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| 1 | Intraocular complications of IFN-α and ribavirin therapy in patients with chronic viral hepatitis C显示文摘We report a panel of severe inflammatory and vascular intraocular disorders occurring during interferon-alpha (IFN-α) treatment in eight hepatitis C virus (HCV)-infected patients. These events include three cases of Vogt-Koyanagi-Harada like (VKH) disease (an association of panuveitis, retinal detachment, ear and meningeal detachment and skin and hair changes), two cases of central retinal vein occlusion, one case of central retinal artery occlusion, one case of severe hypertensive retinopathy and one case of bilateral ischemic optic neuropathy with severe visual impairment. Rare as they are, such severe ophthalmological complications require a close follow-up of HCV-infected patients under IFN-α treatment with ophthalmological monitoring if any ocular manifestation occurs. | Damien Sène Valérie Touitou Bahram Bodaghi David Saadoun Gabriel Perlemuter Nathalie Cassoux Jean-Charles Piette Phuc Le Hoang Patrice Cacoub | 2007 | World Journal of Gastroenterology2007，13，22： | 5 |
| 2 | Safety and Efficacy of Antigen-Specific Regulatory T-Cell Therapy for Patients With Refractory Crohn’s Disease显示文摘 | Pierre Desreumaux Arnaud Foussat Matthieu Allez Laurent Beaugerie Xavier Hébuterne Yoram Bouhnik Maria Nachury Valérie Brun Hervé Bastian Nathalie Belmonte Michel Ticchioni Agnès Duchange Patricia Morel–Mandrino Virginie Neveu Nathalie Clerget–Chossat Mig | 2012 | Gastroenterology2012，，5： | 4 |
| 3 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 4 | Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease显示文摘 | Gentric Géraldine Maillet Vanessa Paradis Valérie Couton Dominique L’Hermitte Antoine Panasyuk Ganna Fromenty Bernard Celton-Morizur Séverine Desdouets Chantal | 2015 | Journal of Clinical Investigation2015，，： | 2 |
| 5 | Early switch to pentoxifylline in patients with severe alcoholic hepatitis is inefficient in non-responders to corticosteroids显示文摘 | Alexandre Louvet Emmanuel Diaz Sébastien Dharancy Hugues Coevoet Frédéric Texier Thierry Thévenot Pierre Deltenre Valérie Canva Christophe Plane Philippe Mathurin | 2007 | Journal of Hepatology2007，，3： | 2 |
| 6 | Measuring stigma associated with tuberculosis and HIV/AIDS in southern Thailand: Exploratory and confirmatory factor analyses of two new scales显示文摘 | Van Rie A Sengupta S Pungrassami P | 2008 | Trop Med Int Health2008，13，1： | 1 |
| 7 | The role of bacterial vaginosis in preterm labor and preterm birth: A case-control study 显示文摘 | Damien S I Val rie D Fran oise L G | 2002 | Euro J Obstet Gynecol Reprod Biol2002，101，1： | 1 |
| 8 | Heterolayer light-emitting diodes based on new oxadiazole polymers显示文摘 | Meier M Buchwald E Karg S Psch P Greezmiel M Strohriegl P Rie W | 1996 | Synthetic Metals1996，76，： | 1 |
| 9 | UVB radiation preieremally induces recruitment of memory CD4+T cells in normal human skin:long-term effect after a single exposure显示文摘 | Di Nuzn S Sylva-Steenland RMR De Rie MA | 1998 | J Invest Dermatol1998，110，： | 1 |
| 10 | Nutritional knowledge, food habits and health attitude of Chinese university students : a cross sectional study 显示文摘 | RUKA S KENJI T RIE A | 2005 | Nutr J2005，4，： | 1 |
| 11 | Duration of immunity against pertussis after natural infection or vaccination 显示文摘 | WENDELBOE A M VAN RIE A SALMASO S | 2005 | Pediatr Infect Dis J2005，24，5： | 1 |
| 12 | Development and validation of an SPE HG-AAS method for determination of inorganic arsenic in samples of marine origin 显示文摘 | Rie R R Rikke V H Erik H L Jens J S | 2012 | Analytical and Bioanalytical Chemistry2012，403，10： | 1 |
| 13 | Catalytic asymmetric synthesis of R207910显示文摘 | YUTAKA S RIE M SAE M | 2010 | J Am Chem Soc2010，132，： | 1 |
| 14 | The application of pH-stat leaching tests to assess the pH-dependent release of trace metals from soils, sediments and waste materials显示文摘 | Val~rie C Rudy S | 2008 | Journal of Hazardous Materials2008，158，： | 1 |
| 15 | A comparative study of food habits and body shape perception of university students in Japan and Korea显示文摘 | Rie A Yoshie M | 2005 | Nutrition Journal2005，，4： | 1 |
| 16 | Decreased lithium disposition to cerebrospinal fluid in rats with glycerol-induced acute renal failure显示文摘 | Rie S Atsuko I Tomoko N | 2008 | Pharmaceutical Research2008，25，10： | 1 |
| 17 | Monoclonal antibody analysis and insecticidal spectrum of three types of Lepidopteran-specific insecticidal crystal proteins of Bacillus thuringiensis显示文摘 | Hofte H Van Rie J Jansens S | 1988 | Appl Environ Microbiol1988，54，8： | 1 |
| 18 | Duration of immunity against pertussis after natural infection or vaccination显示文摘 | Wendelboe AM Van Rie A Salmaso S | 2005 | Pediatr Infect Dis J2005，24，5： | 1 |
| 19 | HCV/HIV co-infection, HCV viral load and mode of delivery: risk factors for mother-to-child transmission of hepatitis C virus?显示文摘 | Eugènia Mariné-Barjoan Alain Berrébi Valérie Giordanengo Sébastien Fournier Favre Hervé Haas Michel Moreigne Jacques Izopet Joelle Tricoire Albert Tran Christian Pradier André Bongain | 2007 | AIDS2007，，13： | 1 |
| 20 | Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice显示文摘 | RIE S NATSUMI N HIROMI H | 2007 | Biochemical Pharmacology2007，74，11： | 1 |
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