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| 1 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | 静脉血栓栓塞症的抗血栓治疗:美国《胸科学》杂志指南显示文摘包括深静脉血栓和肺栓塞在内的静脉血栓栓塞症是癌症患者的主要并发症,发生率为4%~20%,并且是常见的潜在致命性急症。本文介绍了美国《胸科学》杂志指南中VET的抗血栓治疗的部分内容,其以第9版《美国胸内科医师学会循证临床实践指南》中的《静脉血栓栓塞症的抗血栓治疗:抗血栓治疗和阻止血栓形成》一文为参照,基于静脉血栓栓塞症治疗的Ⅲ期试验的发表年份,对口服抗凝剂(达比加群、利伐沙班、阿哌沙班、依度沙班)进行先后阐述(但是这一排序并不是指南专家组对药剂的优劣排序),以为临床医生提供参考。 | Kearon C Akl EA Ornelas J Blaivas A Jimenez D Bounameaux H Huisman M King CS MorrisT Sood N Stevens SM Vintch JRE Wells P Woller SC Moores CL 本刊编辑部 | 2016 | 中国全科医学2016，19，9： | 10 |
| 3 | Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells显示文摘 | Jackson KA Majka SM Wang H | | 0，，： | 5 |
| 4 | 巴氏腺囊肿显示文摘Key facts Definition:Cystic dilation of Bartholin′s gland.Bartholin′s glands are bilateral mucin-secreting gland lying on posterolateral aspect of vulvar vestibule.Classic imaging appearance is round,well-defined,unilocular cyst lying at posterior aspect of vulva.Bartholin′s gland may also give rise to abscesses,tumors,and cysts.Bartholin′s gland cysts are not commonly bilateral. | Hricak H Reinhold C Ascher SM 关键 | 2015 | 影像诊断与介入放射学2015，24，4： | 4 |
| 5 | Ultrapure dialysis fluid slows loss of residual renal function in new dialysis patients.显示文摘 | Schiffl H Lang SM Fischer R | | 0，，： | 3 |
| 6 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 7 | Temperature elevation caused by bone cement polymerization during vertebroplasty显示文摘 | Deramond H Wright NT Belkoff SM | 1999 | Bone1999，25，2： | 2 |
| 8 | Plasma endothelin level changes during hemorrhagic shock显示文摘 | Chang H Wu GJ Wang SM | 1993 | J Trauma1993，35，6： | 2 |
| 9 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 10 | Molecular diversity of microbial community in acid mine drainages of Yunfu sulfide mine显示文摘 | He ZG Xiao SM Xie XH Zhong H Hu YH Li QH Gao FL Li GY Liu JS Qiu GZ | 2007 | 中国生物学文摘2007，21，6： | 2 |
| 11 | The phosphatidylinositol 3- kinase/AKt pathway regulates the HCCR-1 oncogene expression 显示文摘 | CHO GW SHIN SM NAMKOONG H | 2006 | Gene2006，384，： | 1 |
| 12 | Insulin resistance implications for type 2 diabetes mellitus and coronary heart disease显示文摘 | Haffner SM Miettinen H | 1997 | Am J Med1997，103，2： | 1 |
| 13 | Amyloid P-component and the skin 显示文摘 | Brethnach SM Hintner H | 1990 | Clin Dermatol1990，8，2： | 1 |
| 14 | Removal or maintenance of inositol-linked aeyl chain in glyeosylphosphatidylinositol is critical in trypanosome life cycle显示文摘 | Yeonchul H Kisaburo N Yasu SM | 2006 | J Biol Chem2006，281，： | 1 |
| 15 | Plasma endothelin levels and surgically correctable pulmonary hypertension 显示文摘 | Wu GJ Wang SM | 1993 | Ann Thorac Surg1993，55，2： | 1 |
| 16 | Fibrates suppress bile acid synthesis via peroxisome proliferator -activated receptor -alpha -mediated downregulation of cholesterol 7alpha - hydroxylase and sterol 27 - hydroxylase expression显示文摘 | Post SM Duez H Gervois PP | 2001 | Arterioscler Thromb Vasc Biol2001，21，11： | 1 |
| 17 | MRI of medulloblastoma in adults显示文摘 | Malheiros SM Carrete H Jr Stavale JN | 2003 | Neuroradiology2003，45，7： | 1 |
| 18 | An ex vivo biomechanical evaluation of a hydroxyapatite cement for use with kyphoplasty显示文摘 | Belkoff SM Mathis JM Deramond H | 2001 | Am J Neuroradiol2001，22，4： | 1 |
| 19 | The homeostasis model in the San Autonio Heart Study 显示文摘 | Haffner SM Mietfinen H Stem MP | 1997 | Diabetes Care1997，20，7： | 1 |
| 20 | Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells显示文摘 | Jackson KA Majika SM Wang H | 2001 | J Clin Invest2001，107，11： | 1 |
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