|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Epidermal growth factor receptor and K-Ras in non-small cell lung cancer-molecular pathways involved and targeted therapies显示文摘Lung cancer is currently the leading cause of cancer death in Western nations.Non-small cell lung cancer(NSCLC)represents 80%of all lung cancers,and adenocarcinoma is the predominant histological type.Despite the intensive research carried out on this field and therapeutic advances,the overall prognosis of these patients remains unsatisfactory,with a 5-year overall survival rate of less than 15%.Nowadays,pharmacogenetics and pharmacogenomics represent the key to successful treatment.Recent studies suggest the existence of two distinct molecular pathways in the carcinogenesis of lung adenocarcinoma:one associated with smoking and activation of the K-Ras oncogene and the other not associated with smoking and activation of the epidermal growth factor receptor(EGFR).The K-ras mutation is mainly responsible for primary resistance to new molecules which inhibit tyrosine kinase EGFR(erlotinib and gefitinib)and most of the EGFR mutations are responsible for increased tumor sensitivity to these drugs.This article aims to conduct a systematic review of the literature regarding the molecular pathways involving the EGFR,K-Ras and EGFR targeted therapies in NSCLC tumor behavior. | Ramon Andrade de Mello Dania Sofia Marques Rui Medeiros António MF Araújo | 2011 | World Journal of Clinical Oncology2011，2，11： | 16 |
| 2 | The influence of the operational environment on the efficiency of water utilities 显示文摘 | Pedro Carvalho Rui Cunha Marques | 2011 | Journal of Environment Management2011，8，： | 1 |
| 3 | Modification of wheat straw lignin by solid state fermentation with white-rot fungi显示文摘 | Maria J. Dinis Rui M.F. Bezerra Fernando Nunes Albino A. Dias Cristina V. Guedes Luís M.M. Ferreira John W. Cone Guilhermina S.M. Marques Ana R.N. Barros Miguel A.M. Rodrigues | 2009 | Bioresource Technology2009，，20： | 1 |
| 4 | Photonic smart bandage for wound healing assessment显示文摘Chronic wounds affect around 2% of the world population with an annual multi-billion dollar cost to the healthcare system. This background pushes the development of new therapies and procedures for wound healing and its assessment. Among them, the potential of hydrogen(pH) assessment is an important indicator of the wound healing stage and condition. This paper presents the development of the first optical fiber-embedded smart wound dressing for pH assessment. An intrinsically pH-sensitive optical fiber is fabricated using a polydimethylsiloxane(PDMS) precursor doped with rhodamine B dye. Raman and Fourier transform infrared(FTIR) spectroscopies are performed in order to verify the presence of rhodamine B and PDMS in the fiber samples. Then, the fiber is embedded in gauze fabric and hydrocolloid wound dressing. In addition, such low Young’s modulus of PDMS fiber enables its use as a highly sensitive pressure sensor, where the results show that the fiber-embedded bandage can measure pressures as low as 0.1 kPa with a high linearity in the range of 0 to 0.3 kPa. The smart bandage is subjected to different pH, which resulted in a wavelength shift of 0.67 nm/pH when the absorption peak at 515 nm was analyzed. Furthermore, pH increase leads to linear decrease of the transmitted optical power(R2 of 0.998), with rise and fall times below 20 s and 30 s, respectively. Therefore, the proposed optical fiber-embedded smart bandage enables the simultaneous assessment of pressure and pH on the wound region. | Arnaldo Leal-Junior Jingjing Guo Rui Min Antonio Jose Fernandes Anselmo Frizera Carlos Marques | 2021 | Photonics Research2021，9，3： | 1 |
| 5 | Efficiency and its determinants in Portuguese hotels inthe Algarve显示文摘 | Ricardo Oliveira Maria Isabel Pedro Rui Cunha Marques | 2013 | Tourism Management2013，36，： | 1 |
| 6 | Methane oxidation by NO and O 2 from reverse spillover on alumina supported palladium catalysts显示文摘 | Rui Marques Sandra Capela Stéphanie Da Costa Franck Delacroix Gérald Djéga-Mariadassou Patrick Da Costa | 2008 | Catalysis Communications2008，，8： | 1 |
| 7 | EDDS and EDTA-enhanced zinc accumulation by solanum nig- rum inoculated with arbuscular mycorrhizal fungi grown in contaminated soil显示文摘 | Ana P G C Marques Rui S Oliveira Kalina A Samardjieva | 2008 | Chemosphere2008，70，6： | 1 |
| 8 | Identification of DNA markers linked to an induced mutated gene conferring resistance to powdery mildew in pea ( Pisum sativum L.)显示文摘 | Gra?a Pereira Cátia Marques Rui Ribeiro Sandra Formiga Mafalda Damaso M. Tavares Sousa Mário Farinhó José M. Leit?o | 2010 | Euphytica2010，，3： | 1 |
| 9 | Flexible Contracts to Cope with Uncertainty in Public-private Partnerships显示文摘 | Carlos Oliveira Cruz Rui Cunha Marques | 2013 | International Journal of Project Management2013，，31： | 1 |
| 10 | Optical nanocompositeplanar waveguides doped with rare-earth and noble metal elements 显示文摘 | RUI M A MARQUES A C FERRARI M | 2003 | J Sol–gel Sci Technol2003，26，89： | 1 |
| 11 | Economic cost recovery in the recycling of packaging waste: the case of Portugal显示文摘 | Nuno Ferreira da Cruz Pedro Simoes Rui Cunha Marques | 2012 | Journal of Cleaner Production2012，37，： | 1 |
| 12 | Cardiovascular Risk Assessment of Pulmonary Embolism With the GRACE Risk Score显示文摘 | Luis V. Paiva Rui C. Providencia Sergio N. Barra Ana C. Faustino Ana M. Botelho António L. Marques | 2012 | The American Journal of Cardiology2012，，： | 1 |
| 13 | ‘Rocha’ pear firmness predicted by a Vis/NIR segmented model显示文摘 | Ana M. Cavaco Pedro Pinto M. Dulce Antunes Jorge Marques da Silva Rui Guerra | 2008 | Postharvest Biology and Technology2008，，3： | 1 |
| 14 | Flexible contracts to cope with uncertainty in public–private partnerships显示文摘 | Carlos Oliveira Cruz Rui Cunha Marques | 2012 | International Journal of Project Management2012，，： | 1 |
| 15 | Flexible contracts to cope with uncertainty in Public-Private Partnerships显示文摘 | Carlos Oliveira Cruz A Rui Ckmha Marques | 2013 | International Journal of Project Management2013，，7： | 1 |
| 16 | Flexible contracts to cope with uncertainty in public–private partnerships显示文摘 | Carlos Oliveira Cruz Rui Cunha Marques | 2012 | International Journal of Project Management2012，，： | 1 |
| 17 | ‘Rocha’ pear firmness predicted by a Vis/NIR segmented model显示文摘 | Ana M. Cavaco Pedro Pinto M. Dulce Antunes Jorge Marques da Silva Rui Guerra | 2008 | Postharvest Biology and Technology2008，，3： | 1 |
| 18 | Flexible contracts to cope with uncertainty in public-private partnerships 显示文摘 | Carlos Oliveira Cruz Rui Cunha Marques | 2013 | Inter- national Journal of Project Management2013，31，3： | 1 |
| 19 | Plasma-assisted catalytic oxidation of methane on the influence of plasma energy deposition and feed composition显示文摘 | Rui Marques Stephanie Da Costa Patrick | 2008 | Applied Catalysis B: Environmental2008，82，： | 1 |
| 20 | Comparison of morphological and functional outcomes of mouse sciatic nerve repair with three biodegradable polymer conduits containing poly (lactic acid)显示文摘Poly(lactic acid)(PLA)-containing nerve guidance conduits(NGCs) are currently being investigated for nerve repair as an alternative to autograft, which leads to permanent functional impairment in the territory innervated by the removed nerve. Combination of polymers modifies the physical properties of the conduits, altering their nerve-guidance properties. Conduits made from PLA-only or combined with other polymers have been used successfully for nerve repair, but their efficiency has not been compared. We compared the morphological and functional outcomes of peripheral nerve repair by using NGCs made of poly(lactic acid) and combined or not with polycaprolactone(PLA/PCL) or polyvinylpyrrolidone(PLA/PVP). To assess the functional recovery, we employed a mechanical hyperalgesia analysis, sciatic functional index(SFI), and electroneuromyography. The mechanical hyperalgesia analysis showed that the PLA group improved more rapidly than the PLA/PVP and PLA/PCL groups; similarly, in the electroneuromyography assay, the PLA group exhibited higher amplitude than the PLA/PCL and PLA/PVP groups. However, the SFI improvement rates did not differ among the groups. Morphologically, the PLA group showed more vascularization, while the nerve fiber regeneration did not differ among the groups. In conclusion, the PLA-only conduits were superior to the other NGCs tested for nerve repair. | Fernanda Marques Pestana Rui C.C.Domingues Júlia Teixeira Oliveira Daniela F.P.A.Durco Camila Oliveira Goulart Henrique Rocha Mendonca Anne Caroline Rodrigues dos Santos Natália Tavares de Campos Beatriz Theodoro da Silva Cristina Cardoso Pereira Cristiano Piacsek Borges Ana Maria Blanco Martinez | 2018 | Neural Regeneration Research2018，13，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员