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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Dietary Fiber Intakes and Insulin Requirements Pregnant Women with Type 1 Diabetes显示文摘 | HEIDI J KALKWARF RHONDA C BELL JANE C KHOURY ANDA LOU GOUGE MENACHEM MIODOVNIK | 2001 | Journal of the American Dietetic Association2001，，3： | 1 |
| 3 | Perceptions, correction and defec- tions: implications for service recovery in the restaurant industry显示文摘 | Rhonda M Rene M John C | 2000 | Managing Service Quality2000，10，6： | 1 |
| 4 | Compressive strengthening of sapphire by neutron irradiation显示文摘 | REGAN T M HARRIS D C RHONDA M | 2001 | Proc SPIE2001，4375，： | 1 |
| 5 | Transcription factors in plant defense and stress response显示文摘 | Karam B Singh Rhonda C Foley Lius OnateSanchez | 2002 | Cell Signaling and Gene Regulation2002，，5： | 1 |
| 6 | Molecular Indices of Neuronal and Glial Plasticity in the Hippocampal Formation in a Rodent Model of Age - Induced Spatial Learning Impairment 显示文摘 | Kiminobu S Michael C Rhonda G | 1996 | Journal of Neuroscience1996，16，10： | 1 |
| 7 | Amplification of bacterial16S ribosomal DNA with polymerase chain reaction显示文摘 | Kenneth H W Rhonda B B Ronald C G | 1990 | J Clin Microbiol1990，28，9： | 1 |
| 8 | Analysis of type 1 metat-lothionein cDNAs in Viciafaba显示文摘 | RHONDA C ZHI Mei-liang KARAM B | 1997 | Plant Molecular Biology1997，33，4： | 1 |
| 9 | Modified high-fat diet induces insulin resistance in rat skeletal muscle but not adipocytes 显示文摘 | Wilkes Arend bonen Rhonda C | | Am J Physiol0，275，41： | 1 |
| 10 | Transcription factors in plant defense and stress responses显示文摘 | Karam B Singh Rhonda C Foley Luis O?ate-Sánchez | 2002 | Current Opinion in Plant Biology2002，，5： | 1 |
| 11 | Comparison of Effects of Nisoldipine -Extended Release and Amlodipine in Patients With Systemic Hypertension and Chronic Stable Angina Pectoris显示文摘 | Carl J Pepine Rhonda M Cooper-DeHoff Robert J Weiss Michael Koren Neville Bittar Udho Thadani Margaret C Minkwitz Eric L Michelson Howard G Hutchinson | 2003 | The American Journal of Cardiology2003，，3： | 1 |
| 12 | Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression显示文摘 | Wartman Lukas D Larson David E Xiang Zhifu Ding Li Chen Ken Lin Ling Cahan Patrick Klco Jeffery M Welch John S Li Cheng Payton Jacqueline E Uy Geoffrey L Varghese Nobish Ries Rhonda E Hoock Mieke Koboldt Daniel C McLellan Michael D Schmid | 2011 | Journal of Clinical Investigation2011，，： | 1 |
| 13 | Effects of Tai Chi on glucose homeostasis and insulin sensitivity in older adults with type 2 diabetes: a randomized double-blind sham-exer- cise-controlled trial显示文摘 | Tracey T Rhonda O Paul L Elizabeth C Maria F S | 2008 | Age Ageing2008，37，： | 1 |
| 14 | All possible modes of gene action are observed in a global comparison of gene expression in a maize F1 hybrid and its inbred parents 显示文摘 | Ruth A Yi J Rhonda D C | 2006 | PANS2006，103，18： | 1 |
| 15 | Neutron irradiation of sapphire for compressive strengthening显示文摘 | THOMAS M R DANIEL C H RHONDA M S | 2002 | J Nucl Mater2002，300，： | 1 |
| 16 | Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial显示文摘 | William D Schweickert Mark C Pohlman Anne S Pohlman Celerina Nigos Amy J Pawlik Cheryl L Esbrook Linda Spears Megan Miller Mietka Franczyk Deanna Deprizio Gregory A Schmidt Amy Bowman Rhonda Barr Kathryn E McCallister Jesse B Hall John P Kress | 2009 | 2009 (9678)2009，，9678： | 1 |
| 17 | Medical,behavioural and social preconception and interconception risk factors among pregnancy planning and recently pregnant Canadian women显示文摘Objectives The objective of this study is to describe the clustering of medical,behavioural and social preconception and interconception health risk factors and determine demographic factors associated with these risk clusters among Canadian women.Design Cross-sectional data were collected via an online questionnaire assessing a range of preconception risk factors.Prevalence of each risk factor and the total number of risk factors present was calculated.Multivariable logistic regression models determined which demographic factors were associated with having greater than the mean number of risk factors.Exploratory factor analysis determined how risk factors clustered,and Spearman’s r determined how demographic characteristics related to risk factors within each cluster.Setting Canada.Participants Participants were recruited via advertisements on public health websites,social media,parenting webpages and referrals from ongoing studies or existing research datasets.Women were eligible to participate if they could read and understand English,were able to access a telephone or the internet,and were either planning a first pregnancy(preconception)or had≥1 child in the past 5 years and were thus in the interconception period.Results Most women(n=1080)were 34 or older,and were in the interconception period(98%).Most reported risks in only one of the 12 possible risk factor categories(55%),but women reported on average 4 risks each.Common risks were a history of caesarean section(33.1%),miscarriage(27.2%)and high birth weight(13.5%).Just over 40%had fair or poor eating habits,and nearly half were not getting enough physical activity.Three-quarters had a body mass index indicating overweight or obesity.Those without a postsecondary degree(OR 2.35;95%CI 1.74 to 3.17)and single women(OR 2.22,95%CI 1.25 to 3.96)had over twice the odds of having more risk factors.Those with two children or more had 60%lower odds of having more risk factors(OR 0.68,95%CI 0.52 to 0.86).Low education and being born outside Canada were correlated with the greatest number of risk clusters.Conclusions Many of the common risk factors were behavioural and thus preventable.Understanding which groups of women are prone to certain risk behaviours provides opportunities for researchers and policy-makers to target interventions more efficiently and effectively. | Cindy-Lee Dennis Alessandra Prioreschi Hilary K Brown Sarah Brennenstuhl Rhonda C Bell Stephanie Atkinson Dragana Misita Flavia Marini Sarah Carsley Nilusha Jiwani-Ebrahim Catherine Birken | 2022 | Family Medicine and Community Health2022，10，3： | 0 |
| 18 | Sequential stenotic strictures of the small bowel leading to obstruction显示文摘小肠阻塞(SBO ) 被粘附,脱肠,瘤,或煽动性的苛评首先引起。管腔内苛评是 SBO 的一个不平常的原因。这份报告在一个唯一的案例中描述我们的调查结果顺序,小型机关枪的一种小肠的耳的管腔内苛评,讨论管腔内的肠的苛评,和评论的鉴别诊断关于管腔内的文学病理。 | George Van Buren Ⅱ Davis C Teichgraeber Rhonda P Ghorbani Eduardo A Souchon | 2007 | World Journal of Gastroenterology2007，13，40： | 0 |
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