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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Early warning fire detection system using a probabilistic neural network 显示文摘 | SUSAN L ROSE P | 2003 | Fire Technology2003，39，： | 1 |
| 3 | Growth of anaerobic rumen fungi on defined and semi-defined media lacking rumen fluid显示文摘 | Susane E L Michael K T Anthony P J T | 1985 | J General Microbiology1985，131，： | 1 |
| 4 | Modeling non calamitous individual tree mortality using logistic regression, neural networks, and support vector methods 显示文摘 | SUSAN L KING KRISTIN P BENNETT SHANNON LIST | 2000 | Computers and Electronics in Agriculture2000，27，3： | 1 |
| 5 | Physical activity and reduced occurrence of non-insulin-dependent diabetes meilitus显示文摘 | Susan P H David R R Rita W L | 1991 | N Engl J Med1991，325，3： | 1 |
| 6 | Predicting progeny variance from parental divergence in hard spring wheat 显示文摘 | Rebecca L B Susan P L Roy J M | 1998 | Crop Science1998，38，： | 1 |
| 7 | Bio- control agents applied individually and in combination for suppression of soilborne diseases of cucumber 显示文摘 | DANIEL P R SCOTF M L SUSAN L F | 2005 | Crop Protection2005，24，： | 1 |
| 8 | Modeling non- catastrophic individual tree mortality using logistic re- gression neural networks and support vector methods 显示文摘 | SUSAN L KING K P BENNETY S L | 2000 | Computers and Electronics in Agriculture2000，27，13： | 1 |
| 9 | Genome shuffing of Lactoba- cillus for improved acid tolerance显示文摘 | RANJAN P SUSAN L VESNA G | 2002 | Nature Biotechnology2002，20，7： | 1 |
| 10 | Multidrug resistance proteins : role of P-glycoprotein, MRP1, MRP2, and BCRP ( ABCG2 ) in tissue defense 显示文摘 | ELAINE M L ROGER G D SUSAN P C | 2005 | Toxicol Appl Pharmacol2005，204，3： | 1 |
| 11 | DIBOA: Fate in soil and effects on root-knot nematode egg numbers显示文摘 | Susan L F Meyer Clifford P Rice Inga A Zasada | 2009 | Soil Biology & Biochemistry2009，41，： | 1 |
| 12 | Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining显示文摘 | Brandi L Mahaney Katheryn Meek Susan P Lees-miller | 2009 | Biochem J2009，417，： | 1 |
| 13 | Predicting progeny variance from parental divergence in hard spring wheat 显示文摘 | Rebecca L B Susan P L Roy J M | 1998 | Crop Science1998，38，： | 1 |
| 14 | H1N1 2009 influenza virus infection during pregnancy in the USA显示文摘 | Denise J Jamieson Margaret A Honein Sonja A Rasmussen Jennifer L Williams David L Swerdlow Matthew S Biggerstaff Stephen Lindstrom Janice K Louie Cara M Christ Susan R Bohm Vincent P Fonseca Kathleen A Ritger Daniel J Kuhles Paula Eggers Hollianne Bruce H | 2009 | The Lancet2009，，9688： | 1 |
| 15 | Toxicologic studies in a fatal overdose of 2 ,4-D, MCPP and chlor-pyrifos 显示文摘 | JOHN O MARCELLO L SUSAN M P | 1983 | J Anal Toxicol1983，7，： | 1 |
| 16 | Modeling noncatastrophic individual tree mortality using logistic regression, neural networks, and support vector methods 显示文摘 | Susan L King Kristin P Bennett Shannon List | 2000 | Computers and electronics in agriculture2000，27，13： | 1 |
| 17 | Cost-effectiveness of MR imaging and core-needle biopsy in the preoperative work-up of suspicious breast lesions显示文摘 | Janie M H Curtis P L Susan G O | 1999 | Breast Imaging1999，213，1： | 1 |
| 18 | The influ- ence of organic organizational cultures,market re- sponsiveness, and product strategy on firm显示文摘 | Wei Y H(Susan) Samiee S Ruby P L | 2013 | Management Journal2013，19，2： | 1 |
| 19 | Predicting progeny variance from parental divergence in hard red spring wheat显示文摘 | Rebecca L B Susan P L Roy J M | 1998 | Crop Science1998，38，： | 1 |
| 20 | Volume sensor for damage assessment and situation awareness 显示文摘 | Susan L Rose P Christian P | 2006 | Fire Safety Journal2006，，41： | 1 |
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