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| 1 | Tubulin detyrosination promotes human trophoblast syncytium formation显示文摘Human trophoblast syncytialization is one of the most important yet least understood events during placental development.In this study,we found that detyrosinated a-tubulin(detyr-a-tub),which is negatively regulated by tubulin tyrosine Ugase(TTL),was elevated during human placental cytotrophoblast fusion.Correspondingly,relatively high expression of TTL protein was observed in first-trimester human placental cytotrophoblast cells,but fusing trophoblast cells exhibited much lower levels of T T L Notably,fusion of preeclamptic cytotrophoblast cells was compromised but could be partially rescued by knockdown of TTL levels.Mechanistically,chronic downregulation of TTL in trophoblast cells resulted in significantly elevated expression of detyra-tub.Restoration of detyr-a-tub thus contributed to the cell surface localization of the fusogenic protein Syncytin-2 and the gap junction protein Connexin 43(Cx43),which in turn promoted successful fusion between trophoblast cells.Taken together,the results suggest that tubulin detyrosination plays an essential role in human trophoblast fusogenic protein aggregation and syncytialization.Insufficient tubulin detyrosination leads to defects in syncytialization and potentially to the onset of preeclampsia. | Rui Wang Ruoxuan Yu Cheng Zhu Hai-Yan Lin Xiaoyin Lu Hongmei Wang | 2019 | Journal of Molecular Cell Biology2019，11，11： | 1 |
| 2 | LncRNA DACH1 protects against pulmonary fibrosis by binding to SRSF1 to suppress CTNNB1 accumulation显示文摘Idiopathic pulmonary fibrosis(IPF)is a progressive disease with unknown etiology and limited therapeutic options.Activation of fibroblasts is a prominent feature of pulmonary fibrosis.Here we report that lncRNA DACH1(dachshund homolog 1)is downregulated in the lungs of IPF patients and in an experimental mouse model of lung fibrosis.LncDACH1 knockout mice develop spontaneous pulmonary fibrosis,whereas overexpression of LncDACH1 attenuated TGF-β1-induced aberrant activation,collagen deposition and differentiation of mouse lung fibroblasts.Similarly,forced expression of LncDACH1 not only prevented bleomycin(BLM)-induced lung fibrosis,but also reversed established lung fibrosis in a BLM model.Mechanistically,LncDACH1 binding to the serine/arginine-rich splicing factor 1(SRSF1)protein decreases its activity and inhibits the accumulation of Ctnnb1.Enhanced expression of SRSF1 blocked the anti-fibrotic effect of LncDACH1 in lung fibroblasts.Furthermore,loss of LncDACH1 promoted proliferation,differentiation,and extracellular matrix(ECM)deposition in mouse lung fibroblasts,whereas such effects were abolished by silencing of Ctnnb1.In addition,a conserved fragment of LncDACH1 alleviated hyperproliferation,ECM deposition and differentiation of MRC-5 cells driven by TGF-β1.Collectively,LncDACH1 inhibits lung fibrosis by interacting with SRSF1 to suppress CTNNB1 accumulation,suggesting that LncDACH1 might be a potential therapeutic target for pulmonary fibrosis. | Jian Sun Tongzhu Jin Zhihui Niu Jiayu Guo Yingying Guo Ruoxuan Yang Qianqian Wang Huiying Gao Yuhan Zhang Tianyu Li Wenxin He Zhixin Li Wenchao Ma Wei Su Liangliang Li Xingxing Fan Hongli Shan Haihai Liang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 1 |
| 3 | SJES14110700258856显示文摘 | Janice E. Carrillo Asoo J. Vakharia Ruoxuan Wang | 2014 | European Journal of Operational Research2014，，3： | 1 |
| 4 | The newsvendor problem: Review and directions for future research显示文摘 | Yan Qin Ruoxuan Wang Asoo J. Vakharia Yuwen Chen Michelle M.H. Seref | 2010 | European Journal of Operational Research2010，，2： | 1 |
| 5 | The newsvendor problem: Review and directions for future research显示文摘 | Yan Qin Ruoxuan Wang Asoo J. Vakharia Yuwen Chen Michelle M.H. Seref | 2010 | European Journal of Operational Research2010，，2： | 1 |
| 6 | The newsvendor problem: review and directions for future research显示文摘 | QIN Yan WANG Ruoxuan VAKHARIA A J | 2011 | European Journal of Operational Research2011，213，2： | 1 |
| 7 | DLX5 promotes Col10a1 expression and chondrocyte hypertrophy and is involved in osteoarthritis progression显示文摘Osteoarthritis(OA)has been considered non-reversible as articular cartilage wears down with limited repair capacity.Enhanced chondrocyte hypertrophy and increased type X collagen gene(COL10A1)expression have been associated with OA.Therefore,regulators controlling collagen X expression and chondrocyte hypertrophy may play a role in OA intervention.Here,we investigated how Distal-less homeobox 5(DLX5),the distal-less homeobox family member,controls murine Col10a1 gene expression and chondrocyte hypertrophy in chondrogenic cell models and its role in a murine OA model.Through qRT-PCR and Western blot analyses,we detected significantly increased levels of COL10A1 and DLX5 in hypertrophic MCT and ATDC5 cells compared to their proliferative stage.Forced expression of Dlx5 further increases,while knockdown of Dlx5 decreases COL10A1 expression in hypertrophic MCT cells.We have performed dual-luciferase reporter and ChiP assays and demonstrated that DLX5 promotes reporter activity through direct interaction with Col10a1 cis-enhancer.We established a murine OA model and detected markedly increased COL10A1 and DLX5 in the articular cartilage and subchondral bone of the OA mice compared with the controls.Notably,forced overexpression of DLX5 in hypertrophic MCT cells up-regulates RUNX2,and adjacent DLX5 and RUNX2 binding sites have previously been found within the Col10a1 cis-enhancer.Together,our data suggest that DLX5 may cooperate with RUNX2 to control cell-specific Col10a1 expression and chondrocyte hypertrophy and is involved in OA pathogenesis. | Jinnan Chen Fangzhou Chen Xuan Wu Huiqin Bian Chen Chen Xiaojing Zhang Ruoxuan Hei Xiaotong Yang Haochun Yuan Qian Wang Yaojuan Lu Longwei Qiao Qiping Zheng | 2023 | Genes & Diseases2023，10，5： | 1 |
| 8 | Stretchable and durable HD-sEMG electrodes for accurate recognition of swallowing activities on complex epidermal surfaces显示文摘Surface electromyography(sEMG)is widely used in monitoring human health.Nonetheless,it is challenging to capture high-fidelity sEMG recordings in regions with intricate curved surfaces such as the larynx,because regular sEMG electrodes have stiff structures.In this study,we developed a stretchable,high-density sEMG electrode array via layerby-layer printing and lamination.The electrode offered a series of excellent human‒machine interface features,including conformal adhesion to the skin,high electron-to-ion conductivity(and thus lower contact impedance),prolonged environmental adaptability to resist water evaporation,and epidermal biocompatibility.This made the electrode more appropriate than commercial electrodes for long-term wearable,high-fidelity sEMG recording devices at complicated skin interfaces.Systematic in vivo studies were used to investigate its ability to classify swallowing activities,which was accomplished with high accuracy by decoding the sEMG signals from the chin via integration with an ear-mounted wearable system and machine learning algorithms.The results demonstrated the clinical feasibility of the system for noninvasive and comfortable recognition of swallowing motions for comfortable dysphagia rehabilitation. | Ding Zhang Zhitao Chen Longya Xiao Beichen Zhu RuoXuan Wu ChengJian Ou Yi Ma Longhan Xie Hongjie Jiang | 2023 | Microsystems & Nanoengineering2023，9，5： | 0 |
| 9 | Reform of the Teaching Model of Korean Intensive Reading Courses in Vocational High Schools in the Era of All-Media显示文摘The use of multimedia technology in the teaching process is the current mainstream trend in teaching development.The arrival of the all-media era is not only a huge challenge to the traditional teaching model,but also a huge opportunity for the reform of the teaching model.Combining traditional education models with modern scientific and technological means,and learning from each other’s strengths can stimulate students’subjective initiative in learning.On the other hand,it is also an important way for teachers to improve their teaching abilities.This article analyzes the opportunities brought by the all-media era to the reform of education models based on the teaching status and teaching difficulties of Korean intensive reading courses in vocational high schools,and proposes a teaching model reform strategy for Korean intensive reading courses in vocational high schools in the all-media era. | Ruoxuan Chen | 2023 | Journal of Contemporary Educational Research2023，7，11： | 0 |
| 10 | Efficient Multi-User for Task Offloading and Server Allocation in Mobile Edge Computing Systems显示文摘Mobile edge computing has emerged as a new paradigm to enhance computing capabilities by offloading complicated tasks to nearby cloud server.To conserve energy as well as maintain quality of service,low time complexity algorithm is proposed to complete task offloading and server allocation.In this paper,a multi-user with multiple tasks and single server scenario is considered for small network,taking full account of factors including data size,bandwidth,channel state information.Furthermore,we consider a multi-server scenario for bigger network,where the influence of task priority is taken into consideration.To jointly minimize delay and energy cost,we propose a distributed unsupervised learning-based offloading framework for task offloading and server allocation.We exploit a memory pool to store input data and corresponding decisions as key-value pairs for model to learn to solve optimization problems.To further reduce time cost and achieve near-optimal performance,we use convolutional neural networks to process mass data based on fully connected networks.Numerical results show that the proposed algorithm performs better than other offloading schemes,which can generate near-optimal offloading decision timely. | Qiuming Liu Jing Li Jianming Wei Ruoxuan Zhou Zheng Chai Shumin Liu | 2022 | China Communications2022，19，7： | 0 |
| 11 | Tribological performance and scuffing behaviors of several automobile piston rings mating with chrome-plated cylinder liner显示文摘The friction and wear properties,as well as the scuffing resistance,of different piston-ring coatings mating with a chrome-plated cylinder liner were investigated.Interrupted wear tests under the lubricant starvation condition were conducted to examine the wear behavior of Cr-diamond coating(GDC)and diamond-like coating(DLC).The results indicated that the DLC coating had outstanding tribological properties(small coefficient of friction and wear loss)at 150°C,while the GDC coating exhibited better performance at an elevated temperature(240°C).The DLC coating had a better scuffing resistance;no material adhesion occurred for 70 min under the unlubricated condition.The interrupted wear behaviors revealed that the scuffing process of the GDC coating involved the consumption of lubricant oil with relatively stable wear,a reduction in the friction force,and the occurrence of scuffing,in sequence.In contrast,although the friction force also increased after a short period of weak friction,no scuffing was observed.This is attributed to the formation of a mixed oxide and graphitic C tribolayer. | Zeyu MA Ruoxuan HUANG Xiaoshuai YUAN Yan SHEN Jiujun XU | 2022 | Friction2022，10，8： | 0 |
| 12 | The Dynamic Behaviors of a Shape Memory Polymer Membrane显示文摘 | Yauxin Li Ruoxuan Liu Zishun Liu | 2018 | Acta Mechanica Solida Sinica2018，31，5： | 0 |
| 13 | Autumn nitrogen enrichment destabilizes ecosystem biomass production in a semiarid grassland显示文摘Nitrogen(N)deposition decreases the temporal stability of ecosystem aboveground biomass production(ecosystem stability).However,little is known about how the responses of ecosystem stability differ based on seasonal N enrichment.By adding N in autumn,winter,or growing season,from October 2014 to May 2020,in a temperate grassland in northern China,we found that only N addition in autumn resulted in a significantly positive correlation between ecosystem mean aboveground net primary productivity(ANPP)and its standard deviation and significantly reduced ecosystem stability.Autumn N-induced reduction in ecosystem stability was associated with the vanished negative effect of community-wide species asynchrony(asynchronous dynamics among populations to environmental perturbations)on the standard deviation of ecosystem ANPP in combination with the emerged positive effect of dominance(Simpson's dominance index that indicates the relative weight of dominant species in a community).Our findings indicate that autumn N addition might overestimate the negative effect of annual atmospheric N deposition on ecosystem stability,suggesting that to better evaluate the influence of N deposition in temperate grasslands,both field experiments and global modeling should consider not only the annual N load but also its seasonal dynamics.Moreover,further studies should pay more attention to the alteration in the ecosystem temporal deviations,which might be more sensitive to human-induced environmental changes. | Yuqiu Zhang Zhengru Ren Haining Lu Xu Chen Ruoxuan Liu Yunhai Zhang | 2023 | Fundamental Research2023，3，2： | 0 |
| 14 | An overview of ML-based applications for next generation optical networks显示文摘Over the past few decades,the demand for the capacity and reliability of optical networks has continued to grow.In the meantime,optical networks with larger knowledge scales have become sources of numerous heterogeneous data.In order to handle these new challenges,many issues need to be resolved,among which the low-margin optical networks design,power optimization,routing and wavelength assignment(RWA),failure management are quite important.However,the use of traditional algorithms in the above four applications shows some shortcomings.Fortunately,artificial intelligence(AI),especially machine learning(ML),is regarded as one of the most promising methods to overcome these shortcomings.In this study,we review the applications of ML methods in solving these four issues.Although many ML-based researches have emerged,the applications of ML techniques in optical networks still face challenges.Therefore,we also discuss some possible future directions of investigating ML-based approaches in optical networks. | Ruoxuan GAO Lei LIU Xiaomin LIU Huazhi LUN Lilin YI Weisheng HU Qunbi ZHUGE | 2020 | Science China(Information Sciences)2020，63，6： | 0 |
| 15 | 温带半干旱草原克隆禾草叶性状对氮沉降铵硝比输入的响应:叶序不可忽略显示文摘叶片是植物光合作用的主要器官。叶片可塑性在很大程度上决定了植物对富氮环境的适应。然而在自然条件和富氮环境中,测定植物叶片性状时需要采集的最佳数量或比例是否一致并不明确;同时大气氮沉降主要组分铵态氮与硝态氮比例变化是否会改变叶片最佳测量数量缺少实验证据支撑。因此本研究依托自2014年在中国北方温带草原开展的铵硝比添加实验(即对照和5:1、1:1和1:5的NH_(4)^(+)-N/NO_(3)^(−)-N比例),于2020年8月(植物群落生物量高峰时期)测量了两个形态相似的优势多年生禾本科物种(即羊草和冰草)在叶序水平的叶面积、叶厚度和叶绿素含量。我们发现在对照处理(自然条件),除羊草叶面积需要测定5片(占单株总叶片数的78.82%),其它性状通过测量两片完全展开叶即可代表整株该叶性状的单叶平均特征。铵硝比添加处理显著改变了叶性状最大值所在叶序,导致需要增加叶片测定数才能代表整株叶片的单叶平均特征。铵硝比添加显著改变了受叶序调控的叶性状间权衡关系,即叶片虽变大却变薄。因此,本研究结果表明,通过测量全部完全展开叶或者提供一个合适的尺度推绎参数方能更好地评估氮沉降效应下植株叶片性状的响应特征。 | Ruoxuan Liu Jungang Chen Zhengru Ren Xu Chen Haining Lu Yuqiu Zhang Yunhai Zhang | 2023 | Journal of Plant Ecology2023，16，4： | 0 |
| 16 | Two-stage Stochastic Programming for Coordinated Operation of Distributed Energy Resources in Unbalanced Active Distribution Networks with Diverse Correlated Uncertainties显示文摘This paper proposes a stochastic programming(SP)method for coordinated operation of distributed energy resources(DERs)in the unbalanced active distribution network(ADN)with diverse correlated uncertainties.First,the threephase branch flow is modeled to characterize the unbalanced nature of the ADN,schedule DER for three phases,and derive a realistic DER allocation.Then,both active and reactive power resources are co-optimized for voltage regulation and power loss reduction.Second,the battery degradation is considered to model the aging cost for each charging or discharging event,leading to a more realistic cost estimation.Further,copulabased uncertainty modeling is applied to capture the correlations between renewable generation and power loads,and the twostage SP method is then used to get final solutions.Finally,numerical case studies are conducted on an IEEE 34-bus three-phase ADN,verifying that the proposed method can effectively reduce the system cost and co-optimize the active and reactive power. | Ruoxuan Leng Zhengmao Li Yan Xu | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，1： | 0 |
| 17 | Tailoring the multiscale mechanics of tunable decellularized extracellular matrix (dECM) for wound healing through immunomodulation显示文摘With the discovery of the pivotal role of macrophages in tissue regeneration through shaping the tissue immune microenvironment, various immunomodulatory strategies have been proposed to modify traditional biomaterials. Decellularized extracellular matrix (dECM) has been extensively used in the clinical treatment of tissue injury due to its favorable biocompatibility and similarity to the native tissue environment. However, most reported decellularization protocols may cause damage to the native structure of dECM, which undermines its inherent advantages and potential clinical applications. Here, we introduce a mechanically tunable dECM prepared by optimizing the freeze-thaw cycles. We demonstrated that the alteration in micromechanical properties of dECM resulting from the cyclic freeze-thaw process contributes to distinct macrophage-mediated host immune responses to the materials, which are recently recognized to play a pivotal role in determining the outcome of tissue regeneration. Our sequencing data further revealed that the immunomodulatory effect of dECM was induced via the mechnotrasduction pathways in macrophages. Next, we tested the dECM in a rat skin injury model and found an enhanced micromechanical property of dECM achieved with three freeze-thaw cycles significantly promoted the M2 polarization of macrophages, leading to superior wound healing. These findings suggest that the immunomodulatory property of dECM can be efficiently manipulated by tailoring its inherent micromechanical properties during the decellularization process. Therefore, our mechanics-immunomodulation-based strategy provides new insights into the development of advanced biomaterials for wound healing. | Pu Luo Ruoxuan Huang You Wu Xingchen Liu Zhengjie Shan Li Gong Shudan Deng Haiwen Liu Jinghan Fang Shiyu Wu Xiayi Wu Quan Liu Zetao Chen Kelvin W.K.Yeung Wei Qiao Shoucheng Chen Zhuofan Chen | 2023 | Bioactive Materials2023，，10： | 0 |
| 18 | Two‑Level Biomimetic Designs Enable Intelligent Stress Dispersion for Super‑Foldable C/NiS Nanofiber Free‑Standing Electrode显示文摘Due to the lack of in-depth understanding about the folding issues of the electronic materials,it is a huge challenge to pre-pare a super-foldable and highly electrochemical faradic electrode.Here,inspired from from the fully nimble structures of cuit cocoons and cockscomb petals,with two-level biomimetic design,for the first time we prepared a super-foldable and electrochemically functional freestanding cathode,made of C-fiber@NiS-cockscomb(SFCNi).In virtue of its nimble biomi-metic structures,SFCNi can remarkably sustain over 100,000 times,repeated true-folding without composite fibers fracture,functional matters detachment,conductivity degradation,or electrochemical performance change.The main mechanism behind these behaviors was disclosed by Real-time scanning electron microscopy and mechanical simulations,on the folding process.Results unveil that the cockscomb-like NiS with atomic thickness can deform freely due to the need of bending,and the cuit-cocoon-like SFCNi can generate an“ε-shape”folding structure at the crease.Such a smart self-adaptive deforma-tion capability can effectively reduce the effect of stresses and local excessive deformations,so that the chemical bonds can preserve their interaction,and the material won’t fracture.This subtle and exceptional mechanical behavior realizes a super-foldable property.The two-level biomimetic design strategy is a novel method for fabrication of super-foldable composite electrodes and integrated multi-functional super-foldable devices. | Guangtao Zan Tong Wu Wenya Dong Junchen Zhou Teng Tu Ruoxuan Xu Yun Chen Ying Wang Qingsheng Wu | 2022 | Advanced Fiber Materials2022，4，5： | 0 |
| 19 | Reproductive height determines the loss of clonal grasses with nitrogen enrichment in a temperate grassland显示文摘Tall clonal grasses commonly display competitive advantages with nitrogen(N)enrichment.However,it is currently unknown whether the height is derived from the vegetative or reproductive module.Moreover,it is unclear whether the height of the vegetative or reproductive system regulates the probability of extinction and colonization,and determines species diversity.In this study,the impacts on clonal grasses were studied in a field experiment employing two frequencies(twice a year vs.monthly)crossing with nine N addition rates in a temperate grassland,China.We found that the N addition decreased species frequency and increased extinction probability,but did not change the species colonization probability.A low frequency of N addition decreased species frequency and colonization probability,but increased extinction probability.Moreover,we found that species reproductive height was the best index to predict the extinction probability of clonal grasses in N-enriched conditions.The low frequency of N addition may overestimate the negative effect from N deposition on clonal grass diversity,suggesting that a higher frequency of N addition is more suitable in assessing the ecological effects of N deposition.Overall,this study illustrates that reproductive height was associated with the clonal species extinction probability under N-enriched environment. | Xu Chen Haining Lu Zhengru Ren Yuqiu Zhang Ruoxuan Liu Yunhai Zhang Xingguo Han | 2024 | Plant Diversity2024，46，2： | 0 |
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