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| 1 | Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring显示文摘树鼯有一种靠近的关系到首领并且在生物医学的研究比啮齿类动物有许多优点。然而,基因操作方法的缺乏妨碍了这个动物的更宽的使用。Spermatogonial 干细胞(SSC ) 成功地在文化被扩展了允许复杂基因在老鼠和老鼠编辑。这里,没有干细胞性质的损失,我们为树鼯 SSC 的长期的扩大描述一个文化系统。在我们的学习,胸腺房间抗原 1 被用来充实树鼯 SSC。定序 RNA 分析表明表明小径的 Wnt/-catenin 在无差别的 SSC 是活跃的,但是是在 SSC 区别的开始之上的 downregulated。树鼯的暴露到 recombinant Wnt3a 蛋白质的主要 SSC 在文化的起始的段落期间提高了 SSC 的幸存。当 feeder 被发现为树鼯 SSC 增长必要,树鼯 Sertoli 房间,然而并非老鼠使用胚胎的成纤维细胞,导致柔韧的房间扩大和长期的文化。扩展的树鼯 SSC 是有提高的绿色的 transfected 荧光灯表示 lentiviral 向量的蛋白质(EGFP ) 。在进消毒的成年的男树鼯睾丸的移植以后,标注 EGFP 的 SSC 能恢复精子发生并且成功地产生转基因的后代。而且,这些 SSC 对 CRISPR/Cas9-mediated 基因修正合适。在有编辑的基因的联合的树鼯 SSC 接近膨胀的一个文化系统的发展用树鼯为精确染色体操作铺平道路。 | Chao-Hui Li Lan-Zhen Yan Wen-Zan Ban Qiu TH Yong Wu Lin Wang Rui Bi Shuang Ji Yu-Hua Ma Wen-Hui Nie Long-Bao Lv Yong-Gang Yao Xu-Dong Zhao Ping Zheng | 2017 | Cell Research2017，27，2： | 22 |
| 2 | Identification of Seven Novel Mutations in the Acid Alpha-glucosidase Gene in Five Chinese Patients with Late-onset Pompe Disease显示文摘 | Hua-Xu Liu Chuan-Qiang Pu Qiang Shi Yu-Tong Zhang Rui Ban | 2018 | Chinese Medical Journal2018，，4： | 2 |
| 3 | Description of a new species of the genus Uropsilus(Eulipotyphla:Talpidae:Uropsilinae)from the Dabie Mountains,Anhui,Eastern China显示文摘During a terrestrial vertebrate survey of the Dabie Mountains in Anhui Province,eastern China,we collected four Asian shrew mole specimens(hereafter,shrew moles).Based on published literature and comparison with previously collected materials,the four specimens were similar to shrew moles from the mountains of Southwest China;however,no species in this group has been previously recorded from the Dabie Mountains.The genetic and morphological characteristics of the specimens were analyzed,based upon which a new species of shrew mole is described,named Uropsilus dabieshanensis sp.nov. | Ting-Li Hu Zhen Xu Heng Zhang Ying-Xun Liu Rui Liao Guang-Dao Yang Ruo-Lei Sun Jie Shi Qian Ban Chun-Lin Li Shao-Ying Liu Bao-Wei Zhang | 2021 | Zoological Research2021，42，3： | 2 |
| 4 | Epidemiological and clinical characteristics of 65 hospitalized patients with COVID-19 in Liaoning, China显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)has spread rapidly to multiple countries through its infectious agent severe acute respiratory syndrome coronavirus 2.The severity,atypical clinical presentation,and lack of specific anti-viral treatments have posed a challenge for the diagnosis and treatment of COVID-19.Understanding the epidemiological and clinical characteristics of COVID-19 cases in different geographical areas is essential to improve the prognosis of COVID-19 patients and slow the spread of the disease.AIM To investigate the epidemiological and clinical characteristics and main therapeutic strategy for confirmed COVID-19 patients hospitalized in Liaoning Province,China.METHODS Adult patients(n=65)with confirmed COVID-19 were enrolled in this retrospective study from January 20 to February 29,2020 in Liaoning Province,China.Pharyngeal swabs and sputum specimens were collected from the patients for the detection of severe acute respiratory syndrome coronavirus 2 nucleic acid.Patient demographic information and clinical data were collected from the medical records.Based on the severity of COVID-19,the patients were divided into nonsevere and severe groups. All patients were followed until March 20,2020.RESULTSThe mean age of 65 COVID-19 patients was 45.5 ± 14.4 years, 56.9% were men,and 24.6% were severe cases. During the 14 d before symptom onset, 25 (38.5%)patients lived or stayed in Wuhan, whereas 8 (12.3%) had no clear history ofexposure. Twenty-nine (44.6%) patients had at least one comorbidity;hypertension and diabetes were the most common comorbidities. Compared withnonsevere patients, severe patients had significantly lower lymphocyte counts[median value 1.3 × 10^(9)/L (interquartile range 0.9-1.95) vs 0.82 × 10^(9)/L (0.44-1.08),P < 0.001], elevated levels of lactate dehydrogenase [450 U/L (386-476) vs 707 U/L(592-980), P < 0.001] and C-reactive protein [6.1 mg/L (1.5-7.2) vs 52 mg/L (12.7-100.8), P < 0.001], and a prolonged median duration of viral shedding [19.5 d (16-21) vs 23.5 d (19.6-30.3), P = 0.001]. The overall median viral shedding time was19.5 d, and the longest was 53 d. Severe patients were more frequently treatedwith lopinavir/ritonavir, antibiotics, glucocorticoid therapy, immunoglobulin,thymosin, and oxygen support. All patients were discharged following treatmentin quarantine.CONCLUSIONOur findings may facilitate the identification of severe cases and inform clinicaltreatment and quarantine decisions regarding COVID-19. | Wei Zhang Yuan Ban Yun-Hai Wu Jin-Yang Liu Xing-Hai Li Hao Wu Huan Li Rui Chen Xiao-Xu Yu Rui Zheng | 2021 | World Journal of Clinical Cases2021，9，10： | 1 |
| 5 | Exploring the relationship between streetcentrality and land use in Stockholm显示文摘 | Rui Yikang Ban Yifang | 2014 | International Journal of Ge-ographical Information Science2014，28，7： | 1 |
| 6 | A Novel Mutation of Mitochondrial T14709C Causes Myoclonic Epilepsy with Ragged Red Fibers Syndrome in a Chinese Patient显示文摘 | Rui Ban Jun-Hong Guo Chuan-Qiang Pu Qiang Shi Hua-Xu Liu Yu-Tong Zhang | 2018 | Chinese Medical Journal2018，，13： | 1 |
| 7 | Anti-aliasing lifting scheme for mechanical vibration fault feature extraction 显示文摘 | Ban Wen Zhou Rui Yang Jianggno | 2009 | Mechanical system and Signal Processing2009，23，5： | 1 |
| 8 | Crack growth life estimating for MSD panel显示文摘 | Zhang Jiayu Ban Rui Zhao Libin | 2008 | Advanced Materials Research2008，3334，： | 1 |
| 9 | Curing of the Bacillus subtills plasmid using sodium dodecyl sulfate显示文摘 | Lou Kai Ban Rui Zhao Xue-ming | 2002 | Transactions of Tianjin University2002，8，3： | 1 |
| 10 | Exploring the patterns and evolution of self- organized urban street networks through modeling显示文摘 | RUI Y K BAN Y F WANG J C | 2013 | The European Physical Journal B2013，86，3： | 1 |
| 11 | Network-meta analysis of 9 kinds of patent Chinese medicine for nourishing qi and activating blood in the treatment of angina pectoris of coronary heart disease显示文摘Objective:To evaluate the efficacy and safety of Yiqi Huoxue oral Chinese patent medicine in the treatment of angina pectoris.Methods:the databases of EMBASE,PubMed,CNKI,Wanfang and VIP were searched by computer,and the randomized controlled trial(RCT)of Yiqi Huoxue Chinese patent medicine in the treatment of angina pectoris of coronary heart disease(CHD)was searched until December 2019.By using stata15.1 software,the total clinical effective rate,the improvement rate of ECG,the improvement rate of angina pectoris,the attack frequency and duration of angina pectoris were taken as the outcome indicators for network meta analysis and mapping.Results:51 RCTs were included,including 9 kinds of traditional Chinese medicine.The results of network meta analysis showed that:in terms of clinical total effective rate,the order was Shexiang Baoxin Pill(78.2%)>xueshuanxinming tablet>Dengzhan Shengmai capsule>Shengui Capsule>Tongxinluo capsule>Tongmai Yangxin pill>Yangxin tablet>Shexiang Tongxin drop pill>Naoxintong capsule;the improvement of ECG was Tongmai Yangxin pill(85.2%)>Yangxin tablet>Dengzhan Shengmai capsule>Shexiang Tongxin drop pill>Shexiang Baoxin Pill>Tongxinluo gum Capsule>Shengui Capsule>Naoxintong capsule;in order to reduce the frequency and duration of angina pectoris,they are conventional Naoxintong capsule(88.6%)>Shengui Capsule>Tongmai Yangxin pill>Shexiang Baoxin Pill>xueshuanxinmingpian>Tongxinluo capsule>Shexiang Tongxin drop pill>Dengzhan Shengmai capsule;Shexiang Baoxin Pill(66.9%)>Dengzhan Shengmai capsule>Shexiang Tongxin drop pill>Tongxinluo capsule>xueshuanxinmingning capsule Tablet>Tongmai Yangxin pill.Conclusion:Traditional Chinese medicine combined with western medicine has obvious advantages in the treatment of angina pectoris.Shexiang Baoxin Pill,Dengzhan Shengmai capsule and Tongmai Yangxin pill can be given priority. | Zhuo-Xi Wang Ji-Fang Ban Rou-Le Li Tie-Feng Wang Rui Ke | 2021 | Journal of Hainan Medical University2021，27，11： | 1 |
| 12 | Clinical,Pathological,and Genetic Features of Two Chinese Cases with Filamin C Myopathy显示文摘To the Editor:Filamin C (FLNC)myopathy is an autosomal dominant inherited myopathy caused by mutations in FLNC.FLNC belongs to the filamin superfamily and cross-links actin filaments to form a network,anchoring membrane protein to the cytoskeleton. Human protein filamins comprise three isoforms encoded by the human genome:filamins A,B,and C.Among these,FLNC is a Z-disk protein encoded by the FLNC gene and is mainly expressed in the skeletal and cardiac muscles.FLNC gene is on chromosome 7q32-q35,containing genomic DNA of about 29.5 kb length and 49 encoding exons.FLNC is an isoform of serine protease expressed primarily in the striated muscle,containing 2725 amino acids, at a molecular weight of 291,000.FLNC protein contains two domains.The amino terminus consists of two ealponin homology domains that together constitute the actin-binding domain (ABD), followed by 24 filamin-type immunoglobulin (Ig-FLMN)repeated domains (rod-overlapping domains),the most carboxy-terminal of which is responsible for dimerization,assembly,and anchor filaments. | Yu-Tong Zhang Chuan-Qiang Pu Rui Ban Hua-Xu Liu Qiang Shi Xiang-Hui Lu | 2018 | Chinese Medical Journal2018，，24： | 0 |
| 13 | Reply to "Mitochondrial tRNA Glutamic Acid Variant 14709T〉C Manifesting as Myoclonic Epilepsy with Ragged Red Fibers"显示文摘 | Rui Ban Jun-Hong Guo Chuan-Qiang Pu Qiang Shi Hua-Xu Liu Yu-Tong Zhang | 2018 | Chinese Medical Journal2018，，20： | 0 |
| 14 | Space advanced technology demonstration satellite显示文摘The Space Advanced Technology demonstration satellite(SATech-01),a mission for low-cost space science and new technology experiments,organized by Chinese Academy of Sciences(CAS),was successfully launched into a Sun-synchronous orbit at an altitude of~500 km on July 27,2022,from the Jiuquan Satellite Launch Centre.Serving as an experimental platform for space science exploration and the demonstration of advanced common technologies in orbit,SATech-01 is equipped with 16 experimental payloads,including the solar upper transition region imager(SUTRI),the lobster eye imager for astronomy(LEIA),the high energy burst searcher(HEBS),and a High Precision Magnetic Field Measurement System based on a CPT Magnetometer(CPT).It also incorporates an imager with freeform optics,an integrated thermal imaging sensor,and a multi-functional integrated imager,etc.This paper provides an overview of SATech-01,including a technical description of the satellite and its scientific payloads,along with their on-orbit performance. | ZHANG XiaoFeng CHEN Wen ZHU XiaoCheng MENG Na HE JunWang BI XingZi ZHANG YongHe SHI Qi LI Fei LIU Rui FENG ZhengGong LIU Liu LI JinSong WU HaiChen XU DongXiao LI TaiJie HUANG JiangJiang LIU Shuo LI TianTong YU XianSheng GAO Yang ZHOU Heng BAN HanYu ZHANG YanLi ZHANG YueTing YANG YingQuan HE Tao DUAN XuLiang CHEN Xin WANG YaMin SUN AnTai ZHANG KuoXiang SUN Ying WANG YaoBin FAN ChengCheng XIONG ShaoLin LI XinQiao WEN XiangYang LING ZhiXing SUN XiaoJin ZHANG Chen BAI XianYong WANG ZhanShan DENG YuanYong TIAN Hui YANG JianFeng XUE HongBo SANG Peng LIU JinGuo ZHENG HuiLong ZHU Xiang HE JianWu LI Hui XU LuXiang XU ShuYan CHEN WenWu LIU ZhenDong WANG ZhaoLi MAO XiangLong GAO Rong LI ZongXuan DING GuoPeng WANG XinYu DOU RunJiang WENG LuBin LUO Hao WANG YaPing LIANG XianFeng FANG ZiRuo | 2024 | Science China(Technological Sciences)2024，67，1： | 0 |
| 15 | Synthesis and Anti-VSMC Vegetation Activities of New Aurone Derivatives显示文摘A series of new aurone derivatives was prepared by means of a practical route and their anti-vascular smooth muscle cells(VSMC) vegetation activities were evaluated by the 3-(4,5-dimethylthlazol-2-yl)-2,5diphenyltetrazolium bromide(MTT) method with tetrandrine as a positive contrast drug.The structures of the compounds were confirmed by 1 H NMR,13 C NMR and electrospray ionization mass spectrometry(ESI-MS).Several new compounds exhibited promising activity against VSMC proliferation and the preliminary structure-activity relationships(SAR) were discussed in order to investigate the essential structures required for their bioactivities. | FAN Rui BAN Shu-rong FENG Xiu-e ZHAO Chen-xiao LI Qing-shan | 2012 | Chemical Research in Chinese Universities2012，28，3： | 0 |
| 16 | Oculopharyngeal Weakness, Hypophrenia, Deafness, and Impaired Vision: A Novel Autosomal Dominant Myopathy with Rimmed Vacuoles显示文摘 | Ting Chen Xiang-Hui Lu Hui-Fang Wang Rui Ban Hua-Xu Liu Qiang Shi Qian Wang Xi Yin Chuan-Qiang Pu | 2016 | Chinese Medical Journal2016，，15： | 0 |
| 17 | High-throughput transcriptomic profiling of mRNAs and lncRNAs in the dermatomyositis muscle by RNA sequencing显示文摘Background:Dermatomyositis(DM)is an idiopathic inflammatory myopathy(IIM).In this study,we investigated the mRNAs and long noncoding RNAs(lncRNAs)in muscle biopsy specimens that are differentially expressed among patients with DM,patients with other IIM,and healthy controls(HCs).Methods:In total,three patients with DM,10 patients with other IIM,and three HCs were included.Muscle biopsy specimens were collected for RNA-sequencing.Gene ontology and pathway analyses were employed to characterize the biological processes and signaling pathways.Results:Compared with HCs,372 differentially expressed mRNAs were identified within the DM group,including 275 upregulated and 97 downregulated ones.Moreover,692 differentially expressed lncRNAs were identified in the DM group compared with HCs,of which 407 were upregulated and 285 were downregulated.Bioinformatic analysis indicated that the type-Ⅰ interferon signaling pathway and biological processes of innate immunity were significantly influenced by the differentially expressed mRNAs.Notably,11 of the top 20 upregulated mRNAs were involved in the type-Ⅰ interferon signaling pathway.Reverse transcription polymerase chain reaction analysis verified the RNA-sequencing data.Target gene prediction analysis suggested that the lncRNA NONHSAG043573.2 potentially targeting transporter associated with antigen processing 1,a key regulator of interferon signaling genes,might play an important role in the pathogenesis of DM.Conclusions:Our study assessed the transcriptomic profiles of differentially expressed mRNAs and lncRNAs in the DM muscle tissue and revealed that the upregulated mRNAs are significantly involved in the innate immune response and the type-Ⅰ interferon signaling pathway,which might play important roles in the pathogenesis of DM. | Ke Li Yubao Ma Shanchun Zhang Rui Ban Qiang Shi | 2023 | Rheumatology & Autoimmunity2023，3，3： | 0 |
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