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| 1 | Amazing structure of respirasome: unveiling the secrets of cell respiration显示文摘Respirasome,执行细胞的呼吸的一台巨大的分子的机器,自从它的发现,获得了成长注意,因为呼吸是在几乎所有生活动物的最不可缺少的生物过程。respirasome 的概念更新了我们呼吸的链组织的理解,并且最最近, respirasome 的结构从清华大学由 Yangs 组解决了(Gu 等。自然 237 (7622 ): 639-643, 2016 ) 第一在这台巨大的分子的机器以内介绍了详细相互作用,并且为药设计提供了重要信息并且屏蔽。然而,细胞的呼吸的学习通过了长历史。这里,我们简短显示出呼吸的链调查的 detoured 历史,然后描述了 respirasome 的令人惊讶的结构。 | Runyu Guo Jinke Gu Meng Wu Maojun Yang | 2016 | Protein & Cell2016，7，12： | 7 |
| 2 | Structure of the intact 14-subunit human cytochrome c oxidase显示文摘 | Shuai Zong Meng Wu Jinke Gu Tianya Liu Runyu Guo Maojun Yang | 2018 | Cell Research2018，28，10： | 5 |
| 3 | Host immune responses of ducks infected with H5N1 highly pathogenic avian influenza viruses of different pathogenicities显示文摘 | Liangmeng Wei Peirong Jiao Yafen Song Lan Cao Runyu Yuan Lang Gong Jin Cui Shuo Zhang Wenbao Qi Su Yang Ming Liao | 2013 | Veterinary Microbiology2013，，： | 1 |
| 4 | Signaling pathways in vascular function and hypertension:molecular mechanisms and therapeutic interventions显示文摘Hypertension is a global public health issue and the leading cause of premature death in humans.Despite more than a century of research,hypertension remains difficult to cure due to its complex mechanisms involving multiple interactive factors and our limited understanding of it.Hypertension is a condition that is named after its clinical features.Vascular function is a factor that affects blood pressure directly,and it is a main strategy for clinically controlling BP to regulate constriction/relaxation function of blood vessels.Vascular elasticity,caliber,and reactivity are all characteristic indicators reflecting vascular function.Blood vessels are composed of three distinct layers,out of which the endothelial cells in intima and the smooth muscle cells in media are the main performers of vascular function.The alterations in signaling pathways in these cells are the key molecular mechanisms underlying vascular dysfunction and hypertension development.In this manuscript,we will comprehensively review the signaling pathways involved in vascular function regulation and hypertension progression,including calcium pathway,NO-NOsGC-cGMP pathway,various vascular remodeling pathways and some important upstream pathways such as renin-angiotensin-aldosterone system,oxidative stress-related signaling pathway,immunity/inflammation pathway,etc.Meanwhile,we will also summarize the treatment methods of hypertension that targets vascular function regulation and discuss the possibility of these signaling pathways being applied to clinical work. | Jun Ma Yanan Li Xiangyu Yang Kai Liu Xin Zhang Xianghao Zuo Runyu Ye Ziqiong Wang Rufeng Shi Qingtao Meng Xiaoping Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 1 |
| 5 | Research journey of respirasome显示文摘Respirasome,as a vital part of the oxidative phosphorylation system,undertakes the task of transferring electrons from the electron donors to oxygen and produces a proton concentration gradient across the inner mitochondrial membrane through the coupled translocation of protons.Copious research has been carried out on this lynchpin of respiration.From the discovery of individual respiratory complexes to the report of the high-resolution structure of mammalian respiratory supercomplex I1III2IV1,scientists have gradually uncovered the mysterious veil of the electron transport chain(ETC).With the discovery of the mammalian respiratory mega complex I2III2IV2,a new perspective emerges in the research field of the ETC.Behind these advances glitters the light of the revolution in both theory and technology.Here,we give a short review about how scientists‘see’the structure and the mechanism of respirasome from the macroscopic scale to the atomic scale during the past decades. | Meng Wu Jinke Gu Shuai Zong Runyu Guo Tianya Liu Maojun Yang | 2020 | Protein & Cell2020，11，5： | 1 |
| 6 | UQCRFSIN assembles mitochondrial respiratory complex-Ill into an asymmetric 21-subunit dimer显示文摘 | Shuai Zong Jinke Gu Tianya Liu Runyu Guo Meng Wu Maojun Yang | 2018 | Protein & Cell2018，9，6： | 1 |
| 7 | Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision显示文摘High precision neuromodulation is a powerful tool to decipher neurocircuits and treat neurological diseases.Current non-invasive neuromodulation methods offer limited precision at the milimeter level.Here,we report opticallygenerated focused ultrasound(OFUS)for non-invasive brain stimulation with ultrahigh precision.OFUS is generated by a soft optoacoustic pad(SOAP)fabricated through embedding candle soot nanoparticles in a curved polydimethylsiloxane film.SOAP generates a transcranial ultrasound focus at 15 MHz with an ultrahigh lateral resolution of 83μm,which is two orders of magnitude smaller than that of conventional transcranial-focused ultrasound(tFUS).Here,we show effective OFUS neurostimulation in vitro with a single ultrasound cycle.We demonstrate submillimeter transcranial stimulation of the mouse motor cortex in vivo.An acoustic energy of 0.6 mJ/cm?,four orders of magnitude less than that of tFUS,is suffcient for successful OFUS neurostimulation.OFUS offers new capabilities for neuroscience studies and disease treatments by delivering a focus with ultrahigh precision noninvasively. | Yueming Li Ying Jiang Lu Lan Xiaowei Ge Ran Cheng Yuewei Zhan Guo Chen Linli Shi Runyu Wang Nan Zheng Chen Yang Ji-Xin Cheng | 2022 | Light(Science & Applications)2022，11，11： | 1 |
| 8 | Pd nanoparticles embedded in N-Enriched MOF-Derived architectures for efficient oxygen reduction reaction in alkaline media显示文摘Developing high efficient Pd-based electrocatalysts for oxygen reduction reaction(ORR) is still challenging for alkaline membrane fuel cell,since the strong oxygen adsorption energy and easy agglomerative intrinsic properties. In order to simultaneously solve these problems, Pd/Co_(3)O_(4)–N–C multidimensional materials with porous structures is designed as the ORR catalysts. In details, the ZIF-67 with polyhedral structure was firstly synthesized and then annealed at high-temperature to prepare the N-doped Co_(3)O_(4)carbon-based material, which was used to homogeneously confine Pd nanoparticles and obtained the Pd/Co_(3)O_(4)–N–C series catalysts. The formation of Co–N and C–N bond could provide efficient active sites for ORR. Simultaneously, the strong electronic interaction in the interface between the Pd and N-doped Co_(3)O_(4)could disperse and avoid the agglomeration of Pd nanoparticles and ensure the exposure of active sites, which is crucial to lower the energy barrier toward ORR and substantially enhance the ORR kinetics. Hence, the Pd/Co_(3)O_(4)–N–C nanocompounds exhibited excellent ORR catalytic performance, ideal Pd mass activity, and durability in 0.1 mol L-1KOH solution compared with Co_(3)O_(4)–N–C and Pd/C. The scalable synthesis method, relatively low cost, and excellent electrochemical ORR performance indicated that the obtained Pd/Co_(3)O_(4)–N–C electrocatalyst had the potential for application on fuel cells. | Daqiang Yan Lin Zhang Lei Shen Runyu Hu Weiping Xiao Xiaofei Yang | 2023 | Green Energy & Environment2023，8，4： | 0 |
| 9 | An efficient wear-leveling-aware multi-grained allocator for persistent memory file systems显示文摘Persistent memory(PM)file systems have been developed to achieve high performance by exploiting the advanced features of PMs,including nonvolatility,byte addressability,and dynamic random access memory(DRAM)like performance.Unfortunately,these PMs suffer from limited write endurance.Existing space management strategies of PM file systems can induce a severely unbalanced wear problem,which can damage the underlying PMs quickly.In this paper,we propose a Wear-leveling-aware Multi-grained Allocator,called WMAlloc,to achieve the wear leveling of PMs while improving the performance of file systems.WMAlloc adopts multiple min-heaps to manage the unused space of PMs.Each heap represents an allocation granularity.Then,WMAlloc allocates less-worn blocks from the corresponding min-heap for allocation requests.Moreover,to avoid recursive split and inefficient heap locations in WMAlloc,we further propose a bitmap-based multi-heap tree(BMT)to enhance WMAlloc,namely,WMAlloc-BMT.We implement WMAlloc and WMAlloc-BMT in the Linux kernel based on NOVA,a typical PM file system.Experimental results show that,compared with the original NOVA and dynamic wear-aware range management(DWARM),which is the state-of-the-art wear-leveling-aware allocator of PM file systems,WMAlloc can,respectively,achieve 4.11×and 1.81×maximum write number reduction and 1.02×and 1.64×performance with four workloads on average.Furthermore,WMAlloc-BMT outperforms WMAlloc with 1.08×performance and achieves 1.17×maximum write number reduction with four workloads on average. | Zhiwang YU Runyu ZHANG Chaoshu YANG Shun NIE Duo LIU | 2023 | Frontiers of Information Technology & Electronic Engineering2023，24，5： | 0 |
| 10 | Exploring formation mechanism and source attribution of ozone during the 2019 Wuhan Military World Games:Implications for ozone control strategies显示文摘A series of emission reduction measures were conducted in Wuhan,Central China,to ensure good air quality during the 7th Military World Games(MWG)in October 2019.To better understand the implications for ozone(O_(3))pollution control strategies,we applied integrated analysis approaches based on the de-weathered statistical model,parameterization methods,chemical box model,and positive matrix factorization model.During the MWG,concentrations of O_(3),NO_x,and volatile organic compound(VOCs),OFP(O_(3)formation potential),L_(OH)(OH radical loss rate)were 83μg/m^(3),43μg/m^(3),26 ppbv,188μg/m^(3),and 3.9 s^(-1),respectively,which were 26%,18%,3%,15%,and 13%lower than pre-MWG values and 6%,39%,30%,33%,and 50%lower than post-MWG values,respectively.After removing meteorological influence,O_(3)and its precursors during the MWG decreased largely compared with post-MWG values,and only O_(3),NO_(2),and oxygenated VOCs(OVOCs)declined compared with pre-MWG values,which revealed the emission reduction measures during the MWG played an important role for O_(3)decline.For six VOCs sources,the mass contributions of biomass burning and solvents usage during the MWG decreased largely compared with pre-MWG values.O_(3)production was sensitive to VOCs and the key species were aromatics,OVOCs,and alkenes,which originated mainly from solvents usage,biomass burning,industrial-related combustion,and vehicle exhaust.Decreasing O_(3)concentration during the strict control was mainly caused by OVOCs reduction due to biomass burning control.Generally,the O_(3)abatement strategies of Wuhan should be focused on the mitigation of high-reactivity VOCs. | Lei Zhang Lili Wang Runyu Wang Nan Chen Yuan Yang Ke Li Jie Sun Dan Yao Yuesi Wang Minghui Tao Yang Sun | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 11 | A study on resonance Rayleigh scattering spectra of Humic Acid (HA)显示文摘This paper deals with the influences of pH, acidity and ionic intensity of the solutions on the resonance Rayleigh scattering spectra and fluorescence spectra of humic acid. When the pH value is low and the acidity and ionic intensity are high, the resonance Rayleigh spectra and fluorescence spectra both show a tendency of increasing, though the former's intensity is much higher. In combination with the transmission electron microscope data, the factors leading to the occurrence and enhancement of the resonance Rayleigh scattering spectra of humic acid were explored. It is considered that particle enlargement caused by aggregation, the increase of heterogeneity, the increase of hydrophobility, the formation of interface, etc., are the factors leading to the occurrence and enhancement of the resonance Rayleigh scattering spectra of humic acid. As the intensity of the resonance Rayleigh scattering spectra of humic acid is much higher, resonance Rayleigh scattering spectroscopy can be used as a newly developed spectrum technology, which is more sensitive and simpler, to study humic acid and its complicated behaviors. | YU Deshun LIU Shaopu ZHANG Lili ZHU Huiwu TIAN Yifu ZHANG Runyu YANG Jun | 2012 | Chinese Journal Of Geochemistry2012，31，1： | 0 |
| 12 | Structure of intact human MCU supercomplex with the auxiliary MICU subunits显示文摘Dear Editor,Mitochondrial Ca2+homeostasis regulates energy production,cell division,and cell death.The basic properties of mitochondrial Ca2+uptake have been firmly established.The Ca2+influx is mediated by MCU,driven by membrane potential and using a uniporter mechanism(Vasington and Murphy,1962).Patch-clamp analysis of MCU currents demonstrated that MCU is a channel with exceptionally high Ca2+selectivity(Kirichok et al.,2004). | Wei Zhuo Heng Zhou Runyu Guo Jingbo Yi Laixing Zhang Lei Yu Yinqiang Sui Wenwen Zeng Peiyi Wang Maojun Yang | 2021 | Protein & Cell2021，12，3： | 0 |
| 13 | 荆三棱在多等级基质异质性与水淹处理下的克隆表现显示文摘环境异质性可以影响克隆水生植物的表现。鲜有研究者关注两个层次的环境异质性并将其融入对克隆植物生态学的研究中。本研究的目的是:(1)检验不同基质异质性与水淹处理是否对植物表现产生相似效应,(2)探索克隆植物的觅食行为。本研究将荆三棱(Scirpus yagara)置于不同基质异质性与水淹处理之中。基质处理包括1个均质性基质处理(湖泥与沙等体积混合)与3个异质性基质处理(湖泥斑块与沙斑块交错构建的两斑块、四斑块与八斑块基质)。水淹处理包括:0、10和30 cm。本实验测量了克隆分株数、克隆代数、叶数、球茎数、克隆分株高度、茎长、根状茎长、克隆半径、间隔子长、间隔子厚度、总生物量、球茎生物量与单个球茎生物量等性状数据。研究结果表明,水位上升导致克隆分株数、克隆代数、叶数和球茎数显著减少,同时基质异质性造成间隔子长度与间隔子厚度的显著变化。水位与基质异质性两因子对克隆分株数、叶数和间隔子长度产生了显著的交互效应。在两斑块基质与四斑块基质中,荆三棱对湖泥斑块表现出显著的觅食行为,更多的构件被放置于湖泥斑块中。尤其在两斑块基质中,所有的构件被放置于湖泥斑块中。在八斑块基质中,荆三棱表现出双向觅食,这导致构件在不同斑块中的均匀放置。研究结果表明,荆三棱的觅食行为与斑块大小具有相关性。 | Tong Wang Liyu Yang Runyu Shao Jiangtao Hu Chunhua Liu Dan Yu | 2021 | Journal of Plant Ecology2021，14，5： | 0 |
| 14 | A recombineering system for Bacillus subtilis based on the native phage recombinase pair YqaJ/YqaK显示文摘Bacillus subtilis plays an important role in fundamental and applied research,and it has been widely used as a cell factory for the production of enzymes,antimicrobial materials,and chemicals for agriculture,medicine,and industry.However,genetic manipulation tools for B.subtilis have low efficiency.In this work,our goal was to develop a simple recombineering system for B.subtilis.We showed that genome editing can be achieved in B.subtiliis 1A751 through co-expression of YqaJ/YqaK,a native phage recombinase pair found in B.sub-tilis 168,and the competence master regulator ComK using a double-stranded DNA substrate with short ho-mology arms(100 bp)and a phosphorothioate modification at the 5′-end.Efficient gene knockouts and large DNA insertions were achieved using this new recombineering system in B.subtilis 1A751.As far as we know,this is the first recombineering system using the native phage recombinase pair YqaJ/YqaK in B.subtilis.In conclusion,this new recombineering system provides a simple and fast tool for genetic manipulation of B.sub-tilis,and it will promote studies of genome function,construction of production strains,and genome mining in B.subtilis. | Qingshu Liu Ruijuan Li Hongbo Shi Runyu Yang Qiyao Shen Qingwen Cui Xiuling Wang Aiying Li Youming Zhang Jun Fu | 2023 | Engineering Microbiology2023，3，3： | 0 |
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