|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 2 | Current understanding of ovarian aging显示文摘The reproductive system of human female exhibits a much faster rate of aging than other body systems.Ovarian aging is thought to be dominated by a gradual decreasing numbers of follicles,coinciding with diminished quality of oocytes.Menopause is the final step in the process of ovarian aging.This review focuses on the mechanisms underlying the ovarian aging involving a poor complement of follicles at birth and a high rate of attrition each month,as well as the alternated endocrine factors.We also discuss the possible causative factors that contribute to ovarian aging,e.g.,genetic factors,accumulation of irreparable damage of microenvironment,pathological effect and other factors.The appropriate and reliable methods to assess ovarian aging,such as quantification of follicles,endocrine measurement and genetic testing have also been discussed.Increased knowledge of the ovarian aging mechanisms may improve the prevention of premature ovarian failure. | LI Qian GENG XiaoDan ZHENG Wei TANG Jie XU Bo SHI QingHua | 2012 | Science China(Life Sciences)2012，55，8： | 14 |
| 3 | Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells显示文摘Sjögren’s syndrome(SS)is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands and lacrimal glands.Our previous studies showed that myeloid-derived suppressor cells(MDSCs)exhibited impaired immunosuppressive function during disease progression in patients with SS and mice with experimental Sjögren’s syndrome(ESS),but it remains unclear whether restoring the function of MDSCs can effectively ameliorate the development of ESS.In this study,we found that murine olfactory ecto-mesenchymal stem cell-derived exosomes(OE-MSC-Exos)significantly enhanced the suppressive function of MDSCs by upregulating arginase expression and increasing ROS and NO levels.Moreover,treatment with OE-MSC-Exos via intravenous injection markedly attenuated disease progression and restored MDSC function in ESS mice.Mechanistically,OE-MSC-Exo-secreted IL-6 activated the Jak2/Stat3 pathway in MDSCs.In addition,the abundant S100A4 in OE-MSC-Exos acted as a key factor in mediating the endogenous production of IL-6 by MDSCs via TLR4 signaling,indicating an autocrine pathway of MDSC functional modulation by IL-6.Taken together,our results demonstrated that OE-MSC-Exos possess therapeutic potential to attenuate ESS progression by enhancing the immunosuppressive function of MDSCs,possibly constituting a new strategy for the treatment of Sjögren’s syndrome and other autoimmune diseases. | Ke Rui Yue Hong Qiugang Zhu Xiaofei Shi Fan Xiao Hailong Fu Qing Yin Yida Xing Xinfeng Wu Xiaodan Kong Huaxi Xu Jie Tian Shengjun Wang Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，2： | 12 |
| 4 | Decrement of Sugar Consumption in Rice Young Panicle Under High Temperature Aggravates Spikelet Number Reduction显示文摘Two rice genotypes Huanghuazhan(HHZ, heat-resistant) and IR36(heat-susceptible) were subjected to high-temperature(HT, 40℃) and normal-temperature(NT, 32℃) treatments at the spikelet differentiation stage. HT treatment inhibited spikelet differentiation, aggravated spikelet degeneration, reduced spikelet size, and disordered carbohydrate allocation. Meanwhile, HT treatment increased nonstructural carbohydrate content in leaves, but decreased that in stems and young panicles, and the same tendencies of sucrose and starch contents were observed in leaves and stem. However, HT treatment significantly increased the sucrose content and sharply decreased the glucose and fructose contents in young panicles. Lower activity levels of soluble acid invertase(EC3.2.1.26) and sucrose synthase(EC2.4.1.13) were observed under HT treatment. Moreover, HT treatment reduced the activities of key enzymes associated with glycolysis and the tricarboxylic acid cycle, which indicated sucrose consumption was inhibited in young panicles under HT treatment. Exogenous glucose and fructose applied under HT treatment increased the spikelet number more than exogenous sucrose. In conclusion, the results demonstrated that the reduction of spikelet number under high temperature was more affected by the decrease in sugar consumption than the blocking of sucrose transport. The impairment of sucrose hydrolysis was the main reason for the inhibition of sugar utilization. | WANG Yaliang ZHANG Yikai SHI Qinghua CHEN Huizhe XIANG Jing HU Guohui CHEN Yanhua WANG Xiaodan WANG Junke YI Zihao ZHU Defeng ZHANG Yuping | 2020 | Rice science2020，27，1： | 6 |
| 5 | Advances in preimplantation genetic diagnosis/screening显示文摘Preimplantation genetic diagnosis(PGD)gives couples who have a high risk of transmitting genetic disorders to their baby the chance to have a healthy offspring through embryo genetic analysis and selection.Preimplantation genetic screening(PGS)is an effective method to select euploid embryos that may prevent repeated implantation failure or miscarriage.However,how and to whom PGS should be provided is a controversial topic.The first successful case of PGD of a human being was reported in 1990,and there have been tremendous improvements in this technology since then.Both embryo biopsy and genetic technologies have been improved dramatically,which increase the accuracy and expand the indications of PGD/PGS. | YAN LiYing WEI Yuan HUANG Jin ZHU XiaoHui SHI XiaoDan XIA Xi YAN Jie LU CuiLing LIAN Ying LI Rong LIU Ping QIAO Jie | 2014 | Science China(Life Sciences)2014，57，7： | 3 |
| 6 | Ultrafine monolayer Co-containing layered double hydroxide nanosheets for water oxidation显示文摘For many two-dimensional(2D)materials,low coordination edges and corner sites offer greatly enhanced catalytic performance compared to basal sites,motivating the search for new synthetic approaches towards ultrathin and ultrafine 2D nanomaterials with high specific surface areas.To date,the synthesis of catalysts that are both ultrathin(monolayer)and ultrafine(lateral size<10nm)has proven extremely challenging.Herein,using a facile ultrasonic exfoliation procedure,we describe the successful synthesis of ultrafine ZnCo-LDH nanosheets(denoted as ZnCo-UF)with a size^3.5 nm and thickness^0.5 nm.The single layer ZnCo-UF nanosheets possess an abundance of oxygen vacancies(Vo)and unsaturated coordination s让es,thereby affording outstanding electrocatalytic water oxidation performance.DFT calculations confirmed that Vo on the surface of ZnCo-UF enhanced H20 adsorption via increasing the electropositivity of the nanosheets. | Xiaodan Jia Xin Zhang Jiaqing Zhao Yufei Zhao Yunxuan Zhao Geoffrey I.N.Waterhouse Run Shi Li-Zhu Wu Chen-Ho Tung Tierui Zhang | 2019 | Journal of Energy Chemistry2019，28，7： | 3 |
| 7 | A Vesicular Stomatitis Virus-Based Vaccine Carrying Zika Virus Capsid Protein Protects Mice from Viral Infection显示文摘Dear Editor,Zika virus (ZIKV) is a mosquito-borne virus that belongs to the Flavivirus family along with dengue virus (DENV),yellow fever virus, West Nile virus, and Japanese encephalitis virus (Ming et al. 2016). ZIKV is a singlestranded positive-sense RNA virus encoding three structural proteins, including nucleocapsid protein C, prM/M,envelope glycoprotein E, and seven non-structural proteins.Since 2015. | Xiaodan Shi Jingping Hu Jing Guo Chuanjian Wu Sidong Xiong Chunsheng Dong | 2019 | Virologica Sinica2019，34，1： | 2 |
| 8 | An infrared thermographic analysis of the sensitization acupoints of women with primary dysmenorrhea显示文摘OBJECTIVE:To explore the sensitization acupoints of women with primary dysmenorrhea(PD)by comparing infrared radiation temperatures between acupoints and non-acupoints.METHODS:We tested 10 acupoints of every woman with PD and healthy subjects on premenstrual,menstrual,and postmenstrual days using an infrared imaging device.The primary outcome was the absolute value of body surface temperature difference(AVTD)between the left and right sides of the same testing point.RESULTS:A total of 58 PD patients and 57 healthy volunteers completed the test from May 2016 to May 2017.Compared with the healthy group,we observed a significant reduction and increase in the AVTD in Taichong(LR3)and Sanyinjiao(SP6),respectively,during menstrual days in the PD group(P=0.01;P=0.04);while during postmenstrual days,all AVTDs of Shuiquan(KI5),Diji(SP8),and Xuehai(SP10)were diminished in the PD group(P=0.01;P=0.03;P=0.01,respectively).No significant differences in AVTD were detected at any other points or testing times.CONCLUSIONS:Compared with the healthy group,the AVTDs of Taichong(LR3),Sanyinjiao(SP6),Shuiquan(KI5),Diji(SP8),and Xuehai(SP10)at menstruationrelevant points of PD patients were sensitized,providing a reference for the selection of acupoints in the treatment of PD. | FAN Xisheng DU Xiaoyi PAN Lijia SONG Xiaodan LIU Jun ZHANG Juncha CHEN Hao GAO Yayu ZHANG Mingjian SHI Xuliang SHE Yanfen | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 2 |
| 9 | Traditional Chinese Medicine guidelines for coronavirus disease 2019显示文摘OBJECTIVE:To summarize the evidence from Traditional Chinese Medicine(TCM)practice in the treatment of coronavirus disease 2019(COVID-19)and provide timely clinical practice guidance.METHODS:The guidelines were developed in accordance with the World Health Organization rapid guideline process.The evidence on TCM for COVID-19 from published guidelines,direct and indirect published clinical evidence,first hand clinical data,and expert experience and consensus were collected.The grading of recommendations assessment,development and evaluation(GRADE)method was used to grade the evidence and make the recommendations.RESULTS:Based on the available evidence,the guidelines recommended 17 Chinese medicines for COVID-19:2 Chinese herbal granules,7 Chinese patent medicines,and 8 Chinese herbal injections.CONCLUSION:As the literature search was conducted on March,any subsequent versions of these guidelines require an up-to-date literature review.We hope that the evidence summary in these guidelines will be helpful in global efforts to address COVID-19. | Liang Ning Ma Yanfang Wang Jingya Li Huizhen Wang Xiaohui Jiao Liwen Liu Bin Ma Yan Zhao Chen Luo Xufei Zhao Siya Lu Meng Cao Jin Hu Wenpin Zhang Hairong Liu Guoxiu Lu Cheng Liu Mengyu Li Li Han Xuejie Liu Yuqi Wang Liying Zhao Xueyao Wei Dongfeng Bai Jing Sun Mingyu Yang Yong Wu Xiaodan Chen Yaolong Shi Nannan Wang Yanping Wang Yongyan | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 2 |
| 10 | Electrostatic assembly functionalization of poly(γ-glutamic acid)for biomedical antibacterial applications显示文摘Poly(γ-glutamic acid)(γ-PGA)has been found widespread applications in biomedical field because of its excellent water solubility,biocompatibility,and bioactivity.Herein,a water-insoluble γ-PGA antibacterial compound is facilely fabricated via one-pot electrostatic assembly of γ-PGA with cationic ethyl lauroyl arginate(ELA).The functionalized γ-PGA compound(γ-PGA-ELA)ethanol solution can facilely produce colorless and transparent coatings on various inorganic,metal,and polymeric substrates,especially for the lumen of slender catheters(length up to 2 m,and inner diameter down to 1 mm).The functionalized γ-PGA coating presents remarkable antibacterial efficacy in vitro and in vivo.In addition,the γ-PGA compound is used as antibacterial additives of polyolefin via melting extrusion,and the asprepared antibacterial polyolefin demonstrates advantageous antibacterial efficacy.More importantly,the functionalized γ-PGA coating exhibit good hemocompatibility,low cytotoxicity,and satisfactory histocompatibility.The as-proposed γ-PGA compound has a great potential to serve as a safe and multifunctional antibacterial candidate to combat biomedical devices-related infections. | Xiaodan Wang Hengchong Shi Haoyu Tang Huan Yu Qiuyan Yan Huawei Yang Xu Zhang Shifang Luan | 2020 | Journal of Materials Science & Technology2020，59，24： | 1 |
| 11 | Treatment of Irreducible Old Atlantoaxial Subluxation With Cable-Dragged Reduction and Cantilever Beam Internal Fixation显示文摘 | Xi Liu Hao Liu Tao Li Quan Gong Yueming Song Limin Liu Rui Shi Xiaodan Zhao Wenli Zhang Ganjun Feng Beiyu Wang | 2011 | Spine2011，，15： | 1 |
| 12 | Enhanced thermoelectric properties of SnSe thin films grown by pulsed laser glancing-angle deposition显示文摘SnSe single crystals have been demonstrated to possess excellent thermoelectric properties.In this work,we demonstrate a grain size control method in growing nanocrystalline SnSe thin films through a glancing angle pulsed-laser deposition approach.Structural characterization reveals that the SnSe film deposited at a normal angle has a preferred orientation along a axis,while by contrast,the SnSe film deposited at an 80glancing angle develops a nanopillar structure with the growth direction towards the incident atomic flux.The glancing angle deposition greatly reduces the grain size of the thin film due to a shadowing effect to the adatoms,resulting in significantly increased power factor for more than 100%.The maximum Seebeck coefficient and power factor are 498.5 mV=K and 18.5 mWcm^(-1)K^(-2),respectively.The enhancement of thermoelectric property can be attributed to the potential barrier scattering at grain boundaries owing to the reduced grain size and increased grain boundaries in the film.Given this enhanced power factor,and considering the fact that the nanopillar structure should have much lower thermal conductivity than a plain film,the zT value of such made SnSe film could be significantly larger than the corresponding single crystal film,making it a good candidate for thin film-based thermoelectric device. | Chun Hung Suen Dongliang Shi Y.Su Zhi Zhang Cheuk Ho Chan Xiaodan Tang Y.Li Kwok Ho Lam Xinxin Chen B.L.Huang X.Y.Zhou Ji-Yan Dai | 2017 | Journal of Materiomics2017，3，4： | 1 |
| 13 | Gene cloning, expression and characterization of an α-galactosidase from Pedobacter nyackensis MJ11 CGMCC 2503 with potential as an aquatic feed additive显示文摘 | Xiaodan Liu Kun Meng Yaru Wang Pengjun Shi Tiezheng Yuan Peilong Yang Huiying Luo Yingguo Bai Bin Yao | 2009 | World Journal of Microbiology and Biotechnology2009，，9： | 1 |
| 14 | Power control algorithm in cognitive radio system based on modified Shuffled Frog Leaping Algorithm 显示文摘 | Zhang Xiaodan Zhang Yifeng Shi Yuhui | 2012 | Intemational Journal of Electronics and Communications (S1434-8411)2012，66，6： | 1 |
| 15 | DFH-5 Platform Development Speeds Up显示文摘Recently,multiple critical technologies have been mastered in the DFH-5satellite platform development.The DFH-5 satellite platform is the next-generation geosynchronous orbitplatform,with capacity and technical specifications at an international advanced level.The development of the platform leads in technical innovation in spacecraft development and drives the upgrade of | SHI Xiaodan ZHANG Guohang | 2015 | Aerospace China2015，16，4： | 1 |
| 16 | Power control algorithm in cognitive radio system based on modified Shuffled Frog Leaping Algorithm显示文摘 | Xiaodan Zhang Yifeng Zhang Yuhui Shi Li Zhao Cairong Zou | 2011 | AEUE - International Journal of Electronics and Communications2011，，6： | 1 |
| 17 | Cost-sensitive support vector machine for semi-supervised learning显示文摘 | Qi Zhiquan Tian Yingjie Shi Yong Yu Xiaodan | 2013 | Procedia Computer Science2013，18，1： | 1 |
| 18 | CoFe204 magnetic nanoparticles as a peroxidase mimic mediated chemiluminescence for hydrogen peroxide and glucose 显示文摘 | Shi Wenbing Zhang Xiaodan He Shaohui | 2011 | Chem Commun2011，47，10： | 1 |
| 19 | Gel electrolytes containing several kinds of particles used in quasi-solid-state dye-sensitized solar cells显示文摘Composite gel electrolytes containing several kinds of particles used as the quasi-solid-state electrolytes in dye-sensitized solar cells (DSSCs) were reported. Mesoporous particles (MCM-41) with unique structures composed of ordered nanochannels were served as a new kind of gelator for quasi-solid-state electrolytes. MCM-41, hydrophobic fumed silica Aerosil R972 and TiO2 nanopatricles P25 were dispersed into gel electrolytes respectively. The solar energy-to-electricity conversion efficiency of these cells is 4.65%, 6.85% and 5.05% respectively under 30 mW·cm-2 illumination. The preparation methods and the particles sizes exert an influence on the performance of corresponding solar cells. Owing to unique pore structures and high specific BET surface area, mesoporous silica MCM-41 was expected to have the potential to afford conducting nanochannels for redox couple diffusion. | GENG Yi SUN Xiaodan CAI Qiang SHI Yantao LI Hengde | 2006 | Rare Metals2006，25，z1： | 1 |
| 20 | Suppressed recombination for monolithic inorganic perovskite/silicon tandem solar cells with an approximate efficiency of 23%显示文摘Potentially temperature-resistant inorganic perovskite/silicon tandem solar cells(TSCs)are promising devices for boosting efficiency past the single-junction silicon limit.However,undesirable non-radiative recombination generally leads to a significant voltage deficit.Here,we introduce an effective strategy using nickel iodide,an inorganic halide salt,to passivate iodine vacancies and suppress non-radiative recombination.NiI_(2)-treated CsPbI_(3-x)Br_(x) inor-ganic perovskite solar cells with a 1.80 eV bandgap exhibited an efficiency of 19.53%and a voltage of 1.36 V,corresponding to a voltage deficit of 0.44 V.Importantly,the treated device demonstrated excellent operational stability,maintaining 95.7%of its initial efficiency after maximum power point tracking for 300 h under continuous illumination in a N_(2) atmosphere.By combining this inorganic perovskite top cell with a narrower bandgap silicon bottom cell,we for the first time achieved monolithic inorganic perovskite/silicon TSCs,which exhibited an effi-ciency of 22.95%with an open-circuit voltage of 2.04 V.This work provides a promising strategy for using inorganic passivation materials to achieve efficient and stable solar cells. | Sanlong Wang Pengyang Wang Bingbing Chen Renjie Li Ningyu Ren Yucheng Li Biao Shi Qian Huang Ying Zhao Michael Grätzel Xiaodan Zhang | 2022 | eScience2022，2，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员