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| 1 | m6A RNA modification controls autophagy through upregulating ULK1 protein abundance显示文摘 | Shouheng Jin Xiya Zhang Yanyan Miao Puping Liang Kaiyu Zhu Yuanchu She Yaoxing Wu Di-Ao Liu Junjiu Huang Jian Ren Jun Cui | 2018 | Cell Research2018，28，9： | 12 |
| 2 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 3 | Interfacial Characteristic of as-Deformed SiCp-Reinforced Magnesium Matrix Composite显示文摘The(submicron+micron) Si Cp-reinforced magnesium matrix composite was fabricated by stir casting. After the application of forging and extrusion, the interface between Si Cp and Mg in the composite was investigated by transmission electron microscopy. Results show that the interfacial characterization was different at the interfaces of micron-Si Cp/Mg and submicron-Si Cp/Mg. While most interfaces between micron-Si Cp and Mg were clean, the precipitated Mg17Al12 phase as well as dispersedly distributed nano-Mg O particles was observed at some interfaces. Unlike the interface between micron-Si Cp and Mg, no interfacial reaction product was found at the interface between submicron-Si Cp and Mg in the present study. Besides, the specific orientation relationships were found at the interfaces between submicronSi Cp and Mg, which was thought to have developed during hot deformation process. At the fracture surface of the composite, the microcracks were found at the interface between micron-Si Cp and Mg, while the interfacial bonding between submicron-Si Cp and Mg was very well. | Kun Kun Deng Jian Chao Li Jian Feng Fan Xiao Jun Wang Kun Wu Bing She Xu | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，5： | 2 |
| 4 | Simultaneous detection and characterization of toxigenic Clostridium difficile directly from clinical stool specimens显示文摘我们采用了结合的复合聚合酶链反应(PCR ) 指向六的毛状的电气泳动(mPCR-CE ) 在为 toxigenic C 的同时的察觉和描述的 tcdC 的 Clostridium 顽固基因,包括的 tpi, tcdA, tcdB, cdtA, cdtB,和删除。顽固直接从烘便的标本。mPCR-CE 每反应有 10 个形成殖民地的单位的察觉的限制没有与另外的相关细菌的基因跨反应。临床的确认在 354 上被执行连续地与怀疑的 C 从病人收集了凳子标本。顽固感染并且 45 孤立。结果与与 BD 最大 Cdiff,即时房间分析试金(RTCA ) ,和 mPCR-CE 相结合的一个参考标准相比。toxigenic C。顽固种类在 36 被检测孤立并且由 mPCR-CE 的 45 个凳子标本,它提供了 20.3% 的积极的率(81/399 ) 。mPCR-CE 有 97.2% 的特性和 96.0% 的敏感,它比 RTCA 高(x 2= 5.67, P = 0.017 ) 但是比 BD 最大 Cdiff 低(P = 0.245 ) 。在 45 紧张之中,(97.8%) 44 作为 non-ribotype 被决定 027 由 mPCR-CE,它充分被适合于 PCR ribotyping。尽管 ribotypes 017 (n = 8, 17.8%) , 001 (n = 6, 13.3%) ,并且 012 (n = 7, 15.6%) 在这个区域是占优势的, ribotype 027 重要遗传型习惯性地被监视。mPCR-CE 为 toxigenic C 的同时的察觉提供了一个其他的诊断工具。在凳子顽固、在 RT027 和 non-RT027 之间潜在地区分。 | Hanjiang Lai Chen Huang Jian Cai Julian Ye Jun She Yi Zheng Liqian Wang Yelin Wei Weijia Fang Xianjun Wang Yi-Wei Tang Yun Luo Dazhi Jin | 2018 | Frontiers of Medicine2018，12，2： | 2 |
| 5 | The Taxonomic Status of Spermophilus in the Plague Area of Dingbian County,Shaanxi Province,China显示文摘这研究被进行在 Shaanxi 省在 Dingbian 县的瘟疫区域定义 Spermophilus 的分类地位,中国通过词法特征的二因素的变化分析, DNA barcoding,和染色体 karyotype 分析。从 Dingbian 和 Zhengxiang Baiqi 县收集的 Spermophilus 样品在他们的词法大小展出了重要差别。所有 Spermophilus 样品形成二根不同树枝在加入邻居(NJ ) 树。一根树枝包括了从内部蒙古收集的 Spermophilus 样品,并且另外的树枝包括了从 Shaanxi 省和 Ningxia 区域的瘟疫 foci 收集的样品。从 Dingbian 县收集的 Spermophilus 样品有 2n = 的一个染色体数字 38 在 84.40% 所有他们的房间。从 Dingbian 县的瘟疫区域收集的 Spermophilus 种类作为 Spermophilus alashanicus (S.alashamicus ) 被分类。调查结果在这报导学习为在西方中央的中国的这个区域监视瘟疫是流行病学地重要的。 | AN Cui Hong CHEN Bao Bao FAN Suo Ping SUN Yang Xin LYU Wen SHE Jian Jun | 2018 | Biomedical and Environmental Sciences2018，31，3： | 1 |
| 6 | Formation mechanism of tight sandstone gas in areas of low hydrocarbon generation intensity: A case study of the Upper Paleozoic in north Tianhuan depression in Ordos Basin, NW China显示文摘The Upper Paleozoic in the north part of Tianhuan depression in the Ordos Basin,NW China has lower hydrocarbon generation intensity and complex gas-water relationship,the main factors controlling the formation of tight sandstone gas and the distribution of tight sandstone gas in the low hydrocarbon generation intensity area are studied.Through two-dimensional physical simulation experiment of hydrocarbon accumulation,analysis of reservoir micro-pore-throat hydrocarbon system and dissection of typical gas reservoirs,the evaluation models of gas injection pressure,reservoir physical property,and gas generation threshold were established to determine the features of tight gas reservoirs in low hydrocarbon intensity area:(1)at the burial depth of less than 3 000 m,the hydrocarbon generation intensity ofis high enough to maintain effective charging;(2)tight sandstone in large scale occurrence is conducive to accumulation of tight gas;(3)differences in reservoir physical property control the distribution of gas pool,for the channel sandstone reservoirs,ones with better physical properties generally concentrate in the middle of sandstone zone and local structural highs;ones with poor physical properties have low gas content generally.Based on the dissection of the gas reservoir in the north Tianhuan depression,the formation of tight gas reservoirs in low hydrocarbon generating intensity area are characterized by'long term continuous charging under hydrocarbon generation pressure,gas accumulation in large scale tight sandstone,pool control by difference in reservoir physical property,and local sweet spot',and the tight gas pools are distributed in discontinuous'sheets'on the plane.This understanding has been proved by expanding exploration of tight sandstone gas in the north Tianhuan depression. | ZHANG Fudong LI Jun WEI Guoqi LIU Xinshe GUO Jianying LI Jian FAN Liyong SHE Yuanqi GUAN Hui YANG Shen SHAO Liyan | 2018 | Petroleum Exploration and Development2018，45，1： | 0 |
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