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| 1 | BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts显示文摘Adult bone structural integrity is maintained by remodeling via the coupling of osteoclastic bone resorption and osteoblastic bone formation.Osteocytes or osteoblasts express receptor activator of nuclear factor k-B ligand(Rankl)or osteoprotegerin(Opg)to promote or inhibit osteoclastogenesis,respectively.Bone morphogenetic protein(BMP)is a potent bone inducer,but its major role in adult bone is to induce osteocytes to upregulate sclerostin(Sost)and increase the Rankl/Opg expression ratio,resulting in promotion of osteoclastogenesis.However,the precise effect of BMP-target gene(s)in osteoblasts on the Rankl/Opg expression ratio remains unclear.In the present study,we identified atonal homolog 8(Atoh8),which is directly upregulated by the BMPSmadl axis in osteoblasts.In vivo,Atoh8 was detected in osteoblasts but not osteocytes in adult mice.Although global Atoh8-knockout mice showed only a mild phenotype in the neonate skeleton,the bone volume was decreased and osteoclasts were increased in the adult phase.Atoh8-null marrow stroma cells were more potent than wild-type cells in inducing osteoclastogenesis in marrow cells.Atoh8 loss in osteoblasts increased Runx2 expression and the Rankl/Opg expression ratio,while Runx2 knockdown normalized the Rankl/Opg expression ratio.Moreover,Atoh8 formed a protein complex with Runx2 to inhibit Runx2 transcriptional activity and decrease the Rankl/Opg expression ratio.These results suggest that bone remodeling is regulated elaborately by BMP signaling;while BMP primarily promotes bone resorption,it simultaneously induces Atoh8 to inhibit Runx2 and reduce the Rankl/Opg expression ratio in osteoblasts,suppressing osteoclastogenesis and preventing excessive BMP-mediated bone resorption. | Yuhei Yahiro Shingo Maeda Masato Morikawa Daizo Koinuma Go Jokoji Toshiro ljuin Setsuro Komiya Ryoichiro Kageyama Kohei Miyazono Noboru Taniguchi | 2020 | Bone Research2020，8，3： | 6 |
| 2 | Screening for hilar biliary invasion in ampullary cancer patients显示文摘BACKGROUND The treatment for ampullary cancer is pancreatoduodenectomy or local ampullectomy.However,effective methods for the preoperative investigation of hilar biliary invasion in ampullary cancer patients have not yet been identified.AIM To determine the necessity of and an appropriate method for investigating hilar biliary invasion of ampullary cancer.METHODS Among 43 ampullary cancer patients,34 underwent endoscopic treatment(n=9)or surgery(n=25).The use of imaging findings(thickening and enhancement of the bile duct wall on contrast-enhanced computed tomography,irregularity on endoscopic retrograde cholangiography,thickening of the entire bile duct wall on intraductal ultrasonography(IDUS),and partial thickening of the bile duct wall on IDUS)and biliary biopsy results for diagnosing hilar biliary invasion of ampullary cancer was compared.RESULTS Hilar invasion was not observed in every patient.Among the patients who did not undergo biliary stent insertion,the combination of partial thickening of the bile duct wall on IDUS and biliary biopsy results showed the highest accuracy(100%)for diagnosing hilar biliary invasion.However,each imaging method and biliary biopsy yielded some false-positive results.CONCLUSION Although some false-positive results were obtained with each method,the combination of partial thickening of the bile duct wall on IDUS and biliary biopsy results was useful for diagnosing hilar biliary invasion of ampullary cancer.However,hilar invasion of ampullary cancer is rare;therefore,the investigation of hilar biliary invasion of ampullary cancer might be unnecessary. | Tadayuki Takagi Mitsuru Sugimoto Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Jun Nakamura Mika Takasumi Minami Hashimoto Tsunetaka Kato Ryoichiro Kobashi Takumi Yanagita Yuko Hashimoto Shigeru Marubashi Takuto Hikichi Hiromasa Ohira | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，9： | 2 |
| 3 | Roles of bHLH genes in neural stem cell differentiation显示文摘 | Ryoichiro K Toshiyuki O Jun Hatakeyama | 2005 | Exp Cell Res2005，306，： | 1 |
| 4 | Oscillations in Notch Signaling Regulate Maintenance of Neural Progenitors显示文摘 | Hiromi Shimojo Toshiyuki Ohtsuka Ryoichiro Kageyama | 2008 | Neuron2008，，1： | 1 |
| 5 | Oscillations in Notch Signaling Regulate Maintenance of Neural Progenitors显示文摘 | Hiromi S Toshiyuki O Ryoichiro K | 2008 | Neuron2008，58，1： | 1 |
| 6 | The bHLH Gene Hes1 Regulates Differentiation of Multiple Cell Types显示文摘 | Ryoichiro Kageyama Toshiyuki Ohtsuka Koichi Tomita | 2000 | Molecules and Cells2000，，1： | 1 |
| 7 | Oscillations in Notch Signaling Regulate Maintenance of Neural Progenitors显示文摘 | Hiromi Shimojo Toshiyuki Ohtsuka Ryoichiro Kageyama | 2008 | Neuron2008，，1： | 1 |
| 8 | Integrated Regulation of Toll-like Receptor Responses by Notch and Interferon-γ Pathways显示文摘 | Xiaoyu Hu Allen Y. Chung Indira Wu Julia Foldi Janice Chen Jong Dae Ji Tomoko Tateya Young Jun Kang Jiahuai Han Manfred Gessler Ryoichiro Kageyama Lionel B. Ivashkiv | 2008 | Immunity2008，，5： | 1 |
| 9 | Roles of bHLH genes in neural stem cell differentiation显示文摘 | Ryoichiro K Toshiyuki O Jun Hatakeyama | 2005 | Experimental Cell Research2005，306，： | 1 |
| 10 | Candidate markers for stem and early progenitor cells, Musashi-1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine显示文摘 | Takahisa Kayahara Mitsutaka Sawada Shigeo Takaishi Hirokazu Fukui Hiroshi Seno Hiroaki Fukuzawa Katsumasa Suzuki Hiroshi Hiai Ryoichiro Kageyama Hideyuki Okano Tsutomu Chiba | 2003 | FEBS Letters2003，，1： | 1 |
| 11 | Roles of bHLH genes in neural stem cell differentiation显示文摘 | Ryoichiro K Toshiyuki O Jun H | 2005 | Experimental Cell Research2005，306，2： | 1 |
| 12 | The Role of Notch Signaling in Adult Neurogenesis显示文摘 | Itaru Imayoshi Ryoichiro Kageyama | 2011 | Molecular Neurobiology2011，44，1： | 1 |
| 13 | A Mechanism for Gene-Environment Interaction in the Etiology of Congenital Scoliosis显示文摘 | Duncan B. Sparrow Gavin Chapman Allanceson J. Smith Muhammad Z. Mattar Joelene A. Major Victoria C. O’Reilly Yumiko Saga Elaine H. Zackai John P. Dormans Benjamin A. Alman Lesley McGregor Ryoichiro Kageyama Kenro Kusumi Sally L. Dunwoodie | 2012 | Cell2012，，2： | 1 |
| 14 | The role of notch signaling in the development of intrahepatic bile ducts显示文摘 | Yuzo Kodama Makoto Hijikata Ryoichiro Kageyama Kunitada Shimotohno Tsutomu Chiba | 2004 | Gastroenterology2004，，6： | 1 |
| 15 | Hes1 -deficient mice show precocious differentiation of Paneth cells in the small intestine显示文摘 | Katsumasa Suzuki Hirokazu Fukui Takahisa Kayahara Mitsutaka Sawada Hiroshi Seno Hiroshi Hiai Ryoichiro Kageyama Hideyuki Okano Tsutomu Chiba | 2005 | Biochemical and Biophysical Research Communications2005，，1： | 1 |
| 16 | Id Sustains Hes1 Expression to Inhibit Precocious Neurogenesis by Releasing Negative Autoregulation of Hes1显示文摘 | Ge Bai Nengyin Sheng Zhihui Xie Wei Bian Yoshifumi Yokota Robert Benezra Ryoichiro Kageyama Francois Guillemot Naihe Jing | 2007 | Developmental Cell2007，，2： | 1 |
| 17 | Research of the Manufacturing Technique of Pressure Hull for Manned Deep-Ocean Submersibles显示文摘 | Endo Michimasa Yokota Kimio Sasano Ryoichiro | 1984 | Journal of the Society of Naval Architechts of Japan1984，156，： | 1 |
| 18 | The role of notch signaling in the development of intrahepatic bile ducts显示文摘 | Yuzo Kodama Makoto Hijikata Ryoichiro Kageyama Kunitada Shimotohno Tsutomu Chiba | 2004 | Gastroenterology2004，，6： | 1 |
| 19 | Biliary metal stents should be placed near the hilar duct in distal malignant biliary stricture patients显示文摘BACKGROUND Endoscopic biliary drainage using a self-expandable metallic stent(SEMS)has been widely performed to treat distal malignant biliary obstruction(DMBO).However,the optimal position of the stent remains unclear.AIM To determine the ideal position for SEMS placement.METHODS In total,135 DMBO patients underwent SEMS(uncovered or covered)placement over a ten-year period.A total of 127 patients with biliary obstruction between the junction of the cystic duct and Vater’s papilla were enrolled.An SEMS was placed through the upper common bile duct 2 cm from the biliary hilar duct in 83 patients(Hilar group)or near the top of the biliary obstruction in 44 patients(Lower group).Technical and functional success,adverse events,and risk factors for SEMS dysfunction were evaluated.RESULTS The stent patency period was significantly longer in the Hilar group than in the Lower group(P value<0.01).In multivariate analysis,the only statistically significant risk factor for SEMS dysfunction was being in the Lower group(hazard ratio:9.94,95%confidence interval:2.25–44.0,P<0.01).CONCLUSION A longer patency period was achieved by positioning the SEMS near the biliary hilar duct. | Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Yoshinori Okubo Jun Nakamura Mika Takasumi Minami Hashimoto Tsunetaka Kato Ryoichiro Kobashi Takumi Yanagita Takuto Hikichi Hiromasa Ohira | 2022 | World Journal of Gastroenterology2022，28，17： | 0 |
| 20 | Dysbiosis of the duodenal microbiota as a diagnostic marker for pancreaticobiliary cancer显示文摘BACKGROUND Pancreaticobiliary cancer(PB Ca)is a lethal disease,and a useful diagnostic marker is urgently needed.A correlation between the human microbiota and malignant gastrointestinal diseases was recently reported.AIM To investigate the efficacy of the duodenal microbiota for diagnosing PB Ca.METHODS We recruited 22 patients with benign pancreaticobiliary diseases(benign group)and 12 patients with PB Ca(malignant group).The duodenal microbiota of each patient was analyzed by the 16S rDNA terminal restriction fragment length polymorphism method.Patient characteristics,tumor markers,and relative abundances of the duodenal microbiota were compared between the benign and malignant groups.RESULTS Cancer antigen 19-9(CA19-9),Bifidobacterium,Clostridium cluster XVIII,and Prevotella levels differed significantly between the benign and malignant groups.Clostridium cluster XVIII had the greatest area under the receiver operating characteristic curve(AUC)among the four factors with respect to diagnosing PB Ca(cutoff value:3.038%;sensitivity:58.3%;specificity:95.2%;AUC:0.81).The combination of Clostridium cluster XVIII(cutoff value:3.038%)and CA19-9 Levels(cutoff value:18.8 U/mL)showed 91.7%sensitivity and 71.4%specificity for diagnosing PB Ca.CONCLUSION The duodenal microbiota may be useful for PB Ca screening. | Mitsuru Sugimoto Kazumichi Abe Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi Kikuchi Mika Takasumi Minami Hashimoto Tsunetaka Kato Ryoichiro Kobashi Takuto Hikichi Hiromasa Ohira | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 0 |
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