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| 1 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 2 | Improved Brassica rapa reference genome by single-molecule sequencing and chromosome conformation capture technologies显示文摘Brassica rapa comprises several important cultivated vegetables and oil crops.Current reference genome assemblies of Brassica rapa are quite fragmented and not highly contiguous,thereby limiting extensive genetic and genomic analyses.Here,we report an improved assembly of the B.rapa genome(v3.0)using single-molecule sequencing,optical mapping,and chromosome conformation capture technologies(Hi-C).Relative to the previous reference genomes,our assembly features a contig N50 size of 1.45 Mb,representing a~30-fold improvement.We also identified a new event that occurred in the B.rapa genome~1.2 million years ago,when a long terminal repeat retrotransposon(LTR-RT)expanded.Further analysis refined the relationship of genome blocks and accurately located the centromeres in the B.rapa genome.The B.rapa genome v3.0 will serve as an important community resource for future genetic and genomic studies in B.rapa.This resource will facilitate breeding efforts in B.rapa,as well as comparative genomic analysis with other Brassica species. | Lei Zhang Xu Cai Jian Wu Min Liu Stefan Grob Feng Cheng Jianli Liang Chengcheng Cai Zhiyuan Liu Bo Liu Fan Wang Song Li Fuyan Liu Xuming Li Lin Cheng Wencai Yang Mai-he Li Ueli Grossniklaus Hongkun Zheng Xiaowu Wang | 2018 | Horticulture Research2018，5，1： | 10 |
| 3 | High levels of circulating GM-CSF^(+) CD4^(+) T cells are predictive of poor outcomes in sepsis patients: a prospective cohort study显示文摘Granulocyte colony-stimulating factor(GM-CSF),produced by CD4^(+)T cells,has recently been implicated in the pathogenesis of inflammatory diseases,such as multiple sclerosis and juvenile arthritis.However,the role of GM-CSF-producing CD4^(+)T cells in sepsis remains unknown.This study reports peripheral changes in GM-CSF-producing CD4^(+)T cells in septic patients and the possible underlying mechanism by which GM-CSF influences the outcome of sepsis.Forty-three septic patients,20 SIRS patients,and 20 healthy controls were enrolled in this study and followed for 28 days to assess mortality.We measured the peripheral frequency of GM-CSF^(+)CD4^(+)T cells and recorded their associated relationship with disease progression.Our data demonstrated that peripheral GM-CSF-producing CD4^(+)T cells were significantly higher in septic patients than in both SIRS patients and healthy controls.These cells exhibit a memory phenotype and impaired IFN-γ-secreting capacity in sepsis patients.Using a receiver operating curve analysis with 8.01%as a cut-off point,the percentage of GM-CSF^(+)CD4^(+)T cells could predict the outcome of septic patients.Combined with the increase in GM-CSF-producing CD4^(+)T cells,inflammatory cytokines IL-1βand IL-6 were also upregulated.Using an in vitro neutrophil model,we found that GM-CSF inhibited C3aR expression,while inducing IL-8 production.Furthermore,this effect was transferrable in plasma from sepsis patients and was attenuated by inhibition of GM-CSF using an anti-GM-CSF antibody.These results indicate that GM-CSF-producing CD4^(+)T cells may serve as a marker of sepsis severity.Thus,targeting GM-CSF overproduction may benefit sepsis patients. | Huihuang Huang Siyu Wang Tianjun Jiang Rong Fan Zheng Zhang Jinsong Mu Ke Li Yonggang Wang Lei Jin Fang Lin Jie Xia Lijian Sun Biao Xu Chengcheng Ji Jing Chen Juan Chang Bo Tu Bing Song Chao Zhang Fu-Sheng Wang Ruonan Xu | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 4 | Two-step pyrolysis of ZIF-8 functionalized with ammonium ferric citrate for efficient oxygen reduction reaction显示文摘Zeolitic imidazolate frameworks(ZIFs) are widely employed in catalyst synthesis as parental materials for electrochemical energy storage and conversion. Herein, we have demonstrated a facile synthesis of highly efficient catalyst for oxygen reduction reaction in both alkaline and acidic medium, which is derived from ZIF-8 functionalized with ammonium ferric citrate via two-step pyrolysis in Ar and NH_3 atmosphere.The results reveal that the catalytic activity improvement after NH3 pyrolysis benefits from mesoporedominated morphology and high utilization of Fe-containing active sites. The optimum catalyst shows excellent performance in zinc-air battery and polymer electrolyte membrane fuel cell tests. | Yifan Ye Fan Cai Chengcheng Yan Yanshuo Li Guoxiong Wang Xinhe Bao | 2017 | Journal of Energy Chemistry2017，26，6： | 2 |
| 5 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 6 | Author Correction:Improved Brassica rapa reference genome by single-molecule sequencing and chromosome conformation capture technologies显示文摘Since the publication of this article,the authors have noticed that the total gene models(45,985),tandem arrays(2077),tandem genes(4963),redundancy removed(43,099),syntenic genes(39,858),nonsyntenic genes(3241),genes on chromosomes(45,411),genes on scaffolds(574)of B.rapa reference genome v3.0 were mistaken in the article. | Lei Zhang Xu Cai Jian Wu Min Liu Stefan Grob Feng Cheng Jianli Liang Chengcheng Cai Zhiyuan Liu Bo Liu Fan Wang Song Li Fuyan Liu Xuming Li Lin Cheng Wencai Yang Mai-he Li Ueli Grossniklaus Hongkun Zheng Xiaowu Wang | 2019 | Horticulture Research2019，6，1： | 2 |
| 7 | The Solar Upper Transition Region Imager(SUTRI)Onboard the SATech-01 Satellite显示文摘The Solar Upper Transition Region Imager(SUTRI)onboard the Space Advanced Technology demonstration satellite(SATech-01),which was launched to a Sun-synchronous orbit at a height of~500 km in 2022 July,aims to test the on-orbit performance of our newly developed Sc/Si multi-layer reflecting mirror and the 2k×2k EUV CMOS imaging camera and to take full-disk solar images at the Ne VII 46.5 nm spectral line with a filter width of~3 nm.SUTRI employs a Ritchey-Chrétien optical system with an aperture of 18 cm.The on-orbit observations show that SUTRI images have a field of view of~416×416 and a moderate spatial resolution of~8″without an image stabilization system.The normal cadence of SUTRI images is 30 s and the solar observation time is about16 hr each day because the earth eclipse time accounts for about 1/3 of SATech-01's orbit period.Approximately15 GB data is acquired each day and made available online after processing.SUTRI images are valuable as the Ne VII 46.5 nm line is formed at a temperature regime of~0.5 MK in the solar atmosphere,which has rarely been sampled by existing solar imagers.SUTRI observations will establish connections between structures in the lower solar atmosphere and corona,and advance our understanding of various types of solar activity such as flares,filament eruptions,coronal jets and coronal mass ejections. | Xianyong Bai Hui Tian Yuanyong Deng Zhanshan Wang Jianfeng Yang Xiaofeng Zhang Yonghe Zhang Runze Qi Nange Wang Yang Gao Jun Yu Chunling He Zhengxiang Shen Lun Shen Song Guo Zhenyong Hou Kaifan Ji Xingzi Bi Wei Duan Xiao Yang Jiaben Lin Ziyao Hu Qian Song Zihao Yang Yajie Chen Weidong Qiao Wei Ge Fu Li Lei Jin Jiawei He Xiaobo Chen Xiaocheng Zhu Junwang He Qi Shi Liu Liu Jinsong Li Dongxiao Xu Rui Liu Taijie Li Zhenggong Feng Yamin Wang Chengcheng Fan Shuo Liu Sifan Guo Zheng Sun Yuchuan Wu Haiyu Li Qi Yang Yuyang Ye Weichen Gu Jiali Wu Zhe Zhang Yue Yu Zeyi Ye Pengfeng Sheng Yifan Wang Wenbin Li Qiushi Huang Zhong Zhang | 2023 | Research in Astronomy and Astrophysics2023，23，6： | 1 |
| 8 | Plasma Mutation Breeding of High Yield γ-Aminobutyric Acid Lactic Acid Bacteria显示文摘γ-amino butyric acid (GABA) is a non-protein amino acid widely distributed in nature. It has analgesic effect, promotes growth hormone secretion and prevents the physiological function of Alzheimer's disease.In order to improve the yield of GABA, the strain of strain HX-3-6 was tested by Atmospheric and Room Temperature Plasma (ARTP), and the strain with more than 90% lethality was selected for fermentation, and through the gradient plate according to the level of GABA concentration and colony size of the screening. Then, use the fermentation medium for re-screening and genetic stability test. The yield of the mutant strain L-120-1 was 5.828 g/L, which was 18.84% higher than that before the mutation (4.904). The mutant strain L-120-1 was used as the starting strain for ARTP mutagenesis. The yield of the stable mutant strain 90s-high was 6.178g / L, which was 16.15% higher than that before the mutation (5.319g / L). The yield of HX-3-6 strain was higher than that of GABA mutant strain 90s-high 2, which was stable and high yield GABA was 25.98%. | Chengcheng Gao Fan Yang Yao Liu | 2017 | Gene Science & Engineering2017，1，1： | 1 |
| 9 | Long noncoding RNA(lncRNA)H19:An essential developmental regulator with expanding roles in cancer,stem cell differentiation,and metabolic diseases显示文摘Recent advances in deep sequencing technologies have revealed that,while less than 2%of the human genome is transcribed into mRNA for protein synthesis,over 80%of the genome is transcribed,leading to the production of large amounts of noncoding RNAs(ncRNAs).It has been shown that ncRNAs,especially long non-coding RNAs(lncRNAs),may play crucial regulatory roles in gene expression.As one of the first isolated and reported lncRNAs,H19 has gained much attention due to its essential roles in regulating many physiological and/or pathological processes including embryogenesis,development,tumorigenesis,osteogen-esis,and metabolism.Mechanistically,H19 mediates diverse regulatory functions by serving as competing endogenous RNAs(CeRNAs),Igf2/H19 imprinted tandem gene,modular scaffold,cooperating with H19 antisense,and acting directly with other mRNAs or lncRNAs.Here,we summarized the current understanding of H19 in embryogenesis and development,cancer development and progression,mesenchymal stem cell lineage-specific differentiation,and metabolic diseases.We discussed the potential regulatory mechanisms underlying H19’s func-tions in those processes although more in-depth studies are warranted to delineate the exact molecular,cellular,epigenetic,and genomic regulatory mechanisms underlying the physiolog-ical and pathological roles of H19.Ultimately,these lines of investigation may lead to the development of novel therapeutics for human diseases by exploiting H19 functions. | Junyi Liao Bowen Chen Zhenglin Zhu Chengcheng Du Shengqiang Gao Guozhi Zhao Piao Zhao Yonghui Wang Annie Wang Zander Schwartz Lily Song Jeffrey Hong William Wagstaff Rex CHaydon Hue HLuu Jiaming Fan Russell RReid Tong-Chuan He Lewis Shi Ning Hu Wei Huang | 2023 | Genes & Diseases2023，10，4： | 1 |
| 10 | TPE based aggregation induced emission fluorescent sensors for viscosity of liquid and mechanical properties of hydrogel显示文摘Two amphiphilic TPE E/Z isomers with aggregation induced emission(AIE)property have been synthesized and characterized.The logarithmic fluorescent intensity of the two molecules was in positive relationship with logarithmic viscosity of liquid.To note,the Z-TPE isomer exhibited more sensitivity in the viscosity of liquid sensing in comparison with the corresponding E-TPE counterpart(around 1.80 folds).Furthermore,two molecules could be used as fluorescent sensors for mechanical properties(viscosity and storage modulus)of hydrogel as well.In addition,two sensors displayed low cytotoxicity in normal tissue cell line(L929)within the concentration range of 2–10μmol/L.These results potentially promised their applications as fluorescent sensors for mechanical properties in the fields of biological and biomedical. | Na Wang Hang Yao Qi Tao Jing Sun Hao Ma Yang Wang ChengCheng Zhou Hongying Fan Hongxia Shao Aijian Qin Dawei Su Chenyin Wang Hui Chong | 2022 | Chinese Chemical Letters2022，33，1： | 1 |
| 11 | Circulating cell-free DNA for cancer early detection显示文摘Effective screening modalities are currently available for only a small subset of cancers,and they generally have suboptimal performance with complicated procedures.Therefore,there is an urgent need to develop simple,accurate,and non-invasive methods for early detection of cancers.Genetic and epigenetic alterations in plasma circulating cell-free DNA(cfDNA)have shown the potential to revolutionize methods of early detection of cancers and facilitate subsequent diagnosis to improve survival of patients.The medical interest in cfDNA assays has been inspired by emerging single-and multi-early detection of cancers studies.This review summarizes current technological and clinical advances,in the hopes of providing insights into the development and applications of cfDNA assays in various cancers and clinical scenarios.The key phases of clinical development of biomarkers are highlighted,and the future developments of cfDNA-based liquid biopsies in early detection of cancers are outlined.It is hoped that this study can boost the potential integration of cfDNA-based early detection of cancers into the current clinical workflow. | Qiang Gao Qiang Zeng Zhijie Wang Chengcheng Li Yu Xu Peng Cui Xin Zhu Huafei Lu Guoqiang Wang Shangli Cai Jie Wang Jia Fan | 2022 | The Innovation2022，3，4： | 1 |
| 12 | Design Optimization of Ocean Thermal Energy Conversion(OTEC)Considering the Off-Design Condition显示文摘The comprehensive optimization of thermodynamic and economic performances is significant for the engineering application of ocean thermal energy conversion(OTEC).Motivated by this,this paper develops a thermo-economic OTEC model and conducts a sensitivity analysis of the OTEC system concerning its thermodynamic and economic performances.Specifically,the impact of warm-seawater temperature and cold-seawater pumping depth on the net thermal efficiency and the total investment cost are investigated.The results indicate that,an increase in warm-seawater temperature and cold-seawater pumping depth can improve the net thermal efficiency and a higher installed capacity is beneficial to the system economics.Building on these,a design optimization method with considering the on-design and off-design conditions is proposed in this paper,and the dynamic variation of warm-seawater temperature are considered in this method.In multi-objective optimization procedure,with the objective functions being the average net thermal efficiency and unit power cost within the operational cycle,the non-dominated sorting genetic algorithm Ⅱ(NSGA-Ⅱ) is employed to maximize the net thermal efficiency and minimize the unit power investment cost,resulting in the Pareto front.The net thermal efficiencies of OTEC systems using ammonia and R245fa as working fluids are 4.13% and 3.8%,respectively.This represents an improvement of 19.4% and 57.0%,respectively,compared to traditional optimization methods that do not account for off-design conditions. | FAN Chengcheng CHEN Yongping | 2023 | Journal of Thermal Science2023，32，6： | 0 |
| 13 | A parallel data generator for efficiently generating “realistic” social streams显示文摘A social stream refers to the data stream that records a series of social entities and the dynamic interac-tions between two entities. It can be employed to model the changes of entity states in numerous applications. The social streams, the combination of graph and streaming data, pose great challenge to efficient analytical query processing, and are key to better understanding users' behavior. Considering of privacy and other related issues, a social stream genera-tor is of great significance. A framework of synthetic social stream generator (SSG) is proposed in this paper. The gener-ated social streams using SSG can be tuned to capture sev-eral kinds of fundamental social stream properties, includ-ing patterns about users' behavior and graph patterns. Ex-tensive empirical studies with several real-life social stream data sets show that SSG can produce data that better fit to real data. It is also confirmed that SSG can generate social stream data continuously with stable throughput and memory consumption. Furthermore, we propose a parallel implemen-tation of SSG with the help of asynchronized parallel pro-cessing model and delayed update strategy. Our experiments verify that the throughput of the parallel implementation can increase linearly by increasing nodes. | Chengcheng YU Fan XIA Weining QIAN Aoying ZHOU | 2019 | Frontiers of Computer Science2019，13，5： | 0 |
| 14 | Optimization method to obtain appropriate spacing parameters for crop cultivation显示文摘Considering the time-consuming and tedious work of the current methods to control plant layout,which is mostly based on expert experience or field trials,we propose an algorithm to optimize and simulate a planting layout based on a virtual plant model and an optimization algorithm.A functional-structural plant model,which combines the structure and physiological function of plants,is used to construct a planting scene.The planting and row spacing are set as the genetic factors and the chromosomes of the genetic algorithm are encoded with a binary method.The photosynthetic yield of the unit planting area is denoted as the fitness value.By using this method,the intercropping of maize and soybean plants and the sole cropping of rice plants are studied.Experimental results show that the proposed method can obtain a high yield planting plan. | Weilong Ding Chengcheng Fan Lifeng Xu Tao Xie Yang Liu Zangxin Wan Nelson Max | 2020 | International Journal of Agricultural and Biological Engineering2020，13，1： | 0 |
| 15 | Generation of multi-gene knockout rabbits using the Cas9/gRNA system显示文摘The prokaryotic clustered regularly interspaced short palindromic repeat(CRISPR)-associated system(Cas)is a simple,robust and efficient technique for gene targeting in model organisms such as zebrafish,mice and rats.In this report,we applied CRISPR technology to rabbits by microinjection of Cas9 mRNA and guided RNA(gRNA)into the cytoplasm of pronuclear-stage embryos.We achieved biallelic gene knockout(KO)rabbits by injection of 1 gene(IL2rg)or 2 gene(IL2rg and RAG1)Cas9 mRNA and gRNA with an efficiency of 100%.We also tested the efficiency of multiple gene KOs in early rabbit embryos and found that the efficiency of simultaneous gene mutation on target sites is as high as 100%for 3 genes(IL2rg,RAG1 and RAG2)and 33.3%for 5 genes(IL2rg,RAG1,RAG2,TIKI1 and ALB).Our results demonstrate that the Cas9/gRNA system is a highly efficient and fast tool not only for single-gene editing but also for multi-gene editing in rabbits. | Quanmei Yan Quanjun Zhang Huaqiang Yang Qingjian Zou Chengcheng Tang Nana Fan Liangxue Lai | 2014 | Cell Regeneration2014，3，1： | 0 |
| 16 | Generation of pigs with humanized type Ⅱ collagen by precise human COL2A1 gene knock-in显示文摘Osteoarthritis(OA)is the most common chronic disease,characterized by progressive cartilage breakdown,subchondral bone sclerosis,and aberrant bone outgrowth(Yucesoy et al.,2015;Hussain et al.,2016).OA is one of the leading causes of cartilage damage.Patients with severe cartilage damage require transplantation of articular cartilage to improve their quality of life.Type Ⅱ collagen is a major component of articular cartilage and intervertebral discs and plays an important role in the structure and strength of connective tissues that support muscles and joints(Byers,1994). | Ting Lan Yuling Zheng Yangyang Suo Yuhui Wei Hui Shi Quanmei Yan Zhenpeng Zhuang Huangyao Chen Quanjun Zhang Nana Fan Yu Zhao Zhen Ouyang Chengdan Lai Zhaoming Liu Jizeng Zhou Chengcheng Tang Nam-Hyung Kim Qingjian Zou Xiaomin Wang | 2023 | Journal of Genetics and Genomics2023，50，3： | 0 |
| 17 | Space advanced technology demonstration satellite显示文摘The Space Advanced Technology demonstration satellite(SATech-01),a mission for low-cost space science and new technology experiments,organized by Chinese Academy of Sciences(CAS),was successfully launched into a Sun-synchronous orbit at an altitude of~500 km on July 27,2022,from the Jiuquan Satellite Launch Centre.Serving as an experimental platform for space science exploration and the demonstration of advanced common technologies in orbit,SATech-01 is equipped with 16 experimental payloads,including the solar upper transition region imager(SUTRI),the lobster eye imager for astronomy(LEIA),the high energy burst searcher(HEBS),and a High Precision Magnetic Field Measurement System based on a CPT Magnetometer(CPT).It also incorporates an imager with freeform optics,an integrated thermal imaging sensor,and a multi-functional integrated imager,etc.This paper provides an overview of SATech-01,including a technical description of the satellite and its scientific payloads,along with their on-orbit performance. | ZHANG XiaoFeng CHEN Wen ZHU XiaoCheng MENG Na HE JunWang BI XingZi ZHANG YongHe SHI Qi LI Fei LIU Rui FENG ZhengGong LIU Liu LI JinSong WU HaiChen XU DongXiao LI TaiJie HUANG JiangJiang LIU Shuo LI TianTong YU XianSheng GAO Yang ZHOU Heng BAN HanYu ZHANG YanLi ZHANG YueTing YANG YingQuan HE Tao DUAN XuLiang CHEN Xin WANG YaMin SUN AnTai ZHANG KuoXiang SUN Ying WANG YaoBin FAN ChengCheng XIONG ShaoLin LI XinQiao WEN XiangYang LING ZhiXing SUN XiaoJin ZHANG Chen BAI XianYong WANG ZhanShan DENG YuanYong TIAN Hui YANG JianFeng XUE HongBo SANG Peng LIU JinGuo ZHENG HuiLong ZHU Xiang HE JianWu LI Hui XU LuXiang XU ShuYan CHEN WenWu LIU ZhenDong WANG ZhaoLi MAO XiangLong GAO Rong LI ZongXuan DING GuoPeng WANG XinYu DOU RunJiang WENG LuBin LUO Hao WANG YaPing LIANG XianFeng FANG ZiRuo | 2024 | Science China(Technological Sciences)2024，67，1： | 0 |
| 18 | Parallel numerical simulation on CO2 geologic storage in Ordos Basin, China显示文摘The authors developed a 3-D numerical injection model on parallel TOUGH2-FLAC3 D based on the site-specific stratigraphic information in Ordos Basin to simulate the Shenhua CO_2 geological storage( CGS)demonstration project injection process for three years and forecast CO_2 migration and layers displacement after injection for seven years. The results suggested that CO_2 migration did not stop after three years of consecutive injection,but migration rate was slowing down with time. As a result,displacement near injection well increased with injection and decreased slowly after injection. The maximum displacement of surface center occurred near the end of injection,which was only 1. 24 cm. According to the displacement result,it is safe to continue injecting for this project. | LEI Honglei ZHANG Yanjun WU Fan HU Zhongjun YU Ziwang ZHU Chengcheng LU Tianqi | 2017 | Global Geology2017，20，3： | 0 |
| 19 | Design Optimization of a Novel Axial-radial Flux Permanent Magnet Claw Pole Machine with SMC Cores and Ferrite Magnets显示文摘Soft magnetic composite(SMC)material is an ideal soft magnetic material employed for developing 3D magnetic flux electromagnetic equipment,due to its advantages of 3D magnetic isotropy characteristic,low eddy current loss,and simple manufacturing process.The permanent magnet claw pole machine(PMCPM)with SMC cores is a good case that the SMC to be adopted for developing 3D flux electrical machines.In this paper,a novel axial-radial flux permanent magnet claw pole machine(ARPMCPM)with SMC cores and ferrite magnets is proposed.Compared with the traditional PMCPM,the proposed ARPMCPM is designed with only one spoke PM rotor and its whole structure is quite compact.For the performance prediction,the 3D finite element method(FEM)is used.Meanwhile,for the performance evaluation,a previously developed axial flux claw pole permanent magnet machine(AFCPM)is employed as the benchmark machine and all these machines are optimized by using the combined multilevel robust Taguchi method.It can be seen that the proposed ARPMCPM is with higher torque/weight density and operation efficiency. | Chengcheng Liu Fan Yang Wenfeng Zhang Youhua Wang | 2023 | CES Transactions on Electrical Machines and Systems2023，7，4： | 0 |
| 20 | Improving the initialization speed for long-range NRTK in network solution mode显示文摘Initialization speed is one of the most important factors in network real time kinematic(NRTK)performance.Owing to the low correlation among the error sources of reference stations,it is difficult to fix reference station ambiguities of long-range NRTK quickly.In traditional reference stations ambiguity resolution(AR)methods,baselines are usually solved independently which is called baseline solution(BS)mode in this study.Because the correlations among baselines are not taken into consideration in ambiguities estimation,the AR speed is slow.Generally,tens of minutes or longer time is required to initialize.We propose a network solution(NS)mode approach,in which the correlations among the double-difference ambiguities(DDAs)as well as double-difference ionospheric delays(DDIDs)of different baselines are considered in estimating float ambiguity solutions.Experimental results show that the float ambiguity solutions obtained are more accurate with an improved consistency.Thus,initialization speed is significantly increased by 18%in NS mode. | ZHANG Ming LÜJinHu BAI ZhengDong LIU Hui FAN ChengCheng | 2020 | Science China(Technological Sciences)2020，63，5： | 0 |
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