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| 1 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 2 | A data-driven health indicator extraction method for aircraft air conditioning system health monitoring显示文摘Prognostics and Health Management(PHM) has become a very important tool in modern commercial aircraft. Considering limited built-in sensing devices on the legacy aircraft model,one of the challenges for airborne system health monitoring is to find an appropriate health indicator that is highly related to the actual degradation state of the system. This paper proposed a novel health indicator extraction method based on the available sensor parameters for the health monitoring of Air Conditioning System(ACS) of a legacy commercial aircraft model. Firstly, a specific Airplane Condition Monitoring System(ACMS) report for ACS health monitoring is defined. Then a non-parametric modeling technique is adopted to calculate the health indicator based on the raw ACMS report data. The proposed method is validated on a single-aisle commercial aircraft widely used for short and medium-haul routes, using more than 6000 ACMS reports collected from a fleet of aircraft during one year. The case study result shows that the proposed health indicator can effectively characterize the degradation state of the ACS, which can provide valuable information for proactive maintenance plan in advance. | Jianzhong SUN Chaoyi LI Cui LIU Ziwei GONG Ronghui WANG | 2019 | Chinese Journal of Aeronautics2019，32，2： | 14 |
| 3 | Oil maturity assessment using maturity indicators based on methylated dibenzothiophenes显示文摘Aromatic fractions of 140 oils and condensates that originated from different types of source rocks(marine shale, terrestrial shale and marine carbonate) were analyzed using gas chromatography–mass spectrometry(GC–MS) to investigate the relative distributions of methylated dibenzothiophenes with respect to thermal maturity. The positions of methyl groups of trimethyldibenzothiophene isomers(TMDBTs) including those used in the definition of maturity indicator TMDBT index in previous studies were firmly identified by co-elution of internal standards in GC–MS analysis and by comparing with reported retention indices. A new maturity ratio related to dimethyldibenzothiophenes(DMDBTs) is proposed on the basis of the differences in thermodynamic stability among different DMDBT isomers. Another maturity index(TMDBT-I2) based on TMDBTs is also suggested on the basis of our empirical observations and presumed thermodynamic stability of TMDBT isomers. These two newly proposed(2,6 + 3,6)-/1,4-DMDBT ratio and TMDBT-I2 correlate well with MDR(4-/1-methyldibenzothiophene) and 2,4-/1,4-DMDBT ratios, suggesting their common chemical reaction mechanisms and similar behavior with increasing maturity. Therefore, they can be effectively applied for maturity assessments. Furthermore, the TMDBTs related maturity parameters are more reliable for over-mature oils and condensates due to the relatively higher concentrations of thermodynamically unstable TMDBT isomers, i.e. 1,4,6-, 1,4,8- and 3,4,6-TMDBT in this study than those of 1-methyldibenzothiophene(1-MDBT) or 1,4-DMDBT. In contrast with 4,6-/1,4-DMDBT, the newly proposed(2,6 + 3,6)-/1,4-DMDBT ratios for oils that originated from different types of source rocks have approximately same relationship with the oil maturity(Rc %). This suggests that the lithology and organic facies may have relatively less influence on(2,6 + 3,6)-/1,4-DMDBT ratio compared to 4,6-/1,4-DMDBT. The maturity parameters based on methylated dibenzothiophenes are particularly useful in the maturity assessments of post- and over-mature oils and condensates and can complement maturity indicators based on steranes and terpanes. | Li Meijun Wang T.-G Shi Shengbao Zhu Lei Fang Ronghui | 2014 | Petroleum Science2014，11，2： | 13 |
| 4 | Great progress in study on aerosol and its impact on the global environment显示文摘The transport from atmosphere is a more important pathway than that from rivers for certain elements and compounds in the remote ocean. The desert and those arid/semi-arid areas in the northwest of China and the Loess Plateau are the sources of those aerosols over the Pacific. Atmospheric iron is the limiting factor of the productivity in certain ocean regions. The dust storms must now be seen as repeated sources of pollution elements as well as soil elements to the East China Sea and, farther out, to the North Pacific Ocean and even to the USA. The long-range transport of aerosols, especially the dust storm, from China and the positive feedbacks of iron coupled with sulfur in atmosphere might be one of the important mechanisms that would affect the primary productivity in the Pacific and/or the global climate change and deserve to be further studied. It can be seen clearly that the dust storms would affect not only the health of human beings and the local or regional climate, but also the global climate change that has been the focus of environmental study internationally. | ZHUANG Guoshun, HUANG Ronghui, WANG Mingxing, Q. ZHOU, GUO Jinghua, YUAN Hui and RAO Zhiming(1. The Center for Atmospheric Environmental Study, Beijing Normal University, Beijing 100875, China 2. The Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China 3. University of New Mexico, Albuquerque, NM 87131, USA 4. Zhangzhou Teachers College, Zhangzhou 363000, China) | 2002 | Progress in Natural Science:Materials International2002，12，6： | 12 |
| 5 | Relation of hepatic EROD activity and cytochrome P4501A level in Sebastiscus marmoratus exposed to benzo[a]pyrene显示文摘这研究被设计调查 benzo 的体内效果[一]有细胞色素 P4501A ( CYP1A )蛋白质的活动和它的关联在 Sebastiscus marmoratus 铺平的肝的 ethoxyresorufin-O-deethylase (侵蚀)上的分核( BaP )通过水列暴露于 BaP , 10 , 100 , 1000 ng/L ,分别地)或与 BaP 的 intraperitoneal 注射被对待( 0.5 , 1 , 5 , 10 mg/kg ,分别地)每 7 d 。结果证明在到 1000 ng/L BaP 的水运的暴露的 25 d 以后,捞肝的 CYP1A 层次和侵蚀活动显著地被导致。相反,侵蚀活动没被改变在第二 intraperitoneal 注射以后的 7 d,而, CYP1A 蛋白质层次被增加。胆汁的 BaP 代谢物的剂量依赖者增加证明 CYP1A 的催化活动被处理与 BaP 导致。关于胆汁的 BaP 代谢物(100 ng/L ) 的最低可见效果集中与侵蚀活动(1000 ng/L ) 的参考是比那低得多的。结果建议那胆汁的多不的芳族烃(哼) 代谢物被显示更好反映污染坡度比侵蚀哼活动。它看起来必要测量 CYP1A 蛋白质层次在相关毒物学的评价补充 EROD 活动。 | WANG Yun ZHENG Ronghui ZUO Zhenghong CHEN Yixin WANG Chonggang | 2008 | Journal of Environmental Sciences2008，20，1： | 10 |
| 6 | Sensitivity of ENSO Variability to Pacific Freshwater Flux Adjustment in the Community Earth System Model显示文摘The effects of freshwater flux(FWF) on modulating ENSO have been of great interest in recent years. Large FWF bias is evident in Coupled General Circulation Models(CGCMs), especially over the tropical Pacific where large precipitation bias exists due to the so-called 'double ITCZ' problem. By applying an empirical correction to FWF over the tropical Pacific, the sensitivity of ENSO variability is investigated using the new version(version 1.0) of the NCAR's Community Earth System Model(CESM1.0), which tends to overestimate the interannual variability of ENSO accompanied by large FWF into the ocean. In response to a small adjustment of FWF, interannual variability in CESM1.0 is reduced significantly,with the amplitude of FWF being reduced due to the applied adjustment part whose sign is always opposite to that of the original FWF field. Furthermore, it is illustrated that the interannual variability of precipitation weakens as a response to the reduced interannual variability of SST. Process analysis indicates that the interannual variability of SST is damped through a reduced FWF–salt–density–mixing–SST feedback, and also through a reduced SST–wind–thermocline feedback. These results highlight the importance of FWF in modulating ENSO, and thus should be adequately taken into account to improve the simulation of FWF in order to reduce the bias of ENSO simulations by CESM. | KANG Xianbiao HUANG Ronghui WANG Zhanggui ZHANG Rong-Hua | 2014 | Advances in Atmospheric Sciences2014，31，5： | 8 |
| 7 | Big Grain3, encoding a purine permease, regulates grain size via modulating cytokinin transport in rice显示文摘Grain size is an important agronomic trait affecting grain yield,but the underlying molecular mechanisms remain to be elucidated.Here,we isolated a dominant mutant,big grainy(bg3-D),which exhibits a remarkable increase of grain size caused by activation of the PURINE PERMEASE gene,OsPUP4.BC3/OSPUP4 is predominantly expressed in vascular tissues and is specifically suppressed by exogenous cytokinin application.Hormone profiling revealed that the distribution of different cytokinin forms,in roots and shoots of the bg3-D mutant,is altered.Quantitative reverse transcription-PCR(qRT-PCR)analysis indicated that expression of rice cytokinin type-A RESPONSE REGULATOR(OsRR)genes is enhanced in the roots of the bgj-D mutant.These results suggest that OSPUP4 might contribute to the long-distance transport of cytokinin,by reinforcing cytokinin loading into vascular bundle cells.Furthermore,plants overexpressing OsPUP7,the closest homolog of OsPUP4,also exhibited a similar phenotype to the bg3-D mutant.Interestingly,subcellular localization demonstrated that OSPUP4 was localized on the plasma membrane,whereas OSPUP7 was localized to the endoplasmic reticulum.Based on these findings,we propose that OSPUP4 and OSPUP7 function in a linear pathway to direct cytokinin cell-to-cell transport,affecting both its long-distance movement and local allocation. | Yunhua Xiao Dapu Liu Guoxia Zhang Shaopei Gao Linchuan Liu Fan Xu Ronghui Che Yiqin Wang Hongning Tong Chengcai Chu | 2019 | Journal of Integrative Plant Biology2019，61，5： | 7 |
| 8 | Therapeutic effect of electroacupuncture,massage,and blocking therapy on external humeral epicondylitis显示文摘OBJECTIVE:To compare two therapeutic methods:electroacupuncture + massage + blocking therapy,and blocking therapy alone in the treatment of external humeral epicondylitis.METHODS:Eighty-six patients were randomized into two groups with 43 in each. The treatment group received electroacupuncture + massage +blocking therapy, while the control group received blocking therapy only. A course of electroacupuncture treatment included therapy once a day for 10days. There were 10 treatments in a massage course and massage was given once a day, with a1-week interval given before the next course. A course of blocking treatment included therapy once a week, for twototaltreatments,andgenerallyno more than three times. The therapeutic effects were evaluated with the visual analog scale(VAS),grip strength index(GSI) score, and Mayo elbow performance score(MEPS) before treatment and at0, 6, 12, and 24 months after treatment to observe thetotaleffectiverate.RESULTS: In the treatment and control groups before treatment and at 0, 6, 12, and 24 months after treatment, the VAS scores were: 6.5±1.9 and 6.4±1.6; 4.6±1.3 and 4.6±1.7; 4.8±1.3 and 4.8±1.2; 4.6±1.2 and 6.6±1.6; and 6.5±1.6 and 6.5±1.3, respectively. The GSI scores were 63±8 and 63±8; 84±6and82±7;82±7and82±6;84±6and62±8;and64±6 and 64±7, respectively.The MEPS of both groups were65±7and66±8;85±6and84±7;84±5and84±7;80±7and66±6;and65±6and65±7,respectively.The total effective rates of the treatment and control groups at 0, 6, 12, and 24 months after treatment were 87.5% and 85.0%; 85.0% and 82.5%;80.0% and 12.5%; and 2.5% and 5.0%, respectively.Compared with the treatment group, the control group had greater joint function, better the rapeutic effect, and lower pain intensity(P<0.01), indicating a high recurrence rate in the 12th month after treatment.There were no differences inVAS, GSI, or MEPS at 0, 6, and 24 months after treatment(P>0.05)betweenthetwogroups.CONCLUSION: We found that both methods were effective for external humeral epicondylitis. After 6months of treatment,the effects were good in both groups. However, in the 12th month, the control group had a relatively severe relapse. After 24months, both groups relapsed. The effect of electroacupuncture, massage, and blocking therapy used in combination lasted longer, delaying the recurrence of the disease. | Xinjian Li Kun Zhou Enming Zhang Zhen xiQi Weiqing Sun Liangfu Xu Jianfeng Xu Youzhi Cai Ronghui Wang | 2014 | Journal of Traditional Chinese Medicine2014，34，3： | 6 |
| 9 | Detection of Staphylococcus Aureus using quantum dots as fluorescence labels显示文摘Staphylococcus aureus(S.aureus)has been identified as one of the major foodborne pathogenic bacteria.The development of rapid detection methods for S.aureus is needed for assuring food safety.In this study,quantum dots were used as fluorescent labels in an immunoassay for quantitative detection of S.aureus.Firstly,biotin-labeled anti-S.aureus antibody was conjugated with streptavidin-coated magnetic nanobeads(180 nm diameter)and used to separate S.aureus cells.Then streptavidin coated quantum dots(QDs)were conjugated with biotin-labeled anti-S.aureus antibody and used as the fluorescence labels to mix with the separated S.aureus.Finally the fluorescence intensity of the bead-cell-QD complexes was measured at a wavelength of 620 nm.A linear relationship between S.aureus cell number(X)and fluorescence intensity(Y)was found for cell numbers ranging from 10^(3) to 10^(6) CFU(Colony Forming Unit)/mL,and the detection limit was 10^(3) CFU/mL.The regression model can be expressed as Y=7.68X+35.06 with R^(2)=0.94.The detection of S.aureus in food sample was explored initially.The fluorescence intensity of food sample was close to the background,so it was not satisfied.Further study will focus on the application of the method for detection of S.aureus in food sample. | Hu Yaohua Wang Chengcheng Bai Bing Li Mintong Ronghui Wang Yanbin Li | 2014 | International Journal of Agricultural and Biological Engineering2014，7，1： | 6 |
| 10 | Comparison of benzothiazole-based dyes for sensitive DNA detection显示文摘For efficient and quantitative DNA detection,fluorescence staining is the most often explored approach,which relies on non-covalent binding of dyes with double stranded DNA(dsDNA).Ethidium bromide(EB)is the most classic DNA stain,but suffers from its high carcinogenicity.A series of less toxic alternatives were developed,many of which contain the core structure of the benzothiazole ring.However,the relationship between the structure and the DNA detection performance was not illustrated.Herein,five benzothiazole dyes,namely thiazole orange,SYBR Green I,Pico Green,SYBR Safe,and thioflavine-T,were compared for DNA detection through direct fluorescence and gel electrophoresis,with particular focus on the structure-performance relationship.It turned out that SYBR Green I is currently the best choice for DNA detection.The results in this work may be useful for future DNA-staining dye developments. | Yanying Wang Ronghui Zhou Wenxue Liu Chao Liu Peng Wu | 2020 | Chinese Chemical Letters2020，31，11： | 4 |
| 11 | Flexible and reusable cap-like thin Fe2O3 film for SERS applications显示文摘Cap-like α-Fe2O3 films are fabricated and deposited onto quartz fabric by using radio frequency magnetron sputtering and annealing.The treated fabric sample in this study shows highly sensitive surface-enhanced Raman scattering (SERS) and excellent flexibility,reproducibility and stability.In addition,the sample can be recovered after a washing process with an organic solvent and repeatedly used.The sensitive SERS performance is attributed to chemical enhancement through a charge transfer process.Moreover,the SERS performance is also found to be dependent on the light coupling effect.When the light absorbance rate of the α-Fe2O3 films increases at a wavelength near that of laser light,the film shows excellent sensitivity due to light coupling effect. | Jiangtao Xu Xiaoting Li Yuxiang Wang Ronghui Guo Songmin Shang Shouxiang Jiang | 2019 | Nano Research2019，12，2： | 3 |
| 12 | 量子点免疫标记法同时检测2种食源性致病菌显示文摘目的:建立快速检测金黄色葡萄球菌、福氏志贺氏菌的量子点免疫标记方法。方法:利用免疫磁珠富集,量子点标记,微型光纤光谱仪对金黄色葡萄球菌、福氏志贺氏菌进行定量检测,建立荧光强度与菌浓度的定量模型,并对捕获条件进行优化。结果:两种目标菌的最佳捕获条件为免疫捕获时间45 min、磁分离时间1.5 min、PBS浓度0.01 mol/L。目标菌浓度在10~2~10~5 CFU/m L范围,目标菌与荧光强度的线性关系为:金葡菌FI=9.2744lg N+50.14,福氏志贺氏菌FI=18.616lg N+53.784,N为目标菌细菌菌落数,CFU/m L;FI为荧光强度值。金黄色葡萄球菌决定系数R^2=0.9626,福氏志贺氏菌决定系数R^2=0.9778,说明具有很好的拟合性。重复性测试结果中相对标准偏差为2.9%,检测时间在2 h内。结论:本文建立的检测方法简单,快速,灵敏度高,特异性好,具有很好的应用前景。 | 白冰 胡耀华 李敏通 Ronghui Wang Yanbin Li | 2016 | 中国食品学报2016，16，1： | 3 |
| 13 | Joint tracking and classification of extended targets with complex shapes显示文摘This paper addresses the problem of joint tracking and classification(JTC) of a single extended target with a complex shape. To describe this complex shape, the spatial extent state is first modeled by star-convex shape via a random hypersurface model(RHM), and then used as feature information for target classification. The target state is modeled by two vectors to alleviate the influence of the high-dimensional state space and the severely nonlinear observation model on target state estimation, while the Euclidean distance metric of the normalized Fourier descriptors is applied to obtain the analytical solution of the updated class probability. Consequently, the resulting method is called the 'JTC-RHM method.' Besides, the proposed JTC-RHM is integrated into a Bernoulli filter framework to solve the JTC of a single extended target in the presence of detection uncertainty and clutter, resulting in a JTC-RHM-Ber filter. Specifically, the recursive expressions of this filter are derived. Simulations indicate that:(1) the proposed JTC-RHM method can classify the targets with complex shapes and similar sizes more correctly, compared with the JTC method based on the random matrix model,(2) the proposed method performs better in target state estimation than the star-convex RHM based extended target tracking method,(3) the proposed JTC-RHM-Ber filter has a promising performance in state detection and estimation, and can achieve target classification correctly. | Liping WANG Ronghui ZHAN Yuan HUANG Jun ZHANG Zhaowen ZHUANG | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，6： | 2 |
| 14 | LabVIEW-based impedance biosensing system for detection of avian influenza virus显示文摘In order to detect the multiple avian influenza viruses(AIVs)rapidly,specifically and sensitively,a LabVIEW and microelectrode array-based impedance biosensor was developed and demonstrated.A laptop with LabVIEW software was used to generate excitation signals at different frequencies with an audio card and measure the impedance of target viruses through a data acquisition card.The audio card of the laptop was used as a function generator,while a data acquisition card was used for data communication.A virtual instrument was programmed with LabVIEW to provide a platform for impedance measurement,data processing,and control.Six interdigitated microelectrodes were placed at the bottom of six wells on a microplate to form six sensors for different AIVs and controls.Then,AIV specific ligands were immobilized on the microelectrode surface to capture target viruses.To enhance the sensitivity,AIV specific aptamers conjugated gold nanoparticles and thiocyanuric acid were employed to form a network structure and used as an amplifier.Results of the measured impedance were compared with a commercial IM6 impedance analyzer,and the error was less than 5%.The developed biosensor was portable with the sensitivity and specificity for applications to on-site or in-field rapid screening of avian influenza viruses. | Zhang Benhua Ronghui Wang Yixiang Wang Yanbin Li | 2016 | International Journal of Agricultural and Biological Engineering2016，9，4： | 2 |
| 15 | Logistic regres-sion analysis of factors related to hospital infection patientswith cirrhosis显示文摘 | Cui Ronghui Wang Liqin Qi Wentao | 2009 | clinical focus2009，23，20： | 1 |
| 16 | A nanobeads amplified QCM immtmosensor for the detection of avian influenza virus H5N1显示文摘 | LI Dujuan WANG Jianping WANG Ronghui | | 0，，10： | 1 |
| 17 | Bacteria capture, concentration and detection by alternating current dielectrophoresis and self-assembly of dispersed single-wall carbon nanotubes显示文摘 | Zhou Ronghui Wang Ping Chang Hsueh-Chia | 2006 | Electrophoresis2006，27，： | 1 |
| 18 | TiO2 nanowire bundle microelectrode based impedance immunosensor for rapid and sensitive detection of Listeria monocytogenes显示文摘 | Wang Ronghui Ruan Chuanmin Li Yanbin | | 0，，9： | 1 |
| 19 | Model test and numerical analysis of a special joint for a truss bridge显示文摘 | WANG Ronghui HUANG Yonghui LI Qiusheng | 2009 | Journal of Constructional Steel Research2009，65，6： | 1 |
| 20 | Downregulation of nc886 contributes to prostate cancer cell invasion and TGFβ1-induced EMT显示文摘Epithelial-to-mesenchymal transition (EMT) activation is important in cancer progression and metastasis. Evidence indicates that nc886 is a representative Pol III gene that processes microRNA products via Dicer and further downregulates its target gene transforming growth factor- β1 (TGF-β1), which is the most prominent inducer of EMT in prostate cancer (PC). Consistent with the previous literature, we found that nc886 downregulation was strongly associated with metastatic behavior and showed worse outcomes in PC patients. However, little is known about the association between nc886 and the EMT signaling pathway. We developed a PC cell model with stable overexpression of nc886 and found that nc886 changed cellular morphology and drove MET. The underlying mechanism may be related to its promotion of SNAIL protein degradation via ubiquitination, but not to its neighboring genes, TGFβ-induced protein (TGFBI) and SMAD5, which are Pol II-transcribed. TGF-β1 also override nc886 promotion of MET via transient suppression the transcription of nc886, promotion of TGFBI or increase in SMAD5 phosphorylation. Both nc886 inhibition and TGFBI activation occur regardless of their methylation status. The literature suggests that MYC inhibition by TGF-β1 is attributed to nc886 downregulation. We incidentally identified MYC-associated zinc finger protein (MAZ) as a suppressive transcription factor of TGFBI, which is controlled by TGF-β1. We elucidate a new mechanism of TGF-β1 differential control of Pol II and the transcription of its neighboring Pol III gene and identify a new EMT unit consisting of nc886 and its neighboring genes. | Ronghui Yang Lingkun Zuo Hui Ma Ying Zhou Ping Zhou Liyong Wang Miao Wang Mahrukh Latif Lu Kong | 2022 | Genes & Diseases2022，9，4： | 1 |
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