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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Three dimensional velocity structure and accurate earthquake location in Changning–Gongxian area of southeast Sichuan显示文摘In order to understand the crustal structure and tectonic background of the Changning–Gongxiang area, southeastern Sichuan Province, where a series of moderate-to-strong earthquakes occurred in recent years, we utilized the seismic phase data both from a local dense array and from the regional seismic networks;we used the tomoDD program to invert for the high-resolution three-dimensional velocity structure within the depth range of 0–10 km and for accurate hypocentral locations in this area. We analyzed the seismogenic structures for the events of Xingwen M5.7 in 2018 and Gongxian M5.3 and Changning M6.0 in 2019. The results show that:(1) widespread lateral inhomogeneity exists in the velocity structure of the study area, and the location of the velocity anomaly is largely consistent with known structures. In the range of distinguishable depth, the inhomogeneity decreases with increasing depth, and the velocity structure anomalies in some areas are continuous in depth;(2) earthquakes occurred in clusters, showing the characteristics of zonal folding trends in the NW-SE and NE-SW directions;the focal depth in the area is generally shallow in both the sedimentary cap and the crystalline basement. The seismogenic structures of small earthquake clusters are different in size and occurrence in different sections, and the clusters occurred mostly in regions with high P-or S-wave velocities;(3) synthesis of a variety of data suggests that the seismogenic structures of the Xingwen M5.7 and Changning M6.0 earthquakes are associated with slip faults that trend NW-SE in, respectively, the south wing and the axis of the Changning–Shuanghe anticline, while that of the Gongxian M5.3 earthquake is associated with thrust faults that trend N-S in the Jianwu syncline region. The dynamic sources of the three earthquakes are all from the SE pushing of the Qinghai–Tibet block on the Sichuan basin;(4) the risk of future strong earthquakes in this area must be reevaluated in light of the facts(a)that in recent years, moderate-to-strong earthquake swarms have occurred frequently in southeast Sichuan;(b) that the complex structural area exhibits the easy-to-trigger characteristic, and(c) that the small-scale faults in this area are characterized by the phenomenon of stress 'lock and release'. | Feng Long ZhiWei Zhang YuPing Qi MingJian Liang Xiang Ruan WeiWei Wu GuoMao Jiang LongQuan Zhou | 2020 | Earth and Planetary Physics2020，4，2： | 13 |
| 3 | Changing Proportions of HIV-1 Subtypes and Transmitted Drug Resistance Among Newly Diagnosed HIV/AIDS Individuals—China,2015 and 2018显示文摘Introduction:With the expansion of human immunodeficiency virus(HIV)antiretroviral therapy(ART),HIV drug resistance is becoming more and more serious.This study describes the changing prevalence of HIV-1 subtypes and transmitted drug resistance(TDR)among newly diagnosed individuals in China,2015 and 2018.Methods:A total of 8,980 individuals in 2015 and 2018 from 31 provincial-level administrative divisions(PLADs)were enrolled in this study.Viral RNAs were amplified and sequenced using an in-house polymerase chain reaction(PCR)protocol.The Stanford HIV Drug Resistance Database(HIVdb)was used to predict susceptibility to 12 antiretroviral drugs.Results:The prevalence of TDR was not significantly increased over time.The prevalence of TDR was 3.8%and 4.4%in 2015 and 2018,respectively(P=0.13).The prevalence of CRF55_01B increased from 2.3%in 2015 to 3.9%in 2018(P<0.001).The drug resistance prevalence of nonnucleoside reverse transcriptase inhibitors(NNRTI)increased from 2.4%in 2015 to 3.3%in 2018(P<0.01).The prevalence of E138(P<0.001),H221(P=0.03),and V179(P<0.001)mutations increased from 0.30%,0.09%,and 0.70%in 2015 to 1.10%,0.30%,and 1.70%in 2018,respectively.Conclusions:HIV drug resistance affects the effect of antiretroviral treatment,so the monitoring of HIV TDR should be strengthened to control the transmission of HIV drug resistance. | Jingjing Hao Shan Zheng Mengze Gan Aobo Dong Ruihua Kang Miaomiao Li Shuai Zhao Jing Hu Chang Song Lingjie Liao Yi Feng Yiming Shao Yuhua Ruan Hui Xing | 2021 | China CDC weekly2021，3，53： | 13 |
| 4 | Thermally conductive polyvinyl alcohol composite films via introducing hetero-structured MXene@silver fillers显示文摘Ag nanoparticles were in-situ grown on the surface of MXene nanosheets to prepare thermally conductive hetero-structured MXene@Ag fillers.With polyvinyl alcohol(PVA)as the polymer matrix,thermally conductive MXene@Ag/PVA composite films were fabricated by the processes of solution blending,pouring,evaporative self-assembly.With the same mass fraction,MXene@Ag-III(MXene/Ag,2:1,w/w)presents more significant improvement in thermal conductivity coefficient(λ)than MXene@Ag,single MXene,Ag,simply blending MXene/Ag.MXene@Ag-III/PVA composite films show dual functions of excellent thermal conductivity and electromagnetic interference(EMI)shielding.When the mass fraction of MXene@Ag-III is 60 wt.%,the in-planeλ(λ_(∥)),through-planeλ(λ_(⊥)),EMI shielding effectiveness(EMI SE)are 3.72 and 0.41 W/(m∙K),32 dB,which are increased by 3.1,1.3,105.7 times than those of pure PVA film(0.91 and 0.18 W/(m∙K),0.3 dB),respectively.The 60 wt.%MXene@Ag-III/PVA composite film also has satisfying mechanical and thermal properties,with Young’s modulus,glass transition temperature,heat resistance index of 3.8 GPa,58.5 and 175.3℃,respectively. | Mukun Li Yuyao Sun Dianying Feng Kunpeng Ruan Xia Liu Junwei Gu | 2023 | Nano Research2023，16，5： | 10 |
| 5 | Epidemiology,clinical and laboratory characteristics of currently alive HIV-1 infected former blood donors naive to antiretroviral therapy in Anhui Province,China显示文摘Background Unregulated commercial blood/plasma collection among farmers occurred between 1992 and 1995 in central China and caused the second major epidemic of human immunodeficiency virus type 1 (HIV-1) infection in China. It is important to characterize HIV-1-infected former blood donors and to study characteristics associated with disease progression for future clinical intervention and vaccine development. Methods A cross-sectional study was performed on HIV-1-infected former blood donors (FBDs) and age-matched HIV-seronegative local residents. Demographic, epidemiologic, clinical and key laboratory data were collected from all study participants. Both unadjusted and adjusted multivariate linear regressions were employed to analyze the association of the decrease of CD4+ T-cell counts with other characteristics. Results Two hundred and ninety-four HIV-1-infected FBDs and 59 age-matched HIV-seronegative local residents were enrolled in this study. The unregulated blood/plasma collection occurred more than a decade (10.8 -12.8 years) ago, which caused the rapid spread of HIV-1 infection and the high prevalence of co-infection with hepatitis C virus (HCV, 89.5%); hepatitis B virus (HBV) co-infection was observed in only 11 HIV+participants (3.7%). Deterioration in both clinical manifestation and laboratory parameters and increase of viral loads were observed in parallel with the decrease of CD4+ T-cell counts. The decrease of total lymphocyte counts (P<0.001) and hemoglobin levels (P<0.001) and the appearance of dermatosis (P=0.03) were observed in parallel with the decrease of CD4+ T-cell counts whereas viral loads (P<0.001) and CD8+ T-cell counts (P=0.01) were inverselyassociated with CD4+ T-cell counts. Conclusions Co-infection with HCV but not HBV is highly prevalent among HIV-1-infected FBDs. CD4+ T-cell counts is a reliable indicator for disease progression among FBDs. Total lymphocyte counts, hemoglobin level and appearance of dermatosis were positively associated with CD8+ T-cell counts and viral loads were inversely associated with the decreased CD4+ T-cell counts. | XU Jian-qing WANG Jian-jun HAN Li-feng XU Chen RUAN Yu-hua XU Zhen-hou CHEN Xi LIU Zhen-dong WANG Jun SU Bing DING Xin-ping GAO Bing GU Yong-bin CAO Xiao-yun XING Hui HONG Kun-xue PENG Hong ZHAO Quan-bi YUAN Lin FENG Yi ZHANG Gui-yun MA Li-ying WU Lan SHAO Yi-ming | 2006 | Chinese Medical Journal2006，，23： | 9 |
| 6 | Hydrological changes and settlement migrations in the Keriya River delta in central Tarim Basin ca. 2.7–1.6 ka BP: Inferred from ^(14)C and OSL chronology显示文摘Over one hundred artifacts, including shards, chopped wood, bronze and iron ware debris as well as footprints, have been discovered during archaeological investigations at and around the central Taklamakan Desert Yuansha Site (38°52′N, 81°35′E). Dating (14C and OSL) and landform study show that the present-day dry Keriya River once sustained an oasis human settle- ment in 2.6 ka BP, historically falling into the Spring and Autumn Period (716-475 BCE) of Chinese history. The chronology and archaeological interpretations also show that some 400 years later, the local Keriya River channel had shifted 40 km southeast to sustain a Western Han (206 BCE-25 CE) Wumi settlement at the Karadun site. In the meantime, river-channel migration had allowed reoccupation of a site west of Yuansha City around 1.9 ka BP (abandoned again by 1.6 ka BP). The remains' chronology shows that this site was affiliated to Wumi culture and Eastern Han (24-220 CE) dynasty rule. Palaeoclimatic records indicate that the migrations of the river and oasis settlers between 2.7 and 1.6 ka BP were coeval with Central Asian climate changes. Yuansha City was built just after the end of 2.8 ka BP glacier advances in western China, suggesting that release of more water during the subsequent glacier recession may have facilitated oasis development such that Iron Age European peoples could settle in the Tarim Basin. As shown from analysis of archeological remains, not only at Yuansha but also in other ancient cities in the Tarim such as Loulan and Jingjue (Niya), conditions around 1.6 ka BP were dry enough to cause oasis decline. Thus, the results reported here enhance our knowledge about environmental changes and their effects on human activities and cultural evolution in western China and will stimulate further interdisciplinary studies of landscape and oasis history in the Tarim Basin. | ZHANG Feng WANG Taoi Hamid . YIMIT SHI QingDong RUAN QiuRong SUN ZhiQiong LI Fang | 2011 | Science China Earth Sciences2011，54，12： | 6 |
| 7 | Effect of Gd addition on mechanical and microstructural properties of Mg-xGd-2.6Nd-0.5Zn-0.5Zr cast alloys显示文摘The Mg-xGd-2.6Nd-0.5Zn-0.5Zr(x=0,3.0,4.5 and 6.0,wt.%)alloys were prepared by gravity casting and then T6 treatment.Microstructures of the alloy were observed using optical microscopy and scanning electron microscopy.Results show that the as-cast alloys contained network Mg3Gd phases,blocky and needle-like Mg12(Nd,Gd)phases.The a(Zr)particle inclusions in the a(Mg)matrix are also observed.Content of the secondary phases decreases as Gd content increases.Tensile test results show that the tensile and yield strengths of all the alloys increase as Gd content increases under the as-cast and T6 conditions,but the elongation exhibits the opposite trend.The blocky Mg12(Nd,Gd)phases appear and act as crack initiator and deteriorates the experimental alloys’ductility with the increase of Gd content,especially as Gd content increases to 6.0 wt.%,so the Mg-6.0Gd-2.6Nd-0.5Zn-0.5Zr alloy has the lowest elongation value compared to the other alloys studied.After T6 treatment,the Mg-4.5Gd-2.6Nd-0.5Zn-0.5Zr alloy exhibits the optimal mechanical properties both at room temperature and 250℃. | Liang Zhan Yi-zhi Le Zhi-jun Feng Yan-chun Lou Ming Ruan Hua-wen Li | 2020 | China Foundry2020，17，3： | 6 |
| 8 | Preparation and Ethanol Sensing Properties of ZnO Nanofibers显示文摘ZnO nanofibers with an average diameter of about 90 nm were prepared by an electrospinning method combined with a calcination process. The as-electrospun nanofibers before and after calcination were characterized by means of differential thermal analysis(DTA), thermal gravimetric analysis(TGA), X-ray diffraction(XRD) and scanning electron microscopy(SEM). The fibers after calcination at 600 °C belong to the hexagonal wurtzite structure. The sensor based on ZnO nanofibers exhibited excellent ethanol sensing properties at 206 °C such as good linear dependence in the low concentration(1―100 μL/L), high response, and good selectivity. Fast response(less than 2 s) and recovery(about 16 s) were also observed in our investigations. | FENG Cai-hui RUAN Sheng-ping ZHU Ling-hui LI Chao LI Wei CHEN Wei-you CHEN Li-hua ZHANG Xin-dong | 2011 | Chemical Research in Chinese Universities2011，27，5： | 5 |
| 9 | Linking leach chemistry and microbiology of low-grade copper ore bioleaching at different temperatures显示文摘The effects of temperature on chalcocite/pyrite oxidation and the microbial population in the bioleaching columns of a low-grade chalcocite ore were investigated in this study. Raffinate from the industrial bioleaching heap was used as an irrigation solution for columns operated at 20, 30, 45, and 60℃. The dissolution of copper and iron were investigated during the bioleaching processes, and the microbial community was revealed by using a high-throughput sequencing method. The genera of Ferroplasma, Acidithiobacillus, Leptospirillum, Acidiplasma, and Sulfobacillus dominated the microbial community, and the column at a higher temperature favored the growth of moderate thermophiles. Even though microbial abundance and activity were highest at 30℃, the column at a higher temperature achieved a much higher Cu leaching efficiency and recovery, which suggested that the promotion of chemical oxidation by elevated temperature dominated the dissolution of Cu. The highest pyrite oxidation percentage was detected at 45℃. Higher temperature resulted in precipitation of jarosite in columns, especially at 60℃. The results gave implications to the optimization of heap bioleaching of secondary copper sulfide in both enhanced chalcocite leaching and acid/iron balance, from the perspective of leaching temperature and affected microbial community and activity. | Yan Jia He-yun Sun Qiao-yi Tan Hong-shan Gao Xing-liang Feng Ren-man Ruan | 2018 | International Journal of Minerals,Metallurgy and Materials2018，25，3： | 5 |
| 10 | Orbit determination and time synchronization for BDS-3 satellites with raw inter-satellite link ranging observations显示文摘To provide competitive global positioning and timing services under the condition that monitoring stations are confined to Chinese territory,inter-satellite link(ISL)technology is used by the third-generation BeiDou Navigation Satellite System(BDS-3).The ISL,together with the dual one-way links between satellites and anchor stations,may enable autonomous navigation for BDS-3.In this paper,we propose a general observation model for orbit determination(OD)and time synchronization(TS)directly using non-simultaneous observations,such as raw ISL pseudoranges.With the proposed model,satellite orbits,clocks,and hardware delay biases of ISL equipment can be determined simultaneously by jointly processing inter-satellite one-way pseudorange data and observation data from ground monitoring stations.Moreover,autonomous OD and TS are also achievable with one-way pseudorange data from anchor stations and satellites.Data from eight BDS-3 satellites,two anchor stations,and seven monitoring stations located in China were collected to validate the proposed method.It is shown that by jointly processing data from the ISL and seven monitoring stations,the RMS of overlap orbit differences in radial direction is 0.019 m,the overlap clock difference(95%)is 0.185 ns,and the stability of the estimated hardware delay biases for each satellite is greater than 0.5 ns.Compared with the results obtained with the seven stations,the improvements of orbits in radial direction and clocks are 95.7%and 90.5%,respectively.When the hardware delay biases are fixed to predetermined values,the accuracies of orbits and clocks are further improved.By jointly processing pseudoranges from the satellites and the two anchor stations,the RMS of overlap orbit differences is 0.017 m in the radial direction,and the overlap clock difference(95%)is 0.037 ns.It has also been demonstrated that under the condition of one-way ranging links,the accuracies of orbits and clocks obtained by the above two modes are still significantly better than those obtained by using the data from the monitoring stations alone. | Rengui Ruan Xiaolin Jia Laiping Feng Jun Zhu Zongbo Huyan Jie Li Ziqing Wei | 2020 | Satellite Navigation2020，1，1： | 5 |
| 11 | HYDRAULIC CHARACTERISTICS OF PARTIAL OPENING OF THE WORKING GATE FOR A DISCHARGE TUNNEL显示文摘The partial opening of the working gate for a discharge tunnel is used more and more widely in the various conditions, such as releasing discharge to meet the needs of the various stages under construction, or of the operations at low reservoir levels. In this article the hydraulic characteristics were investigated of the partial opening of the working gate based on the physical model experiments of the discharge tunnel for the Longtan Hydropower Project, including the discharge coefficient, the surface profile of the free flow section, the bottom pressure distribution of the tunnel with an aerator, the cavity length just from the ramp, and the wall pressure of the curve section of the outlet. Some new issues were discussed and the properties were presented of the partial opening of the gate. | WU Jian-hua FENG Shu-rong WU Wei-wei RUAN Shi-ping | 2007 | Journal of Hydrodynamics2007，19，4： | 5 |
| 12 | Mitochondrial expression and activity of P-glycoprotein under oxidative stress in outer blood-retinal barrier显示文摘AIM: To investigate the role of oxidative stress in regulating the functional expression of P-glycoprotein(P-gp) in mitochondria of D407 cells.METHODS: D407 cells were exposed to different ranges of concentrations of H_2O_2. The mitochondrial location of P-gp in the cells subjected to oxidative stress was detected by confocal analysis. Expression of P-gp in isolated mitochondria was assessed by Western blot. The pump activity of P-gp was evaluated by performing the efflux study on isolated mitochondria with Rhodamine 123(Rho-123) alone and in the presence of P-gp inhibitor(Tariquidar) using flow cytometry analysis. The cells were pretreated with 10 mmol/L N-acetylcysteine(NAC) for 30 min before exposing to H_2O_2, and analyzed the mitochondrial extracts by Western blot and flow cytometry.RESULTS: P-gp was co-localized in the mitochondria by confocal laser scanning microscopy, and it was also detected in the mitochondria of D407 cells using Western blot. Exposure to increasing concentrations of H_2O_2 led to gradually increased expression and location of P-gp in the mitochondria of cells. Rho-123 efflux assay showed higher uptake of Rho-123 on isolated mitochondria in the presence of Tariquidar both in normal and oxidative stress state. H_2O_2 up-regulated P-gp in D407 cells, which could be reversed by NAC treatment. CONCLUSION: H_2O_2 could up-regulate the functional expression of P-gp in mitochondria of D407 cells, while antioxidants might suppress oxidative-stress-induced over-expression of functional P-gp. It is indicative that limiting the mitochondrial P-gp transport in retinal pigment epithelium cells would be to improve the effect of mitochondria-targeted antioxidant therapy in age-related macular degeneration-like retinopathy. | Yue-Hong Zhang Juan Li Wei-Zhong Yang Zhuan-Hua Xian Qi-Ting Feng Xiang-Cai Ruan | 2017 | International Journal of Ophthalmology(English edition)2017，10，7： | 5 |
| 13 | A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer显示文摘Objective:To compare the efficacy and safety of hyperthermic intravesical chemotherapy(HIVEC)and intravesical chemotherapy(IVEC)in patients with intermediate and high risk nonmuscle-invasive bladder cancer(NMIBC)after transurethral resection.Methods:We included 560 patients diagnosed with primary or recurrent NMIBC between April 2009 and December 2015 at 1 of 6 tertiary centers.We matched 364 intermediate or high risk cases and divided them into 2 groups:the HIVEC+IVEC group[chemohyperthermia(CHT)composed of 3 consecutive sessions followed by intravesical instillation without hyperthermia]and the IVEC group(intravesical instillation without hyperthermia).The data were recorded in the database.The primary endpoint was 2-year recurrence-free survival(RFS)in all NMIBC patients(n=364),whereas the secondary endpoints were the assessment of radical cystectomy(RC)and 5-year overall survival(OS).Results:There was a significant difference in the 2-year RFS between the two groups in all patients(n=364;HIVEC+IVEC:82.42%vs.IVEC:74.18%,P=0.038).Compared with the IVEC group,the HIVEC+IVEC group had a lower incidence of RC(P=0.0274).However,the 5-year OS was the same between the 2 groups(P=0.1434).Adverse events(AEs)occurred in 32.7%of all patients,but none of the events was serious(grades 3–4).No difference in the incidence or severity of AEs between each treatment modality was observed.Conclusions:This retrospective study showed that HIVEC+IVEC had a higher 2-year RFS and a lower incidence of RC than IVEC therapy in intermediate and high risk NMIBC patients.Both treatments were well-tolerated in a similar manner. | Qiang Ruan Degang Ding Bin Wang Chaohong He Xuequn Ren Zhenhua Feng Zhigang Pang Jin Wang Xiangliang Zhang Hongsheng Tang Jiahong Wang Qingjun He Ziying Lei Quanxing Liao Jiali Luo Shuzhong Cui | 2021 | Cancer Biology & Medicine2021，18，1： | 4 |
| 14 | Adiponectin receptor 1 and small ubiquitin-like modifier 4 polymorphisms are associated with risk of coronary artery disease without diabetes显示文摘编码 adiponectin 受体 1 的基因( ADIPOR1 )和小象ubiquitin一样修饰词( SUMO4 ) 4 被连接了到 anti-atherogenic 效果,但是很少对是否被知道在二基因的多型性,独立行动或交往,没有 diabetes.MethodsWe genotyped ,影响冠的动脉疾病( CAD )的风险没有糖尿病的 200 个 CAD 病人和没有 CAD 的 200 控制,它被选择基于前一个没有 diabetes.ResultsRisk 等位基因,协会也是的潜力在 ADIPOR1 (rs7539542-G, rs7514221-C 和 rs3737884-G ) 在三 SNP 在这些 SNP 和 CAD 的临床的特征之间探索了,没有糖尿病,在在 SUMO4 的 SNP rs237025 的 G 等位基因显著地增加了 CAD 的风险,与从 1.79 ~ 4.44 的 ORs。任何这四风险等位基因的搬运人出现了类似不利 ? 临床的特征。与有 CC 或 GC 遗传型的个人相比,有在 rs3737884 的 GG 遗传型的那些在影响了左前面的下降冠的动脉的 CAD 的显著地更高的风险(或:6.77, P = 0.009 ) ,恰好冠的动脉(或:4.81, P = 0.028 ) 或容器的一个相对大的数字(P = 0.04 ) 。没有糖尿病,在 SUMO4 在 SNP 象风险等位基因一样在 ADIPOR1 在三 SNP 中的至少一个带风险等位基因的个人比不带任何风险等位基因的个人在 CAD 的显著地更高的风险(或:5.82, 95% CI:1.2327.7, P = 0.013 ) 没有糖尿病,在 ADIPOR1 和 SUMO4 的 .ConclusionsSNPs 与 CAD 的提高的风险被联系,并且在二基因的 SNP 可以交往联合影响疾病风险。 | Hong LI Ze YANG Lian-Mei PU Xiang LI Yang RUAN Fan YANG Shuai MENG Duo YANG Wei YAO Hao FU Feng ZHANG Ze-Ning JIN | 2016 | Journal of Geriatric Cardiology2016，13，9： | 4 |
| 15 | Back-n white neutron source at CSNS and its applications显示文摘Back-streaming neutrons from the spallation target of the China Spallation Neutron Source(CSNS)that emit through the incoming proton channel were exploited to build a white neutron beam facility(the so-called Back-n white neutron source),which was completed in March 2018.The Back-n neutron beam is very intense,at approximately 29107 n/cm2/s at 55 m from the target,and has a nominal proton beam with a power of 100 kW in the CSNS-I phase and a kinetic energy of 1.6 GeV and a thick tungsten target in multiple slices with modest moderation from the cooling water through the slices.In addition,the excellent energy spectrum spanning from 0.5 eV to 200 MeV,and a good time resolution related tothe time-of-flight measurements make it a typical white neutron source for nuclear data measurements;its overall performance is among that of the best white neutron sources in the world.Equipped with advanced spectrometers,detectors,and application utilities,the Back-n facility can serve wide applications,with a focus on neutron-induced cross-sectional measurements.This article presents an overview of the neutron beam characteristics,the experimental setups,and the ongoing applications at Backn. | Jing-Yu Tang Qi An Jiang-Bo Bai Jie Bao Yu Bao Ping Cao Hao-Lei Chen Qi-Ping Chen Yong-Hao Chen Zhen Chen Zeng-Qi Cui Rui-Rui Fan Chang-Qing Feng Ke-Qing Gao Xiao-Long Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Xi-Ru Huang Hao-Yu Jiang Wei Jiang Zhi-Jie Jiang Han-Tao Jing Ling Kang Bo Li Chao Li Jia-Wen Li Qiang Li Xiao Li Yang Li Jie Liu Rong Liu Shu-Bin Liu Xing-Yan Liu Ze Long Guang-Yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Jia Sun Zhi-Xin Tan Xin-Yi Tang Bin-Bin Tian Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Xiao-Yun Yang Yi-Wei Yang Han Yi Li Yu Tao Yu Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Zhi-Yong Zhang Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu 无 | 2021 | Nuclear Science and Techniques2021，32，1： | 4 |
| 16 | Satellite Positioning and Orbit Determination System(SPODS):Introduction and Evaluation显示文摘The Satellite Positioning and Orbit Determination System(SPODS)is a software package for GNSS positioning/orbit determination,developed by the Xi’an Research Institute of Surveying and Mapping.So far it has been able to analyse GPS data and has the capability of high precision GPS positioning and orbit determination.The underlying theory and the performance evaluation are briefly addressed in this paper.The experiments are carried out with GPS data collected from about 127 IGS stations during 4~10 January 2009.The results show that the RMS 1D difference is 1.1 cm between SPODS orbits and final IGS combined orbits,and that the repeatability of daily solutions of station coordinates is 1.5 mm for horizontal components,and 4.5 mm for vertical component,and that the consistency of ERP solutions with IGS final products is 0.025 mas,0.093 mas and 0.013 ms/d respectively for pole coordinates and LOD. | Ziqing WEI Rengui RUAN Xiaolin JIA Xianbing WU Xiaoyong SONG Yue MAO Laiping FENG Yongxing ZHU | 2018 | Journal of Geodesy and Geoinformation Science2018，1，1： | 4 |
| 17 | Mitotic motor CENP-E cooperates with PRC1 in temporal control of central spindle assembly显示文摘Error-free cell division depends on the accurate assembly of the spindle midzone from dynamic spindle microtubules to ensure chromatid segregation during metaphase-anaphase transition.However,the mechanism underlying the key transition from the mitotic spindle to central spindle before anaphase onset remains elusive.Given the prevalence of chromosome instability phenotype in gastric tumorigenesis,we developed a strategy to model context-dependent cell division using a combination of light sheet microscope and 3D gastric organoids.Light sheet microscopic image analyses of 3D organoids showed that CENP-E inhibited cells undergoing aberrant metaphase-anaphase transition and exhibiting chromosome segregation errors during mitosis.Highresolution real-time imaging analyses of 2D cell culture revealed that CENP-E inhibited cells undergoing central spindle splitting and chromosome instability phenotype.Using biotinylated syntelin as an affinity matrix,we found that CENP-E forms a complex with PRC1 in mitotic cells.Chemical inhibition of CENP-E in metaphase by syntelin prevented accurate central spindle assembly by perturbing temporal assembly of PRC1 to the midzone.Thus,CENP-E-mediated PRC1 assembly to the central spindle constitutes a temporal switch to organize dynamic kinetochore microtubules into stable midzone arrays.These findings reveal a previously uncharacterized role of CENP-E in temporal control of central spindle assembly.Since CENP-E is absent from yeast,we reasoned that metazoans evolved an elaborate central spindle organization machinery to ensure accurate sister chromatid segregation during anaphase and cytokinesis. | Xu Liu Leilei Xu Junying Li Phil Y.Yao Wanjuan Wang Hazrat Ismail Haowei Wang Bryce Liao Zhihong Yang Tarsha Ward Ke Ruan Jianchun Zhang Quan Wu Ping He Xia Ding Dongmei Wang Chuanhai Fu Zhen Dou Feng Yan Wenwen Wang Xing Liu Xuebiao Yao | 2020 | Journal of Molecular Cell Biology2020，12，8： | 3 |
| 18 | Relationship Between Drug Resistance and Death in HIV-Infected Patients Receiving Antiretroviral Therapy—7 PLADs,China,2010−2019显示文摘Summary What is already known about this topic?With increasing coverage of antiretroviral therapy(ART)for HIV-infected patients,more and more attention has been paid to the impact of HIV drug resistance on death in those patients in China.What is added by this report?Among HIV-infected patients receiving ART,the risk of death is higher in patients with HIV drug resistance[adjusted odds ratio(AOR)=4.25. | Tianhao Zhang Lingjie Liao Yiming Shao Yi Feng Yuhua Ruan Hui Xing | 2021 | China CDC weekly2021，3，14： | 3 |
| 19 | Understanding divergent domestication traits from the whole-genome sequencing of swamp-and river-buffalo populations显示文摘Domesticated buffaloes have been integral to rice-paddy agro-ecosystems formillennia,yet relatively little is known about the buffalo genomics.Here,we sequenced and assembled reference genomes for both swamp and river buffaloes and we re-sequenced 230 individuals(132 swamp buffaloes and 98 river buffaloes)sampled from across Asia and Europe.Beyond the many actionable insights that our study revealed about the domestication,basic physiology and breeding of buffalo,we made the striking discovery that the divergent domestication traits between swamp and river buffaloes can be explained with recent selections of genes on social behavior,digestion metabolism,strengths and milk production. | Xier Luo Yu Zhou Bing Zhang Yi Zhang Xiaobo Wang Tong Feng Zhipeng Li Kuiqing Cui Zhiqiang Wang Chan Luo Hui Li Yanfei Deng Fenghua Lu Jianlin Han Yongwang Miao Huaming Mao Xiaoyan Yi Cheng Ai Shigang Wu Alun Li Zhichao Wu Zijun Zhuo Do Da Giang Bikash Mitra Mohammad Farhad Vahidi Shahid Mansoor Sahar Ahmed Al-Bayatti Eka Meutia Sari Neena Amatya Gorkhali Sigit Prastowo Laiba Shafique Guoyou Ye Qian Qian Baoshan Chen Deshun Shi Jue Ruan Qingyou Liu | 2020 | National Science Review2020，7，3： | 3 |
| 20 | Oxidation of As^Ⅲ by Several Manganese Oxide Minerals in Absence and Presence of Goethite显示文摘Oxidation of AsⅢ by three types of manganese oxide minerals affected by goethite was investigated by chemical analysis, equilibrium redox, X-ray diffraction (XRD) and transmission electron microscopy (TEM). Three synthesized Mn oxide minerals of different types, birnessite, todorokite, and hausmannite, could actively oxidize AsⅢ to AsⅤ, and greatly varied in their oxidation ability. Layer structured birnessite exhibited the highest capacity of AsⅢ oxidation, followed by the tunnel structured todorokite. Lower oxide hausmannite possessed much low capacity of AsⅢ oxidation, and released more Mn2+ than birnessite and todorokite during the oxidation. The maximum amount of AsⅤ produced during the oxidation of AsⅢ by Mn oxide minerals was in the order: birnessite (480.4 mmol/kg) > todorokite (279.6 mmol/kg) > hausmannite (117.9 mmol/kg). The oxidation capacity of the Mn oxide minerals was found to be relative to the composition, crystallinity, and surface properties. In the presence of goethite oxidation of AsⅢ by Mn oxide minerals increased, with maximum amounts of AsⅤ being 651.0 mmol/kg for birnessite, 332.3 mmol/kg for todorokite and 159.4 mmol/kg for hausmannite. Goethite promoted AsⅢ oxidation on the surface of Mn oxide minerals through adsorption of the AsⅤ produced, incurring the decrease of AsⅤ concentration in solutions. Thus, the combined effects of the oxidation (by Mn oxide minerals)-adsorption (by goethite) lead to rapid oxidation and immobilization of As in soils and sediments and alleviation of the AsⅢ toxicity in the environments. | FENG Xionghan TAN Wenfeng LIU Fan Huada Daniel RUAN HE Jizheng | 2006 | Acta Geologica Sinica(English Edition)2006，80，2： | 3 |
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