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| 1 | Real-time whole-brain imaging of hemodynamics and oxygenation at micro-vessel resolution with ultrafast wide-field photoacoustic microscopy显示文摘High-speed high-resolution imaging of the whole-brain hemodynamics is critically important to facilitating neurovascular research.High imaging speed and image quality are crucial to visualizing real-time hemodynamics in complex brain vascular networks,and tracking fast pathophysiological activities at the microvessel level,which will enable advances in current queries in neurovascular and brain metabolism research,including stroke,dementia,and acute brain injury.Further,real-time imaging of oxygen saturation of hemoglobin(sO_(2))can capture fast-paced oxygen delivery dynamics,which is needed to solve pertinent questions in these fields and beyond.Here,we present a novel ultrafast functional photoacoustic microscopy(UFF-PAM)to image the whole-brain hemodynamics and oxygenation.UFF-PAM takes advantage of several key engineering innovations,including stimulated Raman scattering(SRS)based dual-wavelength laser excitation,water-immersible 12-facet-polygon scanner,high-sensitivity ultrasound transducer,and deep-learning-based image upsampling.A volumetric imaging rate of 2 Hz has been achieved over a field of view(FOV)of 11×7.5×1.5 mm^(3) with a high spatial resolution of~10 μm.Using the UFF-PAM system,we have demonstrated proof-of-concept studies on the mouse brains in response to systemic hypoxia,sodium nitroprusside,and stroke.We observed the mouse brain's fast morphological and functional changes over the entire cortex,including vasoconstriction,vasodilation,and deoxygenation.More interestingly,for the first time,with the whole-brain FOV and micro-vessel resolution,we captured the vasoconstriction and hypoxia simultaneously in the spreading depolarization(SD)wave.We expect the new imaging technology will provide a great potential for fundamental brain research under various pathological and physiological conditions. | Xiaoyi Zhu Qiang Huangl Anthony Dispirito Tri Vu Qiangzhou Rong Xiaorui Peng Huaxin Sheng Xiling Shen Qifa Zhou Laiming Jiang Ulrike Hoffmann Junjie Yao | 2022 | Light(Science & Applications)2022，11，6： | 2 |
| 2 | High sensitive fiber optic refractometer based on a core-diameter-mismatch Math Zehnder interferometer 显示文摘 | Qiangzhou Rong | 2012 | IEEE Sensors Journal2012，12，7： | 1 |
| 3 | Observation of the evolution of mode-locked solitons in different dispersion regimes of fiber lasers 显示文摘 | Shao Zhihua Qiao Xueguang Rong Qiangzhou | 2015 | Optics Communications2015，345，： | 1 |
| 4 | Effectofinorganicmatteronreactivityandkineticsofcoalpyrolysis显示文摘 | Quanrun Liu Haoquan Hu QiangZhou etal | 2004 | Fuel2004，83，： | 1 |
| 5 | A fiber Fabry–Perot interferometer based on a PVA coating for humidity measurement显示文摘 | Dan Su Xueguang Qiao Qiangzhou Rong Hao Sun Jing Zhang Zhengyuan Bai Yanying Du Dingyi Feng Yupeng Wang Manli Hu Zhongyao Feng | 2013 | Optics Communications2013，，： | 1 |
| 6 | Temperature and refractive index sensing characteristics of an MZI-based multimode fiber–dispersion compensation fiber–multimode fiber structure显示文摘 | Hao Sun Shen Yang Jing Zhang Qiangzhou Rong Lei Liang Qinfang Xu Guanghua Xiang Dingyi Feng Yanying Du Zhongyao Feng Xueguang Qiao Manli Hu | 2012 | Optical Fiber Technology2012，，6： | 1 |
| 7 | Temperature-calibrated fiber-optic refractometer based on a compact FBG-SMS structure 显示文摘 | Rong Qiangzhou Qiao Xueguang Guo Tuan | 2012 | Chinese Optics Letters2012，10，03： | 1 |
| 8 | Effects of limited proteolysis and high-pressure homogenisation on structural and functional characteristics of glycinin 显示文摘 | LUO Donghui ZHAO Qiangzhou ZHAO Mounting | 2010 | Food Chemistry2010，122，： | 1 |
| 9 | Crosstalk-Aware Routing Resource Assignment显示文摘Crosstalk noise is one of the emerging issues in deep sub-micrometer technology which causes many undesired effects on the circuit performance. In this paper, a Crosstalk-Aware Routing Resource Assignment (CARRA) algorithm is proposed, which integrates the routing layers and tracks to address the crosstalk noise issue during the track/layer assignment stage. The CARRA problem is formulated as a weighted bipartite matching problem and solved using the linear assignment algorithm. The crosstalk risks between nets are represented by an undirected graph and the maximum number of the concurrent crosstalk risking nets is computed as the max clique of the graph. Then the nets in each max clique are assigned to disadjacent tracks. Thus the crosstalk noise can be avoided based on the clique concept. The algorithm is tested on IBM benchmarks and the experimental results show that it can improve the final routing layout a lot with little loss of the completion rate. | Hai-LongYao Yi-CiCai QiangZhou Xian-LongHong | 2005 | Journal of Computer Science & Technology2005，20，2： | 1 |
| 10 | High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator显示文摘3D photoacoustic computed tomography(3D-PACT)has made great advances in volumetric imaging of biological tissues,with high spatial-temporal resolutions and large penetration depth.The development of 3D-PACT requires high-performance acoustic sensors with a small size,large detection bandwidth,and high sensitivity.In this work,we present a new high-frequency 3D-PACT system that uses a microring resonator(MRR)as the acoustic sensor.The MRR sensor has a size of 80μm in diameter and was fabricated using the nanoimprint lithography technology.Using the MRR sensor,we have developed a transmission-mode 3D-PACT system that has achieved a detection bandwidth of~23 MHz,an imaging depth of~8 mm,a lateral resolution of 114μm,and an axial resolution of 57μm.We have demonstrated the 3D PACT’s performance on in vitro phantoms,ex vivo mouse brain,and in vivo mouse ear and tadpole.The MRR-based 3D-PACT system can be a promising tool for structural,functional,and molecular imaging of biological tissues at depths. | Qiangzhou Rong Youngseop Lee Yuqi Tang Tri Vu Carlos Taboada Wenhan Zheng Jun Xia David A.Czaplewski Hao F.Zhang Cheng Sun Junjie Yao | 2022 | Biomedical Engineering Frontiers2022，3，1： | 0 |
| 11 | 过套管电阻率测井在储层监测中的应用显示文摘在过去的20年中,服务公司成功地克服了许多过套管电阻率测井中信号小的困难。同时,过钢套管电阻率测井已经在许多油区从理论到实际应用中取得了很好的效果。过套管电阻率测井可以区分在套管封固后的含油地层或水层。这种方法可以用来作储层监控,残余油储量估算,或者是应用于由于钻井环境而导致的不能在裸眼井中进行测量的情况。我们已经在两个服务公司中对过套管电阻率进行了一系列实验。我们提供服务的地层包括砂岩和碳酸盐岩,在砂岩地层中电阻率从10Ω·m到几十欧姆米,而在碳酸盐岩地层中的电阻率可达到几百欧姆米或者更高。我们在最近钻探的下套管井与封固几年或者几十年的老井中实验这种仪器。曲线出现异常的地方都与套管接箍、套管靴、射孔段,或者与水泥胶结有关。同时我们注意到测井速度对测井质量影响很大,特别是在高电阻率地层中。尽管对过套管电阻率测量有一些争议,但它的发现对于岩石物理和油藏研究仍是令人激动的事情。总体上说,过套管电阻率的测量与裸眼井电阻率测井很相近。在套管井与裸眼井都进行电阻率测量的井段内,两种测井之间的差异经常反映在含水饱和度的变化上。过套管电阻率测井比其它过套管剩余油饱和度评价方法有较大优势,因为它不受低孔欧度的影响,并且探测深度也更深。但另一方面,应用过套管电阻率法计算Sw必须清楚地了解该地区地层水的矿化度。在提高采收率采油的地区,由于原生水和注入水混合的原因,必须采取一定的措施获取准确的含水饱和度。 | QiangZhou 武清创 李丽 闵家华 | 2003 | 测井与射孔2003，6，2： | 0 |
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