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| 1 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 2 | Biostratigraphy and geography of the Ordovician-Silurian Lungmachi black shales in South China显示文摘Based on the new material of seven Ordovician-Silurian boundary sections investigated recently, together with previously published data, we analyze the temporal and spatial distributions of the Lungmachi black shales, a key petroleum source bed widely distributed in South China. The Lungmachi black shales range in age from the Normalograptus persculptus Biozone of the uppermost Ordovician to the Spirograptus guerichi Biozone of the lower Telychian, and ten graptolite biozones can be recognized within this unit. The basal and upper contacts of the Lungmachi black shales are diachronous. The basal contact ranges from the N. persculptus to the C. cyphus biozones, a span of five graptolite biozones over two stages. The upper contact ranges from the D. pectinatus-M. argenteus Biozone to the Spirograptus guerichi Biozone, which spans four graptolite biozones over two stages. The Yichang Uplift resulted in the formation of the Hunan-Hubei Submarine High in the border area of Hubei, Hunan, and Chongqing. This is supported by a break in sedimentation in this area spanning all or part of the Hirnantian, and in many areas extending into the underlying Katian and overlying Rhuddanian. Comparison of the distribution of the Katian to Rhuddanian strata in this area indicates a growth and subsequent reduction in area of the Hunan-Hubei Submarine High particularly in the Hirnantian to early Rhuddanian. This may partly represent the influence of the process of formation and melting of ice sheet in Ordovician South Pole and consequent sea level change. | FAN JunXuan Michael J MELCHIN CHEN Xu WANG Yi ZHANG YuanDong CHEN Qing CHI ZhaoLi CHEN Feng | 2011 | Science China Earth Sciences2011，54，12： | 24 |
| 3 | Association of N-terminal pro-brain natriuretic peptide with the severity of coronary artery disease in patients with normal left ventricular ejection fraction显示文摘 | Wu NQ Guo YL Li XL Liu J Qing P Xu RX Zhu CG Jia Y J Liu G Dong Q Jiang LX Li J J Ma FL | 2014 | Chinese Medical Journal2014，，4： | 23 |
| 4 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 5 | Erucine suppresses ethanol intake and preference in alcohol-preferring Fawn-Hooded rats显示文摘 | Yu-ling LI Qing LIU Qi GONG Jun-xu LI Shou-peng WEI Yan-ting WANG Hui LIANG Min ZHANG Li JING ZhengYONG Andrew J LAWRENCE Jian-hui LIANG | 2014 | Acta Pharmacologica Sinica2014，35，7： | 3 |
| 6 | Clonal integration enhances flood tolerance of Spartina alterniflora daughter ramets显示文摘 | Xiao Y Tang J B Qing H | 2010 | Aquatic Botany2010，92，1： | 1 |
| 7 | Statistical inference of atime-to-failure distribution derived from linear degradationdata显示文摘 | Lu J C Park J QING Yang | 1997 | Technometrics1997，39，4： | 1 |
| 8 | Multi-Walled Carbon Nanotube-Based Gas Sensors for NH3 Detection显示文摘 | Wang SG Qing Zhang Yang D J Sellin P J Zhong G F | 2004 | Diamond and Related Materials2004，13，： | 1 |
| 9 | A primary study of high perform- ance transgenic rice through maize UBI-1 promoter fusing se- lective maker gene II 显示文摘 | Shen J Cai P Qing F | 2012 | Pakistan Journal of Botany2012，44，2： | 1 |
| 10 | Identification and characterization of lactic acid bacteria isolated from traditional pickles in Sichuan, China显示文摘 | Yu J Gao W Qing M | 2012 | The Journal of general and applied microbiology2012，58，3： | 1 |
| 11 | Alar flap combined with free auricular composite flap for the reconstruction of nasal alar defect 显示文摘 | Lin W Qing Y Liu J | 2015 | J Craniofac Surg2015，26，2： | 1 |
| 12 | In vitro cytotoxicity of salvicine,a novel diterpenoid quinone显示文摘 | Qing C Zhang JS Ding J | 1999 | Acta Pharmacol Sin1999，20，4： | 1 |
| 13 | Arginine-derived nitric oxide reduces facal oocyst shedding in nude mice infected with Cryptosporidium parvum显示文摘 | Leitch G J Qing H E | 1994 | Infection and Immunity1994，62，11： | 1 |
| 14 | Probabilistic feature relevance learning for content-based image retrieval 显示文摘 | Peng J Bhanu B Qing S | 1999 | Computer Vision and Image Understanding1999，75，12： | 1 |
| 15 | The Recombinant Nonstructural Polyprotein NS1 of Porcine Parvovirus (PPV) as Diagnostic Antigen in ELISA to Differentiate Infected from Vaccinated Pigs显示文摘 | QING L LV J LI H | 2006 | Vet Res Commun2006，30，2： | 1 |
| 16 | Biweekly and 21-30-day variations of the subtropical summer monsoon rainfall over the lower reach of the Yangtze River basin显示文摘 | YANG J WANG B QING B | 2010 | J Climate2010，23，5： | 1 |
| 17 | Modulation of lianbizhi injection (andrographolide) on some immune functions显示文摘 | Zhou F Qing J Zhu J Z | 2004 | Nanjing Med Univ2004，18，1： | 1 |
| 18 | In vitro cytotoxicity of Salvicinc, a noval diterpenoid qninone 显示文摘 | QING C ZHANG J DING J | 1999 | Acta Pharmacol Sin1999，20，4： | 1 |
| 19 | A new clustering algorithm based on artificial immune network and K-means method显示文摘 | Qing J J | 2010 | IEEE Natural Computation2010，6，： | 1 |
| 20 | A study on the dissonant standing-wave tube with variable section and its extremely nonlinear standing-wave field显示文摘 | Qi M Qing Y z Jia J T | 2012 | Physics Letters A2012，377，12： | 1 |
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