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| 1 | Biomechanical Comparison of Two Kinds of Internal Fixation in a Type C Zone II Pelvic Fracture Model显示文摘 | Tao Wu Wei Chen Qi Zhang Zhan-Le Zheng Hong-Zhi Lyu Yun-Wei Cui Xiao-Dong Cheng Ying-Ze Zhang Yan-Jiang Yang | 2015 | Chinese Medical Journal2015，，17： | 27 |
| 2 | Comparative study of minimally invasive versus open esophagectomy for esophageal cancer in a single cancer center显示文摘 | Mu Juwei Yuan Zuyang Zhang Baihua Li Ning Lyu Fang Mao Yousheng Xue Qi Gao Shugeng Zhao Jun Wang Dali Li Zhishan Gao Yushun Zhang Liangze Huang Jinfeng Shao Kang Feng Feiyue Zhao Liang Li Jian Cheng Guiyu Sun Kelin He Jie | 2014 | Chinese Medical Journal2014，，4： | 13 |
| 3 | Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy显示文摘 | Kefang Liu ShuguangTan Yan Chai Danqing Chen Hao Song Catherine Wei-Hong Zhang yi Shi Jun Liu Wenjie Tan Jianxin Lyu Shah Gao Jinghua Yan Jianxun Qi George F Gao | 2017 | Cell Research2017，27，1： | 11 |
| 4 | Postoperative Regulatory T-Cells and Natural Killer Cells in Stage I Nonsmall Cell Lung Cancer Underwent Video-assisted Thoracoscopic Lobectomy or Thoracotomy显示文摘 | Sai Zhang Sai-Bo Pan Qing-Hua Lyu Pin Wu Guang-Ming Qin Qi Wang Zhong-Liang He Xue-Ming He Ming Wu Gang Chen | 2015 | Chinese Medical Journal2015，，11： | 10 |
| 5 | Development and Standardization of a New Cognitive Assessment Test Battery for Chinese Aphasic Patients: A Preliminary Study显示文摘 | Ji-Bao Wu Zhi-Hong Lyu Xiao-Jia Liu Hai-Peng Li Qi Wang | 2017 | Chinese Medical Journal2017，，19： | 9 |
| 6 | Analysis of Health Service Utilization and its Influencing Factors among Patients with Pneumoconiosis in China显示文摘Pneumoconiosis,an interstitial lung disease that occurs from breathing in certain kinds of damaging dust particles,is a major occupational disease in China.Patients diagnosed with occupational pneumoconiosis can avail of free medical treatment,whereas patients without a diagnosis of occupational diseases cannot not claim free medical treatment in most provinces from the government before 2019.This study aimed to analyze the priority of medical facility selection and its influencing factors among patients with pneumoconiosis. | WANG Huan Qiang JIA Jun Lin JIANG Zhao Qiang JIN Qi LI Dong Xia LING Rui Jie LI Ying CUI Ping CHEN Gang ZHAO Hong Yu LI Yan WEN Ke LYU Xiang Pei LOU Jian Lin LI Tao | 2021 | Biomedical and Environmental Sciences2021，34，1： | 9 |
| 7 | Long-term follow-up of auditory performance and speech perception and effects of age on cochlear implantation in children with pre-lingual deafness显示文摘Background: The development of auditory and speech perception ability of children with hearing loss is affected by many factors after they undergo cochlear implantation (CI). Age at CI (CI age) appears to play an important role among these factors. This study aimed to evaluate the development of auditory and speech perception ability and explore the impact of CI age on children with pre-lingual deafness present before 3 years of age. Methods: Two hundred and seventy-eight children with pre-lingual deafness (176 boys and 102 girls) were included in this study, and the CI age ranged from 6 to 36 months (mean age, 19 months). Categorical auditory performance (CAP) was assessed to evaluate auditory ability, and the speech intelligibility rating was used to evaluate speech intelligibility. The evaluations were performed before CI and 1, 3, 6, 12, 18, 24, 36, 48, and 60 months after CI. Results: The auditory ability of the pre-lingually hearing-impaired children showed the fastest development within 6 months after CI (k = 0.524, t = 30.992, P < 0.05);then, the progress started to decelerate (k = 0.14, t = 3.704, P < 0.05) and entered a plateau at the 24th month (k = 0.03, t = 1.908, P < 0.05). Speech intelligibility showed the fastest improvement between the 12th and 24th months after CI (k = 0.138, t = 5.365, P < 0.05);then, the progress started to decelerate (k = 0.026, t = 1.465, P < 0.05) and entered a plateau at the 48th month (k = 0.012, t = 1.542, P < 0.05). The CI age had no statistical significant effect on the auditory and speech abilities starting at 2 years after CI (P > 0.05). The optimal cutoff age for CI was 15 months. Conclusions: Within 5 years after CI, the auditory and speech ability of young hearing-impaired children continuously improved, although speech development lagged behind that of hearing. An earlier CI age is recommended;the optimal cutoff age for CI is at 15 months. | Jing Lyu Ying Kong Tian-Qiu Xu Rui-Juan Dong Bei-Er Qi Shuo Wang Yong-Xin Li Hai-Hong Liu Xue-Qing Chen | 2019 | Chinese Medical Journal2019，，16： | 9 |
| 8 | Psychophysiological Effects of Bamboo Plants on Adults显示文摘The present study was conducted to clarify the psychophysiological relaxation effects of viewing bamboo on university students. Forty healthy Chinese participants enrolled in this study to clarify the psychophysiological relaxation effects of viewing bamboo. The effects of visual stimulation using a pot both with and without a bamboo were recorded by measuring the student's blood pressure, EEG and STAI. We observed that viewing bamboo plants resulted in significantly lower systolic(female, P < 0.001; male, P < 0.001; P < 0.05) and diastolic(female,P < 0.001; male, P < 0.001; P < 0.05) blood pressures, but no changes in the pulse rate(female, P = 0.09; male, P = 0.07; P > 0.05) were observed. The results of the EEG analysis indicated brainwave variation(all P < 0.05) and lower anxiety scores(P < 0.01) after 3 min of viewing bamboo compared with the control. These findings indicate that visual stimulation with bamboo plants induced psychophysiological relaxation effects on adults. | Ahmad Hassan CHEN Qi Bing JIANG Tao LYU Bing Yang LI Nian LI Shu SHANGGUAN Zi Yue LI Yun Ting JUN Zhou Li LUO Qian CHEN Xin Yi WANG Yi Yan ZENG Cheng Cheng YANG Jun Muhammad Sohaib Tahir | 2017 | Biomedical and Environmental Sciences2017，30，11： | 8 |
| 9 | Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids显示文摘The re-emergence of Zika virus(ZIKV)in the Western Hemisphere has resulted in global public health crisis since 2015.ZIKV preferentially infects and targets human neural progenitor cells(hNPCs)and causes fetal microcephaly upon maternal infection.hNPCs not only play critical roles during fetal brain development,but also persist in adult brain throughout life.Yet the mechanism of innate antiviral immunity in hNPCs remains largely unknown.Here,we show that ZIKV infection triggers the abundant production of virus-derived small interfering RNAs in hNPCs,but not in the more differentiated progenies or somatic cells.Ablation of key RNAi machinery components significantly enhances ZIKV replication in hNPCs.Furthermore,enoxacin,a broad-spectrum antibiotic that is known as an RNAi enhancer,exerts potent anti-ZIKV activity in hNPCs and other RNAi-competent cells.Strikingly,enoxacin treatment completely prevents ZIKV infection and circumvents ZIKV-induced microcephalic phenotypes in brain organoid models that recapitulate human fetal brain development.Our findings highlight the physiological importance of RNAi-mediated antiviral immunity during the early stage of human brain development,uncovering a novel strategy to combat human congenital viral infections through enhancing RNAi. | Yan-Peng Xu Yang Qiu Boya Zhang Guilai Chen Qi Chen Miao Wang Fan Mo Jiuyue Xu Jin Wu Rong-Rong Zhang Meng-Li Cheng Na-Na Zhang Bao Lyu Wen-Liang Zhu Meng-Hua Wu Qing Ye Da Zhang Jiang-Hong Man Xiao-Feng Li Jie Cui Zhiheng Xu Baoyang Hu Xi Zhou Cheng-Feng Qin | 2019 | Cell Research2019，29，4： | 8 |
| 10 | Association between Perceived Stressfulness of Stressful Life Events and the Suicidal Risk in Chinese Patients with Major Depressive Disorder显示文摘 | Jing-Yu Lin Yu Huang Yun-Ai Su Xin Yu Xiao-Zhen Lyu Qi Liu Tian-Mei Si | 2018 | Chinese Medical Journal2018，，8： | 7 |
| 11 | Effect of Weight Loss on Survival in Esophageal Cancer Patients undergoing Neoadjuvant Chemoradiotherapy and Surgery显示文摘Objective This study aimed to determine the impact of weight loss during neoadjuvant chemoradiotherapy on the survival of patients with esophageal carcinoma.Methods We retrospectively examined 102 consecutive patients with esophageal carcinoma who underwent neoadjuvant chemoradiotherapy followed by radical resection at Sichuan Cancer Hospital&Institute between 2003 and 2017.The patients were divided into three groups based on the amount of body weight lost during neoadjuvant chemoradiotherapy:severe weight loss(>10%),high weight loss(5%~10%),and low weight loss(<5%).The correlations of weight loss with toxicity,progressionfree survival,and overall survival were investigated.Results The median overall survival was 49.7 months in the low weight loss group compared with 35.4 and 25.1 months in the high and severe weight loss groups(P=0.041).The 1-year overall survival rates in the severe,high,and low weight loss groups were 62.5%,85.0%,and 90.7%,respectively;the corresponding 3-year overall survival rates were 21.9%,47.3%,and 68.8%,respectively,and the corresponding 5-year overall survival rates were 21.9%,31.0%,and 44.4%,respectively.The multivariate analysis indicated that a pathological complete response and severe weight loss were independent prognostic factors for overall survival.Any leukopenia(P=0.024),leukopenia of at least grade 3(P=0.021),and anemia(P=0.042)occurred more frequently in the severe weight loss group.Conclusions Weight loss during neoadjuvant CRT is an independent and adverse prognostic factor in esophageal carcinoma patients,whereas a stable weight confers a better prognosis. | Jia Hua Lyu Tao Li Yong Tao Han Lei Wu Lin Peng Qi Feng Wang Long Liang | 2020 | Journal of Nutritional Oncology2020，5，3： | 6 |
| 12 | Spatiotemporal visualization for the global COVID-19 surveillance by balloon chart显示文摘Background:Considering the widespread of coronavirus disease 2019(COVID-19)pandemic in the world,it is important to understand the spatiotemporal development of the pandemic.In this study,we aimed to visualize time-associated alterations of COVID-19 in the context of continents and countries. | Ming-Fan Pang Zuo-Ru Liang Zhi-Da Cheng Xin-Ping Yang Jie-Wen Wu Ke Lyu Jing-Jing Xi Zhong-Jie Li Guo-Qing Shi Yan-Ping Zhang George FGao Xiao-Peng Qi Xiao-Ping Dong | 2021 | Infectious Diseases of Poverty2021，10，2： | 6 |
| 13 | Antiferromagnetic element Mn modified PtCo truncated octahedral nanoparticles with enhanced activity and durability for direct methanol fuel cells显示文摘Pt-based magnetic nano catalysts are one of the most suitable cand idates for electrocatalytic materials due to their high electrochemistry activity and retrievability.Unfortunately,the inferior durability prevents them from being scaled-up,limiting their commercial applications.Herein,an antiferromagnetic element Mn was introduced into PtCo nanostructured alloy to synthesize uniform Mn-PtCo truncated octahedral nanoparticles(TONPs)by one-pot method.Our results show that Mn can tune the blocking temperature of Mn-PtCo TONPs due to its an tiferromag netism.At low temperatures,Mn-PtCo TONPs are ferromag netic,and the coercivity in creases gradually with in creasi ng Mn contents.At room temperature,the Mn-PtCo TONPs display superparamag netic behavior,which is greatly helpful for in dustrial recycling.Mn doping can not only modify the electronic structure of PtCo TONPs but also enhanee electrocatalytic performance for methanol oxidation reaction.The maximum specific activity of Mn-PtCo-3 reaches 8.1 A`m^-2,3.6 times of commercial Pt/C(2.2 A·m^-2)and 1.4 times of PtCo TONPs(5.6 A`m^-2),respectively.The mass activity decreases by only 30%after 2,000 cycles,while it is 45%and 99%(nearly inactive)for PtCo TONPs and commercial Pt/C catalysts,respectively. | Qiqi Zhang Jialong Liu Tianyu Xia Jie Qi Haochang Lyu Baoyuan Luo Rongming Wang Yizhong Guo Lihua Wang and Shouguo Wang | 2019 | Nano Research2019，12，10： | 5 |
| 14 | Plasma RANTES level is correlated with cardio-cerebral atherosclerosis burden in patients with ischemic cerebrovascular disease显示文摘Background::Regulated upon activation, normal T-cell expressed, and secreted (RANTES) is a chemokine actively involved in the initiation and progression of atherosclerosis (AS), which is the major cause of ischemic cerebrovascular disease (ICVD). This study aimed to determine the associations between circulating RANTES level and overall AS conditions of cardiac and cerebral vessel beds in patients with ICVD.Methods::Patients with ICVD admitted to the department of neurology of Xuanwu Hospital from April 1, 2019 to June 30, 2019 were prospectively enrolled in the study. Plasma RANTES level was measured by enzyme-linked immunosorbent assay to represent the circulating RANTES level. The integrated AS burden of the cervicocephalic and coronary arteries was examined using computed tomography angiography and reflected by 'cardio-cerebral AS burden (CCAB)' as a continuous variable. Then, the relationship of plasma RANTES level and CCAB in patients with ICVD was analyzed by correlation analyses and general linear models.Results::A total of 40 patients with ICVD were included in the study. There was a significant positive correlation between CCAB and plasma RANTES level in ICVD ( r = 0.786, P < 0.001), independent of age, sex, acute or chronic phase of ICVD, and mono or dual antiplatelet therapy (adjusted B for ln RANTES, 12.063;95% confidence interval, 7.572-16.533). The association of plasma RANTES level with AS conditions (burden, severity, and extent) in single cardiac or cerebral vessel bed was similar to that with CCAB, but the correlation coefficient for CCAB was higher (increment ranged from 0.126 to 0.397). Conclusions::Plasma RANTES level was an independent indicator for the integrated AS burden of the cervicocephalic and coronary arteries in ICVD. Comprehensive evaluation of AS conditions using the novel continuous index CCAB might be important in revealing the systematic relationship between circulating RANTES and AS in patients with ICVD. | Kong Qi Ma Xin Lyu Jun-Xuan Wang Chen Du Xiang-Ying Guan Yun-Qian | 2020 | Chronic Diseases and Translational Medicine2020，6，1： | 5 |
| 15 | TCP7 functions redundantly with several Class Ⅰ TCPs and regulates endoreplication in Arabidopsis显示文摘TCP(TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR) proteins, a family of plantspecific transcription factors, play important roles in many developmental processes. However, genetic and functional redundancy among class I TCP limits the analysis of their biological roles. Here, we identified a dominantnegative mutant of Arabidopsis thaliana TCP7 named leaf curling-upward(lcu), which exhibits smaller leaf cells and shorter hypocotyls than the wild type, due to defective endoreplication. A septuple loss-of-function mutant of TCP7, TCP8, TCP14, TCP15, TCP21, TCP22, and TCP23 displayed similar developmental defects to those of lcu.Genome-wide RNA-sequencing showed that lcu and the septuple mutant share many misexpressed genes.Intriguingly, TCP7 directly targets the CYCLIN D1;1 (CYCD1;1) locus and activates its transcription. We determined that the C-terminus of TCP7 accounts for its transcriptional activation activity. Furthermore, the mutant protein LCU exhibited reduced transcriptional activation activity due to the introduction of an EAR-like repressive domain at its C-terminus. Together, these observations indicate that TCP7 plays important roles during leaf and hypocotyl development, redundantly, with at least six class I TCPs, and regulates the expression of CYCD1;1 to affect endoreplication in Arabidopsis. | Guofang Zhang Hongtao Zhao Chunguang Zhang Xiaoyun Li Yuanyuan Lyu Dongmei Qi Yanwei Cui Lin Hu Zhenjie Wang Zheng Liang Sujuan Cui | 2019 | Journal of Integrative Plant Biology2019，61，11： | 5 |
| 16 | Umbilical cord blood application analysis of Guangdong Cord Blood Bank显示文摘To the Editor:With the development of clinical research and the application of cord blood,the clinical value of umbilical cord blood(UCB)has drawn more and more attention.UCB has been increasingly applied to treatments of hematological diseases,autoimmune diseases,and malignant tumors in children and adults[1]and has achieved high overall survival.[1–3]UCB contains substantial amounts of various stem cells,including hematopoietic stem cells(HSC),mesenchymal stem cells,endothelial progenitor cells,and so on[4];among them,HSC are most widely used in study and clinical application.Transplantation,where UCB HSC are implanted into patients,requires ruining the immune system and hematopoietic system before the procedure.Another therapeutic method is UCB infusion,where UCB is regarded as a nutrient,to improve the outcome of peripheral blood HSC transplantation[5]or symptoms via paracrine pathway of UCB stem cells.[6]In addition to the application of allogeneic UCB,autologous UCB has also been used in clinical treatment research.Autologous UCB is not limited to treating hemopathy,but also used to treat non-genetic metabolic disease,immune disease,and nervous system injury.[6] | Cong-Ying Shi Wei Wei Li-Juan Lyu Qi Wang | 2020 | Chinese Medical Journal2020，，16： | 5 |
| 17 | Plant Diversity Performance After Natural Restoration in Reclaimed Deyeuxia angustifolia Wetland显示文摘Deyeuxia angustifolia wetlands were widely distributed in the Sanjiang Plain in Northeast China. Due to strong demand for food production, large-area wetlands were reclaimed to farmlands, which threatened regional ecological security greatly. Since the 21 th century, returning farmlands to wetlands was widely adopted for natural restoration in the Sangjiang Plain. As the first reflection of wetland restoration, vegetation succession of restored D. angustifolia wetlands should be fully assessed. In this study, vegetation investigation was carried out in three restored D. angustifolia wetlands with 5, 8 and 12 yr restoration, respectively. Meanwhile, a natural D. angustifolia wetland was selected as reference wetland. Results showed that community composition changed greatly and there was visible community succession. Community dominant species changed from composite to gramineae as restoration time increasing.At first, weeds community appeared in the restored wetlands, especially the xerophytes developed to the pioneer species rapidly. And then, mesophytes and wetland species became the dominant species in the restored wetlands. Finally, wetland species, especially D. angustifolia, occupied the dominant position of restored community. Shannon-wiener index(H) and Simpson index(D) both decreased to close to natural D. angustifolia wetlands. Compared with natural D. angustifolia wetland, species composition and diversity in restored wetlands were more complex and higher. As restoration time increasing, there were not significant differences between community characteristics of restored wetlands and natural wetland. All these suggested that vegetation in reclaimed D. angustifolia wetland could be restored naturally, but its restored period is 10 yr at least. From another angle, it is important to protect current natural wetlands. | WANG Xuehong TONG Shouzheng LI Yunzhao Qi Qing ZHANG Dongjie LYU Xianguo GUO Yue LIU Yan | 2019 | Chinese Geographical Science2019，29，3： | 5 |
| 18 | T Helper 1 and T Helper 2 Cytokines Differentially Modulate Expression of Filaggrin and its Processing Proteases in Human Keratinocytes显示文摘 | Zheng-Hong Di Lei Ma Rui-Qun Qi Xiao-Dong Sun Wei Huo Li Zhang Ya-Ni Lyu Yu-Xiao Hong Hong-Duo Chen Xing-Hua Gao | 2016 | Chinese Medical Journal2016，，3： | 5 |
| 19 | Effect of high temperature on compression property and deformation recovery of ceramic fiber reinforced silica aerogel composites显示文摘Ceramic fiber reinforced silica aerogel composites are novel insulation materials in the thermal protection field for hypersonic vehicles. Before the aerogel composites are applied in load-bearing structures, it is necessary to investigate their mechanical properties including load-bearing and deformation recovery capabilities. High temperature from service conditions will have important effects on the mechanical properties of thermal protection materials. In this paper, compression tests including loading and unloading stages were conducted for ceramic fiber reinforced silica aerogel composites at room temperature and elevated temperatures(300℃, 600℃ and 900℃). Influences of thermal exposure to high temperature and high temperature service environment on the compression property and deformation recovery were both investigated. Scanning electron microscopy(SEM), Fourier transform infrared spectroscopy(FT-IR) and X-ray diffraction(XRD) were applied to help understand the mechanisms of mechanical property variations. The experimental results show that the compression modulus and strength both increase with the increasing thermal exposure temperature and testing temperature,but the deformation recovery capability decreases. The micro structure changes caused by thermal sintering are considered as the main reason for the property variations.Viscous flow and matter transport due to high temperature resulted in the fusion of aerogel particles. This made the particle skeleton thicker and stronger, which led to higher stiffness and strength of the composites. However, matrix cracks induced by the formation and fracture of larger pores made unrecoverable deformation more serious. In the tests at elevated temperatures,the aggregation of aerogel particles in a fused state got more severe because of the addition of mechanical load. As a result, the degradation of deformation recovery capability became more significant. | LYU ShuangQi YANG XiaoGuang SHI DuoQi QI HongYu JING Xin LI ShaoLin | 2017 | Science China(Technological Sciences)2017，60，11： | 4 |
| 20 | MicroRNA-27a-mediated repression of cysteine-rich secretory protein 2 translation in asthenoteratozoospermic patients显示文摘充满半胱氨酸的能分泌的蛋白质(CRISP2 ) 2 是在在 modulating 精子 flagellar 活动性, acrosome 反应,和配偶子熔化起作用的精子的重要蛋白质。精子缺乏 CRISP2 展览低精子活动性和反常形态学。然而,在 asthenoteratozoospermia (ATZ ) 位于 CRISP2 的减小下面的分子的机制仍然保持未知。在这研究, CRISP2 蛋白质而非它的 mRNA 的低表示作为与 normozoospermic 男性相比从 ATZ 病人在呼喊的精子被观察。随后,生物信息的预言,酶记者试金,和 microRNA-27a (miR-27a ) transfection 实验表明 miR-27a 明确地由绑定指向 CRISP2 到它的 3 untranslated 区域(3-UTR ) , posttranscriptionally 压制 CRISP2 表示。进一步的证据被高 miR-27a 表示的临床的观察从在 miR-27a 表示和 CRISP2 蛋白质表示之间的 ATZ 病人和否定关联在呼喊的精子提供。最后,回顾的后续研究支持了那两高 miR-27a 表情和低 CRISP2 蛋白质表示与低进步精子活动性,反常形态学,和不孕被联系。这研究在 ATZ 表明为减少的 CRISP2 表示负责的新奇机制,它可以为对待男不孕,或为男避孕提供一个潜在的治疗学的目标。 | Jun-Hao Zhou Qi-Zhao Zhou Jian-Kun Yang Xiao-Ming Lyu Jun Bian Wen-Bin Guo Zi-Jian Chen Ming Xia Hui Xia Tao Qi Xin Li Cun-Dong Liu | 2017 | Asian Journal of Andrology2017，19，5： | 4 |
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