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| 1 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 2 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 3 | Deregulation of microRNA-503 Contributes to Diabetes Mellitus–Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia显示文摘 | Andrea Caporali Marco Meloni Christine V?llenkle Desiree Bonci Graciela B. Sala-Newby Roberta Addis Gaia Spinetti Sergio Losa Rachel Masson Andrew H. Baker Reuven Agami Carlos le Sage Gianluigi Condorelli Paolo Madeddu Fabio Martelli Costanza Emanueli | 2011 | Circulation2011，，3： | 2 |
| 4 | Breast cancer incidence before and after diagnosis of type 2 diabetes naellitus in women: increased risk in the prediabetes phase显示文摘 | Adedayo A Onitilo Rachel V Stankowski Richard L Berg | 2014 | European journal of cancer prevention : the official journal of the European Cancer Prevention Or- ganisation (ECP)2014，23，2： | 1 |
| 5 | Coastal water source of short- lived halocarbons in New England 显示文摘 | Zhou Y Ruth K V Rachel S R | 2005 | Journal of Geophysical Research2005，，： | 1 |
| 6 | Activated carbon liron oxide magnetic composites for the adsorption of contaminants in water 显示文摘 | Oliveira Luiz C A Rios Rachel V R A Jos D | 2002 | Carbon2002，40，： | 1 |
| 7 | Immobilization of TiO2 on pumice stone for the photocatalytic degradation of dyes and dye industry pollu tants显示文摘 | Rao K V S Rachel A Subrahmanyam M | 2003 | Applied Catalysis B: Environmental2003，46，1： | 1 |
| 8 | Clay-iron oxide magnetic composites for the adsorption of contaminants in water 显示文摘 | Luiz C A Oliveira Rachel V R A Rios Jose D Fabris | 2003 | Applied Clay Science2003，22，： | 1 |
| 9 | Clay-iron oxide magnetic composites for the adsorption of contaminants in water显示文摘 | Rachel V R A Jose' D | 2003 | Applied Clay Science2003，22，： | 1 |
| 10 | Physical properties of straw lignin- based polymer blends显示文摘 | Rachele P Vincenzo V Carlo B | 2004 | Polymer2004，45，12： | 1 |
| 11 | Immobilization of TiO2 on Pumice Stone for the Photocatalytic Degradation of Dyes and Dye Industry Pallutants显示文摘 | Rao K V S Rachel A Subrahmanyam M | 2003 | Appl Catal B2003，，46： | 1 |
| 12 | Do R&D tax credits work? Evidence from a panel of countries 1979-1997显示文摘 | Bloom N Rachel G Reenen J V | | 0，，01： | 1 |
| 13 | Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial显示文摘 | Raj R Makkar Rachel R Smith Ke Cheng Konstantinos Malliaras Louise EJ Thomson Daniel Berman Lawrence SC Czer Linda Marbán Adam Mendizabal Peter V Johnston Stuart D Russell Karl H Schuleri Albert C Lardo Gary Gerstenblith Eduardo Marbán | 2012 | The Lancet2012，，9819： | 1 |
| 14 | Application of a Re- gional Hurricane Wind Risk Forecasting Model forWood-Frame Houses 显示文摘 | Kumar V Rachel A D | 2007 | Risk Analysis2007，，1： | 1 |
| 15 | Activated carbon/iron oxide magnetic composites for the adsorption of contaminats in water显示文摘 | Rios Rachel V R A Fabris José D | 2002 | Carbon2002，40，12： | 1 |
| 16 | Conflict and Conquest : Creation, Emanation and the Female in William Blake' s Mythology 显示文摘 | Billigheimer Rachel V | 2000 | Modern Language Studies2000，30，1： | 1 |
| 17 | Immobilization of TiO2 on pumice stone for the photocatatytic degradation of dyes and dye industry pollutants 显示文摘 | RAO K V S RACHEL A SURAHMANYAM M | 2003 | Appl Cata B : Environ2003，46，： | 1 |
| 18 | Post-stroke depression:a report of 90 patients显示文摘 | Rachele MG Scamonatti L Mascia V | 1997 | Eur J Intern Med1997，8，： | 1 |
| 19 | Major depressive disorder in thegeneral hospital显示文摘 | Rachel V Alexandre B Pierre B | 2003 | General Hospital Psychiatry2003，25，6： | 1 |
| 20 | Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets显示文摘 | Kate A. Markey Motoko Koyama Rachel D. Kuns Katie E. Lineburg Yana A. Wilson Stuart D. Olver Neil C. Raffelt Alistair L. J. Don Antiopi Varelias Renee J. Robb Melody Cheong Christian R. Engwerda Raymond J. Steptoe Hayley S. Ramshaw Angel F. Lopez Javier V | 2012 | Blood2012，，24： | 1 |
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