Weixiong Yu Xiaohong Zeng Shichang Tang Yongfeng li Lin Yu | 2022 | Chinese Journal of Chemical Engineering2022，35，4： | 1 |
| 12 | Spin-selective corner reflector for retro-reflection and absorption by a circular dichroitic manner显示文摘Recently, we have witnessed an extraordinary spurt in attention toward manipulating electromagnetic waves by metasurfaces. Particularly, tailoring of circular polarization has attracted great amounts of interest in both microwave and optics regimes. Circular dichroism, an exotic chiroptical effect of natural molecules, has aroused discussion about this issue, yet it is still in its infancy. Herein, we initiate circular dichroism followed by controlling spin-selective wavefronts via chiral metasurfaces. An N-shaped chiral resonator loaded with two lumped resistors is proposed as the meta-atom producing an adequate phase gradient. Assisted by the ohmic dissipation of the introduced resistors, the effect of differential absorption provides an auxiliary degree of freedom for developing circularly polarized waves with a designated spin state. A planar corner reflector that can achieve retro-reflection and absorption for right-and left-handed circularly polarized incidence is theoretically simulated and experimentally observed at microwave frequency. Thus, our effort provides an alternative approach to tailoring electromagnetic waves in a circular dichroitic manner and may also find applications in multi-functional systems in optics and microwave regimes. | HE WANG YAO JING YONGFENG LI LINGLING HUANG MAOCHANG FENG QI YUAN JIAFU WANG JIEQIU ZHANG SHAOBO QU | 2021 | Photonics Research2021，9，5： | 1 |
| 13 | Variations of mesoscale eddy SST fronts based on an automatic detection method in the northern South China Sea显示文摘SST fronts at the mesoscale eddy edge(ME fronts)were investigated from 2007–2017 in the northern South China Sea(NSCS)based on an automatic method using satellite sea level anomaly(SLA)and SST data.The relative probabilities between the number of anticyclonic/cyclonic ME fronts(AEF/CEF)and the number of anticyclones/cyclones reached 20%.The northeastern and southwestern parts of these anticyclones had more fronts than the northwestern and southeastern parts,although CEFs were nearly equally distributed in all directions.The number of ME fronts had remarkable seasonal variations,while the eddy kinetic energy(EKE)showed no seasonal variations.The total EKE at the ME fronts was three times of that within the MEs,and it was much stronger in AEFs than in CEFs.The interannual variability in the number of ME fronts and EKE had no significant correlation with the El Ni?o-Southern Oscillation(ENSO)index.Possible mechanisms of ME fronts were discussed,but the contributions of mesoscale eddies to SST fronts need to be quantified in future studies. | Chunhua Qiu Juan Ouyang Jiancheng Yu Huabin Mao Yongfeng Qi Jiaxue Wu Danyi Su | 2020 | Acta Oceanologica Sinica2020，39，11： | 1 |
| 14 | Shape memory alloy-based 3D morphologically reconfigurable chiral metamaterial for tailoring circular dichroism by voltage control显示文摘Three-dimensional chiral materials with intrinsic chirality play a crucial role in achieving a strong chiral response and flexible light manipulation.Reconfigurable chirality through the 3D morphological transformation of chiral materials is significant for greater freedom in tailoring light but remains a challenge.Inspired by the unique 3D morphological memory capability of shape memory alloys(SMAs),we demonstrate and discuss a chiral resonator in the microwave regime that can realize reconfigurable chirality through 3D morphological transformation.The introduction of heating film realizes voltage control of SMA’s morphology for utilizing the temperature sensitivity of SMA better,enabling arbitrary control of circular dichroism(CD)flip and CD intensity.The qualitative and quantitative analysis of the surface current distribution of chiral enantiomers reveals that the chirality of metaatoms originates from the surge of electric dipole pxand electric quadrupole Q.It is worth mentioning that the proposed strategy to achieve reconfigurable chirality using 3D morphological transformations can be directly extended to other higher frequencies,such as visible,infrared,and terahertz bands.Significantly,our paradigm to study the relationship between complex 3D morphology and chirality holds potential for application in biosensing,spin detection,and spin-selective devices. | LIXIN JIANG QI YUAN HAO YANG YONGFENG LI LIN ZHENG ZHIBIAO ZHU SHUANG LIANG YONGQIANG PANG HE WANG JIAFU WANG SHAOBO QU | 2023 | Photonics Research2023，11，3： | 0 |
| 15 | MCMOD:The Multi-Category Large-Scale Dataset for Maritime Object Detection显示文摘The marine environment is becoming increasingly complex due tothe various marine vehicles,and the diversity of maritime objects poses a challengeto marine environmental governance.Maritime object detection technologyplays an important role in this segment.In the field of computer vision,there is no sufficiently comprehensive public dataset for maritime objects inthe contrast to the automotive application domain.The existing maritimedatasets either have no bounding boxes(which are made for object classification)or cover limited varieties of maritime objects.To fulfil the vacancy,this paper proposed the Multi-Category Large-Scale Dataset for MaritimeObject Detection(MCMOD)which is collected by 3 onshore video camerasthat capture data under various environmental conditions such as fog,rain,evening,etc.The whole dataset consists of 16,166 labelled images alongwith 98,590 maritime objects which are classified into 10 classes.Comparedwith the existing maritime datasets,MCMOD contains a relatively balancedquantity of objects of different sizes(in the view).To evaluate MCMOD,this paper applied several state-of-the-art object detection approaches fromcomputer vision research on it and compared their performances.Moreover,a comparison between MCMOD and an existing maritime dataset was conducted.Experimental results indicate that the proposed dataset classifies moretypes of maritime objects and covers more small-scale objects,which canfacilitate the trained detectors to recognize more types of maritime objects anddetect maritime objects over a relatively long distance.The obtained resultsalso showthat the adopted approaches need to be further improved to enhancetheir capabilities in the maritime domain. | Zihao Sun Xiao Hu Yining Qi Yongfeng Huang Songbin Li | 2023 | Computers, Materials & Continua2023，，4： | 0 |
| 16 | Application of Trigonometric Spline Wavelets in ECG Detection显示文摘 | GUO Qi WANG Kuanquan YUAN Yongfeng YANG Yongtian | 2009 | Chinese Journal of Electronics2009，18，1： | 0 |
| 17 | PHOTOIONIZATION AND TUNABLE LASER OF COLOR CENTERS IN KMgF_(3)显示文摘The density of 570nm centers in KMgF_(3) crystals colored by electron beam bombardment at 200K could be increased by irradiating the crystals with 337nm,400nm,and 445nm lasers at room temperature or 200K,respectively.The near infrared laser operation using 570nm centers in KMgF_(3) crystals was realized at room temperature.The tunable range of the laser is from 720nm to 820nm. | GU Hongen QI Lan RUAN Yongfeng | 1990 | Chinese Physics Letters1990，7，6： | 0 |
| 18 | Measurement and Correlation of Electrical Conductivity of β-Cyclodextrin in Water Solution显示文摘The electrical conductivity of 4% β-cyclodextrin in water solution had been measured by electrode method from(323.65~353.65) K at atmospheric pressure. The experimental data were correlated with the modified Arrhenius equation, and themodel estimations showed good agreement with the experimental data. | Shanshan Jin Xuewei Cui Yingping Qi Yongfeng Shen Hua Li | 2018 | 材料科学与工程(中英文B版)2018，8，4： | 0 |
| 19 | Blockchain-Based Light-Weighted Provable Data Possession for Low Performance Devices显示文摘Provable Data Possession(PDP)schemes have long been proposed to solve problem of how to check the integrity of data stored in cloud service without downloading.However,with the emerging of network consisting of low performance devices such as Internet of Things,we find that there are still two obstacles for applying PDP schemes.The first one is the heavy computation overhead in generating tags for data blocks,which is essential for setting up any PDP scheme.The other one is how to resist collusion attacks from third party auditors with any possible entities participating the auditing.In this paper,we propose a novel blockchain-based light-weighted PDP scheme for low performance devices,with an instance deployed on a cloud server.We design a secure outsourced tag generating method for low performance devices,which enables a kind of“hash-sign-switch”two-phase tag computing.With this method,users with low performance devices can employ third party auditors to compute modular exponential operations that accounts for the largest portion of computation overhead in tag generation,without leaking their data content.Chaincodes in blockchain network ensure the correctness of such outsourcing and prevent collusion attacks.The security analysis and performance evaluation prove that our scheme is both secure and efficient. | Yining Qi Zhen Yang Yubo Luo Yongfeng Huang Xing Li | 2022 | Computers, Materials & Continua2022，，11： | 0 |
| 20 | Adaptive evolution to the natural and anthropogenic environment in a global invasive crop pest,the cotton bollworm显示文摘The cotton bollworm,Helicoverpa armigera,is set to become the most economically devastating crop pest in the world,threatening food security and biosafety as its range expands across the globe.Key to understanding the eco-evolutionary dynamics of H.armigera,and thus its management,is an understanding of population connectivity and the adaptations that allow the pest to establish in unique environments.We assembled a chromosome-scale reference genome and re-sequenced 503 individuals spanning the species range to delineate global patterns of connectivity,uncovering a previously cryptic population structure. | Minghui Jin Henry L.North Yan Peng Hangwei Liu Bo Liu Ruiqing Pan Yan Zhou Weigang Zheng Kaiyu Liu Bo Yang Lei Zhang Qi Xu Samia Elfekih Wendy A.Valencia-Montoya Tom Walsh Peng Cui Yongfeng Zhou Kenneth Wilson Chris Jiggins Kongming Wu Yutao Xiao | 2023 | The Innovation2023，4，4： | 0 |
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