|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Rapeseed research and production in China显示文摘Rapeseed(Brassica napus L.) is the largest oilseed crop in China and accounts for about 20% of world production.For the last 10 years,the production,planting area,and yield of rapeseed have been stable,with improvement of seed quality and especially seed oil content.China is among the leading countries in rapeseed genomic research internationally,having jointly with other countries accomplished the whole genome sequencing of rapeseed and its two parental species,Brassica oleracea and Brassica rapa.Progress on functional genomics including the identification of QTL governing important agronomic traits such as yield,seed oil content,fertility regulation,disease and insect resistance,abiotic stress,nutrition use efficiency,and pod shattering resistance has been achieved.As a consequence,molecular markers have been developed and used in breeding programs.During 2005–2014,215 rapeseed varieties were registered nationally,including 210 winter-and 5 spring-type varieties.Mechanization across the whole process of rapeseed production was investigated and operating instructions for all relevant techniques were published.Modern techniques for rapeseed field management such as high-density planting,controlled-release fertilizer,and biocontrol of disease and pests combined with precision tools such as drones have been developed and are being adopted in China.With the application of advanced breeding and production technologies,in the near future,the oil yield and quality of rapeseed varieties will be greatly increased,and more varieties with desirable traits,especially early maturation,high yield,high resistance to biotic and abiotic stress,and suitability for mechanized harvesting will be developed.Application of modern technologies on the mechanized management of rapeseed will greatly increase grower profit. | Qiong Hu Wei Hua Yan Yin Xuekun Zhang Lijiang Liu Jiaqin Shi Yongguo Zhao Lu Qin Chang Chen Hanzhong Wang | 2017 | The Crop Journal2017，5，2： | 25 |
| 2 | Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study显示文摘Background:5-Fluorouracil(5-FU)and capecitabine-associated cardiotoxicity ranging from asymptomatic electro-cardiography(ECG)abnormalities to severe myocardial infarction has been reported in a number of studies,but such cardiotoxicity in Chinese patients with malignant diseases has not been investigated to date.In the present study,we aimed to prospectively evaluate the incidence rates and clinical manifestations of 5-FU-and capecitabine-associated cardiotoxicity in cancer patients recruited from multiple centers in China.Methods:Among the 527 patients who completed the study,196 received 5-FU-based chemotherapy and 331 received capecitabine-based chemotherapy as either first-line or adjuvant therapy.Adverse events were reported during the treatment and up to 28 days of follow-up.Outcome measures included ECG,myocardial enzymes,cardiac troponin,brain natriuretic peptide and echocardiography.Univariate analysis and logistic regression were performed for subgroup analysis and identification of significant independent variables that are associated with cardiotoxicity of both agents.Results:In total,161 of 527 patients(30.6%)experienced cardiotoxicity.The incidence rate of cardiotoxicity was 33.8%(112/331)in the capecitabine group,which was significantly higher than the rate of 25%(49/196)in the 5-FU group(P=0.0042).110/527 patients(20.9%)suffered arrhythmia,105/527(19.9%)developed ischemic changes,while only 20/527 patients(3.8%)presented heart failure and 6/527 patients(1.1%)had myocardial infarction.Pre-existing cardiac disease,hypertension,capecitabine-based chemotherapy and duration of treatment were identified as sig-nificant risk factors associated with cardiotoxicity.The odds ratio were 15.7(prior history of cardiac disease versus no history),1.86(capecitabine versus 5-FU),1.06(5-8 versus 1-4 chemotherapy cycles)and 1.58(hypertension versus no hypertension),respectively.Conclusions:Cardiotoxicity induced by fluoropyrimidines in the Chinese population may be underestimated in clini-cal practice.Close monitoring of patients is recommended,especially for those patients at high risk for cardiotoxicity.Possible risk factors are duration of treatment,capecitabine-based chemotherapy,pre-existing cardiac diseases and hypertension.Trial registration This study was initiated on January 22,2014 and has been retrospectively registered with the registra-tion number ChiCTR1800015434 . | Jianjun Peng Chao Dong Chang Wang Weihua Li Hao Yu Min Zhang Qun Zhao Bo Zhu Jun Zhang Wenliang Li Fenghua Wang Qiong Wu Wenhao Zhou Ying Yuan Meng Qiu Gong Chen | 2018 | Cancer Communications2018，38，1： | 23 |
| 3 | A new prognostic histopathologic classification of nasopharyngeal carcinoma显示文摘Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment response.Methods:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from SYSUCC.The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes.We used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis. | Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao | 2016 | Chinese Journal of Cancer2016，35，6： | 10 |
| 4 | Effect of Single-walled Carbon Nanotubes on Cellulose Phenylcarbamate Chiral Stationary Phases显示文摘Single-walled carbon nanotubes(SWNTs)have a high adsorption ability and nanoscale interactions.Cellulose trisphenylcarbamates possess high enantioseparation ability in high-performance liquid chromatography(HPLC).Single-walled carbon nanotubes mixed with cellulose trisphenylcarbamate are coated on the silica gel as chiral stationary phases and higher enantioseparation factors are obtained.After a single-walled carbon nanotube is linked to the 6-position of cellulose 2,3-bisphenylcarbamate,its enantioseparation resolution increases compared to that of the cellulose trisphenylcarbamate.It is the first time that SWNTs have been applied to enantioseparation.The results indicate that the single-walled carbon nanotubes are good promoters of chiral recognition.This method can be used to improve the enantioseparation efficiency of the polysaccharide chiral stationary phases. | CHANG Yin-xia REN Chao-xing RUAN Qiong YUAN Li-ming | 2007 | Chemical Research in Chinese Universities2007，23，6： | 9 |
| 5 | The immunoglobulin D Fc receptor expressed on fibroblast-like synoviocytes from patients with rheumatoid arthritis contributes to the cell activation显示文摘 | Yu-jing WU Wen-sheng CHEN Heng-shi CHEN Xing DAI Jin DONG Ying WANG Ling-ling ZHANG Yan CHANG Qiong HUANG Xiao-yi JIA Wei WEI | 2017 | Acta Pharmacologica Sinica2017，38，11： | 5 |
| 6 | Layered Birnessite Cathode with a Displacement/Intercalation Mechanism for High-Performance Aqueous Zinc-Ion Batteries显示文摘Mn-based rechargeable aqueous zinc-ion batteries(ZIBs)are highly promising because of their high operating voltages,attractive energy densities,and eco-friendliness.However,the electrochemical performances of Mn-based cathodes usually suffer from their serious structure transformation upon charge/discharge cycling.Herein,we report a layered sodium-ion/crystal water co-intercalated Birnessite cathode with the formula of Na0.55Mn2O4·0.57H2O(NMOH)for high-performance aqueous ZIBs.A displacement/intercalation electrochemical mechanism was confirmed in the Mn-based cathode for the first time.Na+and crystal water enlarge the interlayer distance to enhance the insertion of Zn^2+,and some sodium ions are replaced with Zn^2+ in the first cycle to further stabilize the layered structure for subsequent reversible Zn^2+/H^+ insertion/extraction,resulting in exceptional specific capacities and satisfactory structural stabilities.Additionally,a pseudo-capacitance derived from the surface-adsorbed Na^+ also contributes to the electrochemical performances.The NMOH cathode not only delivers high reversible capacities of 389.8 and 87.1 mA h g^−1 at current densities of 200 and 1500 mA g^−1,respectively,but also maintains a good long-cycling performance of 201.6 mA h g^−1 at a high current density of 500 mA g^−1 after 400 cycles,which makes the NMOH cathode competitive for practical applications. | Xian‑Zhi Zhai Jin Qu Shu‑Meng Hao Ya‑Qiong Jing Wei Chang Juan Wang Wei Li Yasmine Abdelkrim Hongfu Yuan Zhong‑Zhen Yu | 2020 | Nano-Micro Letters2020，12，4： | 4 |
| 7 | Famitinib in metastatic renal cell carcinoma: a single center study显示文摘 | ZHANG Wen ZHOU Ai-ping QIN Qiong CHANG Chun-xiao JIANG Hao-yuan MA Jian-hui WANG Jin-wan | 2013 | Chinese Medical Journal2013，，22： | 4 |
| 8 | 96-Week Treatment of Tenofovir Amibufenamide and Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients显示文摘Background and Aims:Tenofovir amibufenamide(TMF)is a novel phosphoramidated prodrug of tenofovir with nonin-ferior efficacy and better bone and renal safety to tenofovir disoproxil fumarate(TDF)in 48 weeks of treatment.Here,we update 96-week comparison results.Methods:Patients with chronic hepatitis B were assigned(2:1)to receive either 25 mg TMF or 300 mg TDF with matching placebo for 96 weeks.The virological suppression was defined as HBV DNA levels<20 IU/mL at week 96.Safety was evaluated thoroughly with focusing on bone,renal,and metabolic pa-rameters.Results:Virological suppression rates at week 96 were similar between TMF and TDF group in both HBeAg-positive and HBeAg-negative populations.Noninferior efficacy was maintained in the pooled population,while it was first achieved in patients with HBV DNA≥7 or 8 log10 IU/mL at baseline.Non-indexed estimated glomerular filtration rate for renal safety assessment was adopted,while a smaller decline of which was seen in the TMF group than in the TDF group(p=0.01).For bone mineral density,patients receiv-ing TMF displayed significantly lower reduction levels in the densities of spine,hip,and femur neck at week 96 than those receiving TDF.In addition,the lipid parameters were stable after week 48 in all groups while weight change still showed the opposite trend.Conclusions:TMF maintained similar efficacy at week 96 compared with TDF with continued superior bone and renal safety profiles(NCT03903796). | Zhihong Liu Qinglong Jin Yuexin Zhang Guozhong Gong Guicheng Wu Lvfeng Yao Xiaofeng Wen Zhiliang Gao Yan Huang Daokun Yang Enqiang Chen Qing Mao Shide Lin Jia Shang Huanyu Gong Lihua Zhong Huafa Yin Fengmei Wang Peng Hu Qiong Wu Chao Pan Wen Jia Chuan Li Chang’an Sun Junqi Niu Jinlin Hou TMF Study Group | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 3 |
| 9 | 5-氟尿嘧啶和卡培他滨对中国患者的心脏毒性:一项前瞻性研究显示文摘背景与目的已有许多研究报道5-氟尿嘧啶(5-Fluorouracil,5-FU)和卡培他滨相关的心脏毒性,严重程度从无症状心电图(electrocardiography,ECG)异常到严重心肌梗塞而不同。目前为止,对中国恶性肿瘤患者的这种心脏毒性尚无研究。本研究旨在前瞻性地对多个中心招募的癌症患者进行5-FU和卡培他滨相关心脏毒性的发生率和临床表现进行评估。方法在完成研究的527例患者中,196例接受基于5-FU的化疗,331例接受基于卡培他滨的化疗并以其为一线或辅助治疗。在治疗期间和长达28 d的随访期间对所发生的不良反应进行记录。疗效测量指标包括心电图、心肌酶、心肌肌钙蛋白、脑钠肽和超声心动图。使用单因素分析和logistic回归方法进行亚组分析和鉴定与两种药物的心脏毒性相关的显著性独立变量。结果 527例患者中有161例(30.6%)出现心脏毒性。卡培他滨组的心脏毒性发生率为33.8%(112/331),显著高于5-FU组25%(49/196)的发生率(P=0.0042)。110/527患者(20.9%)发生心律失常,105/527(19.9%)发生缺血性改变,而只有20/527患者(3.8%)出现心力衰竭,6/527患者(1.1%)出现心肌梗塞。既往的心脏病、高血压、卡培他滨为基础的化疗和治疗时间被确定为与心脏毒性相关的显著风险因素。优势比分别为15.7(心脏病史vs.无病史)、1.86(卡培他滨vs. 5-FU)、1.06(5–8个化疗周期vs. 1–4个化疗周期)和1.58(高血压vs.无高血压)。结论氟嘧啶类药物在中国人群中引起的心脏毒性可能在临床实践中被低估。建议密切监测患者,尤其是对心脏毒性高风险的患者。可能的风险因素包括治疗持续时间、基于卡培他滨的化疗、既往心脏病史和高血压史。 | Jianjun Peng Chao Dong Chang Wang Weihua Li Hao Yu Min Zhang Qun Zhao Bo Zhu Jun Zhang Wenliang Li Fenghua Wang Qiong Wu Wenhao Zhou Ying Yuan Meng Qiu Gong Chen | 2018 | 癌症2018，37，10： | 3 |
| 10 | The Influence of Diabetes, Hypertension, and Hyperlipidemia on the Onset of Age-Related Macular Degeneration in North China: The Kailuan Eye Study显示文摘Objective To analyze the prevalence of dry and wet age-related macular degeneration(AMD)in patients with diabetes,hypertension and hyperlipidemia,and to analyze the risk factors for AMD.Methods A population-based cross-sectional epidemiologic study was conducted involving 14,440 individuals.We assessed the prevalence of dry and wet AMD in diabetic and non-diabetic subjects and analyzed the risk factors for AMD.Results The prevalence of wet AMD in diabetic and non-diabetic patients was 0.3%and 0.5%,respectively,and the prevalence of dry AMD was 17%and 16.4%,respectively.The prevalence of wet AMD in healthy,hypertensive,hyperlipidemic,and hypertensive/hyperlipidemic populations was 0.5%,0.3%,0.2%,and 0.7%,respectively.The prevalence of dry AMD in healthy,hypertensive,hyperlipidemic,and hypertensive/hyperlipidemic populations was 16.6%,16.2%,15.2%,and 17.2%,respectively.Age,sex,body mass index,and use of hypoglycemic drugs or lowering blood pressure drugs were corrected in the risk factor analysis of AMD.Diabetes,diabetes/hypertension,diabetes/hyperlipidemia,and diabetes/hypertension/hyperlipidemia were analyzed.None of the factors analyzed in the current study increased the risk for the onset of AMD.Conclusion There was no significant difference in the prevalence of wet and dry AMD among diabetic and non-diabetic subjects.Similarly,there was no significant difference in the prevalence of wet and dry AMD among subjects with hypertension and hyperlipidemia.Diabetes co-existing with hypertension and hyperlipidemia were not shown to be risk factors for the onset of dry AMD. | ZHANG Yong Peng WANG Ya Xing ZHOU Jin Qiong WANG Qian YAN Yan Ni YANG Xuan YANG Jing Yan ZHOU Wen Jia WANG Ping SHEN Chang YANG Ming LUAN Ya Nan WANG Jin Yuan WU Shou Ling CHEN Shuo Hua WANG Hai Wei FANG Li Jian WAN Qian Qian ZHU Jing Yuan NIE Zi Han CHEN Yu Ning XIE Ying JONAS JB WEI Wen Bin | 2022 | Biomedical and Environmental Sciences2022，35，7： | 2 |
| 11 | A novel isoform of ATOH8 promotes the metastasis of breast cancer by regulating RhoC显示文摘Metastases are the main cause of cancer-related mortality in breast cancer.Although significant progress has been made in the field of tumor metastasis,the exact molecular mechanisms involved in tumor metastasis are still unclear.Here,we report that ATOH8-V1,a novel isoform of ATOH8,is highly expressed in breast cancer and is a negative prognostic indicator of survival for patients.Forced expression of ATOH8-V1 dramatically enhances,while silencing of ATOH8-V1 decreases the metastasis of breast cancer cell lines.Moreover,ATOH8-V1 directly binds to the RhoC promoter and stimulates the expression of RhoC,which in turn enhances the metastasis of breast cancer.Altogether,our data demonstrate that ATOH8-V1 is a novel pro-metastatic factor that enhances cancer metastasis,suggesting that AT0H8-V1 is a potential therapeutic target for treatment of metastatic cancers. | Mengyao Xu Shan Huang Xiaoli Dong Yanan Chen Miao Li Wen Shi Guanwen Wang Chongbiao Huang Qiong Wang Yanhua Liu Peiqing Sun Shuang Yang Rong Xiang Antao Chang | 2021 | Journal of Molecular Cell Biology2021，13，1： | 2 |
| 12 | Gata4, Tbx5 and Baf60c induce differentiation of adipose tissue-de- rived mesenchymal stem cells into beating cardiomyocytes 显示文摘 | LI Qiong GUO Zhikun CHANG Yuqiao | 2015 | Int J Biochem Cell Biol2015，66，： | 1 |
| 13 | Epidemiological Survey of Hemoglobinopathies Based on Next-Generation Sequencing Platform in Hunan Province,China显示文摘Objective This study was aimed at investigating the carrier rate of,and molecular variation in,α-andβ-globin gene mutations in Hunan Province.Methods We recruited 25,946 individuals attending premarital screening from 42 districts and counties in all 14 cities of Hunan Province.Hematological screening was performed,and molecular parameters were assessed.Results The overall carrier rate of thalassemia was 7.1%,including 4.83%forα-thalassemia,2.15%forβ-thalassemia,and 0.12%for bothα-andβ-thalassemia.The highest carrier rate of thalassemia was in Yongzhou(14.57%).The most abundant genotype ofα-thalassemia andβ-thalassemia was-α^(3.7)/αα(50.23%)andβ^(IVS-Ⅱ-654)/β^(N)(28.23%),respectively.Fourα-globin mutations[CD108(ACC>AAC),CAP+29(G>C),Hb Agrinio and Hb Cervantes]and sixβ-globin mutations[CAP+8(C>T),IVS-Ⅱ-848(C>T),-56(G>C),beta nt-77(G>C),codon 20/21(-TGGA)and Hb Knossos]had not previously been identified in China.Furthermore,this study provides the first report of the carrier rates of abnormal hemoglobin variants andα-globin triplication in Hunan Province,which were 0.49%and 1.99%,respectively.Conclusion Our study demonstrates the high complexity and diversity of thalassemia gene mutations in the Hunan population.The results should facilitate genetic counselling and the prevention of severe thalassemia in this region. | XI Hui LIU Qin XIE Dong Hua ZHOU Xu TANG Wang Lan TANG De Guo ZENG Chun Yan WANG Qiong NIE Xing Hui PENG Jin Ping GAO Xiao Ya WU Hong Liang ZHANG Hao Qing QIU Li FENG Zong Hui WANG Shu Yuan ZHOU Shu Xiang HE Jun ZHOU Shi Hao ZHOU Fa Qun ZHENG Jun Qing WANG Shun Yao CHEN Shi Ping ZHENG Zhi Fen MA Xiao Yuan FANG Jun Qun LIANG Chang Biao WANG Hua | 2023 | Biomedical and Environmental Sciences2023，36，2： | 1 |
| 14 | Electron beam emission from a diamond-amplifier cathode显示文摘 | Chang Xiangyun Wu Qiong Ben Z I | 2010 | Phys Rev Lett2010，105，16： | 1 |
| 15 | Targeting TRMT5 suppresses hepatocellular carcinoma progression via inhibiting the HIF-1αpathways显示文摘Accumulating evidence has confirmed the links between transfer RNA(tRNA)modifications and tumor progression.The present study is the first to explore the role of tRNA methyltransferase 5(TRMT5),which catalyzes the m1G37 modification of mitochondrial tRNAs in hepatocellular carcinoma(HCC)progression.Here,based on bioinformatics and clinical analyses,we identified that TRMT5 expression was upregulated in HCC,which correlated with poor prognosis.Silencing TRMT5 attenuated HCC proliferation and metastasis both in vivo and in vitro,which may be partially explained by declined extracellular acidification rate(ECAR)and oxygen consumption rate(OCR).Mechanistically,we discovered that knockdown of TRMT5 inactivated the hypoxia-inducible factor-1(HIF-1)signaling pathway by preventing HIF-1αstability through the enhancement of cellular oxygen content.Moreover,our data indicated that inhibition of TRMT5 sensitized HCC to doxorubicin by adjusting HIF-1α.In conclusion,our study revealed that targeting TRMT5 could inhibit HCC progression and increase the susceptibility of tumor cells to chemotherapy drugs.Thus,TRMT5 might be a carcinogenesis candidate gene that could serve as a potential target for HCC therapy. | Qiong ZHAO Luwen ZHANG Qiufen HE Hui CHANG Zhiqiang WANG Hongcui CAO Ying ZHOU Ruolang PAN Ye CHEN | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，1： | 1 |
| 16 | Preparation of gradient biomaterial used for artificial mechanical heart valve显示文摘INTRODUCTIONSincetheartificialmechanicalheartvavle(AMHV)madeofmetalcoatedwithcarbonpossessesboththefavoratemachinabilityofthe... | WANG Hong wei,YIN Guang fu,ZHENG Chang qiong, RAN Jun guo,WEI Qing Sichuan Union University,Chengdu 610065,China | 1999 | Chinese Journal of Biomedical Engineering(English Edition)1999，8，1： | 1 |
| 17 | Validation and Application of the Chinese Version of the M.D.Anderson Symptom Inventory in Breast Cancer Patients显示文摘Objective To validate and use the Chinese Version of the M.D.Anderson Symptom Inventory(MDASI-C)to assess the symptom burden of breast cancer patients in China.Methods A total of 342 breast cancer patients in China participated in this study.Their symptoms were investigated with the MDASI-C from November 2020 to February 2021,and the reliability and validity of this tool were evaluated,respectively.Cluster analysis and correlation analysis were also performed.Results The Cronbach’s alpha coefficient values of the symptom and interference items were 0.827 and 0.880,respectively.Construct validity revealed a four-factor structure.The Kaiser—Meyer—Olkin value was 0.760.The Karnofsky Performance Status,treatment phase,and cancer stage of the patients were grouped,and the differences of scores within the groups were significant.In addition,the employment status,education level,and age of the patients were significantly correlated with the symptoms.The correlation analysis of the education level of the patients showed that most of the symptoms and interference items were reduced as the education level was increased.The top three symptoms were disturbed sleep(3.10±2.52),difficulty remembering(2.54±2.30),and fatigue(2.24±2.13).The clinical and biochemical indicators such as body mass index and neutral granulocyte lymphocyte ratio had effects on many symptoms.As the patients’BMI increased,the patients’pain,disturbed sleep,and difficulty remembering were aggravated,and numbness was alleviated.Conclusion The MDASI-C is a reliable and effective assessment tool to evaluate patients with breast cancer in China.The symptoms are related to many clinical and biochemical indicators. | Ren-wang CHEN Qiong WANG Ting HU Yu-xiu XIE Hai-yan CHANG Jing CHENG | 2022 | Current Medical Science2022，42，2： | 1 |
| 18 | Synthesis and ap- plications of surface- grafted Th( IV ) -imprinted polymers for selective solid-phase extraction of thorium (IV) 显示文摘 | He Qun Chang Xijun Wu Qiong | 2007 | Analytica Chimica Acta2007，605，2： | 1 |
| 19 | A novel Trmt5-deficient zebrafish model with spontaneous inflammatory bowel disease-like phenotype显示文摘Dear Editor,Inflammatory bowel disease(IBD),a complex syndrome characterized by chronic inflammation of the gastrointestinal tract,is considered a global health problem,especially prevalent in western developed countries and with accelerating incidence in the developing world over the last decade.1 To date,the primary etiology of IBD remains elusive. | Qiong Zhao Hui Chang Jing Zheng Ping Li Lidan Ye Ruolang Pan Di Li Jian-Zhong Shao Robert Chunhua Zhao Ye Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 1 |
| 20 | Effect of long-term fertilization on phosphorus fractions in different soil layers and their quantitative relationships with soil properties显示文摘Investigating the dynamics and distribution of soil phosphorus(P) fractions can provide a basis for enhancing P utilization by crops. Four treatments from a 29-year long-term experiment in black soil with maize cropping were involved in this study: no fertilizer(CK), inorganic nitrogen and potassium(NK), inorganic nitrogen, phosphorus, and potassium(NPK), and NPK plus manure(NPKM). We analyzed soil P fractions in different soil layers using a modified Hedley sequential method. The long-term NPKM treatment significantly increased total P by 0.6–1.6 times in the different soil layers. The Olsen-P concentration far exceeded the environmental threshold for soil Olsen-P(50.6 mg kg) in the NPKM treatment in the 0–60 cm soil profile. Moreover, the concentrations and proportion of labile and partially labile inorganic P(Pi) fractions(i.e., Na HCO-extracted Pi, Na OH-extracted Pi, and dilute HClextracted Pi) to the sum of all P fractions(Pt) in the 0–60 cm soil profile were higher in the NPKM treatment than in the NPK treatment, indicating that manure could promote the transformation of non-labile into more labile forms of P in soil, possibly by manure reducing P fixation by soil particles. Soil organic matter, Mehlich-3 extractable iron(Fe), and organic-bound aluminum were increased by fertilization, and were the main factors influencing the differences in the P fractions in the 0–20 cm soil layer. Soil mineral components, i.e., free Fe oxide and Ca CO, were the main factors influencing the P fractions in the subsoil. The soil P transformation process varied with soil layer and fertilization. Application of manure fertilizer can increase the labile(Olsen) P concentrations of the various soil layers, and thus should reduce the mineral P fertilizer requirement for crop growth and reduce potential environmental damage. | WANG Qiong QIN Zhen-han ZHANG Wei-wei CHEN Yan-hua ZHU Ping PENG Chang WANG Le ZHANG Shu-xiang Gilles COLINET | 2022 | Journal of Integrative Agriculture2022，21，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员