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| 1 | Secrecy Outage Probability for Two-Way Integrated Satellite Unmanned Aerial Vehicle Relay Networks with Hardware Impairments显示文摘In this paper,we investigate the secrecy outage performance for the two-way integrated satellite unmanned aerial vehicle relay networks with hardware impairments.Particularly,the closed-form expression for the secrecy outage probability is obtained.Moreover,to get more information on the secrecy outage probability in a high signalto-noise regime,the asymptotic analysis along with the secrecy diversity order and secrecy coding gain for the secrecy outage probability are also further obtained,which presents a fast method to evaluate the impact of system parameters and hardware impairments on the considered network.Finally,Monte Carlo simulation results are provided to show the efficiency of the theoretical analysis. | Xiaoting Ren Kefeng Guo | 2023 | Computer Modeling in Engineering & Sciences2023，，6： | 0 |
| 2 | TRPC6在人良性与恶性前列腺组织中的表达显示文摘观察瞬时受体电位通道C6(TRPC6)在人良性与恶性前列腺组织及前列腺癌细胞系中的表达,进一步探讨TRPC6的表达与前列腺癌分期、分级及激素依赖性的关系。利用免疫组织化学技术,检测发现45.0%的前列腺增生和86.6%的前列腺癌病例表达TRPC6,两者比较有显著性差异沪〈0.01)。TRPC6的表达与前列腺癌分级和前列腺外转移有关(P〈0.01)。前列腺癌分期增高,TRPC6表达增多,但在T2、T3和DT4期肿瘤病例中,TRPC6表达无显著差异。此外TRPC6在激素依赖性前列腺癌与激素非依赖性前列腺癌中的表达也无显著差异。应用RT-PCR及Westernblot,检测到TRPC6在前列腺癌细胞系中的表达。本研究发现,TRPC6在良性与恶性前列腺组织及前列腺癌细胞系中表达。TRPC6的表达与前列腺癌的组织分级、Gleason评分及前列腺外转移有关。 | Dan Yue Yong Wang Jian-Ying Xiaot Ping Wang Chang-Shan Ren | 2009 | Asian Journal of Andrology2009，11，5： | 8 |
| 3 | Preparation of Ultrafine TATB and the Technology for Crystal Morphology Control显示文摘极其细小的 1,3,5-triamino-2,4,6-trinitrobenzene (TATB ) 被在与象表面活化剂的范畴和剂量那样的谷物尺寸和晶体形态学控制的靠近的关系中使用溶剂和非溶剂方法,和影响因素准备了,到非溶剂的溶剂的卷比率也在这份报纸被考虑了。它证明这些因素在结晶化过程期间在水晶形态学,粒子尺寸和凝块上有显著效果。由使用 0.095%( 集体百分比) 离子的表面活化剂(S) 作为添加剂并且用作为落下的设备喂设备的水花落下, 1.06 g TATB 原料从 30 ~ 50 nm 与谷物尺寸被精制了进免费跑的椭圆体和球形的 TATB 谷物。由使用 0.014%( 集体百分比) 是的非离子的表面活化剂(P) 添加剂,有 50 nm 的粒子直径并且与狭窄的粒子尺寸分发的球形的 TATB 谷物也被获得了。它被 TATB 的极其细小的粒子最好加热抵抗平均和它的 5 秒点火点的描述显示出被 7.5 K 推进。 | Yang,Li Ren,Xiaoting Li,Tiecheng Wang,Shiwei Zhang,Tonglai | 2012 | Chinese Journal of Chemistry2012，30，2： | 8 |
| 4 | Selection of reference genes for gene expression studies in porcine skeletal muscle using SYBR green qPCR显示文摘 | Xiaoting Feng Yuanzhu Xiong Hui Qian Minggang Lei Dequan Xu Zhuqing Ren | 2010 | Journal of Biotechnology2010，，3： | 1 |
| 5 | Thermal simulation of basic volcanic fluid influence on different source rocks显示文摘Based on thermal simulation experiment, interactions between volcanic fluids and source rocks were studied. Gas generations in the dry system and fluid system under different temperatures were analyzed. The results showed that the various types of source rocks are similar in composition, containing gaseous C1-C5 hydrocarbons, H2 and CO2 whose gas yields increase with increasing temperature. The gas yield of source rocks of type is Ⅰ the highest, followed by type Ⅱ, and that of source rocks of type is Ⅲ the lowest, indicating that the yield of hydrocarbon gases is related to their hydrocarbon generating potential. Although the generating potential of type is Ⅲ the lowest, it can still be regarded as a useful gas source when it is buried deeply enough. The basic volcanic fluid restrains the generation of gaseous hydrocarbons in different types of source rocks, but promotes the generation of inorganic gases. | LI Jiyan SHAN Xuanlong SUN Zhe XIE Xiaoting REN Yu | 2014 | Chinese Journal Of Geochemistry2014，33，2： | 0 |
| 6 | Development of carrier-free nanocrystals of poorly water-soluble drugs by exploring metastable zone of nucleation显示文摘There has been increasing interest in research and development of nanocrystals for the delivery of poorly water-soluble drugs that can be directly produced from solution. Compared with traditional carrier-based or encapsulation designs, drug nanocrystals circumvent possible side-effects due to carrier polymers and poor stability issues associated with encapsulation. The production of carrier-free nanocrystals requires careful control of nucleation and thus a thorough understanding of the relevant solution's metastable zone. A solution may stay supersaturated without forming any nuclei and become metastable. The maximal degree of supersaturation is known as the metastable zone width. When nucleation is triggered directly from the metastable zone, it helps to produce homogeneous nuclei leading to uniform nanocrystals. Herein, we report a study in which the solubility and metastable limit of paclitaxel(PTX) in ethanol aqueous solution were measured at 40 °C. A wide range of metastable compositions were studied to prepare carrier-free PTX nanocrystals with particle size smaller than250 nm and PDI less than 0.25. Compared with the raw material, dissolution rate of PTX nanocrystals was significantly increased. The study enables production of high-quality drug nanocrystals for treating patients. | Xiaoting Ren Jianping Qi Wei Wu Zongning Yin Tonglri Li Yi Lu | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 3 |
| 7 | Novel magnetic field computation model in pattern classification显示文摘Field computation, an emerging computation technique,has inspired passion of intelligence science research. A novel field computation model based on the magnetic field theory is constructed. The proposed magnetic field computation(MFC) model consists of a field simulator, a non-derivative optimization algorithm and an auxiliary data processing unit. The mathematical model is deduced and proved that the MFC model is equivalent to a quadratic discriminant function. Furthermore, the finite element prototype is derived, and the simulator is developed, combining with particle swarm optimizer for the field configuration. Two benchmark classification experiments are studied in the numerical experiment, and one notable advantage is demonstrated that less training samples are required and a better generalization can be achieved. | Feng Pan Xiaoting Li Ting Long Xiaohui Hu Tingting Ren Junping Du | 2013 | Journal of Systems Engineering and Electronics2013，24，5： | 0 |
| 8 | Fabrication of electrostatic safety copper azide film with in situ growing MOF显示文摘Due to its extremely low electrostatic sensitivity,copper azide primary explosive is greatly limited in practical applications.In this study,a composite film with Cu-MOF in-situ growth on carbon nanofilm was prepared by electrospinning and solvothermal methods,and CNF@Cu-N3film with electrostatic safety was obtained by carbonization and azide later.Its electrostatic sensitivity(E50)was greatly increased from 0.05 mJ of raw materials to 4.06 mJ,and still maintained a good detonation performance which could successfully detonate the CL-20 secondary explosive.This is mainly due to the synergistic effect of the carbon film and the MOF structure,which greatly improves the conductivity of the entire system and the uniform distribution of copper particles,providing a new preparation strategy for metal azide film that is suitable for the micro-initiator device. | Shuang Wang Li Yang Zhenzhan Yan Jimin Han Xiaoting Ren Wei Li | 2023 | Defence Technology(防务技术)2023，27，9： | 0 |
| 9 | Wavelength-selectivity polarization dependence of optical absorption and photoresponse in SnS nanosheets显示文摘The optical and optoelectronic characteristics of SnS nanosheets with strong anisotropic crystal structure are researched.Transmission electron microscopy and polarized Raman spectra are used to determine the crystal orientation of SnS nanosheets.The photodetector based on SnS nanosheets exhibits the carrier mobility of 37.75 cm^(2)/V·s,photoresponsivity of 310.5 A/W and external quantum efficiency of 8.56×10^(4)%at 450 nm.Optical absorption around the absorption edge presents obvious polarization sensitivity with the highest optical absorption dichroic ratio of 3.06 at 862 nm.Due to anisotropic optical absorption,the polarized photocurrent appears as the periodic change affected by the polarized direction of the incident light at 808 nm.Overall,SnS nanosheets show good potential in the future application of the polarized photodetectors for specific wavelength. | Yu Cui Ziqi Zhou Xinghua Wang Xiaoting Wang Zhihui Ren Longfei Pan Juehan Yang | 2021 | Nano Research2021，14，7： | 0 |
| 10 | Differential proteome and transcriptome analysis of porcine skeletal muscle during development显示文摘 | Yongjie Xu Hui Qian Xiaoting Feng Yuanzhu Xiong Minggang Lei Zhuqing Ren Bo Zuo Dequan Xu Yun Ma Hongyu Yuan | 2012 | Journal of Proteomics2012，，7： | 1 |
| 11 | A kidney-brain neural circuit drives progressive kidney damage and heart failure显示文摘Chronic kidney disease(CKD)and heart failure(HF)are highly prevalent,aggravate each other,and account for substantial mortality.However,the mechanisms underlying cardiorenal interaction and the role of kidney afferent nerves and their precise central pathway remain limited.Here,we combined virus tracing techniques with optogenetic techniques to map a polysynaptic central pathway linking kidney afferent nerves to subfornical organ(SFO)and thereby to paraventricular nucleus(PVN)and rostral ventrolateral medulla that modulates sympathetic outflow.This kidney-brain neural circuit was overactivated in mouse models of CKD or HF and subsequently enhanced the sympathetic discharge to both the kidney and the heart in each model.Interruption of the pathway by kidney deafferentation,selective deletion of angiotensin II type 1a receptor(AT1a)in SFO,or optogenetic silence of the kidney-SFO or SFO-PVN projection decreased the sympathetic discharge and lessened structural damage and dysfunction of both kidney and heart in models of CKD and HF.Thus,kidney afferent nerves activate a kidney-brain neural circuit in CKD and HF that drives the sympathetic nervous system to accelerate disease progression in both organs.These results demonstrate the crucial role of kidney afferent nerves and their central connections in engaging cardiorenal interactions under both physiological and disease conditions.This suggests novel therapies for CKD or HF targeting this kidney-brain neural circuit. | Wei Cao Zhichen Yang Xiaoting Liu Siqiang Ren Huanjuan Su Bihui Yang Youhua Liu Christopher S.Wilcox Fan Fan Hou | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 12 | Impact of climate change on dengue fever epidemics in South and Southeast Asian settings:A modelling study显示文摘The potential for dengue fever epidemic due to climate change remains uncertain in tropical areas.This study aims to assess the impact of climate change on dengue fever transmission in four South and Southeast Asian settings.We collected weekly data of dengue fever incidence,daily mean temperature and rainfall from 2012 to 2020 in Singapore,Colombo,Selangor,and Chiang Mai.Projections for temperature and rainfall were drawn for three Shared Socioeconomic Pathways(SSP126,SSP245,and SSP585)scenarios.Using a disease transmission model,we projected the dengue fever epidemics until 2090s and determined the changes in annual peak incidence,peak time,epidemic size,and outbreak duration.A total of 684,639 dengue fever cases were reported in the four locations between 2012 and 2020.The projected change in dengue fever transmission would be most significant under the SSP585 scenario.In comparison to the 2030s,the peak incidence would rise by 1.29 times in Singapore,2.25 times in Colombo,1.36 times in Selangor,and>10 times in Chiang Mai in the 2090s under SSP585.Additionally,the peak time was projected to be earlier in Singapore,Colombo,and Selangor,but be later in Chiang Mai under the SSP585 scenario.Even in a milder emission scenario of SSP126,the epidemic size was projected to increase by 5.94%,10.81%,12.95%,and 69.60%from the 2030se2090s in Singapore,Colombo,Selangor,and Chiang Mai,respectively.The outbreak durations in the four settings were projected to be prolonged over this century under SSP126 and SSP245,while a slight decrease is expected in 2090s under SSP585.The results indicate that climate change is expected to increase the risk of dengue fever transmission in tropical areas of South and Southeast Asia.Limiting greenhouse gas emissions could be crucial in reducing the transmission of dengue fever in the future. | Yawen Wang Shi Zhao Yuchen Wei Kehang Li Xiaoting Jiang Conglu Li Chao Ren Shi Yin Janice Ho Jinjun Ran Lefei Han Benny Chung-ying Zee Ka Chun Chong | 2023 | Infectious Disease Modelling2023，8，3： | 0 |
| 13 | MiRNA 24-3p-rich exosomes functionalized DEGMA-modified hyaluronic acid hydrogels for corneal epithelial healing显示文摘The damage of corneal epithelium may lead to the formation of irreversible corneal opacities and even blindness.The migration rate of corneal epithelial cells directly affects corneal repair.Here,we explored ocu-microRNA 24-3p(miRNA 24-3p)that can promote rabbit corneal epithelial cells migration and cornea repair.Exosomes,an excellent transport carrier,were exacted from adipose derived mesenchymal stem cells for loading with miRNA 24-3p to prepare miRNA 24-3p-rich exosomes(Exos-miRNA 24-3p).It can accelerate corneal epithelial migration in vitro and in vivo.For application in cornea alkali burns,we further modified hyaluronic acid with di(ethylene glycol)monomethyl ether methacrylate(DEGMA)to obtain a thermosensitive hydrogel,also reported a thermosensitive DEGMA-modified hyaluronic acid hydrogel(THH)for the controlled release of Exos-miRNA 24-3p.It formed a highly uniform and clear thin layer on the ocular surface to resist clearance from blinking and extended the drug-ocular-epithelium contact time.The use of THH-3/Exos-miRNA 24-3p for 28 days after alkali burn injury accelerated corneal epithelial defect healing and epithelial maturation.It also reduced corneal stromal fibrosis and macrophage activation.MiRNA 24-3p-rich exosomes functionalized DEGMA-modified hyaluronic acid hydrogel as a multilevel delivery strategy has a potential use for cell-free therapy of corneal epithelial regeneration. | Xiaomin Sun Wenjing Song Lijing Teng Yongrui Huang Jia Liu Yuehai Peng Xiaoting Lu Jin Yuan Xuan Zhao Qi Zhao Yingni Xu Jingjie Shen Xiaoyun Peng Li Ren | 2023 | Bioactive Materials2023，，7： | 0 |
| 14 | Rapid, automated, and reliable antimicrobial susceptibility test from positive blood culture by CAST‐R显示文摘Antimicrobial susceptibility tests(ASTs)are pivotal in combating multidrug resistant pathogens,yet they can be time‐consuming,labor‐intensive,and unstable.Using the AST of tigecycline for sepsis as the main model,here we establish an automated system of Clinical Antimicrobials Susceptibility Test Ramanometry(CAST‐R),based on D2O‐probed Raman microspectroscopy.Featuring a liquid robot for sample pretreatment and a machine learning‐based control scheme for data acquisition and quality control,the 3‐h,automated CAST‐R process accelerates AST by>10‐fold,processes 96 paralleled antibiotic‐exposure reactions,and produces high‐quality Raman spectra.The Expedited Minimal Inhibitory Concentration via Metabolic Activity is proposed as a quantitative and broadly applicable parameter for metabolism‐based AST,which shows 99%essential agreement and 93%categorical agreement with the broth microdilution method(BMD)when tested on 100 Acinetobacter baumannii isolates.Further tests on 26 clinically positive blood samples for eight antimicrobials,including tigecycline,meropenem,ceftazidime,ampicillin/sulbactam,oxacillin,clindamycin,vancomycin,and levofloxacin reveal 93%categorical agreement with BMD‐based results.The automation,speed,reliability,and general applicability of CAST‐R suggest its potential utility for guiding the clinical administration of antimicrobials. | Pengfei Zhu Lihui Ren Ying Zhu Jing Dai Huijie Liu Yuli Mao Yuandong Li Yuehui He Xiaoshan Zheng Rongze Chen Xiaoting Fu Lili Zhang Lijun Sun Yuanqi Zhu Yuetong Ji Bo Ma Yingchun Xu Jian Xu Qiwen Yang | 2022 | mLife2022，1，3： | 3 |
| 15 | Key progresses of MOE key laboratory of macromolecular synthesis and functionalization in 2022显示文摘In 2022,The MOE Key Laboratory of Macromolecular Synthesis and Functionalization in Zhejiang University had achieved several important results.First,a series of well-defined dinuclear organoboron catalysts were developed to precisely control the enchainment of ether and carbonate segments during the copolymerization of CO_(2)and epoxides.Second,polyester had been synthesized through cationic copolymerization of cyclic anhydride.Third,ring-opening polymerization of carbon dioxide based valerolactone had been achieved,revealing the prospect of 3-ethylidene-6-vinyltetrahydro-2H-pyran-2-one(EVL)in utilizing CO_(2)and synthesizing functional polymers.Fourth,machine learning methods have been applied to biomaterial research,enabling high-throughput screening of functional biomaterial surfaces for implantable devices,and searching for potent antimicrobial peptides in whole combinatorial peptide libraries.Fifth,methods of characterization of biomacromolecule RNA transcription and manipulation of nucleoside modification were developed.Sixth,artificial enzymes-armed Bifidobacterium Longum probiotics were established to tune down gut inflammation.Seventh,three-dimensional(3D)printing technologies were used to engineer tough supramolecular hydrogels.Eighth,hydroplastic foaming graphene frameworks for acoustic and conductive polymer composites were provided for application.Ninth,aggregate photophysics about the nature of through-space interactions(TSIs)and manipulating their strength in small molecules with non-conjugated structure had been elucidated.Tenth,the forming mechanism of a newfound nested texture in poly(L-lactic acid)(PLLA)spherulitic films had been revealed.Finally,the isotropically dyeing mechanism of KDP single crystals grown from hydrogels have been explored.The related works are reviewed in this paper. | Xumeng Deng Kaihao Chen Kai Pang Xiaoting Liu Minsong Gao Jie Ren Guanwen Yang Guangpeng Wu Chengjian Zhang Xufeng Ni Peng Zhang Jian Ji Jianzhao Liu Zhengwei Mao Ziliang Wu Zhen Xu Haoke Zhang Hanying Li | 2024 | Chinese Chemical Letters2024，35，3： | 0 |
| 16 | New Algorithm Rules Out Acute-on-chronic Liver Failure Development within 28 Days from Acute Decompensation of Cirrhosis显示文摘Background and Aims:Approximately 10%of patients with acute decompensated(AD)cirrhosis develop acute-on-chronic liver failure(ACLF)within 28 days.Such cases have high mortality and are difficult to predict.Therefore,we aimed to establish and validate an algorithm to identify these patients on hospitalization.Methods:Hospitalized patients with AD who developed ACLF within 28 days were considered pre-ACLF.Organ dysfunction was defined accord-ing to the chronic liver failure-sequential organ failure as-sessment(CLIF-SOFA)criteria,and proven bacterial infec-tion was taken to indicate immune system dysfunction.A retrospective multicenter cohort and prospective one were used to derive and to validate the potential algorithm,re-spectively.A miss rate of<5%was acceptable for the calcu-lating algorithm to rule out pre-ACLF.Results:In the deri-vation cohort(n=673),46 patients developed ACLF within 28 days.Serum total bilirubin,creatinine,international normalized ratio,and present proven bacterial infection at admission were associated with the development of ACLF.AD patients with≥2 organ dysfunctions had a higher risk for pre-ACLF patients[odds ratio=16.58195%confidence interval:(4.271-64.363),p<0.001].In the derivation co-hort,67.5%of patients(454/673)had≤1 organ dysfunction and two patients(0.4%)were pre-ACLF,with a miss rate of 4.3%(missed/total,2/46).In the validation cohort,65.9%of patients(914/1388)had≤1 organ dysfunction,and four(0.3%)of them were pre-ACLF,with a miss rate of 3.4%(missed/total,4/117).Conclusions:AD patients with≤1 organ dysfunction had a significantly lower risk of developing ACLF within 28 days of admission and could be safely ruled out with a pre-ACLF miss rate of<5%. | Xiaoting Tang Hai Li Guohong Deng Xin Zheng Xianbo Wang Yan Huang Yanhang Gao Zhongji Meng Zhiping Qian Feng Liu Xiaobo Lu Yu Shi Beiling Li Wenyi Gu Xiaomei Xiang Yan Xiong Yixin Hou Jun Chen Na Gao Sen Luo Liujuan Ji Jing Li Rongjiong Zheng Haotang Ren Jinjun Chen | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 1 |
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