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| 1 | Backfilling technology and strata behaviors in fully mechanized coal mining working face显示文摘Based on the principle of fully mechanized backfilling and coal mining technology and combined with the Xingtai Coal Mine conditions,we mainly optimized the coal mining equipment and adjusted the coal mining method in the Xingtai Coal Mine 7606 working face for implementation this technology.Firstly,we define the practical backfilling process as the ''(from backfilling scraper conveyor's) head to tail backfilling,step by step swinging up of the tamping arm,gradual compacting,moving formed backfilling scraper conveyor when the second tamping arm cannot pass and connecting the immediate roof by back material push front material movement''.Meanwhile,the stress changes of backfill body in coal mined out area was monitored by stress sensors,and the roof caving law was analyzed by monitoring the dynamic subsidence of à210 west roadway of this face.The site tests results show that using this new backfilling and coal mining integrated technology,the production capacity in the 7606 working face can reach to 283,000 ton a year,and 282,000 ton of solid materials(waste and fly ash) is backfilled,which meets the needs of high production and efficiency.The goaf was compactly backfilled with solid material and the strata behavior was quite desirable,with an actual maximum vertical stress of the backfill body of 5.5 MPa.Backfill body control the movement of overburden within a certain range,and there is no collapses of major areas in the overlying strata upon backfilled gob.The maximum subsidence and speed were 231 mm and 15.75 mm/d respectively,which proved the practical significance of this integrated technology. | Zhang Qiang Zhang Jixiong Huang Yanli Ju Feng | 2012 | International Journal of Mining Science and Technology2012，22，2： | 55 |
| 2 | Alpine wetlands in the Lhasa River Basin, China显示文摘拉萨河盆是西藏的高原上的高山的沼泽地的典型分发区域之一。为监视,保护和利用得到背景的更好的理解和高山的沼泽地的特征是很重要的。在盆的沼泽地建设和分发包括域调查数据, CBERS 遥感数据和 3S 技术提供的另外的题目的数据基于多来源数据被分析。结果是(1 ) 沼泽地的全部的区域是 209,322.26 hm2,为盆的 6.37% 全部的陆地区域的财务。沼泽地被自然沼泽地主要统治,与仅仅占据 1.09% 沼泽地区域的人工的沼泽地;沼泽地沼泽地是自然沼泽地的主要部分,由 Kobresia littledalei 统治了在河来源区域分布式的沼泽的草地并且 Chali, Damshung 和 Medro 在上游 Gongkar 县。在不同的县的沼泽地的比率和类型显著地不同,它在 Chali 和 Damshung 县(为 62% 全部的沼泽地区域的财务) 是广泛地分布式的。(2 ) 沼泽地的集中的垂直分发在 36005100 m 的举起。沼泽地广泛地从河来源在整个 Yarlung Zangbo 河山谷被散布到河嘴进 Yarlung Zangbo 河。沼泽地沼泽地在来源区域是主导的并且河在上游与湖的马赛克分发, Kobresia littledalei 和 Carex moorcroftii 沼泽的草地,灌木状的沼泽地和河;至于中间下面流,主要类型是河沼泽地并且充满沼泽地。分发在河,小而淡的 Kobresia 和 Carex moorcroftii 的一个马赛克模式沼泽的草地, Phragmites 南极光和辅助的草沼泽地,充满的沼泽地和人工的沼泽地。 | ZHANG Yili WANG Chunlian BAI Wanqi WANG Zhaofeng TU Yanli YANGJAEN Dor Gka | 2010 | Journal of Geographical Sciences2010，20，3： | 32 |
| 3 | Strata movement controlling effect of waste and fly ash backfillings in fully mechanized coal mining with backfilling face显示文摘A fully mechanized coal mining with backfilling (FMCMB) provides advantages of safety and efficiency for coal mining under buildings, railways, and water bodies. According to the field geological conditions, we analyzed the controlling effect of strata movement by the waste and fly ash backfilling in FMCMB face. Based on the key strata theory, we established the equivalent mining thickness model, and analyzed the action of the bulk factor of backfilling body to the equivalent mining thickness. In addition, we numerically simulated the controlling function of the strata movement by backfilling bodies with differ- ent strength. And the numerical simulation result show that the deformation of stratum and the subsi- dence of surface can be controlled by FMCMB. The result provides references to the effective execution of fully mechanized coal mining with solid waste backfilling in goaf. | Zhang Jixiong Zhang Qiang Huang Yanli Liu Jinwei Zhou Nan Zan Dongfeng | 2011 | Mining Science and Technology2011，21，5： | 27 |
| 4 | Molecular Epidemiological Analysis of Echovirus 19 Isolated From an Outbreak Associated With Hand, Foot, and Mouth Disease (HFMD) in Shandong Province of China显示文摘Objective To elucidate the genetic characterization and molecular epidemiological features of Echovirus 19(E19)isolates collected from an outbreak associated with hand,foot and mouth disease(HFMD)in Tai'an city of Shandong Province of China from July to September,2003.Methods Thirty seven Echovirus 19 isolates were isolated from stool specimens and throat swabs collected during the outbreak,then major capsid(VP1)genomic sequence was determined,and phylogenetic tree was done based on the VP1 sequences among these 37 and other E19 viruses deposited in the Genbank.Also a representative strain named CHN-SD03-TN12 was selected for sequencing of 5'-untranslated regions(5'-UTR).Results The identity rate was about 98.9%-100% among all these 37 E19 viruses.The genetic relationships between these 37 E19 isolates and other strains reported were also depicted.The identity rate was about 78.4%-78.9% compared with E19 reference strain Burke.The substitutions in the sequence of 5'-UTR resulted in changes in the conjectural properties of 5'-UTR of E19 viruses.Conclusion The genetic features of E19 viruses isolated during the outbreak in Shandong Province in 2003 may be associated with a genetic and antigenic drift that changes the virulence of the Shandong isolates,but the molecular changes in Shandong E19 viruses contributing to their phenotype remain to be further illuminated.However,the sequences described in this paper substantiate the changes taken place in capsid VP1 and 5'UTR regions.These substitutions may contribute to their tropism and virulence,and play a significant role in pathogenesis and clinical manifestations of the disease. | ZHEN ZHU WEN-BO XU AI-QIANG XU HAI-YAN WANG YONG ZHANG LI-ZHI SONG Hui-LiYANG YANLI FENGJI | 2007 | Biomedical and Environmental Sciences2007，20，4： | 22 |
| 5 | An investigation of surface deformation after fully mechanized,solid back fill mining显示文摘The surface deformation after fully mechanized back filling mining was analyzed.The surface deformation for different backfill materials was predicted by an equivalent mining height model and numerical simulations.The results suggest that:(1) As the elastic modulus,E,of the backfill material increases the surface subsidence decreases.The rate of subsidence decrease drops after E is larger than 5 GPa;(2) Fully mechanized back fill mining technology can effectively control surface deformation.The resulting surface deformation is within the specification grade I,which means surface maintenance is not needed.A site survey showed that the equivalent mining height model is capable of predicting and analyzing surface deformation and that the model is conservative enough for engineering safety.Finally,the significance of establishing a complete error correction system based on error analysis and correction is discussed. | Li Jian Zhang Jixiong Huang Yanli Zhang Qiang Xu Junming | 2012 | International Journal of Mining Science and Technology2012，22，4： | 23 |
| 6 | Plant-derived phosphocholine facilitates cellular uptake of anti-pulmonary fibrotic HJT-sRNA-m7显示文摘Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RNA, HJT-sRNA-m7, from a Chinese herbal medicine Hong Jing Tian(HJT, RHODIOHAE CRENULATAE RADIX ET RHIZOMA, Rhodiola crenulata) can effectively reduce the expressions of fibrotic hallmark genes and proteins both in alveolar in vitro and in mouse lung tissues in vivo. We also discovered over one hundred oil-soluble chemicals from HJT decoctions, most of which are found in lipid extracts from other Chinese herbals decoctions, including Pu Gong Ying(PGY, TARAXACI HERBA, Taraxacum mongolicum), Chuan Xin Lian(CXL, changed to 'ANDROGRAPHIS HERBA, Andrographis paniculata'), and Jin Yin Hua(JYH, lonicera japonica or Honeysuckle). We identified the active component in these decoctions as two forms of phosphocholines, PC(18:0/18:2) and PC(16:0/18:2). These PCs potentially could form liposomes with small RNAs to enter human alveolar and gastric cells. Our experimental results suggest an unprecendent lipid complex route through which botanic small RNA can enter human bodies.Our results provide an innovative treatment strategy for oral delivery of siRNAs as therapeutic medication. | Jianchao Du Zhu Liang Jiantao Xu Yan Zhao Xiaoyun Li Yanli Zhang DANDan Zhao Ruxuan Chen Yang Liu Trupti Joshi Jiahui Chang Zhiqing Wang Yanxu Zhang Jindong Zhu Qiang Liu Dong Xu Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 21 |
| 7 | Flavonoid profiling of a traditional Chinese medicine formula of Huangqin Tang using high performance liquid chromatography显示文摘The quality control processes for herbal medicines have been problematic. Flavonoids are the major active components of Huangqin Tang(HQT, a traditional Chinese medicine formula). In this study, we used a combinative method approach consisting of chromatographic fingerprinting(high performance liquid chromatography; HPLC), quantitative methods and a pharmacodynamic evaluation model to analyze the flavonoids of HQT obtained from different sources. Ten batches of HQT were analyzed by the HPLC fingerprinting method and 26 common peaks were detected, of which 23 peaks corresponded with the chemical profile of HQT. In addition, 11 major compounds were identified by LC–MS analysis(liquid chromatography–tandem mass spectrometer; LC–MS^n) and quantified by the HPLC quantitative method approach. The studied10 batches of HQT were found to be homogeneous in their composition with a similarity between 0.990 and1.000. The distribution of the 11 identified compounds was found to be very similar among the batches. Only slight pharmacodynamic differences were detected between the different batches, confirming the homogeneity of HQT. The results of this study prove that the combination of chromatographic fingerprinting and quantitative analysis can be readily used for comprehensive quality control of herbal medicines. | Tao Li Shuaixing Zhuang Yiwei Wang Yanli Wang Weihao Wang Huihui Zhang Li Chen Dunfang Wang Zhongming Zhou Weipeng Yang | 2016 | Acta Pharmaceutica Sinica B2016，6，2： | 19 |
| 8 | Characteristics of atmospheric single particles during haze periods in a typical urban area of Beijing:A case study in October,2014显示文摘To investigate the composition and possible sources of particles, especially during heavy haze pollution, a single particle aerosol mass spectrometer(SPAMS) was deployed to measure the changes of single particle species and sizes during October of 2014, in Beijing. A total of 2,871,431 particles with both positive and negative spectra were collected and characterized in combination with the adaptive resonance theory neural network algorithm(ART-2a). Eight types of particles were classified: dust particles(dust, 8.1%), elemental carbon(EC, 29.0%), organic carbon(OC, 18.0%), EC and OC combined particles(ECOC, 9.5%),Na-K containing particles(Na K, 7.9%), K-containing particles(K, 21.8%), organic nitrogen and potassium containing particles(KCN, 2.3%), and metal-containing particles(metal,3.6%). Three haze pollution events(P1, P2, P3) and one clean period(clean) were analyzed,based on the mass and number concentration of PM_(2.5)and the back trajectory results from the hybrid single particle Lagrangian integrated trajectory model(Hysplit-4 model). Results showed that EC, OC and K were the major components of single particles during the three haze pollution periods, which showed clearly increased ratios compared with those in the clean period. Results from the mixing state of secondary species of different types of particles showed that sulfate and nitrate were more readily mixed with carbon-containing particles during haze pollution episodes than in clean periods. | Lang Liu Yanli Wang Shiyong Du Wenjie Zhang Lujian Hou Sverre Vedal Bin Han Wen Yang Mindong Chen Zhipeng Bai | 2016 | Journal of Environmental Sciences2016，28，2： | 19 |
| 9 | Changes in visibility with PM_(2.5) composition and relative humidity at a background site in the Pearl River Delta region显示文摘In fall–winter, 2007–2013, visibility and light scattering coefficients(b sp) were measured along with PM_(2.5)mass concentrations and chemical compositions at a background site in the Pearl River Delta(PRD) region. The daily average visibility increased significantly(p < 0.01) at a rate of 1.1 km/year, yet its median stabilized at ~13 km. No haze days occurred when the 24-hr mean PM_(2.5)mass concentration was below 75 μg/m^3. By multiple linear regression on the chemical budget of particle scattering coefficient(b sp), we obtained site-specific mass scattering efficiency(MSE) values of 6.5 ± 0.2, 2.6 ± 0.3, 2.4 ± 0.7 and 7.3 ± 1.2 m2/g,respectively, for organic matter(OM), ammonium sulfate(AS), ammonium nitrate(AN) and sea salt(SS). The reconstructed light extinction coefficient(b ext) based on the Interagency Monitoring of Protected Visual Environments(IMPROVE) algorithm with our site-specific MSE revealed that OM, AS, AN, SS and light-absorbing carbon(LAC) on average contributed 45.9% ± 1.6%,25.6% ± 1.2%, 12.0% ± 0.7%, 11.2% ± 0.9% and 5.4% ± 0.3% to light extinction, respectively.Averaged b ext displayed a significant reduction rate of 14.1/Mm·year(p < 0.05); this rate would be 82% higher if it were not counteracted by increasing relative humidity(RH) and hygroscopic growth factor(f(RH)) at rates of 2.5% and 0.16/year-1(p < 0.01), respectively, during the fall–winter, 2007–2013. This growth of RH and f(RH) partly offsets the positive effects of lowered AS in improving visibility, and aggravated the negative effects of increasing AN to impair visibility. | Xiaoxin Fu Xinming Wang Qihou Hu Guanghui Li Xiang Ding Yanli Zhang Quanfu He Tengyu Liu Zhou Zhang Qingqing Yu Ruqing Shen Xinhui Bi | 2016 | Journal of Environmental Sciences2016，28，2： | 18 |
| 10 | Influence of Gd_2O_3 and Yb_2O_3 Co-doping on Phase Stability,Thermo-physical Properties and Sintering of 8YSZ显示文摘The role of multicomponent rare earth oxides in phase stability, thermophysical properties and sintering for ZrO2-based thermal barrier coatings (TBCs) materials is investigated. 8YSZ codoped with 3 mol% Gd2O3 and 3 mol% Yb2O3 (GYb-YSZ) powders are synthesized by solid state reaction for 24 h at various temperatures. As temperature increases, stabilizers are dissolved into zirconia matrix gradually. Synthesized at 1 500 °C, GYb-YSZ is basically composed of cubic phase. GYb-YSZ exhibits excellent phase stability and sinters lower than 8YSZ by nearly three times. The thermal conductivity of GYb-YSZ is much lower than that of 8YSZ, and the thermal expansion coefficient of GYb-YSZ is comparable to that of 8YSZ. The influence of Gd2O3 and Yb2O3 co-doping on phase stability, thermal conductivity and sintering of 8YSZ is discussed. | ZHANG Yanli GUO Lei YANG Yongping GUO Hongbo ZHANG Hongju GONG Shengkai | 2012 | Chinese Journal of Aeronautics2012，25，6： | 17 |
| 11 | SUMO E3 Ligase AtMMS21 Regulates Drought Tolerance in Arabidopsis thaliana显示文摘Post-translational modifications of proteins by small ubiquitin-like modifiers (SUMOs) play crucial roles in plant growth and development, and in stress responses. The MMS21 is a newly-identified Arabidopsis thaliana L. SUMO E3 ligase gene aside from the SIZ1, and its function requires further elucidation. Here, we show that MMS21 deficient plants display improved drought tolerance, and constitutive expression of MMS21 reduces drought tolerance. The expression of MMS21 was reduced by abscisic acid (ABA), polyethylene glycol (PEG) or drought stress. Under drought conditions, mms21 mutants showed the highest survival rate and the slowest water loss, and accumulated a higher level of free proline compared to wild-type (WT) and MMS21 over-expression plants. Stomatal aperture, seed germination and cotyledon greening analysis indicated that mms21 was hypersensitive to ABA. Molecular genetic analysis revealed that MMS21 deficiency led to elevated expression of a series of ABA-mediated stress-responsive genes, including COR15A, RD22, and P5CS1 The ABA and drought-induced stress-responsive genes, including RAB18, RD29A and RD29B, were inhibited by constitutive expression of MMS21. Moreover, ABA-induced accumulation of SUMO-protein conjugates was blocked in the mms21 mutant. We thus conclude that MMS21 plays a role in the drought stress response, likely through regulation of gene expression in an ABA-dependent pathway. | Shengchun Zhang Yanli Qi Ming Liu Chengwei Yang | 2013 | Journal of Integrative Plant Biology2013，55，1： | 17 |
| 12 | High-accuracy primary and transfer standards for radiometric calibration显示文摘The first research and experimental results obtained in China of high-accuracy radiometric calibration based on cryogenic radiometer are reported. Uncertainties of cryogenic radiometer and trap detectors at 7 wavelengths in the visible spectrum (488-786 nm) were less than 0.023% and 0.035% respectively, which proved the reasonability and possibility of establishing and transferring high-accuracy radiometric standards based on detectors. | Xiaobing Zheng Haoyu Wu Junping Zhang Yucheng Liu Wei Zhou Leyi Wang Yanli Qiao | 2000 | Chinese Science Bulletin2000，45，21： | 12 |
| 13 | Mantle plume activity and melting conditions: Evidence from olivines in picritic-komatiitic rocks from the Emeishan Large Igneous Province, southwestern China显示文摘 | Zhaochong Zhang Jingwen Mao Fusheng Wang Yanli Hao John J. Mahoney | 2005 | Episodes2005，28，3： | 10 |
| 14 | Effect of heat treatment on mechanical properties of heavily cold-rolled Fe-6.5wt%Si alloy sheet显示文摘Fe-6.5wt%Si alloy has excellent soft magnetic properties,but it is hard to be cold-rolled due to appearance of ordered phases in this alloy.In this paper we report that ultra thin Fe-6.5wt%Si sheet of 0.05 mm thick was obtained by heavily cold rolling.By means of optical microscope,micro-hardness indenter,instron,SEM and X-ray diffraction,the effect of heat treatment on mechanical properties of this alloy sheet was investigated.The heavily cold-rolled sheet exhibits some extent of ductility.The ultimate tensile strength reaches 1.93 GPa.After heat treatment,micro-hardness is decreased and the ductility is lost,especially at temperature above 650℃ when recrystallization takes place.The reason for decreasing the ductility lies in the ordered DO3 phase transformation. | LIANG YongFeng,YE Feng,LIN JunPin,WANG YanLi,ZHANG LaiQi & CHEN GuoLiang State Key Laboratory for Advanced Metals and Materials,University of Science and Technology Beijing,Beijing 100083,China | 2010 | Science China(Technological Sciences)2010，53，4： | 10 |
| 15 | Genetic Variation of the VP1 Gene of the Virulent Duck Hepatitis A Virus Type 1(DHAV-1) Isolates in Shandong Province of China显示文摘To investigate the relationship of the variation of virulence and the external capsid proteins of the pandemic duck hepatitis A virus type 1(DHAV-1) isolates,the virulence,cross neutralization assays and the complete sequence of the virion protein 1(VP1) gene of nine virulent DHAV-1 strains,which were isolated from infected ducklings with clinical symptoms in Shandong province of China in 2007-2008,were tested.The fifth generation duck embryo allantoic liquids of the 9 isolates were tested on 12-day-old duck embryos and on 7-day-old ducklings for the median embryonal lethal doses(ELD 50 s) and the median lethal doses(LD 50 s),respectively.The results showed that the ELD 50 s of embryonic duck eggs of the 9 DHAV-1 isolates were between 1.9 × 10 6 /mL to 1.44 × 10 7 /mL,while the LD 50 s were 2.39 × 10 5 /mL to 6.15 × 10 6 /mL.Cross-neutralization tests revealed that the 9 DHAV-1 isolates were completely neutralized by the standard serum and the hyperimmune sera against the 9 DHAV-1 isolates,respectively.Compared with other virulent,moderate virulent,attenuated vaccine and mild strains,the VP1 genes of the 9 strains shared 89.8%-99.7% similarity at the nucleotide level and 92.4%-99.6% at amino acid level with other DHAV-1 strains.There were three hypervariable regions at the C-terminus(aa 158-160,180-193 and 205-219) and other variable points in VP1 protein,but which didn't cause virulence of DHAV-1 change. | Jiming Gao Junhao Chen Xingkui Si Zhijing Xie Yanli Zhu Xingxiao Zhang Shujing Wang Shijin Jiang | 2012 | Virologica Sinica2012，27，4： | 10 |
| 16 | Wrist-ankle acupuncture and Fluoxetine in the treatment of post-stroke depression: a randomized controlled clinical trial显示文摘OBJECTIVE: To investigate the effects of WAA combined with fluoxetine in the clinical treatment of post-stroke depression(PSD).METHODS: In this randomized, controlled and single-blind trial, 105 PSD patients who met the inclusion criteria were randomly divided into three equal groups: Thin wrist-ankle acupuncture(WAA)group(Thin WAA needle + Fluoxetine), Thick WAA group(Thick WAA needle + Fluoxetine), and Sham WAA group(sham WAA needle + Fluoxetine). In this trial, the primary outcome was Hamilton Depression Scale(HAMD), while the secondary outcomes included Zung self-rating depression scale(SDS) and World Health Organization Quality of Life BREF(QQL).RESULTS: Ninety nine PSD patients completed all the treatment. The HAMD scores and SDS scores of all the three groups decreased after treatment(P <0.05);thick WAA group and thin WAA group decreased more obviously than the sham WAA group(P < 0.05). There was no significant difference between the QQL scores of the three groups(P >0.05). There was no significant difference in the scores of the three scales between the thick wrist ankle needles and the thin wrist ankle needles(P >0.05).CONCLUSION: The present study showed that WAA combined with fluoxetine can relieve the symptoms of depression after stroke. WAA therapy could improve the antidepressant effect of fluoxetine. | You Yanli Zhang Tianfang Shu Shi Qian Xiaolu Zhou Shuang Yao Fei | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 10 |
| 17 | Clinical applications of MARSALA for preimplantation genetic diagnosis of spinal muscular atrophy显示文摘Conventional PCR methods combined with linkage analysis based on short tandem repeats(STRs) or Karyomapping with single nucleotide polymorphism(SNP) arrays, have been applied to preimplantation genetic diagnosis(PGD) for spinal muscular atrophy(SMA), an autosome recessive disorder. However, it has limitations in SMA diagnosis by Karyomapping, and these methods are unable to distinguish wildtype embryos with carriers effectively. Mutated allele revealed by sequencing with aneuploidy and linkage analyses(MARSALA) is a new method allowing embryo selection by a one-step next-generation sequencing(NGS) procedure, which has been applied in PGD for both autosome dominant and X-linked diseases in our group previously. In this study, we carried out PGD based on MARSALA for two carrier families with SMA affected children. As a result, one of the couples has given birth to a healthy baby free of mutations in SMA-causing gene. It is the first time that MARSALA was applied to PGD for SMA, and we can distinguish the embryos with heterozygous deletion(carriers) from the wild-type(normal) ones accurately through this NGS-based method. In addition, direct mutation detection allows us to identify the affected embryos(homozygous deletion), which can be regarded as probands for linkage analysis, in case that the affected family member is absent. In the future, the NGS-based MARSALA method is expected to be used in PGD for all monogenetic disorders with known pathogenic gene mutation. | Yixin Ren Xu Zhi Xiaohui Zhu Jin Huang Ying Lian Rong Li Hongyan Jin Yan Zhang Wenxin Zhang Yanli Nie Yuan Wei Zhaohui Liu Donghong Song Ping Liu Jie Qiao Liying Yan | 2016 | Journal of Genetics and Genomics2016，43，9： | 9 |
| 18 | Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites显示文摘 | Maolu Yin Jiuyu Wang Min Wang Xinmei Li Mo Zhang Qiang Wu Yanli Wang | 2017 | Cell Research2017，27，11： | 9 |
| 19 | Status and development of high-power laser facilities at the NLHPLP显示文摘In this paper, we review the status of the multifunctional experimental platform at the National Laboratory of High Power Laser and Physics(NLHPLP). The platform, including the SG-II laser facility, SG-II 9th beam, SG-II upgrade(SG-II UP) facility, and SG-II 5 PW facility, is operational and available for interested scientists studying inertial confinement fusion(ICF) and a broad range of high-energy-density physics. These facilities can provide important experimental capabilities by combining different pulse widths of nanosecond, picosecond, and femtosecond scales. In addition, the SG-II UP facility, consisting of a single petawatt system and an eight-beam nanosecond system, is introduced including several laser technologies that have been developed to ensure the performance of the facility. Recent developments of the SG-II 5 PW facility are also presented. | Jianqiang Zhu Jian Zhu Xuechun Li Baoqiang Zhu Weixin Ma Xingqiang Lu Wei Fan Zhigang Liu Shenlei Zhou Guang Xu Guowen Zhang Xinglong Xie Lin Yang Jiangfeng Wang Xiaoping Ouyang Li Wang Dawei Li Pengqian Yang Quantang Fan Mingying Sun Chong Liu Dean Liu Yanli Zhang Hua Tao Meizhi Sun Ping Zhu Bingyan Wang Zhaoyang Jiao Lei Ren Daizhong Liu Xiang Jiao Hongbiao Huang Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，4： | 8 |
| 20 | MiR-181a-5p inhibits cell proliferation and migration by targeting Kras in non-small cell lung cancer A549 cells显示文摘MicroRNAs 玩在 carcinogenesis 和肿瘤的重要角色进行。肺癌症是世界范围的癌症死亡的领先的原因。在这研究, miR-181a-5p 的功能在 non-small-cell 肺癌症(NSCLC ) 被调查。结果证明 miR-181a-5p 显著地在 NSCLC 纸巾和房间线被减少。有 miR-181a-5p 的 A549 房间 transfected 的增长和迁居模仿显著地被禁止。酶活动试金结果证明 Kras 的二个有约束力的地点能被 miR-181a-5p 直接指向。而且, Kras 由在 transcriptional 和翻译层次的 miR-181a-5p 是下面调整的。调停 SiRNA 的 Kras 下面规定能模仿 miR-181a-5p 的效果在 A549 模仿房间。我们的调查结果建议 miR-181a-5p 由部分指向 Kras 在肿瘤抑制起一个潜在的作用并且在 NSCLC 病人有潜在的治疗学的申请。 | Zhongliang Ma Xiang Qiu Detao Wang Yanli Li Bingjie Zhang Tianwei Yuan Jiali Wei Botao Zhao Xintai Zhao Jiatao LOU Yan Jin Youxin Jin | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
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