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| 1 | Construction and visualization of high-resolution three-dimensional anatomical structure datasets for Chinese digital human显示文摘The objective of the China Digital Human Project (CDH) is to digitize and visualize the anatomical structures of human body. In the project, a database with information of morphology, physical charac-teristics and physiological function will be constructed. The raw data of CDH which was completed in the Southern Medical University is employed. In Huazhong University of Science and Technology (HUST), the frozen section images are preprocessed, segmented, labeled in accordance with the major organs and tissues of human beings, and reconstructed into three-dimensional (3D) models in parallel on high performance computing clusters (HPC). Some visualization software for 2D atlas and 3D mod-els are developed based on the new dataset with high resolution (0.1mm×0.1mm×0.2mm). In order to share, release and popularize the above work, a website (www.vch.org.cn) is online. The dataset is one of the most important parts in the national information database and the medical infrastructure. | LI AnAn LIUQian ZENG ShaoQun TANG Lei ZHONG ShiZhen LUO QingMing | 2008 | Chinese Science Bulletin2008，53，12： | 7 |
| 2 | Firing patterns of long-term cultured neuronal network on multi-electrode array显示文摘Spontaneous neuronal activity plays an important role in the development and plasticity of brain. To explore the developmental changes in the firing pattern of the neuronal networks in vitro, the hippocampal neurons were cultured on the multi-microelectrode array dish for over 14 weeks and the spontaneous activity was recorded. The results showed that random firing was observed in the 1st week and transformed into synchronized activity after two weeks, then tightly synchronized activity appeared in week 2 to 7 and finally the activities transformed into the random firing pattern. These results suggested three stages in the long-term development of neuronal network in vitro: the stage for connection, the stage of synchronized activity and the mature stage. Synchronized firing shown by spontaneous activity was an important phenomenon in high density cultured neuronal network and transformed patterns during development. | LI Xiangning ZHOU Wei LIU Man ZENG Shaoqun LUO Qingming | 2006 | Progress in Natural Science:Materials International2006，16，12： | 7 |
| 3 | Metastatic status of sentinel lymph nodes in breast cancer determined with photoacoustic microscopy via dual-targeting nanoparticles显示文摘Detection of sentinel lymph nodes(SLNs)is critical to guide the treatment of breast cancer.However,distinguishing metastatic SLNs from normal and inflamed lymph nodes(LNs)during surgical resection remains a challenge.Here,we report a CD44 and scavenger receptor class B1 dual-targeting hyaluronic acid nanoparticle(5K-HA-HPPS)loaded with the near-infra-red fluorescent dye DiR-BOA for SLN imaging in breast cancer.The small sized(~40 nm)self-assembled 5K-HA-HPPSs accumulated rapidly in the SLNs after intradermal injection.Compared with normal popliteal LNs(N-LN),there were ~3.2-fold and ~2.4-fold increases in fluorescence intensity in tumour metastatic SLNs(T-MLN)and inflamed LNs(Inf-LN),respectively,6 h after nanoparticle inoculation.More importantly,photoacoustic microscopy(PAM)of 5KHA-HPPS showed a significantly distinct distribution in T-MLN compared with N-LN and Inf-LN.Signals were mainly distributed at the centre of T-MLN but at the periphery of N-LN and Inf-LN.The ratio of PA intensity(R)at the centre of the LNs compared with that at the periphery was 5.93±0.75 for T-MLNs of the 5K-HA-HPPS group,which was much higher than that for the Inf-LNs(R=0.2±0.07)and N-LNs(R=0.45±0.09).These results suggest that 5K-HA-HPPS injection combined with PAM provides a powerful tool for distinguishing metastatic SLNs from pLNs and inflamed LNs,thus guiding the removal of SLNs during breast cancer surgery. | Yanfeng Dai Xiang Yu Jianshuang Wei Fanxin Zeng Yiran Li Xiaoquan Yang Qingming Luo Zhihong Zhang | 2020 | Light(Science & Applications)2020，9，1： | 6 |
| 4 | FluxExplorer: A general platform for modeling and analyses of metabolic net-works based on stoichiometry显示文摘Stoichiometry-based analyses of meta- bolic networks have aroused significant interest of systems biology researchers in recent years. It is necessary to develop a more convenient modeling platform on which users can reconstruct their network models using completely graphical operations, and explore them with powerful analyzing modules to get a better understanding of the properties of metabolic systems. Herein, an in silico platform, FluxExplorer, for metabolic modeling and analyses based on stoichiometry has been developed as a publicly available tool for systems biology research. This platform integrates various analytic approaches, in- cluding flux balance analysis, minimization of meta- bolic adjustment, extreme pathways analysis, shadow prices analysis, and singular value decom- position, providing a thorough characterization of the metabolic system. Using a graphic modeling process, metabolic networks can be reconstructed and modi- fied intuitively and conveniently. The inconsistencies of a model with respect to the FBA principles can be proved automatically. In addition, this platform sup- ports systems biology markup language (SBML). FluxExplorer has been applied to rebuild a metabolic network in mammalian mitochondria, producing meaningful results. Generally, it is a powerful and very convenient tool for metabolic network modeling and analysis. | LUO Ruoyu LIAO Sha ZENG Shaoqun LI Yixue LUO Qingming | 2006 | Chinese Science Bulletin2006，51，6： | 6 |
| 5 | Monitor and control of neuronal activities with femtosecond pulse laser显示文摘Combined with the fluorescence labeling technique, two-photon microscopy excited with femtosecond pulse laser has become an important tool for neuroscience research. In this research, the calcium signals from neurons in rat cortex slice were monitored by a custom-built two-photon microscopy, and the spontaneous calcium signals and the pharmacological responses as well as the responses to femtosecond pulse laser stimulation were recorded. The results showed that the amplitude of the cal-cium signals increased in direct proportion to the corresponding electrical activities. Glutamate induced a calcium transient, but continuous application resulted in smaller response. Simultaneous monitoring of neuronal populations distinguished the neurons of different microcircuits. The femtosecond pulse laser induced local or global calcium signals in the pyramidal neurons. The approach of interrogation and control of neural activities using femtosecond pulse laser is non-contact, nondestructive, repeatable, and without any additional substrates, which will contribute to the development of neuroscience. | ZHOU Wei LIU XiuLi LU XiaoHua LI JiaSong LUO QingMing ZENG ShaoQun | 2008 | Chinese Science Bulletin2008，53，5： | 5 |
| 6 | Urban-rural disparities in mild cognitive impairment and its functional subtypes among community- dwelling older residents in central China显示文摘background Substantial variations in the prevalence of mild cognitive impairment(MCI)and its subtypes have been reported,although mostly in geographically defined developed countries and regions.Less is known about MCI and its subtypes in rural areas of less developed central China.Aims The study aimed to compare the prevalence of MCI and its subtypes in residents aged 65 years or older in urban and rural areas of Hubei Province,China.Methods Participants aged 65 years or older were recruited between 2018 and 2019.Inperson structured interviews and clinical and neuropsychological assessments were performed at city health community centres and township hospitals.results Among 2644 participants without dementia,735 had MCI,resulting in a prevalence of 27.8%for total MCI,20.9%for amnestic MCI(aMCI)and 6.9%for non-amnestic MCI(naMCI).The prevalence of MCI in urban and rural areas was 20.2%and 44.1%,respectively.After adjusting for demographic factors,the prevalence of total MCI,aMCI and naMCI differed significantly between rural and urban areas(adjusted odds ratio(OR)2.10,1.44 and 3.76,respectively).Subgroup analysis revealed an association between rural socioeconomic and lifestyle disadvantage and MCI and its subtypes.Conclusions Our findings suggest that the prevalence of MCI among urban residents in central China is consistent with that in other metropolis areas,such as Shanghai,but the prevalence in rural areas is twice that in urban areas.Prospective studies and dementia prevention in China should focus on rural areas. | Dan Liu Lin Li Lina An Guirong Cheng Cong Chen Mingjun Zou Bo Zhang Xuguang Gan Lang Xu Yangming Ou Qingming Wu Ru Wang Yan Zeng | 2021 | General Psychiatry2021，34，5： | 3 |
| 7 | Optical dynamic imaging of the regional blood flow in the rat mesentery under the effect of noradrenalin显示文摘The regional blood flow in the rat mesentery under the effect of noradrenalin is monitored using the laser speckle imaging method. The results show that at the third minute of application of noradrenalin, the blood flow begins to decrease, and the venule blood flow decreases more rapidly than that in the arteriole. Five minutes later blood flow in part of blood vessels begins to resume and the blood flow in the arteriole recovers more quickly than that in the venule. These suggest that laser speckle imaging can obtain the temporal-spatial characteristic of blood flow in mesentery without the need of scanning. It provides a new approach for investigating the change of regional blood flow in the mesentery in microcirculation studies. | CHENG Haiying, LUO Qingming, ZENG Shaoqun, CEN Jian and LIANG Wenxi(The Key Laboratory of Biomedical Photonics of Ministry of Education of China, Huazhong University of Science and Technology, Wuhan 430074, China) | 2003 | Progress in Natural Science:Materials International2003，13，5： | 3 |
| 8 | Human physiome based on the high-resolution dataset of human body structure显示文摘Physiome Project, as a new concept, is proceeding rapidly with the great advancement of genomics, physiological experiment, biologic modeling and computer simulation technique. The project seeks to provide a quantitative framework for modeling of the human physiological system using computational approaches, which is able to integrate the knowledge of molecular biology, biochemical, biophysical and anatomical information on different levels, including cell, tissue, organ, system and organism. This paper reviews the development of the Physiome Project in the past decade. The role of high-resolution datasets of human body structure in Physiome Project is discussed. The future plan and applications of the high-resolution datasets of human body structure to Physiome Project are discussed as well. | Qian Liu Bo Wu Shaoqun Zeng Qingming Luo | 2008 | Progress in Natural Science:Materials International2008，18，8： | 1 |
| 9 | The development and application of the visible Chinese human model for montecarlo dose calculations显示文摘 | Zhang Guozhi Luo Qingming Zeng Shaoqun | 2008 | Health Physics2008，94，2： | 1 |
| 10 | Femtosecond pulse laser scanning using Acousto-Optic Deflector显示文摘Acousto-optic modulation of the femtosecond laser beam has wide potential in various fields such as microscopic imaging, micromachining and optical storage because of its rapidity, high accuracy and good repeatability. This paper reviews the latest research on acousto-optic modulation of femtosecond laser, describes the effects of spatial and temporal dispersion of such lasers after acousto-optic modulation, introduces the theoretical outcomes on pulse width evolution of the Gaussian laser pulses after acousto-optic modulation, discusses the characteristics of contemporary dispersion-compensating techniques for the acousto-optic modulation of femtosecond laser, and finally refers to the challenges of this technique. | ZENG ShaoQun LUO QingMing LI DeRong Lü XiaoHua | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，5： | 1 |
| 11 | Thoughts on the Professional Training of Scientific and Technological Management Team of High-level Talents in Provincial Agricultural Research Institutes显示文摘From two aspects:the composition of scientific research management institutions and the tasks undertaken by scientific research management departments,the present situation of scientific and technological management team in agricultural research institutes is expounded.Some problems existed in the scientific and technological management team of provincial agricultural research institutes are analyzed,such as uneven knowledge structure of scientific research management personnel,low degree of specialization,poor stability,lack of professional and systematic job training,etc.Professional development countermeasures are proposed,such as optimizing the structure of scientific research management team,establishing a professional management system with the characteristics of agricultural scientific research institutions,formulating corresponding evaluation mechanism for scientific research management personnel,and strengthening the training of agricultural scientific research management personnel. | Lixian CUI Qingming ZENG Yingjie WANG Guangyuan MA Zheng CHEN Jinli LIU | 2022 | Asian Agricultural Research2022，14，7： | 0 |
| 12 | Some Thoughts on the Scientific Research Management of Young Scientific Research Managers in Research Institutes显示文摘By analyzing current situation of youth scientific research management in research institutes,including problems in scientific research management departments and problems faced by young scientific research management workers,it focuses on thinking from two aspects:the job of science and technology management and improving the working ability of young scientific research managers.It points out the four key cores in the work of youth scientific research management,namely,setting up project approval,establishing project technical files,doing well in project acceptance and achievements demonstration and promotion,doing well in achievements reward,and promoting the output of scientific and technological achievements.The working ability is improved by means of research integrity education,learning relevant professional knowledge while improving business capability,research on the art of scientific research management,and improving management level of science and technology innovation managers in the new era by'new four focuses'. | Lixian CUI Jinli LIU Qingming ZENG | 2022 | Asian Agricultural Research2022，14，11： | 0 |
| 13 | Practice and Reflection on Strengthening Grassroots Party Building Work in Agricultural Research Institutes:A Case Study of Changli Pomology Institute,Hebei Academy of Agricultural and Forestry Sciences显示文摘Changli Pomology Institute,Hebei Academy of Agricultural and Forestry Sciences is taken as the research object.Starting from the relationship between party building and scientific research,in response to the problems in grassroots party building in agricultural research institutes such as insufficient theoretical learning,single party building activity mode,and lack of incentive mechanism in party affairs work,the'three integrations'approach and'four integrations'model are proposed to strengthen the deep integration of party building and scientific research in provincial-level agricultural research institutes.The'three integrations'approach is the integrated development of party building and scientific and technological innovation,the integrated development of party building and scientific and technological services,and the integrated development of party building and technology talents.The'four integrations'model includes the implementation of party building innovation projects,the implementation of 1+N branch pairing and co-construction,the implementation of the'party building+'work method,and the implementation of'theme intersection'activities.The research aims to promote the deep integration of party building and scientific research in provincial-level agricultural research institutes. | Lixian CUI Qingming ZENG Jinli LIU | 2023 | Asian Agricultural Research2023，15，7： | 0 |
| 14 | Current Situation and Thinking of Introduction,Cultivation and Use of High-level Talents in Agricultural Research Institutes under the New Era:A Case Study of Hebei Academy of Agriculture and Forestry Sciences显示文摘Current situation of introduction,cultivation and use of high-level talents in agricultural research institutes are analyzed,and the optimized development strategy of further strengthening the construction,introduction,cultivation and use of high-level talent team is thought.It plays a positive role in provincial agricultural research institutes discovering,cultivating and gathering a number of high-quality talents and high-level innovation teams. | Lixian CUI Qingming ZENG Guangyuan MA Yingjie WANG Jinli LIU | 2022 | Asian Agricultural Research2022，14，8： | 0 |
| 15 | Van der Waals integration inch-scale 2D MoSe_(2) layers on Si for highly-sensitive broadband photodetection and imaging显示文摘As one of the most promising materials for two-dimensional transition metal chalcogenides(2D TMDs),molybdenum diselenide(MoSe_(2))has great potential in photodetectors due to its excellent properties like tunable bandgap,high carrier mobility,and excellent air stability.Although 2D MoSe_(2)-based photodetectors have been reported to exhibit admired performance,the large-area 2D MoSe_(2)layers are difficult to be achieved via conventional synthesis methods,which severely impedes its future applications.Here,we present the controllable growth of large-area 2D MoSe_(2)layers over 3.5-inch with excellent homogeneity by a simple post-selenization route.Further,a high-quality n-MoSe_(2)/p-Si van der Waals(vdW)heterojunction device is in-situ fabricated by directly growing 2D n-MoSe_(2)layers on the patterned p-Si substrate,which shows a self-driven broadband photoresponse ranging from ultraviolet to mid-wave infrared with an impressive responsivity of 720.5 mA·W^(−1),a high specific detectivity of 10^(13) Jones,and a fast response time to follow nanosecond pulsed optical signal.In addition,thanks to the inch-level 2D MoSe_(2)layers,a 4×4 integrated heterojunction device array is achieved,which has demonstrated good uniformity and satisfying imaging capability.The large-area 2D MoSe_(2)layer and its heterojunction device array have great promise for high-performance photodetection and imaging applications in integrated optoelectronic systems. | Yupiao Wu Shuo-En Wu Jinjin Hei Longhui Zeng Pei Lin Zhifeng Shi Qingming Chen Xinjian Li Xuechao Yu Di Wu | 2023 | Nano Research2023，16，8： | 0 |
| 16 | Practice and Reflection on the Science and Technology Propaganda Work of Agricultural Research Institutes in the New Era : A Case Study of Changli Pomology Institute, Hebei Academy of Agricultural and Forestry Sciences显示文摘Taking Changli Fruit Tree Research Institute of Hebei Academy of Agricultural and Forestry Sciences as an example,starting from the importance of strengthening scientific and technological propaganda work in agricultural research institutes,the current situation of scientific and technological propaganda work in agricultural research institutes is analyzed in this paper.In response to the problems of lack of targeted evaluation mechanism,lack of distinctive publicity forms,and weak news sensitivity of science and technology propaganda workers in agricultural research institutions,strategies such as establishing a scientific and standardized evaluation system,improving incentive policies,deeply exploring propaganda content,leveraging the joint advantages of new and traditional media,and cultivating and training science and technology propaganda teams are proposed. | Lixian CUI Jinli LIU Qingming ZENG Zheng CHEN | 2023 | Asian Agricultural Research2023，15，9： | 0 |
| 17 | Exploring the psychological impact of the 2022 SARS-CoV-2 Omicron variant outbreak in China显示文摘To the editor:The impact of the coronavirus disease 2019(COVID-19)pandemic in 2020 on mental health was substantialin Chinai2and various other countries.34 Beyond the direct consequences of COVID-19,the pandemic created an environment in which many determinants of mental health were affected.Issues associated with the pandemic,such as loss of livelihood,limited access to medical services,reduced social interactions,and economic downturn,could potentially have adverse effects on the population's mental well-being.5 In November 2021,the World Health Organization(WHO)designated the new variant of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),variant B.1.1.529,as a variant of concern and named it Omicron;its rapid mutation and spread raised a new global health concern. | Gangbin Han Guirong Cheng Feifei Hu Chunli Li Dan Liu Juan Zhou Jing Liu Linya Huang Xiaochang Liu Qianqian Nie Dan Song Deyang Zeng Lang Xu Jinquan Li Yushan Chen Zhen Wei Qiong Wu Xiaoming He Qingming Wu Wei Tan Yufei Mei Xingxing Chen Yangming Ou Jingjing ZhangYafu Yu Mengliu Yang Pengfei Lian Fukai Zhou Renjia Fan Hong Wan Chenlu Hu Yidi Fu Shiyue Li Junyi Wang Cheng Cai Mengdie Pei Yuyang Cui Wanying Cai Yiqing Li Shiyao Pan Chang Chen Yan He Zhaoxia Wu Liu Hu Liang Tao Hongyan Xiao Xinyan Xie Yan Zeng | 2023 | General Psychiatry2023，36，6： | 0 |
| 18 | TRACING COLLATERAL CIRCULATION AFTER ISCHEMIA IN RAT CORTEX BY LASER SPECKLE IMAGING显示文摘The collateral circulation is crucial for the pathophysiology and outcome of acute cortical ischemia.Current understanding of collateral circulation still remains sparse,largely due to prior limitations of spatial or/and temporal resolution in methods to evaluate these diminutive redistributive routes of cerebral blood flow(CBF)especially in leptomeningeal anastomoses that connected cortical arteries.In the study,based on a mini-stroke model,laser speckle imaging with high spatiotemporal resolution was used to assess the dynamic evolution of the collateral circulation around a mini-ischemia in the rat cortex.We found that the blood flow and diameter in the intra-arterial anastomoses were enhanced immediately after the ligation of one branch of middle cerebral artery and recovered to baseline level as arterial recirculation was performed.Whereas the communicative flow-through of the posterior cerebral artery and the middle cerebral artery anastomoses was not significant enough to be determined.This is the evidence that intra-arterial anastomoses were the primary routes to restore blood flow into the ischemic territory during the acute phase of ischemia,and laser speckle imaging method was proven as a powerful tool to be potential for subserving further investigation of the collateral circulation. | WEIHUA LUO PENGCHENG LI ZHEN WANG SHAOQUN ZENG QINGMING LUO | 2008 | Journal of Innovative Optical Health Sciences2008，1，2： | 0 |
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