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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation显示文摘N6-methyladenosine(m6A),and its reader protein YTHDF1,play a pivotal role in human tumorigenesis by affecting nearly everystage of RNA metabolism.Autophagy activation is one of the ways by which cancer cells survive hypoxia.However,the possibleinvolvement of m6A modification of mRNA in hypoxia-induced autophagy was unexplored in human hepatocellular carcinoma(HCO).In this study,specific variations in YTHDF1 expression were detected in YTHDF1-overexpressing,knockout,and-knockdownHCC cells,HCC organoids,and HCC patient-derived xenograft(PDX)murine models.YTHDF1 expression and hypoxia inducedautophagy were significantly correlated in vitro;signifhcant overexpression of YTHDF1 in HCC tissues was associated with poorprognosis,Multivariate cox regression analysis identihed YTHDF1 expression as an independent prognostic factor in patients withHCC.Multiple HC models conhrmed that YTHDF1 deficiency inhibited HCC autophagy,growth,and metastasis.Luciferase reporterassays and chromatin immunoprecipitation demonstrated that HlIF-1a regulated YTHDF1 transcription by directly binding to itspromoter region under hypoxia.The results of methylated RNA immunoprecipitation sequencing,proteomics,and polysomeprofling indicated that YTHDF1 contibuted to the translation of autophagy-related genes ATG2A and ATG14 by binding to m6A-modifhed ATG2A and ATG14 mRNA,thus facilitating autophagy and autophagy-related malignancy of HCC.Taken together,HlE-1d-induced YTHDF1 expression was associated with hypoxia-induced autophagy and autophagy-related HCC progression via promoting translation of autophagy-related genes ATG2A and ATG14 in a m6A-dependent manner.Our fndings suggest thatYTHDF1 is a potential prognostic biomarker and therapeutic target for patients with HCC. | Qing Li Yong Ni Liren Zhang Runqiu Jiang Jing Xu Hong Yang Yuanchang Hu Jiannan Qiu Liyong Pu Jinhai Tang Xuehao Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 24 |
| 3 | Microstructure and Tribological Behavior of a TiO_2/hBN Composite Ceramic Coating Formed via Micro-arc Oxidation of Ti–6Al–4V Alloy显示文摘A composite coating containing hexagonal boron nitride(hBN) particles and titanium oxide(TiO_2) was formed on the surface of Ti–6Al–4V alloy via micro-arc oxidation(MAO). The effect of quantity of the hBN-particles added into electrolyte on microstructure, composition, and wear behavior of the resulting composite coatings was investigated. Microstructure, phase composition, and tribological behavior of the resulting MAO coatings were evaluated via scanning electron microscopy, X-ray diffraction, and ball-on-disc abrasive tests. The results reveal that the TiO_2/hBN composite coating consisting of rutile TiO_2, anatase TiO_2, and an hBN phase was less porous than particle-free coating. Furthermore, the presence of hBN particles in the MAO coating produced an improved anti-friction property. The composite coating produced in the electrolyte containing 2 g/L of hBN particles exhibited the best wear resistance.The outer loose layer of the MAO coatings was removed by a mechanical polishing process, which led to a significant improvement in the wear resistance and anti-friction properties of the MAO coatings and highlighted an essential lubricating role of hBN particles in the composite coatings. However, wear mechanism of the MAO coatings was not relevant to the presence of hBN particles, where fatigue wear dominated the anti-fraction properties of the MAO coatings with and without hBN particles. | Ni Ao Daoxin Liu Shuaixing Wang Qing Zhao Xiaohua Zhang Mengmeng Zhang | 2016 | Journal of Materials Science & Technology2016，32，10： | 19 |
| 4 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 5 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 6 | Association between large artery stenosis,cerebral small vessel disease and risk of ischemic stroke显示文摘We aimed to assess the associations of large artery stenosis(LAS)and cerebral small vessel disease(CSVD)with the risk of ischemic stroke and to investigate their respective and combined contributions.In the prospective population-based Shunyi Study,1,082 stroke-free participants aged 55.9±9.1 years were included.Participants were followed for incident stroke throughout the study period(2013-2019).Total small vessel disease score was used to measure CSVD burden.Cervico-cerebral large artery stenosis was evaluated via brain magnetic resonance angiography and carotid ultrasound.We estimated the risk of ischemic stroke in relation to LAS and CSVD with Cox regression models.During a mean follow-up of 4.2 years,34 participants(3.1%)experienced at least one ischemic stroke.Severe LAS(≥50% stenosis versus no stenosis:HR=3.27(95%CI:1.31-8.18))and high CSVD burden(total small vessel disease score 2-4 versus 0 point:HR=12.73(4.83-33.53))were associated with increased stroke risk independently.In multivariate models,CSVD burden(7.72%)explained a larger portion of the variation in stroke risk than severity of LAS(3.49%).Our findings identified that both LAS and CSVD were associated with future ischemic stroke in asymptomatic subjects,while those with high CSVD burden deserve more attention in primary prevention of stroke. | Fei Han Ding-Ding Zhang Fei-Fei Zhai Jun Xue Jiang-Tao Zhang Shuang Yan Li-Xin Zhou Jun Ni Ming Yao Meng Yang Ming-Li Li Zheng-Yu Jin Qing Dai Shu-Yang Zhang Li-Ying Cui Yi-Cheng Zhu | 2021 | Science China(Life Sciences)2021，64，9： | 9 |
| 7 | Enrichment of heavy metal elements and their adsorption on iron oxides during carbonate rock weathering process显示文摘Analysis of trace elements in the Lower Palaeozoic carbonate rock strata of the Beijing area shows that the Cr, Zn, Cd and Pb contents increase from primary carbonate rocks to weathered carbonate rocks and from primary carbonate rocks to the soil coexisting with carbonate rock. Distributions of Cr, Zn, Cd and Pb have the same trends as that of Fe2O3. Iron oxides play different roles at different stages of weathering of carbonate rock. The adsorption of Cr, Zn, Cd and Pb on Fe2O3 is greater than on FeO in soil. However, FeO, as a main component of clay mineral, is a better adsorbent of Cr, Zn, Cd and Pb than Fe2O3 in weathered and primary carbonate rocks. According to R-type clustering analysis, the main components of carbonate rock are divided into marine and continental sediments. Correlation analysis shows that heavy metal elements mainly exist in continental substances. | Shanqin Ni Yiwen Ju Quanlin Hou Shijie Wang Qing Liu Yudong Wu Lingling Xiao | 2009 | Progress in Natural Science:Materials International2009，19，9： | 8 |
| 8 | Efficacy and safety of Shenyankangfu Tablet,a Chinese patent medicine,for primary glomerulonephritis:A multicenter randomized controlled trial显示文摘Background:Shenyankangfu Tablet(SYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney disease.Objective:This trial compared the efficacy and safety of SYKFT,for the control of proteinuria in primary glomerulonephritis patients,against the standard drug,losartan potassium.Design,setting,participants and intervention:This was a multicenter,double-blind,randomized,controlled clinical trial.Primary glomerulonephritis patients,aged 18-70 years,with blood pressure≤140/90 mmHg,estimated glomerular filtration rate(eGFR)>45 mL/min per 1.73 ㎡,and 24-hour proteinuria level of 0.5-3.0 g,were recruited in 41 hospitals across 19 provinces in China and were randomly divided into five groups:SYKFT,losartan potassium 50 mg or 100 mg,SYKFT plus losartan potassium 50 mg or 100 mg.Main outcome measu res:The primary outcome was change in the 24-hour proteinuria level,after 48 weeks of treatment.Results:A total of 735 participants were enrolled.The percent decline of urine protein quantification in the SYKFT group after 48 weeks was 8.78%±2.56%(P=0.006)more than that in the losartan 50 mg group,which was 0.51%±2.54%(P=1.000)less than that in the losartan 100 mg group.Compared with the losartan potassium 50 mg group,the SYKFT plus losartan potassium 50 mg group had a 13.39%±2.49%(P<0.001)greater reduction in urine protein level.Compared with the losartan potassium 100 mg group,the SYKFT plus losartan potassium 100 mg group had a 9.77%±2.52%(P=0.001)greater reduction in urine protein.With a superiority threshold of 15%,neither was statistically significant.eGFR,serum creatinine and serum albumin from the baseline did not change statistically significant.The average change in TCM syndrome score between the patients who took SYKFT(-3.00[-6.00,-2.00])and who did not take SYKFT(-2.00[-5.00,0])was statistically significant(P=0.003).No obvious adverse reactions were observed in any group.Conclusion:SYKFT decreased the proteinuria and improved the TCM syndrome scores of primary glomerulonephritis patients,with no change in the rate of decrease in the eGFR.SYKFT plus losartan potassium therapy decreased proteinuria more than losartan potassium therapy alone.Trial registration number:NCT02063100 on ClinicalTrials.gov. | Jie Wu Shu-wei Duan Hong-tao Yang Yue-yi Deng Wei Li Ya-ni He Zhao-hui Ni Yong-li Zhan Shan Lin Zhi-yong Guo Jun Zhu Jing-ai Fang Xu-sheng Liu Li-hua Wang Rong Wang Nian-song Wang Xiao-hong Cheng Li-qun He Ping Luo Shi-ren Sun Ji-feng Sun Ai-ping Yin Geng-ru Jiang Hong-yu Chen Wen-hu Liu Hong-li Lin Meng Liang Lu Ma Ming Chen Li-qun Song Jian Chen Qing Zhu Chang-ying Xing Yun Li Ji-ning Gao Rong-shan Li Ying Li Hao Zhang Ying Lu Qiao-ling Zhou Jun-zhou Fu Qiang He Guang-yan Cai Xiang-mei Chen | 2021 | Journal of Integrative Medicine2021，19，2： | 8 |
| 9 | Relationship Between Heterosis and Parental Genetic Distance Based on Molecular Markers for Functional Genes Related to Yield Traits in Rice显示文摘The genetic distances among 18 cytoplasmic male sterile lines and 11 restorer lines were analyzed with molecular markers derived from yield-related functional genes.The correlation between parental genetic distance and heterosis was investigated by analyzing the performance of 47 combinations.The results showed that the genetic distance was significantly correlated with yield heterosis(r=0.29*),but not significantly correlated with heterosis for other traits,such as number of effective panicles per plant,seed setting rate,1000-grain weight,number of grains per panicle and theoretical yield.However, the correlation coefficient was so small that the parental genetic distance could not to be used to predict heterosis. | ZHANG Tao NI Xian-lin JIANG Kai-feng DENG Hua-feng HE Qing YANG Qian-hua YANG Li WAN Xian-Qi CAO Ying-jiang ZHENG Jia-kui | 2010 | Rice science2010，17，4： | 7 |
| 10 | A Cluster Based Feature Selection Method for Cross-Project Software Defect Prediction显示文摘从外部来源软件的标记的数据投射在目标补偿有用数据的缺乏的跨工程的缺点预言(CPDP ) 使用投射,以便造一个有意义的分类模型。然而,在从来源和目标工程提取的软件特征之间的分发差距可能太大,不能为训练使混合数据有用。在这份报纸,我们建议基于簇的新奇方法 FeSCH (用簇的特征选择混合数据) 由特征选择减轻分发差别。FeSCH 包括二个阶段。用一个基于密度的聚类方法聚类阶段簇特征的特征,和特征选择分阶段执行用评价策略从每簇选择特征。为 CPDP,我们在第二个阶段设计三不同启发式的评价策略。调查 FeSCH 的预言性能,我们基于真实世界的软件工程设计实验,并且学习在 FeSCH 的设计选择的效果(例如评价策略,特征选择比率,和分类器) 。试验性的结果证明 FeSCH 的有效性。与最先进的基线方法相比,第一, FeSCH 完成更好的性能,它的表演是使用的分类器影响的更少。第二, FeSCH 由有效地越过特征范畴选择特征提高表演,并且为为缺点预言选择有用特征提供指南。 | Chao Ni Wang-Shu Liu Xiang Chen Qing Gu Dao-Xu Chen Qi-Guo Huang | 2017 | Journal of Computer Science & Technology2017，32，6： | 7 |
| 11 | 透明土中连续球体型锚杆拔出机理研究显示文摘采用透明土材料和粒子图像测速法(PIV)技术,通过物理模型试验研究锚杆拔出机理。在模型试验中采用A、B两种不同尺寸的连续球体锚杆锚固段,试验获得各锚杆锚固段上移对周围土体的扰动规律、锚杆位移与锚固力变化曲线以及拔出破坏时破裂面的位置及形状。通过分析连续球体锚杆锚固段的极限承载力和锚固段破坏机理,推导出连续球体锚杆抗拔力的计算公式。试验结果分析表明:本文试验条件下,锚杆拔出时竖向位移最大影响范围与连续球体的半径和间距有直接关系;A、B型连续球体锚杆的极限承载力,分别比普通圆柱型锚杆提高52%和117%;连续球体锚杆锚固段在上拔破坏过程中抗拔力的贡献可分为3个部分:直杆与土层的黏结、肩部端承力和黏土黏聚力。 | 夏元友 陈晨 NI Qing | 2017 | 岩土工程学报2017，39，5： | 7 |
| 12 | 基于透明土的4种锚杆拔出对比模型试验显示文摘采用透明土材料和粒子图像测速法(PIV)技术,通过物理模型试验研究锚杆拔出机理。在试验中采用普通圆柱型和手榴弹型、糖葫芦型和圣诞树型3种异型共4种不同形状锚固段锚杆,测试获得各锚杆随锚杆锚固段上移对周围土体的扰动规律、锚杆位移与锚固力变化曲线,分析各锚杆锚固段的极限承载力与锚固段破坏机理。试验结果分析表明:在本文试验条件下,在锚杆拔出破坏前,除了手榴弹型锚杆外,各种形状锚杆对土体水平位移影响相对于竖向位移均较小,糖葫芦型和圣诞树型锚杆对土体的竖向位移影响范围最大,达到6.0倍锚杆半径,比普通圆柱型锚杆对土体竖向位移影响范围大1.5倍;异形锚杆可以很有效的提高锚杆极限承载力,比普通圆柱型锚杆可提高66%~91%,其中圣诞树型锚杆的极限承载力最大;锚杆锚固段的有效长度、有效横截面积、有效直径对其极限承载力有直接影响;锚杆极限承载力值是发生在锚杆锚固段与土体接触的界面开始破坏到完全破坏之间,锚杆锚固段与土体接触界面发生破坏,是从锚杆自由段部位开始逐渐往锚杆底部发展,以A型锚杆为例,当破坏发展到距锚杆底部1/3的位置时,锚杆极限承载力达到峰值。 | 夏元友 陈晨 NI Qing | 2017 | 岩土工程学报2017，39，3： | 7 |
| 13 | Solid components and acid buffering capacity of soils in South China显示文摘SolidcomponentsandacidbuferingcapacityofsoilsinSouthChinaQiuRongliang,WuQing,ZhangYunniDepartmentofEnvironmentalScience,Zho... | Qiu Rong liang, Wu Qing, Zhang Yun ni Department of Environmental Science, Zhongshan University, Guangzhou 510275, China | 1998 | Journal of Environmental Sciences1998，10，2： | 6 |
| 14 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 15 | Studies on LCST of poly (N-isopropylacrylamide-co-acrylic acid-co-N-diacetone acrylamide)显示文摘从 N-isopropylacrylamide (尼巴椰子) 的线性共聚物,丙烯酸的酸(AA ) 和双丙酮压克力酰胺(DAA ) 被准备了。他们的下部临界会溶温度(LCST ) 上的作文,离子强度和最适 PH 的效果被调查了。 | Cai Hua Ni Xiao Xia Zhu Qing Lan Wang Xian Yu Zeng | 2007 | Chinese Chemical Letters2007，18，1： | 5 |
| 16 | AtKP1, a kinesin-like protein, mainly localizes to mitochondria in Arabidopsis thaliana显示文摘Kinesins and kinesin-like proteins (KLPs) constitute a large family of microtubule-based motors that play important roles in many fundamental cellular and developmental processes. To date, a number of kinesins or KLPs have been identified in plants including Arabidopsis thaliana. Here, a polyclonal antibody against AtKP1 (kinesin-like protein 1 in A.thaliana) was raised by injection the expressed AtKP1 specific C-terminal polypeptides in rabbits, and immunoblot analysis was conducted with the affinity-purified anti-AtKP1 antibody. The results indicated that this antibody recognized the AtKP1 fusion proteins expressed in E. coli and proteins of ~125 kDa in the soluble fractions of Arabidopsis extracts. The molecular weight was consistent with the calculated molecular weight based on deduced amino acids sequence of AtKP1. To acquire the subcellular localization of the protein, AtKP1 in Arabidopsis root cells was observed by indirect immunofluorescence microscopy. AtKP1 was localized to particle-like organelles in interphase or dividing cells, but not to mitotic microtubule arrays. Relatively more AtKP1 was found in isolated mitochondria fraction on immunoblot of the subcellular fractions. The AtKP1 protein could not be released following a 0.6 M KI washing,indicating that AtKP1 is tightly bind to mitochondria and might function associated with this kind of organelles. | Cheng Zhi NI Hai Qing WANG Tao XU Zhe QU Guo Qin LIU | 2005 | Cell Research2005，15，9： | 5 |
| 17 | A continued saga of Boc5, the first non-peptidic glucagon-like peptide-1 receptor agonist with in vivo activities显示文摘象 Glucagon 一样 peptide-1 (GLP-1 ) 基于治疗为治疗类型 2 糖尿病介绍一种有希望的选择。然而,在市场上或在开发中当前相对 peptidic GLP-1 mimetics 有几限制。这颗担心为 GLP-1 受体(GLP-1R ) 为 non-peptidic 收缩筋在搜索导致了继续的兴趣。这里,我们简短为 GLP-1R 考察发现,描述和 cyclobutane-derivative-based non-peptidic 收缩筋的一个新奇的班的当前的地位,包括 Boc5 和它的最新发现的类似物 WB4-24。尽管如此的混合物的口头的 bioavailability 仍然提出大挑战,到目前为止取得的进步鼓励我们识别一真正“ druggable ”为 GLP-1R 的小分子收缩筋。 | Min HE Ni GUAN Wei-wei GAO Qing LIU Xiao-yan WU Da-wei MA Da-fang ZHONG Guang-bo GE Chuan LI Xiao-yan CHEN LingYANG Jia-yu LIAO Ming-wei WANG | 2012 | Acta Pharmacologica Sinica2012，33，2： | 5 |
| 18 | Acute responses to inhalation of Iloprost in patients with pulmonary hypertension显示文摘 | ZHANG Hong-liang LIU Zhi-hong WANG Yong XIONG Chang-ming NI Xin-hai HE Jian-guo LUO Qin ZHAO Zhi-hui ZHAO Qing SUN Xing-guo | 2012 | Chinese Medical Journal2012，，16： | 5 |
| 19 | Notch signaling:Its essential roles in bone and craniofacial development显示文摘Notch is a cellecell signaling pathway that is involved in a host of activities including development,oncogenesis,skeletal homeostasis,and much more.More specifically,recent research has demonstrated the importance of Notch signaling in osteogenic differentiation,bone healing,and in the development of the skeleton.The craniofacial skeleton is complex and understanding its development has remained an important focus in biology.In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton,skull,and face develop.We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system,and what importance it may play in the future. | Mikhail Pakvasa Pranav Haravu Michael Boachie-Mensah Alonzo Jones Elam Coalson Junyi Liao Zongyue Zeng Di Wu Kevin Qin Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Yongtao Zhang Changchun Niu Meng Wu Xia Zhao Hao Wang Linjuan Huang Deyao Shi Qing Liu Na Ni Kai Fu Michael J.Lee Jennifer Moriatis Wolf Aravind Athiviraham Sherwin S.Ho Tong-Chuan He Kelly Hynes Jason Strelzow Mostafa El Dafrawy Russell R.Reid | 2021 | Genes & Diseases2021，8，1： | 4 |
| 20 | Clinical features and risk factors associated with severe COVID-19 patients in China显示文摘Background::Coronavirus disease 2019(COVID-19),which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has rapidly spread throughout the world.In this study,we aimed to identify the risk factors for severe COVID-19 to improve treatment guidelines.Methods::A multicenter,cross-sectional study was conducted on 313 patients hospitalized with COVID-19.Patients were classified into two groups based on disease severity(nonsevere and severe)according to initial clinical presentation.Laboratory test results and epidemiological and clinical characteristics were analyzed using descriptive statistics.Univariate and multivariate logistic regression models were used to detect potential risk factors associated with severe COVID-19.Results::A total of 289 patients(197 nonsevere and 92 severe cases)with a median age of 45.0(33.0,61.0)years were included in this study,and 53.3%(154/289)were male.Fever(192/286,67.1%)and cough(170/289,58.8%)were commonly observed,followed by sore throat(49/289,17.0%).Multivariate logistic regression analysis suggested that patients who were aged≥65 years(OR:2.725,95%confidence interval[CI]:1.317-5.636;P=0.007),were male(OR:1.878,95%CI:1.002-3.520,P=0.049),had comorbid diabetes(OR:3.314,95%CI:1.126-9.758,P=0.030),cough(OR:3.427,95%CI:1.752-6.706,P<0.001),and/or diarrhea(OR:2.629,95%CI:1.109-6.231,P=0.028)on admission had a higher risk of severe disease.Moreover,stratification analysis indicated that male patients with diabetes were more likely to have severe COVID-19(71.4%vs.28.6%,χ2=8.183,P=0.004).Conclusions::The clinical characteristics of those with severe and nonsevere COVID-19 were significantly different.The elderly,male patients with COVID-19,diabetes,and presenting with cough and/or diarrhea on admission may require close monitoring to prevent deterioration. | Ning Jiang Yan-Nan Liu Jing Bao Ran Li Wen-Tao Ni Xing-Yu Tan Yu Xu Li-Ping Peng Xiao-Rong Wang Yi-Ming Zeng Dai-Shun Liu Qing Xue Jia-Shu Li Ke Hu Ya-Li Zheng Zhan-Cheng Gao | 2021 | Chinese Medical Journal2021，，8： | 3 |
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