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| 1 | Relative position determination of a lunar rover using high-accuracy multi-frequency same-beam VLBI显示文摘Multi-frequency same-beam VLBI means that two explorers with a small separation angle are simultaneously observed with the main beam of receiving antennas. In the same-beam VLBI, the differential phase delay between two explorers and two receiving telescopes can be obtained with a small error of several picoseconds. The differential phase delay, as the observable of the same-beam VLBI, gives the separation angular information of the two explorers in the celestial sphere. The two-dimensional relative position on the plane-of-sky can thus be precisely determined with an error of less than 1 m for a distance of 3.8×105 km far away from the earth, by using the differential phase delay obtained with the four Chinese VLBI stations. The relative position of a lunar rover on the lunar surface can be determined with an error of 10 m by using the differential phase delay data and the range data for the lander when the lunar topography near the rover and the lander can be determined with an error of 10 m. | LIU QingHui1, CHEN Ming1, XIONG WeiMing2, QIAN ZhiHan1, LI JinLing1, HAO WangHong1,4, WANG GuangLi1, ZHENG WeiMin1, GUAN Di3, ZHU RenJie1, WANG WeiHua1, ZHANG XiuZhong1, JIANG DongRong1, SHU FengChun1, PING JinSong1 & HONG XiaoYu11 Shanghai Astronomical Observatory, Chinese Academy of Sciences, Shanghai 200030, China 2 Center for Space Science and Applied Research, Chinese Academy of Sciences, Beijing 100190, China 3 Lunar Explorer Engineering General Department, Chinese Academy of Sciences, Beijing 100012, China 4 Beijing Institute of Tracking and Telecommunications Technology, Beijing 100094, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，3： | 17 |
| 2 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 3 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021，10，2： | 11 |
| 4 | Enhanced Biological Phosphorus Removal with Pseudomonas putida GM6 from Activated Sludge显示文摘提高的生物的磷移动(EBPR ) 方法广泛地从废水为磷移动被采用,然而,很少对它的微生物、分子的机制被知道。因此,在一家大规模市政的污水处理工厂预言并且控制 EBPR 过程的恶化是困难的。使用的这研究在实验室孤立的新奇紧张, Pseudomonas putida GM6,它有高磷酸盐积累能力并且能从败坏的系统很快恢复并且在活性污泥提高磷移动的能力。与 gfp 基因标记的紧张 GM6,被称为 GMTR,被交付进定序低效率的批反应堆(SBR ) 的凳子规模,到调查 GMTR 的殖民和磷的移动。在 21 天以后,而磷移动率是 96% ,在污泥的全部的细菌的 GMTR 的比例到达了 9.2% ,与大约 0.2 mg L 的自河集中 ? 1。在有 GMTR 的增加的反应堆,磷快速被移开,在在厌氧的条件下面的 1 h,并且在在氧气的条件下面的 2 h。这些证据 EBPR 过程是特征的。现场测试与低磷移动能力在一台医院污水处理设备被进行。二十 -- 一天在 Pseudomonas putida GM6 被增加以后,自河磷集中在 0.3 mg L 附近留下了 ? 1,相应于 96.8% 的移动率。它因此被表明为废水的快开始和改进的那 Pseudomonas putida GM6couldbeused 生物的磷移动,它为潜在的大规模工程申请提供了一个科学基础。 | CAI Tian-Ming GUAN Li-Bo CHEN Li-Wei CAI Shu LI Xiao-Dan CUI Zhong-Li LI Shun-Peng | 2007 | Pedosphere2007，17，5： | 9 |
| 5 | Fabrication of kW-level chirped and tilted fiber Bragg gratings and filtering of stimulated Raman scattering in high-power CW oscillators显示文摘Suppression of stimulated Raman scattering(SRS)by means of chirped and tilted fiber Bragg gratings(CTFBGs)has become a key topic.However,research on high-power systems is still lacking due to two problems.Firstly,after the inscription,there are a large number of hydroxyl compounds and hydrogen molecules in CTFBGs that cause significant heating due to their strong infrared absorption.Secondly,CTFBGs can couple Stokes light from the core to the cladding and the coating,which causes serious heating in the coating of the CTFBG.Aimed at overcoming these bottlenecks,a process that combines constant-low-temperature and variable-high-temperature annealing is used to reduce the thermal slope of the CTFBG.Also,a segmented-corrosion cladding power stripping technology is used on the CTFBG to remove the Stokes light which is coupled to the cladding,which solves the problem of overheating in the coating of the CTFBG.Thereby,a CTFBG with both a kilowatt-level power-carrying load and the ability to suppress SRS in a fiber laser has been developed.Further,we establish a kW-level CW oscillator to test the CTFBG.Experimental results demonstrate that the power-carrying load of the CTFBG is close to 1 kW,the thermal slope is lower than 0.015 ℃/W,and the SRS suppression ratio is nearly 23 dB. | Kerong Jiao Jian Shu Hua Shen Zhiwen Guan Feiyan Yang Rihong Zhu | 2019 | High Power Laser Science and Engineering2019，7，2： | 9 |
| 6 | Expression of Peroxiredoxins and Pulmonary Surfactant Protein A Induced by Silica in Rat Lung Tissue显示文摘Silicosis is one of the most serious occupational diseases in China and dates back to centuries ago.In this study,we successfully established a rat model of silicosis by intratracheal silica injection for28 days and determined hydroxyproline levels to evaluate collagen metabolism in lung homogenates.Oxidative stress status was evaluated by detecting catalase and glutathione peroxidase activities. | LIU Nan XUE Ling GUAN Yi LI Qing Zhao CAO Fu Yuan PANG Shu Lan GUAN Wei Jun | 2016 | Biomedical and Environmental Sciences2016，29，8： | 6 |
| 7 | Deep Learning in Chest Radiography:Detection of Pneumoconiosis显示文摘Pneumoconiosis,the predominant occupational disease in China and the world,is a pulmonary disease caused by the inhalation of inorganic dust,that is,particulate matter in the solid phase without living organisms[1].As an irreversible,crippling,and even fatal disease,pneumoconiosis places a heavy burden on society. | LI Xiao LIU Chao Fei GUAN Li WEI Shu YANG Xin LI Shu Qiang | 2021 | Biomedical and Environmental Sciences2021，34，10： | 6 |
| 8 | The Medium Energy X-ray telescope (ME) onboard the Insight-HXMT astronomy satellite显示文摘The Medium Energy X-ray telescope(ME) is one of the three main telescopes on board the Insight hard X-ray modulation telescope(Insight-HXMT) astronomy satellite. ME contains 1728 pixels of Si-PIN detectors sensitive in 5-30 ke V with a total geometrical area of 952 cm^2. The application specific integrated circuit(ASIC) chip, VA32TA6, is used to achieve low power consumption and low readout noise. The collimators define three kinds of field of views(FOVs) for the telescope, 1°×4°, 4°×4°,and blocked ones. Combination of such FOVs can be used to estimate the in-orbit X-ray and particle background components.The energy resolution of ME is ~3 ke V at 17.8 ke V(FWHM) and the time resolution is 255 μs. In this paper, we introduce the design and performance of ME. | XueLei Cao WeiChun Jiang Bin Meng WanChang Zhang Tao Luo Sheng Yang ChunLei Zhang YuDong Gu Liang Sun XiaoJing Liu JiaWei Yang Xian Li Ying Tan ShaoZhen Liu YuanYuan Du FangJun Lu YuPeng Xu Ju Guan ShuangNan Zhang HuanYu Wang TiPei Li ChengMo Zhang XiangYang Wen JinLu Qu LiMing Song XiaoBo Li MingYu Ge YuPeng Zhou ShaoLin Xiong Shu Zhang YongJie Zhang ZeHao Cheng Fei Zhang MaoShun Li XiaoHua Liang Min Gao EnBo Yang XiaoHang Liu HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 5 |
| 9 | Low initial trough concentration of rituximab is associated with unsatisfactory response of first-line R-CHOP treatment in patients with follicular lymphoma with grade 1/2显示文摘For follicular lymphoma(FL)with grade 1/2,the complete response(CR)rate of the first-line R-CHOP treatment was significantly low.In this study,we assessed the rationality of the administration of rituximab for FL patients with grade 1/2 based on concentration–response relationship analyses.Thus,we conducted a prospective pharmacokinetic(PK)study in 68 FL patients with grades 1–3 treated with R-CHOP at 21-day intervals.Plasma rituximab concentrations were quantified using ELISA and the population PK modeling was established with Phoenix®NLMETM.The first cycle trough concentration(C1-trough)of rituximab was a significant independent risk factor for achieving CR in matched-pair logistic regression analysis,rather than the concentrations in later cycles;the recommendatory minimum optimal C1-trough was 13.60μg/mL.Patients with grade 1/2 had significantly lower C1-trough compared with grade 3(12.21μg/mL vs.23.45μg/mL,P<0.001),only 30%patients with grade 1/2 could reach 13.60μg/mL,compared with 91.67%in patients with grade 3,which was in accord with its unsatisfactory CR rates(43.33%vs.76.32%).The stage indicating the tumor burden(the target)was a crucial influence factor for C1-trough,accounting for 40.70%of its variability,70%patients with grade 1/2 were stage IV in this study,since the systemic therapy only started at the disseminated disease stage.The initial dose of 1800 mg was recommended by Monte Carlo simulation for patients with grade 1/2.In summary,low C1-trough accounted for low-grade FL’s unsatisfactory CR rate,designing the first dosage of rituximab should be a very important component of individualized therapy for FL. | Shu Liu He Huang Rong-xin Chen Zhao Wang Yan-ping Guan Chen Peng Xiao-jie Fang Zhuo-jia Chen Shao-xing Guan Xia Zhu Quan-guang Ren Yu-yi Yao Hong-bing Huang Min Huang Xue-ding Wang Tong-yu Lin | 2021 | Acta Pharmacologica Sinica2021，42，4： | 5 |
| 10 | Osteoprotegerin,interleukin and hepatocyte growth factor for prediction of diabetes and hypertension in the third trimester of pregnancy显示文摘BACKGROUND Gestational diabetes mellitus(GDM)raises the risk of high blood pressure and may cause a series of life-threatening complications in pregnant women.Screening and management of GDM and gestational hypertension(GH)in pregnancy helps to control and reduce these risks and prevent adverse effects on mothers and their fetuses.Currently,the majority criteria used for screening of diabetes mellitus is oral glucose tolerance tests,and blood pressure test is usually used for the screening and diagnosis of hypertension.However,these criteria might not anticipate or detect all GDM or GH cases.Therefore,new specific predictive and diagnostic tools should be evaluated for this population.This study selected three biomarkers of osteoprotegerin(OPG),interleukin(IL)and hepatocyte growth factor(HGF)for GDM and GH predication and diagnosis.AIM To explore the feasibility of changes in placental and serum OPG,IL and HGF as tools for prediction and diagnosis of diabetes and hypertension in pregnant women.METHODS From January 2018 to January 2019,44 pregnant women with GDM and GH were selected as an observation group,and 44 healthy pregnant women were selected as a control group in the same period.Serum OPG,IL and HGF were compared between the two groups.RESULTS The levels of OPG and HGF in the observation group were lower than in the control group,and the level of IL-1βwas higher in the observation group than in the control group(all P<0.05).Furthermore,OPG and HGF were negatively associated with gestational diabetes and gestational hypertension,while IL-1βwas positively associated with GDM complicated with GH(all P<0.05).CONCLUSION The evaluation of serum OPG,HGF and IL-1βlevels in patients with coexistent gestational diabetes complicated with hypertension can predict the degree of disease and play an important role in the follow-up treatment and prognosis prediction. | Su-Jing Huang Hong-Wei Wang Hai-Fang Wu Qiu-Yuan Wei Shu Luo Lin Xu Hong-Qiong Guan | 2020 | World Journal of Clinical Cases2020，8，22： | 4 |
| 11 | Frequency-domain diagonal extension imaging显示文摘The pixel size of a charge-coupled device(CCD)camera plays a major role in the image resolution,and the square pixels are attributed to the physical anisotropy of the sampling frequency.We synthesize the high sampling frequency directions from multiple frames acquired with different angles to enhance the resolution by 1.4×over conventional CCD orthogonal sampling.To directly demonstrate the improvement of frequency-domain diagonal extension(FDDE)microscopy,lens-free microscopy is used,as its resolution is dominantly determined by the pixel size.We demonstrate the resolution enhancement with a mouse skin histological specimen and a clinical blood smear sample.Further,FDDE is extended to lens-based photography with an ISO 12233 resolution target.This method paves a new way for enhancing the image resolution for a variety of imaging techniques in which the resolution is primarily limited by the sampling pixel size,for example,microscopy,photography,and spectroscopy. | Shan Jiang Meiling Guan Jiamin Wu Guocheng Fang Xinzhu Xu Dayong Jin Zhen Liu Kebin Shi Fan Bai Shu Wang Peng Xi | 2020 | Advanced Photonics2020，2，3： | 3 |
| 12 | Theory,controls parameter and application of the packed-bed electroosmotic pump显示文摘Theory and controls parameters affecting the output pressure and flow rate of the packed-bed electroos-motic pump (p-EOP), including zeta potential z, electric in-tensity E, length of the column L, cross-section area of the column A, dielectric constant e and viscosity coefficient h of the liquid being pumped, are discussed concisely. And also, the fabrication and application of the p-EOP are introduced. | CHEN Lingxin, GUAN Yafeng, MA Jiping, SHU Xin & TAN Feng Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116012, China Correspondence should be addressed to Guan Yafeng (e-mail: kfguan@ mail.dlptt.ln.cn) | 2003 | Chinese Science Bulletin2003，48，23： | 3 |
| 13 | Drinking Behavior and Associated Factors among Middle School Students in Shanghai,China显示文摘我们的学习的目的是在中学学生估计喝的地位并且理解联系因素。调整的喝的率为一生,过去年,并且分别地的当前的喝酒是 50.9% , 39.8% ,和 15.1% 。Multivariable 逻辑回归与在过去的年期间喝有关断然揭示了下列变量:家庭收入,母亲的教育水平,喝的家庭成员,支持喝的喝的、最好的朋友的父母,鼓励喝的、经常出席的朋友的聚会的朋友,吸烟,并且使活动趋势(P < 0.05 ) 。主要风险因素是朋友(OR=6.77, 95% CI:6.17, 7.43 ) 并且吸烟(OR=4.70, 95% CI:3.44, 6.43 ) 。这些结果贡献在指向的干预获得潜在的联系因素和帮助进中学学生的喝的行为。 | WANG Zheng Yuan SONG Jun ZANG Jia Jie HUANG Cui Hua ZOU Shu Rong MA Guan Sheng | 2015 | Biomedical and Environmental Sciences2015，28，10： | 3 |
| 14 | Multi-beam and seismic investigations of the active Haima cold seeps,northwestern South China Sea显示文摘To confirm the seabed fluid flow at the Haima cold seeps,an integrated study of multi-beam and seismic data reveals the morphology and fate of four bubble plumes and investigates the detailed subsurface structure of the active seepage area.The shapes of bubble plumes are not constant and influenced by the northeastward bottom currents,but the water depth where these bubble plumes disappear(630–650 m below the sea level)(mbsl)is very close to the upper limit of the gas hydrate stability zone in the water column(620 m below the sea level),as calculated from the CTD data within the study area,supporting the“hydrate skin”hypothesis.Gas chimneys directly below the bottom simulating reflectors,found at most sites,are speculated as essential pathways for both thermogenic gas and biogenic gas migrating from deep formations to the gas hydrate stability zone.The fracture network on the top of the basement uplift may be heavily gas-charged,which accounts for the chimney with several kilometers in diameter(beneath Plumes B and C).The much smaller gas chimney(beneath Plume D)may stem from gas saturated localized strong permeability zone.High-resolution seismic profiles reveal pipe-like structures,characterized by stacked localized amplitude anomalies,just beneath all the plumes,which act as the fluid conduits conveying gas from the gas hydrate-bearing sediments to the seafloor,feeding the gas plumes.The differences between these pipe-like structures indicate the dynamic process of gas seepage,which may be controlled by the build-up and dissipation of pore pressure.The 3D seismic data show high saturated gas hydrates with high RMS amplitude tend to cluster on the periphery of the gas chimney.Understanding the fluid migration and hydrate accumulation pattern of the Haima cold seeps can aid in the further exploration and study on the dynamic gas hydrate system in the South China Sea. | Bin Liu Jiangxin Chen Li Yang Minliang Duan Shengxuan Liu Yongxian Guan Pengcheng Shu | 2021 | Acta Oceanologica Sinica2021，40，7： | 3 |
| 15 | AFB1 Bio-Degradation by a New Strain - Stenotrophomonas. sp显示文摘The paper was to find the bacteria to degrade aflatoxin B1 (AFB1) and realize the application of biological degradation on AFB1. Using cumarin as the carbon source and energy on the first screening, then the ten strains which were first screened out were taken to degrade AFB1 100 μg kg-1. Strain NMO-3 was screened out of ten strains, the degradation ratio of AFB1 reached 85.7%, which was more prominent than the others (P < 0.01). With the analysis of colony morphology, physiological and biochemistry experiments, and 16S rDNA gene sequence, the strain NMO-3 was finally identified as Stenotrophomonas sp. Using cumarin as the carbon source and energy could screen out the AFB1 degradation strains. Acute toxicity tests show that the viable number of NMO-3 lower than 3.12 × 1010 cfu mL-1 is safety. The crude enzyme was obtained by 65% ammonium sulfate fractionation, and it could degrade AFB1. It is the first report for the strain’s detoxi- AFB1. | LIANG Zhi-hong LI Jun-xia HE Yun-long GUAN Shu WANG Nin JI Cheng NIU Tian-gui | 2008 | Agricultural Sciences in China2008，7，12： | 3 |
| 16 | Two new compounds derived from bufalin显示文摘由 Platycodon grandiflorus 的房间暂停文化的 bufalin 的简历转变被调查,二份新简历转变了产品被获得,它是 3-epi-telocinobufagin 和 3-epi-bufalin-3-O- β -d 配糖物。 | Jun Zhao Shu Hong Guan Xiao Bin Chen Wei Wang Min Ye De An Guo | 2007 | Chinese Chemical Letters2007，18，11： | 2 |
| 17 | Development of Urban Agriculture:A Case Study of Qianjin Village,Jiangxia District,Wuhan City显示文摘We take the case of Qianjin Village,Jiangxia District,Wuhan City,to research how to establish the system of urban agriculture with distinctive features relying on the advantage of urban resources.Under the guidance of guiding ideology,basic principles and overall objectives of urban agriculture development planning,we analyze the specific construction planning of urban agriculture in Qianjin Village,mainly including the construction of growing areas and construction of leisure areas.Then we put forth the security system of development of urban agriculture as follows: land transfer is the prerequisite of development of urban agriculture;policy support is the important foundation of development of urban agriculture; agricultural science and technology is strong support for development of urban agriculture;good leadership is the organizational guarantee for development of urban agriculture;the industrialization of agriculture is the main objective of development of urban agriculture. | GUAN Bo 1 ,SHU Chang-jun2 1.School of Business Administration,Zhongnan University of Economics and Law,Wuhan 430074,China 2.School of Civil Engineering and Architecture,Wuhan University of Technology,Wuhan 430070,China | 2012 | Asian Agricultural Research2012，4，7： | 2 |
| 18 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 19 | A simple fabricated thickness-based stiffness gradient for cell studies显示文摘In this work, we developed a simple method to fabricate a thickness-based continuous stiffness gradient for biological studies. It was made by glass slides, polydimethylsiloxane(PDMS) pre-polymer, spacer and clips only, without any sophisticated equipment. It is easy to fabricate in any general biological and pharmaceutical laboratories. The stiffness gradient was characterized in terms of apparent Young's modulus by atomic force microscopy(AFM) and the Young's modulus along the gradient was found to be 8.5–120 k Pa, which is within the physiological relevant range. He La-C3 cells were cultured on the gradient to study their morphological behavior according to the substrate stiffness. Furthermore, the drug efficiency of etoposide, an anti-cancer drug, was studied along the substrate stiffness gradient. It was found that He La-C3 cells cultured on the soft region of the gradient(8.5–11 k Pa) are more sensitive to etoposide. We believe the proposed device could promote cell investigations and drug screenings on a substrate with comparable stiffness to the native tissue. | Yiwei Shu HO Nam Chan Dongshi Guan Hongkai Wu Lan Ma | 2017 | Science Bulletin2017，62，3： | 2 |
| 20 | Toxicity of Sodium Fluoride to Caenorhabditis elegans显示文摘Objective To investigate the toxic effect of sodium fluoride(NaF) on the nematode Caenorhabditis elegans(C.elegans).Methods Adult C.elegans were exposed to different concentrations of NaF(0.038 mmol/L,0.38 mmol/L,and 3.8 mmol/L) for 24 h.To assess the physiological effects of NaF,the brood size,life span,head thrashes,and body bend frequency were examined.Reactive oxygen species(ROS) and cell apoptosis were detected as parameters of biochemical response.The gene expressions were determined by real‐time polymerase chain reaction(PCR) to assess the molecular‐level response.Results At the physiological level,the brood size of C.elegans exposed to 0.038 mmol/L,0.38 mmol/L,and 3.8 mmol/L concentrations of NaF were reduced by 6%,26%,and 28% respectively in comparison with the control group.The maximum life spans of C.elegans exposed to 0.038 mmol/L,0.38 mmol/L,and 3.8 mmol/L concentrations of NaF were reduced by 3 days and 5 days,respectively.Head thrashes and body bend frequency both decreased with increasing concentrations of NaF.At the biochemical level,the production of ROS and the incidence of cell apoptosis increased with increasing concentrations of NaF(P<0.05).At the molecular level,different concentrations of NaF exposure raised the expression of stress‐related genes,such as hsp16.1,sod‐3,ctl‐2,dhs‐28,gst‐1,and cep‐1.Conclusion NaF exposure could induce multiple biological toxicities to C.elegans in a concentration‐dependent manner.These toxicities may be relevant to the oxidative stress induced by increased ROS production and accumulation in C.elegans. | LI Qiao ZHANG Shu Hua YU Yuan Hua WANG Li Ping GUAN Shu Wen LI Peng Fei | 2012 | Biomedical and Environmental Sciences2012，25，2： | 2 |
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