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| 1 | Function-regeneration of non-porous hydrolyzed-MOF-derived materials显示文摘A facile synthetic strategy based on a water-based process is developed for the preparation of metal-organic framework (MOF)-derived materials by revisiting the hydrolyzed non-porous metal-organic frameworks (h-MOF). The poor water stability of MOF has been recognized as key limitations for its commercialization and large-scale applications because the hydrolysis resulted in the complete loss of their functionalities. However, we found that the negative effect of hydrolysis on MOF can be nullified during the heat treatment. As similar to the intact MOF, h-MOF can be used as a precursor for the preparation of MOF-derived materials from porous MOF-derived carbons (MDCs) to MDC@ZnO composites. The property of h-MOF-derived materials is almost equivalent to that of MOF-derived materials. In addition, h-MOF turned the weakness of water instability to the strength of facile water-based process for hybridization. With the demonstration of the hybrid composite between h-MDC@ZnO and reduced graphene oxide (rGO) as a prototype example, it exhibited superior electrochemical performance when evaluated as an electrode material for lithium-ion batteries. | Yo Chan Jeong Jin Weon Seo Jae Ho Kim Seunghoon Nam Min Chang Shin Young Shik Cho Jin Syul Byeon Chong Rae Park Seung Jae Yang | 2019 | Nano Research2019，12，8： | 5 |
| 2 | A simple fabricated thickness-based stiffness gradient for cell studies显示文摘In this work, we developed a simple method to fabricate a thickness-based continuous stiffness gradient for biological studies. It was made by glass slides, polydimethylsiloxane(PDMS) pre-polymer, spacer and clips only, without any sophisticated equipment. It is easy to fabricate in any general biological and pharmaceutical laboratories. The stiffness gradient was characterized in terms of apparent Young's modulus by atomic force microscopy(AFM) and the Young's modulus along the gradient was found to be 8.5–120 k Pa, which is within the physiological relevant range. He La-C3 cells were cultured on the gradient to study their morphological behavior according to the substrate stiffness. Furthermore, the drug efficiency of etoposide, an anti-cancer drug, was studied along the substrate stiffness gradient. It was found that He La-C3 cells cultured on the soft region of the gradient(8.5–11 k Pa) are more sensitive to etoposide. We believe the proposed device could promote cell investigations and drug screenings on a substrate with comparable stiffness to the native tissue. | Yiwei Shu HO Nam Chan Dongshi Guan Hongkai Wu Lan Ma | 2017 | Science Bulletin2017，62，3： | 2 |
| 3 | Characterization of Plasmids encoding CTX-M β-lactamase and their Addiction Systems in Escherichia coli isolates from Animals显示文摘 | Migma Dorji Tamang Mamata Gurung Min-Su Kang Hyang-Mi Nam Dong Chan Moon Geum-Chan Jang Suk-Chan Jung Yong Ho Park Suk-Kyung Lim | 2014 | Veterinary Microbiology2014，，： | 1 |
| 4 | Sentinel Node Mapping and Skip Metastases in Patients with Early Gastric Cancer显示文摘 | Sang Eok Lee MD Jun Ho Lee MD Keun Won Ryu MD Soo Jeong Cho MD Jong Yeul Lee MD Chan Gyoo Kim MD Il Ju Choi MD Myung Cherl Kook MD Byung-Ho Nam PhD Sook Ryun Park MD Jong Seok Lee MD Young-Woo Kim MD | 2009 | Annals of Surgical Oncology2009，，3： | 1 |
| 5 | Long-term outcome comparison of endoscopic resection and surgery in early gastric cancer meeting the absolute indication for endoscopic resection显示文摘 | Il Ju Choi Jun Ho Lee Young-Il Kim Chan Gyoo Kim Soo-Jeong Cho Jong Yeul Lee Keun Won Ryu Byung-Ho Nam Myeong-Cherl Kook Young-Woo Kim | 2014 | Gastrointestinal Endoscopy2014，，： | 1 |
| 6 | Abdominal Shape of Gastric Cancer Patients Influences Short-Term Surgical Outcomes显示文摘 | Jun Ho Lee Yong Hae Paik Jong Seok Lee Keun Won Ryu Chan Gyoo Kim Sook Ryeon Park Young Woo Kim Myeong Cherl Kook Byung-ho Nam Jae-Moon Bae | 2007 | Annals of Surgical Oncology2007，，4： | 1 |
| 7 | Learning Curve for Total Gastrectomy with D2 Lymph Node Dissection: Cumulative Sum Analysis for Qualified Surgery显示文摘 | Jun Ho Lee Keun Won Ryu Jin-Hee Lee Sook Ryun Park Chan Gyoo Kim Myoung Cheorl Kook Byung-Ho Nam Young-Woo Kim Jae-Moon Bae | 2006 | Annals of Surgical Oncology2006，，9： | 1 |
| 8 | Sentinel Node Mapping and Skip Metastases in Patients with Early Gastric Cancer显示文摘 | Sang Eok Lee MD Jun Ho Lee MD Keun Won Ryu MD Soo Jeong Cho MD Jong Yeul Lee MD Chan Gyoo Kim MD Il Ju Choi MD Myung Cherl Kook MD Byung-Ho Nam PhD Sook Ryun Park MD Jong Seok Lee MD Young-Woo Kim MD | 2009 | Annals of Surgical Oncology2009，，3： | 1 |
| 9 | Carcinomatosis matters: clinical outcomes and prognostic factors for clinical success of stent placement in malignant gastric outlet obstruction显示文摘 | Han Ho Jeon Chan Hyuk Park Jun Chul Park Choong Nam Shim Sunyong Kim Hyun Jik Lee Hyuk Lee Sung Kwan Shin Sang Kil Lee Yong Chan Lee | 2014 | Surgical Endoscopy2014，，3： | 1 |
| 10 | A Phase-II Clinical Trial of Laparoscopy-Assisted Distal Gastrectomy with D2 Lymph Node Dissection for Gastric Cancer Patients显示文摘 | Jun Ho Lee MD Young-Woo Kim MD Keun Won Ryu MD Jong Ryul Lee MD Chan Gyoo Kim MD Il Ju Choi MD Myoung Cheorl Kook MD Byung-Ho Nam PhD Jae-Moon Bae MD | 2007 | Annals of Surgical Oncology2007，，11： | 1 |
| 11 | Abdominal Shape of Gastric Cancer Patients Influences Short-Term Surgical Outcomes显示文摘 | Jun Ho Lee Yong Hae Paik Jong Seok Lee Keun Won Ryu Chan Gyoo Kim Sook Ryeon Park Young Woo Kim Myeong Cherl Kook Byung-ho Nam Jae-Moon Bae | 2007 | Annals of Surgical Oncology2007，，4： | 1 |
| 12 | Phase II study of palliative S-1 in combination with cisplatin as second-linechemotherapy for gemcitabine?refractory pancreatic cancer patients显示文摘 | Hyun Jung Kim Jina Yun Han Jo Kim Kyoung Ha Kim Se Hyung Kim Tae Hoon Lee Sang-Cheol Lee Sang Byung Bae Chan Kyu Kim Nam Su Lee Jong Ho Moon Sang Heum Park Kyu Taek Lee Seong Kyu Park Jong-Ho Won Hee Sook Park Dae Sik Hong | 2012 | Oncology Letters2012，，6： | 1 |
| 13 | Association of the interval between endoscopies with gastric cancer stage at diagnosis in a region of high prevalence显示文摘 | Ji Hyung Nam Il Ju Choi Soo‐Jeong Cho Chan Gyoo Kim Jae Kwan Jun Kui Son Choi Byung‐Ho Nam Jun Ho Lee Keun Won Ryu Young‐Woo Kim | 2012 | Cancer2012，，20： | 1 |
| 14 | Sentinel Node Mapping and Skip Metastases in Patients with Early Gastric Cancer显示文摘 | Sang Eok Lee MD Jun Ho Lee MD Keun Won Ryu MD Soo Jeong Cho MD Jong Yeul Lee MD Chan Gyoo Kim MD Il Ju Choi MD Myung Cherl Kook MD Byung-Ho Nam PhD Sook Ryun Park MD Jong Seok Lee MD Young-Woo Kim MD | 2009 | Annals of Surgical Oncology2009，，3： | 1 |
| 15 | Comparison of the Haas and the Oxford Classifications for Prediction of Renal Outcome in Patients with IgA Nephropathy显示文摘 | Kyoung Sook Park Seung Hyeok Han Jeong Hae Kie Ki Heon Nam Mi Jung Lee Beom Jin Lim Young Eun Kwon Yung Ly Kim Seong Yeong An Chan Ho Kim Fa Mee Doh Hyang Mo Koo Hyung Jung Oh Shin-Wook Kang Kyu Hun Choi Hyeon Joo Jeong Tae-Hyun Yoo | 2013 | Human Pathology2013，，： | 1 |
| 16 | Developing an Institutional Protocol Guideline for Laparoscopy-Assisted Distal Gastrectomy显示文摘 | Sang Eok Lee MD Young-Woo Kim MD Jun Ho Lee MD Keun Won Ryu MD Soo Jeong Cho MD Jong Yeul Lee MD Chan Gyoo Kim MD Il Ju Choi MD Myeong-Cherl Kook MD Byung-Ho Nam PhD Sook Ryun Park MD Min Ju Kim MD Jong Seok Lee MD | 2009 | Annals of Surgical Oncology2009，，8： | 1 |
| 17 | HM30181A,a potent P-glycoprotein inhibitor,potentiates the absorption and in vivo antitumor efficacy of paclitaxel in an orthotopic brain tumor model显示文摘Objective:Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in the treatment of glioma,owing to the presence of the blood-brain barrier and the activity of P-gp,which pumps its substrate back into the systemic circulation.The aim of the present study was to develop an intravenous formulation of HM30181 A(HM)to inhibit P-gp in the brain to effectively deliver paclitaxel(PTX)for the treatment of malignant glioma.Methods:Two formulations of solubilized HM were designed on the basis of different solid dispersion strategies:i)spray-drying[polyvinlypyrrolidone(PVP)-HM]and ii)solvent evaporation[HP-β-cyclodextrin(cyclodextrin)-HM].The P-gp inhibition of these 2 formulations was assessed on the basis of rhodamine 123 uptake in cancer cells.Blood and brain pharmacokinetic parameters were also determined,and the antitumor effect of cyclodextrin-HM with PTX was evaluated in an orthotopic glioma xenograft mouse model.Results:Although both PVP-HM and cyclodextrin-HM formulations showed promising P-gp inhibition activity in vitro,cyclodextrin-HM had a higher maximum tolerated dose in mice than did PVP-HM.Pharmacokinetic study of cyclodextrin-HM revealed a plasma concentration plateau at 20 mg/kg,and the mice began to lose weight at doses above this level.Cyclodextrin-HM(10 mg/kg)administered with PTX at 10 mg/kg showed optimal antitumor activity in a mouse model,according to both tumor volume measurement and survival time(P<0.05).Conclusions:In a mouse orthotopic brain tumor model,the intravenous co-administration of cyclodextrin-HM with PTX showed potent antitumor effects and therefore may have potential for glioma therapy in humans. | Wu Zeng Betty Yuen Kwan Law Vincent Kam Wai Wong Denise So Bik Chan Simon Wing Fai Mok Joyce Jia Ying Gao Rebecca Ka Yan Ho Xu Liang Jia Hao Li Ming Tsung Lee Weng Li Yoon Michael P Smolinski Johnson Yiu Nam Lau Christopher Wai Kei Lam Manson Fok | 2020 | Cancer Biology & Medicine2020，17，4： | 0 |
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