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| 1 | LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration显示文摘新兴的研究在少些在染色质水平,但是相对调整基因表示记录长非编码的 RNA (LncRNAs ) 的角色被知道他们怎么调整 DNA methylation。这里,我们识别 lncRNA, Dum (发展联系 pluripotency 2 (Dppa2 ) 在上游的有约束力的肌肉 lncRNA ) 在骨胳的 myoblast 房间。Dum 的表示动态地在 vitro 并且在 vivo 在 myogenesis 期间被调整。它被在 myoblast 区别之上有约束力的 MyoD transcriptionally 也导致。功能的分析证明它支持 myoblast 区别和导致损坏的肌肉新生。机械学地, Dum 被发现它的附近的基因到沉默, Dppa2,在通过招募的 cis Dnmt1, Dnmt3a 和 Dnmt3b。而且, intrachromosomal 在 Dum 地点和 Dppa2 倡导者之间循环为 Dum/Dppa2 相互作用是必要的。一起,我们识别了与 Dnmts 交往调整 myogenesis 的新奇 lncRNA。 | Lijun Wang Yu Zhao Xichen Bao Xihua Zhu Yvonne Ka-yin Kwok Kun Sun Xiaona Chen Yongheng Huang Ralf Jauch Miguel A Esteban Hao Sun Huating Wang | 2015 | Cell Research2015，25，3： | 34 |
| 2 | High-throughput RNA interference screens integrative analysis: Towards a comprehensive understanding of the virus-host interplay显示文摘Viruses are extremely heterogeneous entities; the size and the nature of their genetic information, as well as the strategies employed to amplify and propagate their genomes, are highly variable. However, as obligatory intracellular parasites, replication of all viruses relies on the host cell. Having co-evolved with their host for several million years, viruses have developed very sophisticated strategies to hijack cellular factors that promote virus uptake, replication, and spread. Identification of host cell factors(HCFs) required for these processes is a major challenge for researchers, but it enables the identification of new, highly selective targets for anti viral therapeutics. To this end, the establishment of platforms enabling genome-wide high-throughput RNA interference(HT-RNAi) screens has led to the identification of several key factors involved in the viral lifecycle. A number of genome-wide HT-RNAi screens have been performed for major human pathogens. These studies enable first inter-viral comparisons related to HCF requirements. Although several cellular functions appear to be uniformly required for the life cycle of most viruses tested(such as the proteasome and the Golgi-mediated secretory pathways), some factors, like the lipid kinase Phosphatidylinositol 4-kinase Ⅲα in the case of hepatitis C virus, are selectively required for individual viruses. However, despite the amount of data available, we are still far away from a comprehensive understanding of the interplay between viruses and host factors. Major limitations towards this goal are the low sensitivity and specificity of such screens, resulting in limited overlap between different screens performed with the same virus. This review focuses on how statistical and bioinformatic analysis methods applied to HTRNAi screens can help overcoming these issues thus increasing the reliability and impact of such studies. | Sandeep Amberkar Narsis A Kiani Ralf Bartenschlager Gualtiero Alvisi Lars Kaderali | 2013 | World Journal of Virology2013，2，2： | 9 |
| 3 | Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team. | Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 4 | Mobilization of hematopoietic progenitor cells in patients with liver cirrhosis显示文摘AIM:To test the hypothesis that liver cirrhosis is associated with mobilization of hematopoietic progenitor cells. METHODS:Peripheral blood samples from 72 patients with liver cirrhosis of varying etiology were analyzed by flow cytometry.Identified progenitor cell subsets were immunoselected and used for functional assays in vitro. Plasma levels of stromal cell-derived factor-1(SDF-1) were measured using an enzyme linked immunosorbent assay.RESULTS:Progenitor cells with a CD133 + /CD45 + CD14 + phenotype were observed in 61%of th patients.Between 1%and 26%of the peripheral bloo mononuclear cells(MNCs)displayed this phenotype Furthermore,a distinct population of c-kit + progenito cells(between 1%and 38%of the MNCs)could b detected in 91%of the patients.Additionally,18% of the patients showed a population of progenito cells(between 1%and 68%of the MNCs)that wa characterized by expression of breast cancer resistanc protein-1.Further phenotypic analysis disclosed tha the circulating precursors expressed CXC chemokin receptor 4,the receptor for SDF-1.In line with thi finding,elevated plasma levels of SDF-1 were presen in all patients and were found to correlate with th number of mobilized CD133 + progenitor cells. | Ursula M Gehling Marc Willems Kathleen Schlagner Ralf A Benndorf Maura Dandri Jrg Petersen Martina Sterneck Joerg-Matthias Pollok Dieter K Hossfeld Xavier Rogiers | 2010 | World Journal of Gastroenterology2010，16，2： | 4 |
| 5 | Si-C-N三元系统的新陶瓷相显示文摘固体化学合成的氮化物较其他氧化物研究相对较少,然而过去20年来,该研究领域得到重视。超硬 C3N4相所类似的碳氮化物目前已获得深入研究,相比较而言,Si-C-N化合物的研究依旧比较少。在大气条件下首先合成的三元晶体相为Si(NCN)2和 Si2C2(NCN)。本文回顾了近年来采用高温高压反应工艺合成C-N二元和 Si-C-N三元系材料的研究现状。这类新型材料因具有一些独特的性能,如高硬度、磁性、光电性能,而具有重大研究前景。 | RIEDEL Ralf HORVATH-BORDON Elisabeta KLEEBE Hans-Joachim KROLL Peter MIEHE Gerhard van AKEN Peter A LAUTERBACH Stefan | 2007 | 硅酸盐学报2007，35，8： | 2 |
| 6 | Mobilization and functionality of endothelial progenitor cells during antihypertensive treatment in patients with essential hypertension显示文摘 | Ralf A B Ulla M G Daniel A | 2004 | Circulation2004，110，17： | 1 |
| 7 | Mental health outcome of Job stress among Chinese teachers:role of stress resource Factors and burnout显示文摘 | Catherine S K T Wing T A RalfS G S | 2001 | Journal of Organizational Behavior2001，，22： | 1 |
| 8 | Effects of temperature and fertilizer on activity and community structure of soil ammonia oxidizers显示文摘 | Sharon A Werner L Ralf C | 2003 | Environmental Microbiology2003，5，8： | 1 |
| 9 | Modified point diffraction interferometer for inspection and evaluation of ophthalmic components显示文摘 | EVA A SARA C RALF B | 2006 | OSA2006，26，3： | 1 |
| 10 | The effect of dissolved oxygen on PHB accumulation in activated sludge cultures 显示文摘 | Katie A Third Mark Newland Ralf Cord-Ruwisch | 2003 | Biotechnology and Bioengineering2003，82，2： | 1 |
| 11 | Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial显示文摘 | Marcia S Brose Christopher M Nutting Barbara Jarzab Rossella Elisei Salvatore Siena Lars Bastholt Christelle de la Fouchardiere Furio Pacini Ralf Paschke Young Kee Shong Steven I Sherman Johannes W A Smit John Chung Christian Kappeler Carol Pe?a István Mo | 2014 | The Lancet2014，，： | 1 |
| 12 | Simultaneous nitrification and denitrification using stored substratc (PHB)as the electron donor in an SBR 显示文摘 | Katie A Third Natalie Burner Ralf Cord-Ruwisch | 2003 | Biotechnol Bioeng2003，83，6： | 1 |
| 13 | Association of subjective well--be ing,symptoms,and side effects with compliance after 12 months of treatment in schizophrenia显示文摘 | Karow A Joerg C Ralf D | 2007 | Clin Psychiatry2007，68，： | 1 |
| 14 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 15 | Adsorption of polymer ehains onto charged spheres: Experiment and theory 显示文摘 | Peter Haronska Thomas A Vilgis Ralf Grottenmttller | 1998 | Macromoleeular Theory and Simulations1998，7，2： | 1 |
| 16 | Effects of temporary clipping during aneurysm surgery显示文摘 | Chris W Ralf DR Ruth A | 2008 | Neurological Research2008，30，： | 1 |
| 17 | The onset of spherulitic growth in crystallization of calcium carbonate 显示文摘 | Ralf B Jens-Petter A | 2010 | Journal of Crystal Growth2010，312，15： | 1 |
| 18 | Simultaneous Nitrification and Denitrification Using Stored Substrate (PHB) as the Electron Donor in an SBR显示文摘 | KATIE A T NATALIE B RALF C R | 2003 | Biotechnol Bioeng2003，83，： | 1 |
| 19 | Integrating direct and indirect sales channels under decentralized decision -making显示文摘 | Ralf W Seifert Ulrich W Thonemann and Marcel A Sieke | 2006 | International Journal of Production Economics2006，103，： | 1 |
| 20 | Polypeptide-shelled poly(propylene imine) dendrimers and their complexing properties towards copper (Ⅱ) ions显示文摘 | Dietmar A Hartmut K Ralf K | 2005 | Macromolecular Rapid Communications2005，26，8： | 1 |
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