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| 1 | Endocrine role of bone in the regulation of energy metabolism显示文摘Bone mainly functions as a supportive framework for the whole body and is the major regulator of calcium homeostasis and hematopoietic function.Recently,an increasing number of studies have characterized the significance of bone as an endocrine organ,suggesting that bone-derived factors regulate local bone metabolism and metabolic functions.In addition,these factors can regulate global energy homeostasis by altering insulin sensitivity,feeding behavior,and adipocyte commitment.These findings may provide a new pathological mechanism for related metabolic diseases or be used in the diagnosis,treatment,and prevention of metabolic diseases such as osteoporosis,obesity,and diabetes mellitus.In this review,we summarize the regulatory effect of bone and bone-derived factors on energy metabolism and discuss directions for future research. | Ruoyu Zhou Qiaoyue Guo Ye Xiao Qi Guo Yan Huang Changjun Li Xianghang Luo | 2021 | Bone Research2021，9，4： | 11 |
| 2 | Regulation of the inflammatory cycle by a controllable release hydrogel for eliminating postoperative inflammation after discectomy显示文摘Surgery is the final choice for most patients with intervertebral disc degeneration(IDD).Operation-caused trauma will cause inflammation in the intervertebral disc.Serious inflammation will cause tissue defects and induce tissue degeneration,IDD recurrence and the occurrence of other diseases.Therefore,we proposed a scheme to treat recurrence after discectomy by inhibiting inflammation with an aspirin(ASP)-loaded hydrogel to restore the mechanical stability of the spine and relieve local inflammation.ASP-liposomes(ASP-Lips)were incorporated into a photocrosslinkable gelatin-methacryloyl(GelMA)via mixing.This material can effectively alleviate inflammation by inhibiting the release of high mobility group box 1(HMGB1)from the nucleus to the cytoplasm.We further assessed the expression of inflammatory cytokines,such as interleukin 6(IL-6)and tumor necrosis factor-α(TNF-α),and degeneration-related factors,such as type II collagen(COL-2),Aggrecan,matrix metallopeptidases-3(MMP-3),MMP-13,a disintegrin and metalloproteinase with thrombospondin motifs-4(ADAMTS-4)and ADAMTS-5 in rat nucleus pulpous cells.The level of IDD was analyzed through H&E,safranin-O staining and immunohistochemistry in rabbit samples.In vitro,we found that ASP-Lip@GelMA treatment significantly decreased inflammatory cytokines,MMP-3 and-13,and ADAMTS-4 and-5 and up-regulated COL-2 and Aggrecan via the inhibited release of HMGB-1 from the nucleus.In vivo,ASP-Lip@GelMA can effectively inhibit inflammation of local tissue after disc surgery and fill local tissue defects.This composite hydrogel system is a promising way to treat the recurrence of IDD after surgery without persistent complications. | Yu Liu Jiacheng Du Peng Peng Ruoyu Cheng Jiayi Lin Congxin Xu Huilin Yang Wenguo Cui Haiqing Mao Yuling Li Dechun Geng | 2021 | Bioactive Materials2021，6，1： | 6 |
| 3 | FluxExplorer: A general platform for modeling and analyses of metabolic net-works based on stoichiometry显示文摘Stoichiometry-based analyses of meta- bolic networks have aroused significant interest of systems biology researchers in recent years. It is necessary to develop a more convenient modeling platform on which users can reconstruct their network models using completely graphical operations, and explore them with powerful analyzing modules to get a better understanding of the properties of metabolic systems. Herein, an in silico platform, FluxExplorer, for metabolic modeling and analyses based on stoichiometry has been developed as a publicly available tool for systems biology research. This platform integrates various analytic approaches, in- cluding flux balance analysis, minimization of meta- bolic adjustment, extreme pathways analysis, shadow prices analysis, and singular value decom- position, providing a thorough characterization of the metabolic system. Using a graphic modeling process, metabolic networks can be reconstructed and modi- fied intuitively and conveniently. The inconsistencies of a model with respect to the FBA principles can be proved automatically. In addition, this platform sup- ports systems biology markup language (SBML). FluxExplorer has been applied to rebuild a metabolic network in mammalian mitochondria, producing meaningful results. Generally, it is a powerful and very convenient tool for metabolic network modeling and analysis. | LUO Ruoyu LIAO Sha ZENG Shaoqun LI Yixue LUO Qingming | 2006 | Chinese Science Bulletin2006，51，6： | 6 |
| 4 | Th and Treg response induced by Aspergillusfumigatus pulsed dendritic cells in vitro显示文摘 | Wang Runchao Wan Zhe Li Ruoyu | 2014 | Chinese Medical Journal2014，，20： | 6 |
| 5 | On the viscosity of magnetic fluid with low and moderate solid fraction显示文摘The design of a pressurized capillary rheometer operating at prescribed temperature is described to measure the viscosity of magnetic fluids(MFs) containing Fe3O4 magnetic nanoparticles(MNPs).The equipment constant of the rheometer was obtained using liquids with predetermined viscosities.Experimentally measured viscosities were used to evaluate different equations for suspension viscosities.Deviation of measured suspension viscosities from the Einstein equation was found to be basically due to the influence of spatial distribution and aggregation of Fe3O4 MNPs.By taking account of the coating layer on MNPs and the aggregation of MNPs in MFs,a modified Einstein equation was proposed to fit the experimental data.Moreover,the influence of external magnetic field on viscosity was also taken into account.Viscosities thus predicted are in good agreement with experimental data.Temperature effect on suspension viscosity was shown experimentally to be due to the shear-thinning behavior of the MFs. | Zhiqiang Ren Yanping Han Ruoyu Hong Jianmin Ding Hongzhong Li | 2008 | Particuology2008，6，3： | 5 |
| 6 | Comparison of schemes for preparing magnetic Fe_3O_4 nanoparticles显示文摘Magnetic Fe3O4 nanoparticles were prepared by means of coprecipitation using NH3·H2O in water and in alcohol, and using NaOH in water. A series of instruments such as SEM, TEM, HRTEM, FT-IR, XRD and VSM were used to characterize the properties of the magnetic nanoparticles. The results indicated that the magnetism of Fe3O4 nanoparticles synthesized using NH3·H2O in water was the highest, although the reaction time was the longest. The process using NaOH in water was the simplest and the reaction time was the shortest, but the particle characteristics were inferior to those of the other two methods. The mean size of magnetic Fe3O4 nanoparticles prepared by coprecipitation in alcohol was the smallest among the three, but the nanoparticles aggregated severely. The magnetic Fe3O4 nanoparticles were coated with oleic acid using saturated sodium oleate, and the polarity of the surface-modified nanoparticles was measured. Fe3O4 nanoparticles prepared using NH3·H2O, not NaOH, could be coated successfully and thoroughly. | Ruoyu Hong Jianhua Li Jian Wang Hongzhong Li | 2007 | China Particuology2007，5，1： | 5 |
| 7 | Fast and uniform growth of graphene glass using confined-flow chemical vapor deposition and its unique applications显示文摘常规玻璃上的高质量的 graphene 的快、一致的生长为 graphene 玻璃的实际应用程序是很重要的。我们此处为 graphene 玻璃的高效率的制造报导一条范围流动化学药品蒸汽免职(CVD ) 途径。我们的途径的特色是 2-4 m 的制造在玻璃底层上面的宽差距,与很多的跌倒块;这差距被发现显著地增加在对方之间并且与玻璃表面的碳先锋和反应碎片的碰撞概率。作为结果, graphene 玻璃的生长率显著地增加了,和在象与那些相比的生长质量和在常规煤气的流动 CVD 技术的一致性的改进。这些高质量的 graphene 眼镜与以前报导的那些相比以许多更高的 defogging 速度和更高的稳定性展出了优秀 defogging 表演。graphene 蓝宝石玻璃被发现是为种制服和极端光滑的铝氮化物的理想的底层没有缓冲区层的乏味的免职前的薄电影。介绍范围流动 CVD 途径为 graphene 玻璃的大量生产提供一条简单、便宜的线路,它被相信支持各种各样的 graphene 眼镜的实际应用。 | Zhaolong Chen Baolu Guan Xu-dong Chen Qing Zeng Li Lin Ruoyu Wang Manish Kr. Priydarshi Jingyu Sun Zhepeng Zhang Tongbo Wei Jinmin LI Yanfeng Zhang Yingying Zhang Zhongfan Liu | 2016 | Nano Research2016，9，10： | 5 |
| 8 | A CORRELATION EQUATION FOR CALCULATING INCLINED JET PENETRATION LENGTH IN A GAS-SOLID FLUIDIZED BED显示文摘Numerical simulation of gas-solid flow in a two-dimensional fluidized bed with an inclined jet was performed. The numerical model is based on the two-fluid model of gas and solids phase in which the solids constitutive equations are based on the kinetic theory of granular flow. The improved ICE algorithm, which can be used for both low and high-velocity fluid flow, were used to solve the model equations. The mechanism of jet formation was analyzed using both numerical simulations and experiments. The emergence and movement of gas bubbles were captured numerically and experimentally. The influences of jet velocity, nozzle diameter, nozzle inclination and jet position on jet penetration length were obtained. A semi-empirical expression was derived and the parameters were correlated from experimental data. The correlation equation, which can be easily used to obtain the inclined jet penetration length, was compared with our experimental data and published correlation equations. | Ruoyu Hong Haibing Li Jianmin Ding Hongzhong Li | 2005 | China Particuology2005，3，5： | 3 |
| 9 | N, F?Codoped Microporous Carbon Nanofibers as Efficient Metal?Free Electrocatalysts for ORR显示文摘Currently, the oxygen reduction reaction(ORR) mainly depends on precious metal platinum(Pt) catalysts. However, Pt-based catalysts have several shortcomings, such as high cost, scarcity, and poor long-term stability. Therefore, development of e cient metal-free electrocatalysts to replace Pt-based electrocatalysts is important. In this study, we successfully prepared nitrogen-and fluorinecodoped microporous carbon nanofibers(N, F-MCFs) via electrospinning polyacrylonitrile/polyvinylidene fluoride/polyvinylpyrrolidone(PAN/PVDF/PVP) tricomponent polymers followed by a hydrothermal process and thermal treatment, which was achieved for the first time in the literature. The results indicated that N, F-MCFs exhibit a high catalytic activity(E_(onset): 0.94 V vs. RHE, E_(1/2): 0.81 V vs. RHE, and electron transfer number: 4.0) and considerably better stability and methanol tolerance for ORR in alkaline solutions as compared to commercial Pt/carbon(Pt/C, 20 wt%) catalysts. Furthermore, in acidic media, N, F-MCFs showed a four-electron transfer pathway for ORR. This study provides a new strategy for in situ synthesis of N, F-MCFs as highly e cient metal-free electrocatalysts for ORR in fuel cells. | Tianle Gong Ruoyu Qi Xundao Liu Hong Li Yongming Zhang | 2019 | Nano-Micro Letters2019，11，1： | 3 |
| 10 | Application of Bronsted acid ionic liquids as green catalyst in the synthesis of 2-propanol with reactive distillation显示文摘Five Br?nsted acidic ionic liquids(ILs) were prepared and characterized by FT-IR,~1H NMR and ^(13)C NMR. Their catalytic activities for the synthesis of 2-propanol(IPOH) via transesterification of isopropyl acetate(IPAc) with methanol(Me OH) were investigated. Among all the tested ILs, [Ps-mim]HSO_4 performed best and was used as catalyst for further studies. The reaction kinetics were carried out to correlate the parameters in a homogeneous second order kinetic model. It has been found that there is close agreement between the calculated and experimental values. The high-pressure batch reactive distillation experimental apparatus was set up in order to enhance the conversion of IPAc. A high conversion of IPAc of 99.4% was obtained under the optimal reaction conditions. The catalyst [Ps-mim]HSO_4 can be recycled easily by a rotary evaporator and reused without any further treatment. The catalyst had been repeatedly used for four times and no obvious changes in the structure of catalyst could be observed. | Jinbei Yang Dongren Cai Ting Zeng Lihua Zhou Ling Li Ruoyu Hong Ting Qiu | 2016 | Chinese Journal of Chemical Engineering2016，24，11： | 3 |
| 11 | SPOTLIGHTS显示文摘At the end of 2013,theGraduate School of theC h i n a U n i v e r s i t y o fPolitical Science and Laworganized a symposium on HumanRights Construction and Reform andactivities at the university in com-memoration of the 65th anniversaryof the adoption of the UniversalDeclaration of Human Rights.LuoHaocai,who was vice chairmanof the 10th National Committeeof the Chinese People’s PoliticalConsultative Conference and presi-dent of the China Society for HumanRights Studies(CSHRS),PresidentHuang Jin of the China Universityof Political Science and Law,andnearly 50 scholars from the Civil andCommercial Law School,China-EUSchool of Law and the InternationalInstitute of Confucianism also at- | ZHANG WEI LI RUOYU | 2014 | The Journal of Human Rights2014，13，3： | 2 |
| 12 | Synergistic osteogenic and angiogenic effects of KP and QK peptides incorporated with an injectable and self-healing hydrogel for efficient bone regeneration显示文摘Irregular defects generated by trauma or surgery in orthopaedics practice were usually difficult to be fitted by the preformed traditional bone graft substitute. Therefore, the injectable hydrogels have attracted an increasing interest for bone repair because of their fittability and mini-invasivity. However, the uncontrollable spreading or mechanical failures during its manipulation remain a problem to be solved. Moreover, in order to achieve vascularized bone regeneration, alternatives of osteogenic and angiogenic growth factors should be adopted to avoid the problem of immunogenicity and high cost. In this study, a novel injectable self-healing hydrogel system (GMO hydrogel) loaded with KP and QK peptides had been developed for enhancing vascularized regeneration of small irregular bone defect. The dynamic imine bonds between gelatin methacryloyl and oxidized dextran provided the GMO hydrogel with self-healing and shear-thinning abilities, which led to an excellent injectability and fittability. By photopolymerization of the enclosed GelMA, GMO hydrogel was further strengthened and thus more suitable for bone regeneration. Besides, the osteogenic peptide KP and angiogenic peptide QK were tethered to GMO hydrogel by Schiff base reaction, leading to desired releasing profiles. In vitro, this composite hydrogel could significantly improve the osteogenic differentiation of BMSCs and angiogenesis ability of HUVECs. In vivo, KP and QK in the GMO hydrogel demonstrated a significant synergistic effect in promoting new bone formation in rat calvaria. Overall, the KP and QK loaded GMO hydrogel was injectable and self-healing, which can be served as an efficient approach for vascularized bone regeneration via a minimally invasive approach. | Runze Li Chen Zhou Jun Chen Haotian Luo Ruoyu Li Danying Chen Xuenong Zou Weicai Wang | 2022 | Bioactive Materials2022，7，12： | 2 |
| 13 | Signaling pathways in obesity:mechanisms and therapeutic interventions显示文摘Obesity is a complex,chronic disease and global public health challenge.Characterized by excessive fat accumulation in the body,obesity sharply increases the risk of several diseases,such as type 2 diabetes,cardiovascular disease,and nonalcoholic fatty liver disease,and is linked to lower life expectancy.Although lifestyle intervention(diet and exercise)has remarkable effects on weight management,achieving long-term success at weight loss is extremely challenging,and the prevalence of obesity continues to rise worldwide.Over the past decades,the pathophysiology of obesity has been extensively investigated,and an increasing number of signal transduction pathways have been implicated in obesity,making it possible to fight obesity in a more effective and precise way.In this review,we summarize recent advances in the pathogenesis of obesity from both experimental and clinical studies,focusing on signaling pathways and their roles in the regulation of food intake,glucose homeostasis,adipogenesis,thermogenesis,and chronic inflammation.We also discuss the current antiobesity drugs,as well as weight loss compounds in clinical trials,that target these signals.The evolving knowledge of signaling transduction may shed light on the future direction of obesity research,as we move into a new era of precision medicine. | Xue Wen Bohan Zhang Beiyi Wu aitao Xiao Zehua Li Ruoyu Li Xuewen Xu Tao Li | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 2 |
| 14 | Identification of prognostic biomarkers in hepatitis B virus-related hepatocellular carcinoma and stratification by integrative multi-omics analysis显示文摘 | Ruoyu Miao Haitao Luo Huandi Zhou Guangbing Li Dechao Bu Xiaobo Yang Xue Zhao Haohai Zhang Song Liu Ying Zhong Zhen Zou Yan Zhao Kuntao Yu Lian He Xinting Sang Shouxian Zhong Jiefu Huang Yan Wu Rebecca A. Miksad Simon C. Robson Chengyu Jiang Yi Zhao Haita | 2014 | Journal of Hepatology2014，，： | 2 |
| 15 | Prevalent fecal contamination in drinking water resources and potential health risks in Swat, Pakistan显示文摘Fecal bacteria contaminate water resources and result in associated waterborne diseases.This study assessed drinking water quality and evaluated their potential health risks in Swat, Pakistan. Ground and surface drinking water were randomly collected from upstream to downstream in the River Swat watershed and analyzed for fecal contamination using fecal indicator bacteria(Escherichia coli) and physiochemical parameters(potential of hydrogen, turbidity, temperature, electrical conductivity, total dissolved solid, color, odor and taste). The physiochemical parameters were within their safe limits except in a few locations, whereas, the fecal contaminations in drinking water resources exceeded the drinking water quality standards of Pakistan Environmental Protection Agency(Pak-EPA),2008 and World Health Organization(WHO), 2011. Multivariate and univariate analyses revealed that downstream urbanization trend, minimum distance between water sources and pit latrines/sewerage systems, raw sewage deep well injection and amplified urban,pastures and agricultural runoffs having human and animal excreta were the possible sources of contamination. The questionnaire survey revealed that majority of the local people using 10–20 years old drinking water supply schemes at the rate of 73% well supply,13% hand pump supply, 11% spring supply and 3% river/streams supply, which spreads high prevalence of water borne diseases including hepatitis, intestinal infections and diarrhea, dysentery, cholera, typhoid fever, jaundice and skin diseases in children followed by older and younger adults. | Kifayatullah Khan Yonglong Lu Mian Abdal Saeed Hazrat Bilal Hassan Sher Hizbullah Khan Jafar Ali Pei Wang Herman Uwizeyimana Yvette Baninla Qifeng Li Zhaoyang Liu Javed Nawab Yunqiao Zhou Chao Su Ruoyu Liang | 2018 | Journal of Environmental Sciences2018，30，10： | 1 |
| 16 | Progression and prospects of translational medicine in China显示文摘Translational medicine is a new discipline aiming to eliminate the barrier between preclinical and clinical medicine [1]. It converts promising laboratory discoveries into clinical applications and elucidates clinical questions | LI GuangBing MIAO RuoYu ZHAO HaiTao | 2012 | Science China(Life Sciences)2012，55，11： | 1 |
| 17 | pUGTdb:A comprehensive database of plant UDP-dependent glycosyltransferases显示文摘Dear Editor,Plant UDP-dependent glycosyltransferases(UGTs),belonging to the carbohydrate-active enzyme glycosyltransferase 1 family(Louveau and Osbourn,2019),not only play important roles in adaptation to various environments(Cai et al.,2020;Pastorczyk-Szlenkier and Bednarek,2021)but also endow plant natural products with great pharmaceutical and ecological significance(Margolin et al.,2020).In recent years,an increasing number of plant UGTs have been characterized to function in the biosynthesis of many bioactive compounds such as ginsenosides(Wei et al.,2015),breviscapine(Liu et al.,2018),and rubusoside(Xu et al.,2022). | Yuqian Liu Qian Wang Xiaonan Liu Jian Chengi Lei Zhang Huanyu Chu Ruoyu Wang Haoran Li Hong Chang Nida Ahmed Zhonghua Wang Xiaoping Liao Huifeng Jiang | 2023 | Molecular Plant2023，16，4： | 1 |
| 18 | An overview of the switching parameter variation of RRAM显示文摘Resistive random access memory(RRAM) has been considered as one of the most promising candidates for next-generation nonvolatile memory, due to its advantages of simple device structure, excellent scalability, fast operation speed and low power consumption. Deeply understanding the physical mechanism and effectively controlling the statistical variation of switching parameters are the basis of fostering RRAM into commercial application. In this paper, based on the deep understanding on the mechanism of the formation and rupture of conductive filament, we summarize the methods of analyzing and modeling the statistics of switching parameters such as SET/RESET voltage, current, speed or time. Then, we analyze the distributions of switching parameters and the influencing factors. Additionally, we also sum up the analytical model of resistive switching statistics composed of the cell-based percolation model and SET/RESET switching dynamics. The results of the model can successfully explain the experimental distributions of switching parameters of the Ni O- and Hf O2-based RRAM devices. The model also provides theoretical guide on how to improve the uniformity and reliability such as disturb immunity. Finally, some experimental approaches to improve the uniformity of switching parameters are discussed. | Meiyun Zhang Shibing Long Guoming Wang Yang Li Xiaoxin Xu Hongtao Liu Ruoyu Liu Ming Wang Congfei Li Pengxiao Sun Haitao Sun Qi Liu Hangbing L Ming Liu | 2014 | Chinese Science Bulletin2014，59，36： | 1 |
| 19 | Controlled adsorption of cellulase onto pretreated corncob by pH adjustment显示文摘 | Ruoyu Du Rongxin Su Xuan Li Xiaowei Tantai Zhaohui Liu Jifeng Yang Wei Qi Zhimin He | 2012 | Cellulose2012，，2： | 1 |
| 20 | RNA m^(6)A modification orchestrates a LINE-1-host interaction that facilitates retrotransposition and contributes to long gene vulnerability显示文摘The molecular basis underlying the interaction between retrotransposable elements(RTEs)and the human genome remains poorly understood.Here,we profiled N^(6)-methyladenosine(m^(6)A)deposition on nascent RNAs in human cells by developing a new method MINT-Seq,which revealed that many classes of RTE RNAs,particularly intronic LINE-1s(Lis),are strongly methylated. | Feng Xiong Ruoyu Wang Joo-Hyung Lee Shenglan Li Shin-Fu Chen Zian Liao Lana AI Hasani Phuoc T.Nguyen Xiaoyu Zhu Joanna Krakowiak Dung-Fang Lee Leng Han Kuang-Lei Tsai Ying Liu Wenbo Li | 2021 | Cell Research2021，31，8： | 1 |
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