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| 1 | Evidences for mutations in the histone modifying gene SETD2 as critical drivers in leukemia development显示文摘Cancer is thought to be largely caused by genetic mutations that alter nucleotide sequences of DNA,yet epigenetic factors are increasingly recognized to also play causative roles in cancer development.The idea of'epimutations'involves aberrations in chemical modification of the chromatin or DNA that do not change nucleotide sequence.While it is widely accepted that aberrations of DNA methylation contribute to carcinogenesis,the functional importance of his- | WANG QianFei CHENG Tao | 2014 | Science China(Life Sciences)2014，57，9： | 8 |
| 2 | Gut microbiome alterations and its link to corticosteroid resistance in immune thrombocytopenia显示文摘Quantitative metagenomic studies have linked the gut microbiota to autoimmune disorders.Here,we performed deep shotgun metagenomic sequencing of fecal samples from 99 immune thrombocytopenia(ITP)patients and 52 healthy controls.Dysbiosis in the gut microbiome of ITP was detected phylogenetically and functionally,and classifier based on species markers distinguished individuals with ITP from healthy controls.In particular,the abundance of Ruminococcus gnavus,Bifidobacterium longum and Akkermansia muciniphila was markedly increased in treatment-na?ve ITP patients,and the alterations of microbial species were correlated with clinical indices.Functionally,the secondary bile acid biosynthesis and flagellar assembly were depleted in the gut microbiota of ITP,which may contribute to the onset of ITP by affecting the immune system.Furthermore,we found that corticosteroid treatment affected the gut microbiome of ITP.Compared with corticosteroid-sensitive ITP patients,we identified that the corticosteroid-resistant ITP patients displayed a distinct gut microbiome,which was different from that of the treatment-na?ve ITP patients.Together,we provided support for the critical role of gut microbiota in the development of ITP and established a foundation for further research characterizing gut microbiota in relation to corticosteroid resistance of ITP. | Yanan Wang Fengqi Liu Gaochao Zhang Yan Su Xueyan Sun Qi Chen Chencong Wang Haixia Fu Yun He Xiaolu Zhu Xiao Liu Meng Lv Xiangyu Zhao Xiaosu Zhao Yueying Li Qianfei Wang Xiaojun Huang Xiaohui Zhang | 2021 | Science China(Life Sciences)2021，64，5： | 6 |
| 3 | Bamboo charcoal addition enhanced the nitrogen removal of anammox granular sludge with COD:Performance,physicochemical characteristics and microbial community显示文摘The effects of different chemical oxygen demand(COD)concentrations on the anammox granular sludge with Bamboo Charcoal(BC)addition were evaluated in UASB reactor.The results showed that the average total nitrogen(TN)removal efficiency was reduced from 85.9%to 81.4%when COD concentration was increased from 50 to 150 mg/L.However,the TN removal efficiency of BC addition reactors was dramatically 3.1%-6.4%higher than that without BC under different COD concentrations.The average diameter of granular sludge was 0.13 mm higher than that without BC.The settling velocity was increased by elevated COD concentration,while the EPS and VSS/SS were increased with BC addition.The high-throughput Miseq sequencing analyses revealed that the bacterial diversity and richness were decreased under COD addition,and the Planctomycetes related to anammox bacteria were Candidatus Brocadia and Candidatus Kuenenia.The Metagenomic sequencing indicated that the abundance of denitrification related functional genes all increased with elevated COD,while the abundance of anammox related functional genes of decreased.The func-tional genes related to anammox was hydrazine synthase encoding genes(hzsA,hzsB and hzsB).The average relative abundance of hzs genes in the reactor with BC addition was higher than the control at COD concentrations of 50 mg/L and 150 mg/L.The functional genes of denitrification mediated by BC were higher than those without BC throughout the operation phase.It is interesting to note that BC addition greatly enriched the related func-tional genes of denitrification and anammox. | Menglei Guo Ying Jiang Junxiang Xie Qianfei Cao Qun Zhang Adams Mabruk Chongjun Chen | 2022 | Journal of Environmental Sciences2022，34，5： | 5 |
| 4 | Lifetime Evaluating and the Effects of Operation Conditions on Automotive Fuel Cells显示文摘Lifetime is one of the important indicators of automotive proton exchange membrane fuel cells. People used to evaluate the lifetime of vehicular fuel cells by laboratory tests or road tests that usually take thousands hours even years. In order to achieve a rapid evaluation technique and to seek lifetime extension methods, a lifetime calculation formation was drawn out in consideration of the vehicle driving cycle and the working condition factors. Bench experiments were individually carried out on two fuel-cell stacks same as ones applied on vehicle, and the performance decay rates of the two stacks were obtained under four operation conditions of changing load cycle, start-stop cycle, idling and heavy load. As a result, the predicted lifetimes rather conform to the actual running status in road test. And the research on the fuel cell performance decay rates under different load conditions was also done. Consequently, an unexpected finding was discovered that operating under micro-current has an effect on recovering fuel cell performance. The vehicle fuel cell rapid assessment method only requires four laboratory tests of driving cycle, load cycle, idle operating conditions and heavy load conditions, and the whole process merely lasts less than 250 h. These experimental results can be used to predict the vehicular fuel cell lifetimes on various utility models or driving cycles, therefore to optimize the application model to prolong the fuel cell lifetime. Actually in the experiment, it has already been proved successfully that the fuel cell lifetime could be extended from 1 100 h to 2 600 h by optimizing operating mode. The quick evaluation method is helpful to develop extended life fuel cell and to deplete fuel cell for a longer time. | PEI Pucheng YUAN Xing LI Pengcheng CHAO Pengxiang CHANG Qianfei | 2010 | Chinese Journal of Mechanical Engineering2010，23，1： | 3 |
| 5 | Elimination of CD4^low HLA-G^+ T cells overcomes castration- resistance in prostate cancer therapy显示文摘 | Chao Wang Jiahuan Chen Qianfei Zhang Wang Li Shengbo Zhang Yanjie Xu Fang Wang Bing Zhang Yan Zhang Wei-Qiang Gao | 2018 | Cell Research2018，28，11： | 3 |
| 6 | A quick evaluating method for automotive fuel cell lifetime显示文摘 | PEI Pucheng CHANG Qianfei TANG Tian | 2008 | International Journal of Hydrogen Energy2008，33，14： | 1 |
| 7 | Mechanical Properties and Morphological of PC/PE-UHMW Blends with HDPE-g-GMA as a Compatibilizer 显示文摘 | Fanwen Yang Yaoming Zhao Qianfei Gao | 2002 | Polymer Preprints2002，43，1： | 1 |
| 8 | Studies on the bioactivity of aqueous extract of pu-erh tea and its fractions: In vitro antioxidant activity and α-glycosidase inhibitory property, and their effect on postprandial hyperglycemia in diabetic mice显示文摘 | Qianfei Huang Sihang Chen Hao Chen Yuefei Wang Yiqi Wang Danielle Hochstetter Ping Xu | 2013 | Food and Chemical Toxicology2013，，： | 1 |
| 9 | A Quick Evaluating Meth-od for Automotive Fuel Cell Lifetime 显示文摘 | Pei Pucheng Chang Qianfei Tang Tian | 2008 | International Journal ofHydrogen Energy2008，33，14： | 1 |
| 10 | On the mechanism of conductivity enhancement in poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) film through solvent treatment显示文摘 | Jianyong Ouyang Qianfei Xu Chi-Wei Chu Yang Yang Gang Li Joseph Shinar | 2004 | Polymer2004，，25： | 1 |
| 11 | A quick eval- uating method for automotive fuel cell lifetime 显示文摘 | Pei Pucheng Chang Qianfei Tang Tian | 2008 | In- ternational Journal of Hydrogen Energy2008，33，： | 1 |
| 12 | Platinum rianoparticle--graphene hybrids synthesized by liquid phase pulsed laser ablation as cathode catalysts for Li-air batteries 显示文摘 | YANG Yin SHI Min ZHOU Qianfei | 2012 | ElectrochenlistryConlmunications2012，，20： | 1 |
| 13 | A Quick Evaluating Meth- od for Automotive Fuel Cell Lifetime 显示文摘 | Pei Pucheng Chang Qianfei Tang Tian | 2008 | International Journal of Hydrogen Energy2008，33，： | 1 |
| 14 | PDO对西太平洋副热带高压年代际东退的可能贡献显示文摘以往的研究已证实,西太平洋副热带高压(副高)在1970s后期减弱东退.基于大气模式(CAM4)的理想型海温强迫试验,结果表明:副高的东退可能是大气对于正位相太平洋年代际振荡(PDO)的相应.伴随着PDO转变为正位相,西太平洋至印度半岛以及热带东太平洋的对流加热增强,大气表现为Gill型响应,在亚洲大陆至西太平洋上空低层产生气旋性异常,有利于副高东退.同时,高层产生反气旋异常,使得东亚西风急流加强和向南扩展,进而调节西太平洋上空的次级环流,进一步有利于副高东退. | Qi Tong Yanyan Huang Mingkeng Duan Qianfei Zhao | 2021 | Atmospheric and Oceanic Science Letters2021，14，1： | 1 |
| 15 | Therapeutic Effect Observation on Moxi- bustion at Tianshu (ST 25) for Acne Vulgaris显示文摘 | Zhang Yiming Wu Qianfei | 2011 | J Acupunct Tuina Sci2011，9，3： | 1 |
| 16 | On the mechanism of conductivity enhancement in poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) film through solvent treatment显示文摘 | Jianyong Ouyang Qianfei Xu Chi-Wei Chu Yang Yang Gang Li Joseph Shinar | 2004 | Polymer2004，，25： | 1 |
| 17 | On the mechanism of conductivity enhancement in poly (3,4-ethy- lenedioxythiophene) : Poly(styrene sulfonate) film through solvent treatment显示文摘 | J ianyong Ouyang Xu Qianfei Chu Chiwei | 2004 | Polymer2004，45，25： | 1 |
| 18 | A quick evaluating method for automotive fuel cell lifetime 显示文摘 | Pei Pucheng Chang Qianfei Tang Tian | 2008 | International Journal of Hydrogen Energy2008，33，： | 1 |
| 19 | 显示文摘 | Wu Min He Qin Shao Qianfei | 2011 | ACS App1 Mater In- terfaces2011，3，9： | 1 |
| 20 | Studies on the bioactivity of aqueous extract of pu-erh tea and its fractions: In vitro antioxidant activity and α-glycosidase inhibitory property, and their effect on postprandial hyperglycemia in diabetic mice显示文摘 | Qianfei Huang Sihang Chen Hao Chen Yuefei Wang Yiqi Wang Danielle Hochstetter Ping Xu | 2013 | Food and Chemical Toxicology2013，，： | 1 |
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