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| 1 | Rapid species identification of pathogenic bacteria from a minute quantity exploiting three-dimensional quantitative phase imaging and artificial neural network显示文摘The healthcare industry is in dire need of rapid microbial identification techniques for treating microbial infections.Microbial infections are a major healthcare issue worldwide,as these widespread diseases often develop into deadly symptoms.While studies have shown that an early appropriate antibiotic treatment significantly reduces the mortality of an infection,this effective treatment is difficult to practice.The main obstacle to early appropriate antibiotic treatments is the long turnaround time of the routine microbial identification,which includes time-consuming sample growth.Here,we propose a microscopy-based framework that identifies the pathogen from single to few cells.Our framework obtains and exploits the morphology of the limited sample by incorporating three-dimensional quantitative phase imaging and an artificial neural network.We demonstrate the identification of 19 bacterial species that cause bloodstream infections,achieving an accuracy of 82.5%from an individual bacterial cell or cluster.This performance,comparable to that of the gold standard mass spectroscopy under a sufficient amount of sample,underpins the effectiveness of our framework in clinical applications.Furthermore,our accuracy increases with multiple measurements,reaching 99.9%with seven different measurements of cells or clusters.We believe that our framework can serve as a beneficial advisory tool for clinicians during the initial treatment of infections. | Geon Kim Daewoong Ahn Minhee Kang Jinho Park DongHun Ryu YoungJu Jo Jinyeop Song Jea Sung Ryu Gunho Choi Hyun Jung Chung Kyuseok Kim Doo Ryeon Chung In Young Yoo Hee Jae Huh Hyun-seok Min Nam Yong Lee YongKeun Park | 2022 | Light(Science & Applications)2022，11，7： | 2 |
| 2 | Enhanced inflammatory cytokine production at ischemia - reperfusion in human liver resection 显示文摘 | Kim YI Song KE Ryeon HK | 2002 | Hepatogas - troenterology2002，49，46： | 1 |
| 3 | Risk factors and treatment outcomes of bloodstream infection caused by extended-spectrum cephalosporin-resistant Enterobacter species in adults with cancer显示文摘 | Kyungmin Huh Cheol-In Kang Jungok Kim Sun Young Cho Young Eun Ha Eun-Jeong Joo Doo Ryeon Chung Nam Yong Lee Kyong Ran Peck Jae-Hoon Song | 2013 | Diagnostic Microbiology & Infectious Disease2013，，： | 1 |
| 4 | The clinical outcome of FLAG chemotherapy without idarubicin in patients with relapsed or refractory acute myeloid leukemia显示文摘 | Se Ryeon Lee Deok Hwan Yang Jae Sook Ahnl T | | 0，，： | 1 |
| 5 | Enhanced inflammatory cytokine production at ischemia-reperfusion in human liver resection 显示文摘 | Kim YI Song KE Ryeon HK | 2002 | Hepatogastroenterology2002，49，46： | 1 |
| 6 | Antioxidant activity and constituents of propolis collected in various areas of China 显示文摘 | Mok Ryeon Ahn Shigenori Kumazawa Yumiko Usui | 2007 | Food Chemistry2007，，101： | 1 |
| 7 | Enhenced inflammatory cytokine production at ischemia/reperfusion in human liver resection显示文摘 | Kim YI Song KE Ryeon HK | 2002 | Hepatogastroenterology2002，49，46： | 1 |
| 8 | Enhanced inflammatory cy- tokine production at ischemia - reperfusion in human liver resec- tion显示文摘 | Kim YI Song KE Ryeon HK | 2002 | Hepatogastroenterology2002，49，46： | 1 |
| 9 | Enhanced inflammatory cyto- kine production at ischemia-reperfusion in human liver resection 显示文摘 | Kim Y I Song K E Ryeon H K | 2002 | Hepatogastroenterology2002，49，46： | 1 |
| 10 | Enhanced inflammatory cytokine production at ischemia-reperfusion in human liver resection显示文摘 | Kim YI Song KE Ryeon HK | | 0，，46： | 1 |
| 11 | 红外吸收峰的位置波动:归因于单一谱带的频移还是重叠谱带相对强度的变化?显示文摘红外吸收峰的位置波动可能由单一谱带的实际频移或是邻近重叠谱带相对强度的变化而产生。本文通过主成分分析法(PCA)有力地证明了光谱位置波动的根源往往归因于后一种机理。PCA能灵敏有效地区分单一谱带的实际频移与由重叠谱带相对强度变化所产生的最大峰移。对于由分子相互作用强度变化所诱导,并在振动光谱领域较为常见的所谓'带移'的概念,往往由于其隐含了谱带的固有频移而有些概念误导。在许多红外光谱中,峰极大值表面的位移,一般产生于两条重叠谱带相对贡献的变化,而不是分子相互作用强度变化所诱导的单一谱带的缓慢频移。这个观点可以帮助我们解释振动光谱所探测到的分子相互作用。 | Soo Ryeon Ryu Isao Noda Young Mee Jung | 2011 | 生命科学仪器2011，9，3： | 1 |
| 12 | Enhanced inflammatory cytokine production at ischemia-reperfusion in human liver resection显示文摘 | Kim YI Song KE Ryeon HK | 2002 | Hepatogastroenterology2002，49，46： | 1 |
| 13 | Enhanced inflammatory cytokine production at ische mia/reperfusion in human liver resection显示文摘 | Kim YI Song KE Ryeon HK | | 0，，46： | 1 |
| 14 | Enhanced inflammatory cytokine production at ischemia-reperfusion in human liver resection显示文摘 | Kim YI Song KE Ryeon HK | 2002 | Hepatogastroenterology2002，49，46： | 1 |
| 15 | Abdominal Shape of Gastric Cancer Patients Influences Short-Term Surgical Outcomes显示文摘 | Jun Ho Lee Yong Hae Paik Jong Seok Lee Keun Won Ryu Chan Gyoo Kim Sook Ryeon Park Young Woo Kim Myeong Cherl Kook Byung-ho Nam Jae-Moon Bae | 2007 | Annals of Surgical Oncology2007，，4： | 1 |
| 16 | Screening of antioxidative activity ofBifidobacterium species isolated from Korean infant feces and their identification显示文摘 | Ji Youn Kim Soo Im Choi Tae Ryeon Heo | 2003 | Biotechnology and Bioprocess Engineering2003，，3： | 1 |
| 17 | Enhanced inflammatory cytokine production at ischemia/reperfusion in human liver resection 显示文摘 | Kim YI Song KE Ryeon HK | 2002 | Hepatogastroenterology2002，49，46： | 1 |
| 18 | Preparation of a novel bimodal catalytic membrane reactor and its application to ammonia decomposition for CO x -free hydrogen production显示文摘 | Gang Li Masakoto Kanezashi Hye Ryeon Lee Makoto Maeda Tomohisa Yoshioka Toshinori Tsuru | 2012 | International Journal of Hydrogen Energy2012，，17： | 1 |
| 19 | Enhanced inflammatory cytokine production at ische mia/reperfusion in human liver resection显示文摘 | Kim YI Song KE Ryeon HK | 2002 | Hepato- gastroenterology2002，49，： | 1 |
| 20 | Enhanced inflammatory cytokine production at ischemia/reperfusion in human liver resection显示文摘 | Kim YL Song KE Ryeon HK | 2002 | Hepato-gastroenterology2002，49，： | 1 |
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