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| 1 | Relationship between plasma D(-)-lactate and intestinal damage after severe injuries in rats显示文摘AIM To explore the kinetic changes in plasma D (-)lactate and lipopolysaccharide ( LPS ) levels, and investigate whether D (-)-lactate could be used as a marker of intestinal injury in rats following gut ischemia/reperfusion, burn, and acute necrotizing pancreatitis (ANP).METHODS Three models were developed in rats:gut ischemia/reperfusion obtained by one hour of superior severe burn injury created by 30% of total body surface induced by continuous inverse infusion of sodium taurocholate and trypsin into main pancreatic duct.Plasma levels of D( - )-lactate in systemic circulation and LPS in portal circulation were measured by enzymaticspectrophotometric method and limulus amebocyte lysate (LAL) test kit, respectively. Tissue samples of intestine were taken for histological analysis.RESULTS One hour gut ischemia followed by reperfusion injuries resulted in a significant elevation in plasma D( - )lactate and LPS levels, and there was a significant correlation between the plasma D( - )-lactate and LPS (r =0.719, P<0.05). The plasma concentrations of D(-)lactate and LPS increased significantly at 6 h postburn,and there was also a remarkable correlation between them (r = 0.877, P < 0.01). D ( - )-lactate and LPS levels elevated significantly at 2 h after ANP, with a similar significant correlation between the two levels (r-0.798,P < 0.01 ). The desquamation of intestine villi and infiltration of inflammatory cells in the lamina propria were observed in all groups.CONCLUSION The changes of plasma D( - )-lactate levels in systemic blood paralleled with LPS levels in the portal vein blood. The measurement of plasma D (-)-lactate level may be a useful marker to assess the intestinal injury and to monitor an increase of intestinal permeability and endotoxemia following severe injuries in early stage. | Xiao-Qing Sun Xiao-Bing Fu Rong-Zhan Yi Lü Qun Deng Xiao-Guo Jian Zhi-Yong Sheng Bum Institute, 304~(th)Hospital,Beijing 100037,China Department of General Surgery,Chinese PLA 304 Hospital,Beijing 100037,China | 2001 | World Journal of Gastroenterology2001，7，4： | 56 |
| 2 | Altered Disease Development in the eui Mutants and Eui Overexpressors Indicates that Gibberellins Negatively Regulate Rice Basal Disease Resistance显示文摘赤霉素(气体) 形成涉及植物生长和开发的许多方面的一组重要植物 tetracyclic diterpenoid 荷尔蒙。新兴的证据含有那气体也在压力回答起作用。然而,在关於生命的应力的气体的角色大部分是未知的。这里,我们报导那个大美人或 overexpression 伸长最高编码撤销的 GA 的 internode (Eui ) 基因分别地,酶损害或增加疾病抵抗到细菌的老家(Xanthomonas oryzae pv。oyrzae ) 并且米饭强风(Magnaporthe oryzae ) 。分别地, GA3 和 GA 合成(uniconazol ) 的禁止者的外长的申请能增加疾病危险性和抵抗到细菌的老家。同样, uniconazol 恢复了 eui 异种的疾病抵抗, GA3 减少了到细菌的老家的 Eui overexpressors 的疾病抵抗。因此,抵抗的变化把层次归因于 GA。在有这的一致性, GA 新陈代谢基因 OsGA20ox2 和 OsGA2ox1 在病原体挑战期间是下面调整的。我们也发现那 PR1a 正式就职被提高,但是 SA 水平在 Eui overexpressor 被减少,当 JA 水平在 eui 异种被减少时。一起,我们的当前的学习显示气体在米饭起一个否定作用基础疾病电阻,与是的 EUI 通过调整 bioactive 气体的水平的一个积极调节的人。 | Dong-Lei Yang Qun Li Yi-Wen Deng Yong-Gen Lou Mu-Yang Wang Guo-Xing Zhou Ying-Ying Zhang Zu-Hua He | 2008 | Molecular Plant2008，1，3： | 29 |
| 3 | Rice RING protein OsBBI1 with E3 ligase activity confers broad-spectrum resistance against Magnaporthe oryzae by modifying the cell wall defence显示文摘新兴的证据建议 E3 ligases 在多样的生物过程起关键作用,包括在植物的天生的有免疫力的回答。然而,在植物的 E3 ligase 参与的机制天生的免疫是不清楚的。我们报导那米饭基因, OsBBI1,与 E3 ligase 活动编码戒指手指蛋白质,调停用途广泛的疾病抵抗。OsBBI1 的表示被米饭强风真菌 Magnaporthe oryzae,以及化学 inducers 导致, benzothiadiazole 和水杨酸酸。生物化学的分析表明那 OsBBI1 蛋白质在 vitro 拥有 E3 ubiquitin ligase 活动。基因分析表明在一根 Tos17 插入线的 OsBBI1 功能的损失增加了危险性,当在转基因的植物的 OsBBI1 的 overexpression 授与提高的抵抗到 M 的多重赛跑时。oryzae。这显示 OsBBI1 对强风真菌调制用途广泛的抵抗。OsBBI1-overexpressing 植物由 M 在感染地点在房间墙中在酉分的混合物的房间和蛋白质的 cross-linking 显示出 H2O2 累积的高水平。oryzae 与相比野类型(WT ) 植物。房间墙在 OsBBI1-overexpressing 植物是更厚的并且在变异的植物更薄比在 WT 植物。我们的结果建议 OsBBI1 由修改房间墙防卫回答调制用途广泛的抵抗到强风真菌。OsBBI1 的功能的描述为在米饭对最破坏的疾病构造用途广泛的抵抗提供卓见进 E3 调停 ligase 的天生的免疫,和一个实际工具。 | Wei Li Sihui Zhong Guojun Li Qun Li Bizeng Mao Yiwen Deng Huijuan Zhang Longjun Zeng Fengming Song Zuhua He | 2011 | Cell Research2011，21，5： | 30 |
| 4 | Progress in the Research and Manufacture of GH4169 Alloy显示文摘GH4169 alloy has been widely used in fields such as aviation, aerospace, and petrochemical, because of its excellent combination of mechanical and processing properties. These properties include good high-temperature strength, excellent creep and fatigue resistance, and good processing and welding performance. The requirement for high performance, high reliability, and long service life of modern engines has led to the incentive to develop GH4169 alloys with improved performance, such as increased temperature-bearing capacity, improved creep endurance, and better fatigue resistance. Advances during the past thirty years in basic research and industrial technology related to GH4169 alloy were systematically summarized, including advances in alloy modification, melting process optimization, and hot deformation technology. | Jin-hui DU Xu-dong LU Qun DENG Zhong-nan BI | 2015 | Journal of Iron and Steel Research(International)2015，22，8： | 14 |
| 5 | Simulation on the dynamics of forest area changes in Northeast China显示文摘There is plenty of forests in Northeast China which contributes a lot to the conservation of water and land resources, produces timber products, and provides habitats for a huge number of wild animals and plants. With changes of socio-economic factors as well as the geophysical conditions, there are dramatic changes on the spatial patterns of forest area. In this sense, it is of great significance to shed light on the dynamics of forest area changes to find the underlining reasons for shaping the changing patterns of forest area in Northeast China. To explore the dynamics of forest area change in Northeast China, an econometric model is developed which is composed of three equations identifying forestry production, conversion from open forest to closed forest and conversion from other land uses to closed forest so as to explore the impacts on the forest area changes from demographic, social, economic, location and geophysical factors. On this basis, we employ the Dynamics of Land System (DLS) model to simulate land-use conversions between forest area and non-forest cover and the land-use conversions within the sub-classes of forest area for the period 2000–2020 under business as usual scenario, environmental protection scenario and economic growth scenario. The simulation results show that forest area will expand continuously and there exist various kinds of changing patterns for the sub-classes of forest area, for example, closed forest will expand continuously and open forest and shrub will decrease a little bit, while area of other forest will keep intact. The research results provide meaningful decision-making information for conserving and exploiting the forest resources and making out the planning for forestry production in the Northeast China region. | DENG Xiangzheng JIANG Qun'ou ZHAN Jinyan HE Shujin LIN Yingzhi | 2010 | Journal of Geographical Sciences2010，20，4： | 11 |
| 6 | An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis显示文摘Global warming has profound effects on plant growth and fitness.Plants have evolved sophisticated epigenetic machinery to respond quickly to heat,and exhibit transgenerational memory of the heat-induced release of post-transtriptional gene silencing(PTGS).However,how thermomemory is transmitted to progeny and the physiological relevance are elusive.Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2(HSFA2)directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6(REF6),which in turn derepresses HSFA2.REF6 and HSFA2 establish a heritable feedback loop,and activate an E3 ubiquitin ligase,SUPPRESSOR OF GENE SILENCING 3(SGS3)-INTERACTING PROTEIN 1(SGIP1).SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA(tasiRNA).The REF&HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5(HTT5),which drives early flowering but attenuates immunity.Thus,heat induces transmitted phe no types via a coordi nated epigenetic network involvi ng histone demethylases,tran scriptio n factors,and tasiRNAs,ensuring reproductive success and transgenerational stress adaptation. | Junzhong Liu Lili Feng Xueting Gu Xian Deng Qi Qiu Qun Li Yingying Zhang Muyang Wang Yiwen Deng Ertao Wang Yuke He Isabel Baurle Jianming Li Xiaofeng Cao Zuhua He | 2019 | Cell Research2019，29，5： | 10 |
| 7 | Prevalence and molecular characteristics of Listeria monocytogenes in cooked products and its comparison with isolates from listeriosis cases显示文摘这研究试图在 Zigong 城市里在煮的产品调查流行和 Listeria monocytogenes 的分子的特征,中国。L 的全面出现。在商店和羊肉餐馆调查了的 ready-to-eat (RTE ) 的 monocytogenes 是 16.2%(141/873 ) 。13.5% 的出现在 RTE 猪肉被观察, 6.5% 在 RTE 蔬菜,并且非常, 24.0% 在也煮了羊肉或煮了将羊杂切碎加麦片纳入羊胃中煮成的食物。Serotype 1/2b (45.4%) , 1/2a (33.3%) ,和 1/2c (14.2%) 是占优势的类型。由基于 L 的打字的 multilocus 顺序(MLST ) 比较同种细胞的建筑群(CC ) 。从从中国, CC87, CC9, CC8,和 CC3 的不同区域的 Zigong 城市和 33 个 listeriosis 案例里的煮的食物的 monocytogenes 被显示在煮的产品和 CC87 流行, CC3 是在 33 诊所来源紧张的开始的二种经常的类型。所有 CC87 污点怀有最新报导的 Listeria 致病力岛 4 (LIPI-4 ) 基因碎片 ptsA,和所有 CC3 紧张拥有了 Listeria 致病力岛 3 (LIPI-3 ) 基因碎片 llsX。这些可以增加在中国在 listeriosis 情况中属于 CC87 和 CC3 的紧张的出现并且也从 Zigong 由于煮的产品的消费加重感染的风险。ST619 (serotype 1/2b ) 怀有 llsX 和 ptsA,显示在 Zigong 的一种潜在的 hypervirulent 顺序类型。 | Hong Wang Lijuan Luo Zhengdong Zhang Jianping Deng Yan Wang Yimao Miao Ling Zhang Xi Chen Xiang Liu Songsong Sun Bo Xiao Qun Li Changyun Ye | 2018 | Frontiers of Medicine2018，12，1： | 9 |
| 8 | Integrated Water and CGE Model of the Impacts of Water Policy on the Beijing's Economy and Output显示文摘The article used general equilibrium model to analyze the change of gross domestic product and industry output affected by water resources policies in Beijing City by using GEMPACK soft tool.The article researches on rules of water supply and demand,evaluating water resources,building water resources input and output table,establishing water computable general equilibrium model and stimulating water policy.The stimulation gives a scenario that increases water price by 10%.The result shows the following aspects.First,water resources policy infects gross domestic product and industry output in different ways.There are different behaviors in different industries as to the water policy. Agriculture industry has the same tendency as water price change and it has more sensitive to water quantity than to water price.For basic energy industries such as oil and chemistry and gas,they show diversity tendency.As to some high water consumer industry such as paper and textile etc.,water resource economic policy can infect them greatly and can promote them to accomplish more water-saving technology.Waste water and construction and service industries show the same tendency as to water policy.Second,government should pay more attention to water resource policy by macro economic administration.The simulation also shows that the output and supply and consumer price change more than expect as to water policy in a free market economic in water industry.So as to a government policy maker,one should be more carefully and prepare suitable forecast and plan to water policy and its negative impact. | Xia Jun Deng Qun Sun Yangbo | 2010 | Chinese Journal of Population,Resources and Environment2010，8，2： | 6 |
| 9 | Estimation of Land Production and Its Response to Cultivated Land Conversion in North China Plain显示文摘Food safety and its related influencing factors in China are the hot research topics currently,and cultivated land conversion is one of the significant factors influencing food safety in China.Taking the North China Plain as the study area,this paper examines the changes of cultivated land area using satellite images,estimates land productivity from 1985 to 2005 using the model of Estimation System for Land Productivity(ESLP),and analyzes the impact of cultivated land conversion on the land production.Compared with the grain yield data from statistical yearbooks,the results indicate that ESLP model is an effective tool for estimating land productivity.Land productivity in the North China Plain showed a slight decreasing trend from 1985 to 2005,spatially,increased from the north to the south gradu-ally,and the net changes varied in different areas.Cultivated land area recorded a marginal decrease of 8.0 × 105 ha,mainly converted to other land uses.Cultivated land conversion had more significant negative impacts on land produc-tion than land productivity did.Land production decreased by about 6.48 × 106 t caused by cultivated land conversion between 1985 and 2005,accounting for 91.9% of the total land production reduction.Although the land productivity increased in Anhui and Jiangsu provinces,it can not offset the overall adverse effects caused by cultivated land con-version.Therefore,there are significant meanings to control the cultivated land conversion and improve the land pro-ductivity for ensuring the land production in the North China Plain. | JIANG Qun'ou DENG Xiangzheng ZHAN Jinyan HE Shujin | 2011 | Chinese Geographical Science2011，21，6： | 6 |
| 10 | STRIPE2 Encodes a Putative dCMP Deaminase that Plays an Important Role in Chloroplast Development in Rice显示文摘Mutants with abnormal leaf coloration are good genetic materials for understanding the mechanism of chloroplast development and chlorophyll biosynthesis. In this study, a rice mutant st2(stripe2) with stripe leaves was identified from the g-ray irradiated mutant pool.The st2 mutant exhibited decreased accumulation of chlorophyll and aberrant chloroplasts. Genetic analysis indicated that the st2 mutant was controlled by a single recessive locus. The ST2 gene was finely confined to a 27-kb region on chromosome 1 by the map-based cloning strategy and a 5-bp deletion in Os01g0765000 was identified by sequence analysis. The deletion happened in the joint of exon 3 and intron 3 and led to new spliced products of mRNA. Genetic complementation confirmed that Os01g0765000 is the ST2 gene.We found that the ST2 gene was expressed ubiquitously. Subcellular localization assay showed that the ST2 protein was located in mitochondria. ST2 belongs to the cytidine deaminase-like family and possibly functions as the dCMP deaminase, which catalyzes the formation of dUMP from dCMP by deamination. Additionally, exogenous application of dUMP could partially rescue the st2 phenotype.Therefore, our study identified a putative dCMP deaminase as a novel regulator in chloroplast development for the first time. | Jing Xu Yiwen Deng Qun Li Xudong Zhu Zuhua He | 2014 | Journal of Genetics and Genomics2014，41，10： | 3 |
| 11 | QTL mapping for fiber quality and yieldrelated traits across multiple generations in segregating population of CCRI 70显示文摘Background:Cotton is a significant economic crop that plays an indispensable role in many domains.Gossypium hirsutum L.is the most important fiber crop worldwide and contributes to more than 95%of global cotto n production.Identifying stable quantitative trait locus(QTLs)controlling fiber quality and yield related traits are necessary prerequisites for marker-assisted selection(MAS).Results:A genetic linkage map was constructed with 312 simple sequence repeat(SSR)loci and 35 linkage groups using JoinMap 4.0;the map spanned 1 929.9 cM,with an average interval between two markers of 6.19 cM,and covered approximately 43.37%of the cotton genome.A total of 74 QTLs controlling fiber quality and 41 QTLs controlling yield-related traits were identified in 4 segregating generations.These QTLs were distributed across 20 chromosomes and collectively explained 1.01%?27.80%of the observed phenotypic variations.In particular,35 stable QTLs could be identified in multiple generations,25 common QTLs were con sistent with those in previous studies,and 15 QTL clusters were found in 11 chromosome segments.Conclusion:These studies provide a theoretical basis for improving cotton yield and fiber quality for molecular marker-assisted selection. | DENG Xiaoying GONG Juwu LIU Aiying SHI Yuzhen GONG Wankui GE Qun LI Junwen SHANG Haihong WU Yuxiang YUAN Youlu | 2019 | Journal of Cotton Research2019，2，2： | 3 |
| 12 | Warehouse scheduling performance analysis considering LHRL显示文摘Warehouse scheduling efficiency has to do with the length-height ratio of location(LHRL) to some extent, which hasn't been well investigated until now. In this paper a mathematic model is built by analyzing the relation between the travel time of the stacker and LHRL. Meanwhile, warehouse scheduling strategy is studied combining with the project on the automatic production line of an enterprise, and a warehouse scheduling strategy is proposed based on index of quality(IoQ) parameters. Besides, the process of getting the value of IoQ is also simplified with the idea of sparse matrix. Finally, the IoQ scheduling strategy is compared with random strategy and First Come First Out strategy in different LHRLs. The simulation results show that the IoQ scheduling strategy not only improves the quality of the product effectively, but also improves the efficiency of the scheduling substantially. | Wen-Qiang Yang Li Deng Qun Niu Min-Rui Fei | 2013 | Advances in Manufacturing2013，1，2： | 2 |
| 13 | Elimination of a Retrotransposon for Quenching Genome Instability in Modern Rice显示文摘Transposable elements(TEs)constitute the most abundant portions of plant genomes and can dramatically shape host genomes during plant evolution.They also play important roles in crop domestication.However,whether TEs themselves are also selected during crop domestication has remained unknown.Here,we identify an active long terminal repeat(LTR)retrotransposon,HUO,as a potential target of selection during rice domestication and breeding.HUO is a low-copy-number LTR retrotransposon,and is active under natural growth conditions and transmitted through male gametogenesis,preferentially inserting into genomic regions capable of transcription.HUO exists in all wild rice accessions and about half of the archaeological rice grains(1200–7000 years ago)and landraces surveyed,but is absent in almost all modern varieties,indicating its gradual elimination during rice domestication and breeding.Further analyses showed that HUO is subjected to strict gene silencing through the RNA-directed DNA methylation pathway.Our results also suggest that multiple HUO copies may trigger genomic instability through altering genome-wide DNA methylation and small RNA biogenesis and changing global gene expression,resulting in decreased disease resistance and yield,coinciding with its elimination during rice breeding.Together,our study suggests that negative selection of an active retrotransposon might be important for genome stability during crop domestication and breeding. | Yu Peng Yingying Zhang Yijie Gui Dong An Junzhong Liu Xun Xu Qun Li Junmin Wang Wen Wang Chunhai Shi Longjiang Fan Baorong Lu Yiwen Deng Sheng Teng Zuhua He | 2019 | Molecular Plant2019，12，10： | 2 |
| 14 | 10,11-dehydrocurvularin exerts antitumor effect against human breast cancer by suppressing STAT3 activation显示文摘Aberrant activation of signal transducer and activator of transcription 3(STAT3)plays a critical role in many types of cancers.As a result,STAT3 has been identified as a potential target for cancer therapy.In this study we identified 10,11-dehydrocurvularin(DCV),a natural-product macrolide derived from marine fungus,as a selective STAT3 inhibitor.We showed that DCV(2–8μM)dose-dependently inhibited the proliferation,migration and invasion of human breast cancer cell lines MDA-MB-231 and MDA-MB-468,and induced cell apoptosis.In the two breast cancer cell lines,DCV selectively inhibited the phosphorylation of STAT3 Tyr-705,but did not affect the upstream components JAK1 and JAK2,as well as dephosphorylation of STAT3.Furthermore,DCV treatment strongly inhibited IFN-γ-induced STAT3 phosphorylation but had no significant effect on IFN-γ-induced STAT1 and STAT5 phosphorylation in the two breast cancer cell lines.We demonstrated that theα,β-unsaturated carbonyl moiety of DCV was essential for STAT3 inactivation.Cellular thermal shift assay(CETSA)further revealed the direct engagement of DCV with STAT3.In nude mice bearing breast cancer cell line MDA-MB-231 xenografts,treatment with DCV(30 mg·kg^(−1)·d^(−1),ip,for 14 days)markedly suppressed the tumor growth via inhibition of STAT3 activation without observed toxicity.Our results demonstrate that DCV acts as a selective STAT3 inhibitor for breast cancer intervention. | Qun Zhao Yun Bi Jing Zhong Xiang Li Jian Guo Ying-xiang Liu Long-rui Pan Yan Tan Zhang-shuang Deng Xian-jun Yu | 2021 | Acta Pharmacologica Sinica2021，42，5： | 2 |
| 15 | Effect of slow cooling treatment on hot deformation behavior of GH4742 superalloy显示文摘 | Lü Xu-dong DENG Qun DU Jin-hui ZHONG Zeng-yong | | 0，，1： | 1 |
| 16 | On strong commutativity pre-serving maps显示文摘 | Deng Qun Ashraf M | 1996 | Results Math1996，30，1： | 1 |
| 17 | Expression and kinetic changes of alkaline phosphatase and its isoenzymes in experimental rat hepatoma显示文摘ExpressionandkineticchangesofalkalinephosphataseanditsisoenzymesinexperimentalrathepatomaXIAOMingBing,YAODeengFu,ZHANGHong... | XIAO MingBing, YAO DengFu, ZHANG Hong, QIANG Hui, HUANG JieFei, WEI Qun and JIANG FengKeywords liver neoplasms/enzymology alkaline phosphatase/analysis alkaline phosphatase isoenzymes/analysis disease models, animal 2fluoenylacetamide/a | 1998 | World Journal of Gastroenterology1998，4，4： | 1 |
| 18 | A facial strategy to efficiently improve catalytic performance of CoFe_(2)O_(4) to peroxymonosulfate显示文摘Cobalt iron spinel(CoFe_(2)O_(4)) has been considered as a good heterogeneous catalysis to peroxymonosulfate(PMS) in the degradation of persistent organic pollutants due to its magnetic properties and good chemical stability. However, its catalytic activity needs to be further improved. Here, a facial strategy, “in-situ substitution”, was adopted to modify CoFe_(2)O_(4) to improve its catalytic performance just by suitably increasing the Co/Fe ratio in synthesis process. Compared with CoFe_(2)O_(4), the newly synthesized Co_(1.5)Fe_(1.5)O_(4), could not only significantly improve the degradation efficiency of phenol, from 50.69 to 93.6%, but also exhibited more effective mineralization ability and higher PMS utilization. The activation energy advantage for phenol degradation using Co_(1.5)Fe_(1.5)O_(4)was only 44.2 k J/mol, much lower than that with CoFe_(2)O_(4)(127.3 k J/mol). A series of related representations of CoFe_(2)O_(4) and Co_(1.5)Fe_(1.5)O_(4) were compared to explore the possible reasons for the outstanding catalytic activity of Co_(1.5)Fe_(1.5)O_(4). Results showed that Co_(1.5)Fe_(1.5)O_(4)as well represented spinel crystal as CoFe_(2)O_(4)and the excess cobalt just partially replaced the position of iron without changing the original structure. Co_(1.5)Fe_(1.5)O_(4) had smaller particle size(8.7 nm), larger specific surface area(126.3 m^(2)/g), which was more favorable for exposure of active sites. Apart from the superior physical properties, more importantly, more reactive centers Co(Ⅱ) and surface hydroxyl compounds generated on Co_(1.5)Fe_(1.5)O_(4), which might be the major reason. Furthermore, Co_(1.5)Fe_(1.5)O_(4) behaved good paramagnetism, wide range of pH suitability and strong resistance to salt interference, making it a new prospect in environmental application. | Lili Gao Jieqiong Deng Tong Li Kai Qi Jiandong Zhang Qun Yi | 2022 | Journal of Environmental Sciences2022，34，6： | 1 |
| 19 | Impeded Nedd4-1-Mediated Ras Degradation Underlies Ras-Driven Tumorigenesis显示文摘 | Taoling Zeng Qun Wang Jieying Fu Qi Lin Jing Bi Weichao Ding Yikai Qiao Sheng Zhang Wenxiu Zhao Huayue Lin Meilin Wang Binfeng Lu Xianming Deng Dawang Zhou Zhenyu Yin Hong-Rui Wang | 2014 | Cell Reports2014，，3： | 1 |
| 20 | Progress and development directions of shale oil reservoir stimulation technology of China National Petroleum Corporation显示文摘By reviewing the development history of shale oil reservoir stimulation technology of PetroChina Company Limited(PetroChina),we have systematically summarized the main progress of shale oil reservoir stimulation technology of CNPC in five aspects:reservoir stimulation mechanism,fracture-controlled fracturing,geological-engineering integrated reservoir stimulation design platform,low-cost materials,and large well-pad three-dimensional development mode.It is made clear that the major stimulation technology for shale oil reservoir is the high density multi-cluster and fracture-controlled staged fracturing aiming to increase fracture-controlled reserves,lower operation costs and increase economic benefits.Based on comprehensive analysis of the challenges shale oil reservoir stimulation technology faces in three-dimensional development,stimulation parameter optimization for fracture-controlled fracturing,refracturing and low-cost stimulation technology,we proposed five development directions of the stimulation technology:(1)Strengthen the research on integration of geology and engineering to make full use of reservoir stimulation.(2)Deepen the study on fracture-controlled fracturing to improve reserves development degree.(3)Promote horizontal well three-dimensional development of shale oil to realize the production of multiple layers vertically.(4)Research refracturing technology of shale oil reservoir through horizontal well to efficiently tap the remaining reserves between fractures.(5)Develop low-cost stimulation supporting technology to help reduce the cost and increase economic benefit of oilfield development. | LEI Qun WENG Dingwei XIONG Shengchun LIU Hanbin GUAN Baoshan DENG Qjang YAN Xuemei LIANG Hongbo MA Zeyuan | 2021 | Petroleum Exploration and Development2021，48，5： | 1 |
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