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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Method for rapid on-site identification of VOCs显示文摘Rapid on-site identification of volatile organic compounds (VOCs) in ambient air is an important first step in remediation efforts. This study describes modification of a commercially available, portable GC/MS system and development of an analysis protocol for rapid (< 3 min) sampling and identification of VOCs typically found at contaminated sites at the low ppbv level. | Justin D Fair William F Bailey Robert A Felty Amy E Gifford Benjamin Shultes Leslie H Volles | 2009 | Journal of Environmental Sciences2009，21，7： | 8 |
| 3 | Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial显示文摘 | Eric Lawitz Fred F Poordad Phillip S Pang Robert H Hyland Xiao Ding Hongmei Mo William T Symonds John G McHutchison Fernando E Membreno | 2013 | The Lancet2013，，： | 5 |
| 4 | Influence of Adsorbed Gases on the Surface Energy of Graphite:Consequence on the Friction Behavior显示文摘 | Zaidi H Robert F Paulmier D | 1995 | Thin Solid Films1995，264，： | 1 |
| 5 | Underwater Bipedal Locomotion by Octopuses in Disguise显示文摘 | CHRISTINE L H FARNIS B ROBERT J F | 2005 | Science2005，307，： | 1 |
| 6 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 7 | Peak discharge of a Pleistocene lava-dam outburst floods in Grand Canyon,Arizona,USA显示文摘 | CASSANDRA R F ROBERT H W THURE E C | 2006 | Quaternary Research2006，，7： | 1 |
| 8 | High-angle reverse faults, fluid-pressure cycling, and mesothermal gold-quartz de- posits显示文摘 | Sibson R H Robert F Poulsen K H | 1988 | Geology1988，16，： | 1 |
| 9 | Generationof potentially bioactive ergosterol-derived products following pulsedultraviolet light exposure of mushrooms (Agaricus bisporus)显示文摘 | MICHAEL D K ROBERT B B MICHAEL F H | 2012 | FoodChemistry2012，135，2： | 1 |
| 10 | Toxicity of aluminum hydroxide complexes in neutral and basic media to rainbow trout显示文摘 | Robert A F Everhart W H | 1971 | Transactions of the American Fisheries Society1971，100，64： | 1 |
| 11 | Testing the usability of two automated home-based patient-management systems 显示文摘 | RAMESH F JOSEPH F ROBERT H | 2004 | Journal of Medical Systems2004，28，2： | 1 |
| 12 | Young,Look to consumers to Increase Productivity显示文摘 | Lovelock Christopher H Robert F | 1979 | Harvard Business Review1979，57，56： | 1 |
| 13 | Dynamic pattern formation in a vesicle-generating microfluidic device 显示文摘 | Thorsen T Roberts R W Arnold F H | 2001 | Phys Rev Lett2001，86，18： | 1 |
| 14 | High-an- gle reverse fauhs, fluid pressure cycling and mesother- mal gold-quartz deposits 显示文摘 | SINBSON R H ROBERT F POULSEN K H | 1988 | Geology1988，16，： | 1 |
| 15 | Interlocking Directorates : A Strategy for Reducing Environmental Un - certainty显示文摘 | F David Schoorman Max H Bazerman Robert S Atkin | 1981 | A- cademy of Management1981，6，2： | 1 |
| 16 | Solute accumulation in the deep-sea bacterium Photobacterium profundum显示文摘 | Martin D D Bartlett D H Roberts M F | 2002 | Extremophiles2002，6，： | 1 |
| 17 | Fritschel chemical characterizationg of fresh kill landfill refuse and extracts显示文摘 | ROBERT K H MICHELE R N PAUL F | 1993 | Jourmal of Environmental Engineering1993，119，6： | 1 |
| 18 | Developing Buyer-Seller relationship 显示文摘 | Dwyer Robert F Paul H Schurr | 1987 | Journal of Marketing1987，，： | 1 |
| 19 | The effect of lignin-related compounds on the growth and production of laccases by the ascomycete,Botryosphaeria sp显示文摘 | Dekker Robert F H Barbosa Aneli M Sargent Keith | 2002 | Enzyme and Microbial Technology2002，30，3： | 1 |
| 20 | High-angle reverse faults,fluid-pressurecycling and mesothermal gold-quartz deposits显示文摘 | Sibson R H Robert F Poulsen K H | 1988 | Geology1988，16，： | 1 |
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