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| 1 | Process improvement in laser hot wire cladding for martensitic stainless steel based on the Taguchi method显示文摘与低热输入,高精力效率,和高精确的突出的特征,激光热电线 cladding 广泛地被使用因为重新生产的金属分开。然而, cladding 过程需要被使用一个量的方法改善。在这个工作,容量的缺点比率作为标准被建议描述为 cladding 层形成质量的正直。有 FV520B 的激光免职实验, martensitic 不锈钢之一,被使用 Taguchi 方法设计。四个进程变量,也就是激光力量(P) ,扫描速度(V s ), 电线喂率(V f ), 和电线水流(I) ,基于 signal-to-noise (S/N ) 的分析被优化比率。cladding 层的冶金学的观察被进行比较形成的质量并且验证分析方法。有最佳参数联合的稳定、连续的进程与最小的缺点和裂缝生产了一致微观结构,它导致了一个好冶金的结合接口。 | Zilin HUANG Gang WANG Shaopeng WEI Changhong LI Yiming RONG | 2016 | Frontiers of Mechanical Engineering2016，11，3： | 5 |
| 2 | Universal FRFT-based algorithm for parameter estimation of chirp signals显示文摘The realization of the parameter estimation of chirp signals using the fractional Fourier transform (FRFT) is based on the assumption that the sampling duration of practical observed signals would be equal to the time duration of chirp signals contained in the former. However, in many actual circumstances, this assumption seems unreasonable. On the basis of analyzing the practical signal form, this paper derives the estimation error of the existing parameter estimation method and then proposes a novel and universal parameter estimation algorithm. Furthermore, the proposed algorithm is developed which allows the estimation of the practical observed Gaussian windowed chirp signal. Simulation results show that the new algorithm works well. | Rong Chen Yiming Wang | 2012 | Journal of Systems Engineering and Electronics2012，23，4： | 5 |
| 3 | A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity显示文摘Tumor escape from immune-mediated destruction has been associated with immunosuppressive mechanisms that inhibit T-cell activation.A promising strategy for cancer immunotherapy is to disrupt key pathways regulating immune tolerance,such as program death-1(PD-1/PD-L1)pathway in the tumor environment.However,the determinants of response to anti-PD-1 monoclonal antibodies(mAbs)treatment remain incompletely understood.In murine models,PD-1 blockade alone fails to induce effective immune responses to poorly immunogenic tumors,but is successful when combined with additional interventions,such as cancer vaccines.Novel cancer vaccines combined with antibody may offer promising control of cancer development and progression.In this investigation,we generated a novel tumor cell vaccine simultaneously expressing anti-PD-1 mAbs and granulocyte-macrophage colony stimulating factor(GM-CSF)in CT26 colon cancer and B16-F10 melanoma.The antitumor effect of the vaccine was verified by therapeutic and adoptive animal experiments in vivo.The antitumor mechanism was analyzed using Flow cytometry,Elispot and in vivo intervention approaches.The results showed that tumor cell vaccine secreting PD-1 neutralizing antibodies and GM-CSF induced remarkable antitumor immune effects and prolonged the survival of tumor-bearing animals compared with animals treated with either PD-1 mAbs or GM-CSF alone.Antitumor effects and prolonged survival correlated with strong antigen-specific T-cell responses by analyzing CD11c^(+)CD86^(+)DC,CD11b^(+)F4/80^(+)MΦcells,increased ratio of Teff/Treg in the tumor microenvironment,and higher secretion levels of Th1 proinflammatory cytokines in serum.Furthermore,the results of ELISPOT and in vivo blocking strategies further confirmed that the antitumor immune response is acquired by CD4 and CD8 T immune responses,primarily dependent on CD4 Th1 immune response,not NK innate immune response.The combination of PD-1 blockade with GM-CSF secretion potency creates a novel tumor cell vaccine immunotherapy,affording significantly improved antitumor responses by releasing the state of immunosuppressive microenvironment and augmenting the tumor-reactive T-cell responses. | Hongwei Tian Gang Shi Qin Wang Yiming Li Qianmei Yang Chunlei Li Guoyou Yang Min Wu Qian Xie Shuang Zhang Yang Yang Rong Xiang Dechao Yu Yuquan Wei Hongxin Deng | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 4 | LHCGR and ALMS1 defects likely cooperate in the development of polycystic ovary syndrome indicated by double-mutant mice显示文摘Polycystic ovary syndrome(PCOS)is a heterogeneous disorder with evidence of polygenetic components,and obesity may be a risk factor for hyperandrogen ism.Previous studies have shown that LHCGR is en riched in the ovary and LHCGR deficiency causes infertility without typical PCOS phenotypes.ALMS1 is implicated in obesity and hyperandrogenism,the common phenotypes among PCOS patients.Through whole-exome sequencing of 22 PCOS families and targeted candidate gene sequencing of additional 65 sporadic PCOS patients,we identified potential causative mutations in LHCGR and ALMS1 in a sibling-pair PCOS family and three sporadic PCOS patients.The expression of LHCGRL638 P in granulosa-like tumor cell line(KGN)cells promoted cyclic adenosine monophosphate production and granulosa cell proliferation,indicating that LHCGRL638 P is an activating mutation.Lhcgr~(L642 P/L642 P)mice showed an irregular estrous cycle,reduced follicles with dynamic folliculogenesis,and increased testosterone(T),estradiol(E2),and dehydroepiandrosterone.Lhcgr~(+/L642 P)AIms1~(+/PB)mice displayed increased T and E2 but decreased late secondary and preovulatory follicles.We showed that activating mutation of LHCGR likely plays important roles in the pathophysiology of PCOS involving abnormal reproductive physiology,whereas ALMS1 deficiency may promote anovulatory infertility via elevated androgens,suggesting that the disturbed LHCGR and ALMS1 cooperatively induce PCOS phenotypes,characterized as anovulation and hyperandrogenemia frequently observed in PCOS patients with obesity. | Li Yu Lina Wang Wufan Tao Wenxiang Zhang Shuanghao Yang Jian Wang Jia Fei Rui Peng Yiming Wu Xiumei Zhen Hong Shao Weiyue Gu Rong Li Bai-Lin Wu Hongyan Wang | 2021 | Journal of Genetics and Genomics2021，48，5： | 3 |
| 5 | Numerical simulation on solidification and thermal stress of continuous casting billet in mold based on meshless methods显示文摘 | Zhang Lei Shen Hou-Fa Rong Yiming | 2007 | Materials Science and Engineering A2007，，466： | 1 |
| 6 | Fabrication of poly (vinyli- dene fluoride - co - hexafluropropylene ) ( PVDF - HFP) asymmetric microporous hollow fiber membranes 显示文摘 | Lei Shi Rong Wang Yiming Cao | 2007 | Jourmal of Membrane Sci- ence2007，305，： | 1 |
| 7 | Robust methodology for determination of heat transfer coefficient distribution in convection显示文摘 | Bowang Xiao Qigui Wang Gang Wang Richard D. Sisson Yiming Rong | 2010 | Applied Thermal Engineering2010，，17： | 1 |
| 8 | Case based reasoning method for computer aided welding fixture design 显示文摘 | Wang Hui Rong Yiming | 2008 | Computer-Aided Design2008，40，12： | 1 |
| 9 | Effect of the rheology of poly (vinylidene fluoride-co-hexafluropropylene)(PYDF-HFP) dope solutions on the formation of microporous hollow fibers used as membrane contactors显示文摘 | Lei Shi Rong Wang Yiming Cao | 2009 | Journal of Membrane Science2009，344，12： | 1 |
| 10 | Computer-Aided Fixture Design : An Update 显示文摘 | Rong Yiming Wang Hui Li Hua | 2010 | Manufacturing Engineering Maga- zine (SME)2010，144，4： | 1 |
| 11 | Modeling and simulation of load heating in heat treatmen furnace 显示文摘 | Jinwu kang Yiming Rong | 2006 | Journal of Materials Processing Technology2006，，174： | 1 |
| 12 | STEP-NC and function blocks for interoperable manufacturing 显示文摘 | Xu X W Wang Lihui Rong Yiming | 2006 | IEEE Transactions on Automation Science and Engineering2006，3，3： | 1 |
| 13 | Experimental investigation of residual stresses in water and air quenched aluminum alloy castings显示文摘 | Xiao Bowang Rong Yiming Li Keyu | 2011 | Experimental and Applied Mechanics2011，，6： | 1 |
| 14 | Framework of grinding process mod eling and simulation based on microscopic interaction analysis 显示文摘 | LI Xuekun RONG Yiming | 2011 | Robotics and Computer-Integrated Manufacturing2011，27，： | 1 |
| 15 | Case Based Reasoning Method for Computer Aided Welding Fixture Design 显示文摘 | WANG Hui RONG Yiming(Kevin) | 2008 | Computer-Aided Design2008，40，12： | 1 |
| 16 | Automated generation of fixture configuration design 显示文摘 | Bai Yong Rong Yiming | 1995 | American Society of Mechanical Engineers Design Engineering Division (Publication) DE 21stAnnual Design Automation Conference1995，82，1： | 1 |
| 17 | Case based reasoning method for computer aided welding fixture design 显示文摘 | Wang Hui Rong Yiming (Kevin) | 2008 | Com- puter-Aided Design2008，，40： | 1 |
| 18 | Derivation of totipotent-like stem cells with blastocyst-like structure forming potential显示文摘It is challenging to derive totipotent stem cells in vitro that functionally and molecularly resemble cells from totipotent embryos.Here,we report that a chemical cocktail enables the derivation of totipotent-like stem cells,designated as totipotent potential stem(TPS)cells,from 2-cell mouse embryos and extended pluripotent stem cells,and that these TPS cells can be stably maintained long term in vitro.TPS cells shared features with 2-cell mouse embryos in terms of totipotency markers,transcriptome,chromatin accessibility and DNA methylation patterns.In vivo chimera formation assays show that these cells have embryonic and extraembryonic developmental potentials at the single-cell level.Moreover,TPS cells can be induced into blastocyst-like structures resembling preimplantation mouse blastocysts.Mechanistically,inhibition of HDAC1/2 and DOT1L activity and activation of RARγsignaling are important for inducing and maintaining totipotent features of TPS cells.Our study opens up a new path toward fully capturing totipotent stem cells in vitro. | Yaxing Xu Jingru Zhao Yixuan Ren Xuyang Wang Yulin Lyu Bingqing Xie Yiming Sun Xiandun Yuan Haiyin Liu Weifeng Yang Yenan Fu Yu Yu Yinan Liu Rong Mu Cheng Li Jun Xu Hongkui Deng | 2022 | Cell Research2022，32，6： | 1 |
| 19 | Automated customized fixture configuration design for rapid response manufacturing 显示文摘 | Wu Y Rong Yiming Chu T C | 1996 | American Society of Mechanical Engineers Manufacturing Engineering Division MED International Symposium on Information Storage and Processing Systems1996，1996，4： | 1 |
| 20 | Development of a finite element analysis tool for fixture design integrity verification and optimization 显示文摘 | AMARAL N RENCIS J RONG Yiming | 2005 | Int J Adv Manuf Technolo2005，，25： | 1 |
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