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| 1 | Autophagy activation aggravates neuronal injury in the hippocampus of vascular dementia rats显示文摘It remains unclear whether autophagy affects hippocampal neuronal injury in vascular dementia. In the present study, we investigated the effects of autophagy blockade on hippocampal neuronal injury in a rat model of vascular dementia. In model rats, hippocampal CA1 neurons were severely damaged, and expression of the autophagy-related proteins beclin-1, cathepsin B and microtubule-associated protein 1 light chain 3 was elevated compared with that in sham-operated animals. These responses were suppressed in animals that received a single intraperitoneal injection of wortmannin, an autophagy inhibitor, prior to model establishment. The present results confirm that autophagy and autophagy-related proteins are involved in the pathological changes of vascular dementia, and that inhibition of autophagy has neuroprotective effects. | Bin Liu Jing Tang Jinxia Zhang Shiying Li Min Yuan Ruimin Wang | 2014 | Neural Regeneration Research2014，9，13： | 25 |
| 2 | PepperHub, an Informatics Hub for the Chili Pepper Research Community显示文摘 | Feng Liu Huiyang Vu Yingtian Deng Jingyuan Zheng Minglei Liu Lijun Ou Bozhi Yang Xiongze Dai Yanqing Ma Shengyu Feng Shuang He Xuefeng Li Zhuqing Zhang Wenchao Chen Shudong Zhou Rong Chen Minmin Liu Sha Yang Ruimin Wei Huadong Li Feng Li Bo Ouyang Xuexiao Zou | 2017 | Molecular Plant2017，10，8： | 13 |
| 3 | Insights into epigenetic patterns in mammalian early embryos显示文摘Mammalian fertilization begins with the fusion of two specialized gametes,followed by major epigenetic remodeling leading to the formation of a totipotent embryo.During the development of the pre-implantation embryo,precise reprogramming progress is a prerequisite for avoiding developmental defects or embryonic lethality,but the underlying molecular mechanisms remain elusive.For the past few years,unprecedented breakthroughs have been made in mapping the regulatory network of dynamic epigenomes during mammalian early embryo development,taking advantage of multiple advances and innovations in low-input genome-wide chromatin analysis technologies.The aim of this review is to highlight the most recent progress in understanding the mechanisms of epigenetic remodeling during early embryogenesis in mammals,including DNA methylation,histone modifications,chromatin accessibility and 3D chromatin organization. | Ruimin Xu Chong Li Xiaoyu Liu Shaorong Gao | 2021 | Protein & Cell2021，12，1： | 13 |
| 4 | Multiple Feature Fusion in Convolutional Neural Networks for Action Recognition显示文摘Action recognition is important for understanding the human behaviors in the video,and the video representation is the basis for action recognition.This paper provides a new video representation based on convolution neural networks(CNN).For capturing human motion information in one CNN,we take both the optical flow maps and gray images as input,and combine multiple convolutional features by max pooling across frames.In another CNN,we input single color frame to capture context information.Finally,we take the top full connected layer vectors as video representation and train the classifiers by linear support vector machine.The experimental results show that the representation which integrates the optical flow maps and gray images obtains more discriminative properties than those which depend on only one element.On the most challenging data sets HMDB51 and UCF101,this video representation obtains competitive performance. | LI Hongyang CHEN Jun HU Ruimin | 2017 | Wuhan University Journal of Natural Sciences2017，22，1： | 4 |
| 5 | Consumption Structure of Migrant Worker Families in China显示文摘这研究越过在中国城市化区域的四个学生在候鸟的调查上收 12 个城市并且调查城市的候鸟工人家庭和农村消费的结构。结果证明候鸟工人家庭消费的结构被幸存消费统治了。当在他们的农村自已出生的市镇从事明显的消费时,这些家庭趋于节约地住在城市。候鸟工人家庭消费的结构被他们的收入稳定性和财富层次而非他们的当前的收入水平主要塑造。而且,有打算在城市里永久地安定的高教育的层次和那些的候鸟工人家庭是可能的分配实质的开销到地位和快乐消费并且升级他们的城市的消费结构。 | Guangzhong Cao Kai Li Ruimin Wang Tao Liu | 2017 | China & World Economy2017，25，4： | 4 |
| 6 | Fluorination-substitution effect on all-small-molecule organic solar cells显示文摘Due to the strong crystallinity and anisotropy of small molecules, matched molecular photoelectric properties and morphologies between small molecules and non-fullerene acceptors are especially important in all-small-molecule organic solar cells(OSCs).Introducing fluorine atoms has been proved as an effective strategy to achieve a high device performance through tuning molecular energy levels, absorption and assembly properties. Herein, we designed a novel benzodithiophene-based small molecule donor BDTF-CA with deep highest occupied molecular orbital(HOMO) energy level. All-small-molecule OSCs were fabricated by combing non-fullerene acceptor IDIC with different fluorine-atom numbers. Two or four fluorine atoms were introduced to the end-capped acceptor of IDIC, which are named as IDIC-2 F and IDIC-4 F, respectively. With the increase of fluorination from IDIC to IDIC-4 F, the open circuit voltage(Voc) of the devices decreased, while hole and electron mobilities of the active layers increased by one order of magnitude. Contributed to the most balanced Voc, short-circuit current(Jsc) and fill factor(FF), the device based on BDTF-CA/IDIC-2 F achieved the highest power conversion efficiency of 9.11%. | Qiong Wu Dan Deng Jianqi Zhang Wenjun Zou Yang Yang Zhen Wang Huan Li Ruimin Zhou Kun Lu Zhixiang Wei | 2019 | Science China Chemistry2019，62，7： | 3 |
| 7 | Combining chlorination and sulfuration strategies for high-performance all-small-molecule organic solar cells显示文摘Three small-molecule donors based on dithieno [2,3-d:2’,3 ’-d’]-benzo[1,2-b:4,5-b’] dithiophene(DTBDT)unit were designed and synthesized by side chain regulation with chlorinated or/and sulfurated substitutions(namely ZR1,ZR1-Cl,and ZR1-S-Cl respectively),along with a crystalline non-fullerene acceptor IDIC-4 Cl with a chlorinated 1,1-dicyanomethylene-3-indanone(IC) end group.Energy levels,molar extinction coefficients and crystallinities of three donor molecules can be effectively altered by combining chlorination and sulfuration strategies.Especially,the ZR1-S-Cl exhibited the best absorption ability,lowest higher occupied molecular orbital(HOMO) energy level and highest crystallinity among three donors,resulting in the corresponding all-small-molecule organic solar cells to produce a high power conversion efficiency(PCE) of 12.05% with IDIC-4 Cl as an acceptor. | Ruimin Zhou Chen Yang Wenjun Zou Muhammad Abdullah Adil Huan Li Min Lv Ziyun Huang Menglan Lv Jianqi Zhang Kun Lu Zhixiang Wei | 2021 | Journal of Energy Chemistry2021，30，1： | 3 |
| 8 | Facile synthesis of porous nitrogen-doped holey graphene as an efficient metal-free catalyst for the oxygen reduction reaction显示文摘做氮的 graphene 是为氧减小反应(ORR ) 的高贵基于金属的 electrocatalysts 的代替的一个有希望的候选人。进做氮的 graphene 的毛孔和洞的增加由介绍丰富的暴露的边提高 ORR 活动,加速集体转移,并且阻碍 graphene 表的聚集。此处,我们在场为经由脲和镁醋酸盐 tetrahydrate 的热分解产生多孔的有穴的做氮的 graphene (PHNG ) 的直接却有效的策略。由于联合效果在里面 situ 产生了气体和 MgO nanoparticles,综合 PHNG 在弄皱的 graphene 之中展示了不仅众多的 out-of-plane 毛孔在装配 graphene 的表,而且贯穿的 nanoscale (5-15 nm ) 洞。而且,做 PHNG 的配置的氮被 thermal 以后处理在不同温度优化。pyridinic 和第四级的氮的全面内容断然与 ORR 活动相关,这被发现;特别地, pyridinic 氮为 ORR 产生最理想的特征。这个工作为基于 PHNG 的材料的合成揭示新线路并且阐明到 ORR 的各种各样的氮种类的贡献。 | Li Qin Ruimin Ding Huixiang Wang Jianghong Wu Conghui Wang Chenghua Zhang Yao Xu Liancheng Wang Baoliang Lv | 2017 | Nano Research2017，10，1： | 3 |
| 9 | Investigation Into Vibration Characteristic in Vibrothermography显示文摘Vibration characteristic plays an important role in vibrothermography, which directly affects the heating during the test. In this work, involving all the contacts in the vibrothermography, the 'double-mass-thiree-spring' model is established to explore the vibration characteristic. The obtained results show that ultrasonic gun vibrates at fundamental frequency (FF), while the specimen vibrates at multi-frequencies including FF, 2FF, 3FF, and 4FF, which is validated through experimental investigation results. Additionally, the model proposed in this work reveals a high order harmonics in the vibrothermography test and makes the specimen conduct the steady vibration, which indicates that the model is closer to the practical equipment and can ensure the heating efficiency induced by vibration of specimen to improve the detection capability. | Yin LI Anbo MING Ruimin ZHANG Wei ZHANG | 2019 | Photonic Sensors2019，9，2： | 3 |
| 10 | Disruption of the bHLH transcription factor Abnormal Tapetum 1 causes male sterility in watermelon显示文摘Although male sterility has been identified as a useful trait for hybrid vigor utilization and hybrid seed production,its underlying molecular mechanisms in Cucurbitaceae species are still largely unclear.Here,a spontaneous male-sterile watermelon mutant,Se18,was reported to have abnormal tapetum development,which resulted in completely aborted pollen grains.Map-based cloning demonstrated that the causal gene Citrullus lanatus Abnormal Tapetum 1(ClATM1)encodes a basic helix-loop-helix(bHLH)transcription factor with a 10-bp deletion and produces a truncated protein without the bHLH interaction and functional(BIF)domain in Se18 plants.qRT–PCR and RNA in situ hybridization showed that ClATM1 is specifically expressed in the tapetum layer and in microsporocytes during stages 6–8a of anther development.The genetic function of ClATM1 in regulating anther development was verified by CRISPR/Cas9-mediated mutagenesis.Moreover,ClATM1 was significantly downregulated in the Se18 mutant,displaying a clear dose effect at the transcriptional level.Subsequent dual-luciferase reporter,β-glucuronidase(GUS)activity,and yeast one-hybrid assays indicated that ClATM1 could activate its own transcriptional expression through promoter binding.Collectively,ClATM1 is the first male sterility gene cloned from watermelon,and its self-regulatory activity provides new insights into the molecular mechanism underlying anther development in plants. | Ruimin Zhang Jingjing Chang Jiayue Li Guangpu Lan Changqing Xuan Hao Li Jianxiang Ma Yong Zhang Jianqiang Yang Shujuan Tian Li Yuan Xian Zhang Chunhua Wei | 2021 | Horticulture Research2021，8，1： | 3 |
| 11 | Survivin Antisense Oligodeoxy-Nucleotid Induces Apoptosis in Leukaemia Cell Line K562显示文摘OBJECTIVE To investigate the effects of survivin antisense oligodeoxy-nucleotid (ASODN) on proliferation and apoptosis in the chronic myeloid leukemia cell line K562. METHODS Different concentrations of an antisense oligodeoxy-nucleotid and control sequence (scrambled ODN) targeting the survivin gene were transferred into K562 by a lipofectin reagent. The MTT assay was used to measure the growth inhibitory rate, IC50, and to observe the cytotoxicity of survivin ASODN in the K562 cells. The morphologic changes in the nucleus and the apoptotic rate were observed by Hoechst33342/PI staining. Caspase-3 activity was evaluated by a kinase activity assay. The changes of survivin protein expression after transfection were detected by Western blots. RESULTS Eight hours after transfection, fluorescence in the K562 cells was well distributed. Treatment of the cells for 44 h with different concentrations of survivin ASODN produced a IC50 of 800 nmol/L. The growth inhibitory rate with 200, 400, 600 and 1000 nmol/L of survivin ASODN was 15.8±1.6%, 23.8±5.9%, 37.1±5.6% and 77.3±2.5% respectively. After 36 h of of survivin ASODN treatment, distinct morphologic changes characteristic of cell apoptosis such as karyopyknosis and conglomeration were observed by Hoechst33342/PI staining. Caspase-3 activity increased significantly after treatment of the cells with different concentrations of survivin ASODN(P<0.01)and following treatment with 800 nmol/L survivin ASODN, survivin expression decreased significantly. CONCLUSION Survivin ASODN exerts an anti-cancer effect by inducing apoptosis in K562 leukaemia cells. Up-regulated expression of caspase-3 may play a role in this process. | Lijun Chen Qiuyue Jin Hong Xie Ruimin Wang Li Yao | 2006 | Chinese Journal of Clinical Oncology2006，3，6： | 3 |
| 12 | A-π-D-π-A small-molecule donors with different end alkyl chains obtain different morphologies in organic solar cells显示文摘For bulk-heterojunction organic solar cells, the morphology of the blend films highly influence the exciton dissociation and charge transport process. In this work, two novel A-π-D-π-A(A represents the acceptor unit and D represents the donor unit) backbone structure small molecular electron donors based on two dimensional conjugated naphtho[1,2-b:5,6-b']dithiophene(NDT) with different end alkyl chains, named as NDT-3T-EH and NDT-3T-O, have been designed and synthesized. The photovoltaic property of NDT-3T-O-based device is better than that of the NDT-3T-EH and the best efficiency reaches 7.06%, and the photovoltaic property of NDT-3T-EH reaches 6.11%. The difference in the performance should be attributed to the different morphology and phase separation resulted from the different crystallinity and aggregation ability of two donors. The results demonstrate that the optimized end alkyl chains can be used to design A-π-D-π-A backbone structure small molecular electron donors for smallmolecule organic solar cells. | Yanan Shi Chen Yang Huan Li Lixuan Liu Ruimin Zhou Wenjun Zou Zhen Wang Qiong Wu Dan Deng Jianqi Zhang Kun Lu Zhixiang Wei | 2019 | Chinese Chemical Letters2019，30，4： | 3 |
| 13 | The “1-3-7” Approach to Malaria Surveillance and Response--Henan Province, China, 2012−2018显示文摘What is already known about this topic?The“1-3-7”approach to malaria surveillance and response was a key measure for malaria elimination in China and was first introduced into the World Health Organization(WHO)as an international guideline for malaria surveillance and response in 2018.What is added by this report?The“1-3-7”approach was well implemented in Henan Province from 2012−2018.Over this study period,a total of 1,294 malaria cases were detected and reported,and all cases were diagnosed and reported within 1 day with 99.23%(1,284/1,294)of cases were investigated within 3 days.In addition,93.7%(1,212/1,294)of foci were investigated and vector control was implemented within 7 days at all residual non-active foci to prevent further spread.What are the implications for public health practice?The“1-3-7”controlling pattern would be an effective and approachable method for implementation especially in malaria-eliminating countries and regions,but the interval from symptom onset to diagnosis cannot be ignored.Thus,the roles and responsibilities that all actors involved in the health sector must be specified too. | Qunqun Zhang Ying Liu Yabo Hu Yuling Zhao Chengyun Yang Dan Qian Ruimin Zhou Suhua Li Zhou Guan Deling Lu Hongwei Zhang Wanshen Guo | 2020 | China CDC weekly2020，2，17： | 3 |
| 14 | Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-associated protein activation显示文摘The constitutive androstane receptor(CAR, NR3 I1) belongs to nuclear receptor superfamily.It was reported that CAR agonist TCPOBOP induces hepatomegaly but the underlying mechanism remains largely unknown. Yes-associated protein(YAP) is a potent regulator of organ size. The aim of this study is to explore the role of YAP in CAR activation-induced hepatomegaly and liver regeneration.TCPOBOP-induced CAR activation on hepatomegaly and liver regeneration was evaluated in wildtype(WT) mice, liver-specific YAP-deficient mice, and partial hepatectomy(PHx) mice. The results demonstrate that TCPOBOP can increase the liver-to-body weight ratio in wild-type mice and PHx mice.Hepatocytes enlargement around central vein(CV) area was observed, meanwhile hepatocytesproliferation was promoted as evidenced by the increased number of KI67+cells around portal vein(PV)area. The protein levels of YAP and its downstream targets were upregulated in TCPOBOP-treated mice and YAP translocation can be induced by CAR activation. Co-immunoprecipitation results suggested a potential proteineprotein interaction of CAR and YAP. However, CAR activation-induced hepatomegaly can still be observed in liver-specific YAP-deficient(Yape/e) mice. In summary, CAR activation promotes hepatomegaly and liver regeneration partially by inducing YAP translocation and interaction with YAP signaling pathway, which provides new insights to further understand the physiological functions of CAR. | Yue Gao Shicheng Fan Hua Li Yiming Jiang Xinpeng Yao Shuguang Zhu Xiao Yang Ruimin Wang Jianing Tian Frank JGonzalez Min Huang Huichang Bi | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 2 |
| 15 | Temporal variation of heavy metal pollution in urban stormwater runoff显示文摘 | Wen LI Zhenyao SHEN Tian TIAN Ruimin LIU Jiali QIU | 2012 | Frontiers of Environmental Science & Engineering2012，6，5： | 2 |
| 16 | On-line RNN compensated second order nonsingular terminal sliding mode control for hypersonic vehicle显示文摘Purpose–The purpose of this paper is to design a robust control scheme to achieve robust tracking of velocity and altitude commands for a general hypersonic vehicle(HSV)in the presence of parameter variations and external disturbances.Design/methodology/approach–The robust control scheme is composed of nonsingular terminal sliding mode control(NTSMC),super twisting control algorithm(STC)and recurrent neural network(RNN).First,by combing a novel NTSMC and STC algorithm,a second order NTSMC approach for HSV is proposed to provide fast,continuous and high precision tracking control.Second to relax the requirements for the bounds of the lumped uncertainties in control design,a RNN disturbance observer is presented to increase the robustness of the control system.The weights of RNN are updated by adaptive laws based on Lyapunov theorem,thus the closed-loop stability can be guaranteed.Findings–Simulation results demonstrate that the proposed method is effective,leading to promising performance.Originality/value–The main contributions of this work are:first,both parameter variations and external disturbances are considered in control design for the longitudinal dynamic model of HSV;and second,the proposed controller can remove chattering and achieve more favorable tracking performances than conventional sliding mode control. | Ruimin Zhang Li Wang Yingjiang Zhou | 2012 | International Journal of Intelligent Computing and Cybernetics2012，5，2： | 1 |
| 17 | SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate显示文摘Loss-of-function mutations in sorting nexin 14(SNX14)cause autosomal recessive spinocerebellar ataxia 20,which is a form of early-onset cerebellar ataxia that lacks molecular mechanisms and mouse models.We generated Snx14-deficient mouse models and observed severe motor deficits and cell-autonomous Purkinje cell degeneration.SNX14 deficiency disrupted microtubule organization and mitochondrial transport in axons by destabilizing the microtubule-severing enzyme spastin,which is implicated in dominant hereditary spastic paraplegia with cerebellar ataxia,and compromised axonal integrity and mitochondrial function.Axonal transport disruption and mitochondrial dysfunction further led to degeneration of high-energy-demanding Purkinje cells,which resulted in the pathogenesis of cerebellar ataxia.The antiepileptic drug valproate ameliorated motor deficits and cerebellar degeneration in Snx14-deficient mice via the restoration of mitochondrial transport and function in Purkinje cells.Our study revealed an unprecedented role for SNX14-dependent axonal transport in cerebellar ataxia,demonstrated the convergence of SNX14 and spastin in mitochondrial dysfunction,and suggested valproate as a potential therapeutic agent. | Hongfeng Zhang Yujuan Hong Weijie Yang Ruimin Wang Ting Yao Jian Wang Ke Liu Huilong Yuan Chaoqun Xu Yuanyuan Zhou Guanxian Li Lishan Zhang Hong Luo Xian Zhang Dan Du Hao Sun Qiuyang Zheng Yun-Wu Zhang Yingjun Zhao Ying Zhou Huaxi Xu Xin Wang | 2021 | National Science Review2021，8，7： | 1 |
| 18 | Object tracking algorithm based on meanshift algorithm combining with motion vector analysis显示文摘 | TIAN Gang HU RuiMin WANG ZhongYuan ZHU Li | 2009 | IEEE First In- ternational Workshop on Education Technology and Com- puter Science ( $7695 - 3557)2009，10，： | 1 |
| 19 | Effects of odd-even traffic restriction on travel speed and traffic volume:Evidence from Beijing Olympic Games显示文摘This paper reports the effects of using an 'odd and even' traffic restriction policy in Beijing during the 2008 Olympic Games. Based on data from 529 traffic detectors on the expressway network and some main arterials in Beijing, China, a comparative analysis has been carried out on the following parameters: the total traffic volume within the expressway network, the total traffic volume on different ring expressways, the traffic volume and speed of a freeway segment, and an arterial street before and after the implementation of the traffic restriction policy. The results show that during the traffic restriction period, although more than 50% of vehicles were forbidden to travel in Beijing,the traffic volume was only reduced by 20%-40% while the travel speed had been increased by 10%-20%. This suggests that such traffic restriction policy may be an effective shortterm management measure in dealing with increased transportation demand and congestion during major events, such as the Olympic Games. Results also indicate that vehicle travel demand does not decrease with the same proportion as the total vehicles forbidden, at least for the expressway and main arterials in a city. | Ruimin Li Min Guo | 2016 | Journal of Traffic and Transportation Engineering(English Edition)2016，3，1： | 1 |
| 20 | Study on integration of urban traffic control and route guidance based on multi-agent technology显示文摘 | LI Ruimin SHI Qixin | 2003 | IEEE Intelligent Transportation systems2003，2，： | 1 |
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