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| 1 | A germline variant N375S in MET and gastric cancer susceptibility in a Chinese population显示文摘MET tyrosine kinase and its ligand,hepatocyte growth factor(HGF),play a pivotal role in the activties of tumor cells.A germline missense variant in exon 2 of the MET gene,N375S(rs33917957 A>G),may alter the binding affinity of MET for HGF and thus modify the risk of tumorigenesis.In this study,we performed a case-control study to assess the association between N375S and gastric cancer risk in 1,681 gastric cancer cases and 1,858 cancer-free controls.Logistic regression analysis was applied to estimate crude and adjusted odds ratios(ORs) and 95% confidence intervals(CIs) for the associations between genotypes and gastric cancer risk.We found that MET N375S variant genotypes(NS/SS) were associated with a significantly decreased risk of gastric cancer(OR = 0.78,95% CI = 0.63-0.96,P = 0.021) compared with the wildtype homozygote(NN).The finding indicates that this germline variant in MET may decrease gastric cancer susceptibility in Han Chinese. | Yao Liu Qin Zhang Chuanli Ren Yanbing Drag Guangfu Jin Zhibin Hu Yaochu Xu Hongbing Shen | 2012 | The Journal of Biomedical Research2012，26，5： | 2 |
| 2 | Bird nest-like zinc oxide nanostructures for sensitive electrochemical glucose biosensor显示文摘In this research,a novel bird nest-like zinc oxide(BN-ZnO)nanostructures were prepared by a simple solvothermal method.A sensitive electrochemical glucose biosensor was for the first time developed based on the immobilization of glucose oxidase(GOx)on nanostructured BN-ZnO modified electrode.The BN-ZnO nanostructure and the resultant biosensor were characterized by scanning electron microscope,X-ray diffraction spectroscopy,Fourier transform infrared spectroscopy,and electrochemical impedance spectroscopy.BN-ZnO nanostructures have large specific surface area and can load large amounts of GOx molecules.Meanwhile,BN-ZnO provides an excellent microenvironment to retain the native bioactivity of enzymes and to promote direct electron transfer between GOx and electrode surface.The proposed biosensor shows a wide linear range of 0.005–1.6 mmol/L,high sensitivity of15.6 mA L mol^(-1)cm^(-2)with a low detection limit of 0.004 mmol/L.The resulting biosensor also shows excellent selectivity,acceptable stability and reproducibility,and can be successfully applied in the detection of glucose in human serum samples at-0.37 V. | Feng Shi Jinming Xu Zhongfang Hu Chuanli Ren Yadong Xue Yongcai Zhang Juan Li Chengyin Wang Zhanjun Yang | 2021 | Chinese Chemical Letters2021，32，10： | 1 |
| 3 | Detection and molecular analysis of circulating tumor cells for early diagnosis of pancreatic cancer显示文摘 | Chuanli Ren Hui Chen Chongxu Han Guangfu Jin Daxin Wang Daorong Wang Dong Tang | 2013 | Medical Hypotheses2013，，6： | 1 |
| 4 | Malignant characteristics of circulating tumor cells and corresponding primary tumor in a patient with esophageal squamous cell carcinoma before and after surgery显示文摘 | Chuanli Ren Ping He Jinqiang Zhang Zhaoxu Zheng Yuanyuan Qiao Xiaohang Zhao | 2011 | Cancer Biology & Therapy2011，，： | 1 |
| 5 | Detection of apoptotic circulating tumor cells in advanced pancreatic cancer following 5-fluorouracil chemotherapy显示文摘 | Chuanli Ren Chongxu Han Jinqing Zhang Ping He Daxin Wang Buhai Wang Ping Zhao Xiaohang Zhao | 2011 | Cancer Biology & Therapy2011，，8： | 1 |
| 6 | Genetic variants at 5p15 are associated with risk and early onset of gastric cancer in Chinese populations显示文摘 | Jiangbo Du Yaochu Xu Juncheng Dai Chuanli Ren Chen Zhu Ningbin Dai Hongxia Ma Yongyong Shi Zhibin Hu Dongxin Lin Hongbing Shen Guangfu Jin | 2013 | Carcinogenesis2013，，11： | 1 |
| 7 | Catalyst-free tandem Michael addition-cyclization reactions in aqueous media for the synthesis of benzimidazo[1,2-a]pyrimidinone derivatives显示文摘The catalyst-free reactions of Baylis-Hillman alcohols (1a-i) with 2-aminobenzimidazole (2) in THF-H2O (1:4) were developed for the convenient and greener synthesis of benzimidazo[1,2-a]pyrimidinone derivatives (3a-i).The pesticidal activities of 3a-i were examined to investigate a new biological activity of the imidazo[1,2-a]pyrimidinone-type compounds. | REN ChuanLi WANG Yan WANG Dong CHEN YongJun LIU Li | 2010 | Science China Chemistry2010，53，7： | 0 |
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