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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014,11,3: | 31 |
| 2 | 踝关节创伤后关节炎的相关危险因素:一项随访18年的回顾性研究显示文摘踝关节创伤后关节炎十分常见,其发生率比髋膝关节高得多,而目前对其危险因素评估的长期随访研究报道很少。作者对1988年1月-1997年12月的373例进行切开复位内固定的踝关节骨折进行了回顾性研究,并进行统计学分析。Pilon骨折、距骨骨折及年龄〈18岁者未纳入研究。 | Lübbeke A Salvo D Stern R Hoffmeyer P Holzer N Assal M. 于涛 俞光荣 | 2012 | 中国矫形外科杂志2012,20,18: | 14 |
| 3 | 金刚石中硫同位素组成揭示大陆形成过程的差异性显示文摘厚的岩石圈地幔的出现使得地球古老大陆变得稳定,然而关于这些古老大陆岩石圈地幔的形成却存在不同的成因解释。一些学者认为古老的大陆岩石圈地幔可通过俯冲洋壳平流增厚或堆叠等水平构造过程形成,而其他学者则认为地幔柱增生、海洋高原基底的熔融或地幔柱熔融残留物的底辟作用等垂向构造过程,在古老大陆岩石群地幔的形成过程中扮演了重要角色。目前,关于最早岩石圈的形成是通过水平还是垂向增生方式完成依然存在很大的争议,而不同的增生模式对于理解地球早期演化和板块作用的起始时限具有完全不同的意义。 | Smit K V Shirey S B Hauri E H Stern R A 袁超 | 2019 | 矿物岩石地球化学通报2019,38,5: | 5 |
| 4 | Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis显示文摘AIM To investigate of pediatric ulcerative colitis activity index(PUCAI) in ulcerative colitis correlate with mucosal inflammation and endoscopic assessment of disease activity(Mayo endoscopic score).METHODS We reviewed charts from ulcerative colitis patients who had undergone both colonoscopy over 3 years. Clinical assessment of disease severity within 35 d(either before or after) the colonoscopy were included. Patients were excluded if they had significant therapeutic interventions(such as the start of corticosteroids or immunosuppressive agents) between the colonoscopy and the clinical assessment. Mayoendoscopic score of the rectum and sigmoid were done by two gastroenterologists. Inter-observer variability in Mayo score was assessed.RESULTS We identified 99 patients(53% female, 74% pancolitis) that met inclusion criteria. The indications for colonoscopy included ongoing disease activity(62%), consideration of medication change(10%), assessment of medication efficacy(14%), and cancer screening(14%). Based on PUCAI scores, 33% of patients were in remission, 39% had mild disease, 23% had moderate disease, and 4% had severe disease. There was 'moderate-substantial' agreement between the two reviewers in assessing rectal Mayo scores(kappa = 0.54, 95%CI: 0.41-0.68). CONCLUSION Endoscopic disease severity(Mayo score) assessed by reviewing photographs of pediatric colonoscopy has moderate inter-rater reliability, and agreement was less robust in assessing patients with mild disease activity. Endoscopic disease severity generally correlates with clinical disease severity as measured by PUCAI score. However, children with inflamed colons can have significant variation in their reported clinical symptoms. Thus, assessment of both clinical symptoms and endoscopic disease severity may be required in future clinical studies. | Basavaraj Kerur Heather J Litman Julia Bender Stern Sarah Weber Jenifer R Lightdale Paul A Rufo Athos Bousvaros | 2017 | World Journal of Gastroenterology2017,23,18: | 5 |
| 5 | SFBs of Japanese plum(Prunussalicina):Cloning seven alleles and determining their linkage to the S-RNase gene显示文摘 | SAPIR G STERN R A GOLDWAY M | 2007 | Hortscience2007,42,7: | 1 |
| 6 | Mushrooms,Tumors, and Irnmunily 显示文摘 | Borchers A T Stern J S Hanckman R M | 1999 | Proceedings of the Society for Experimental Biology and Medicine1999,221,: | 1 |
| 7 | Structure/permeability relationships of siliconcontaining polyimides显示文摘 | Stern S A Vaidyanathan R | 1990 | Journal of Membrane Science1990,49,1: | 1 |
| 8 | Mauritius' lychee fruitdevelopment and reduced abscission after treatment with the auxin2,4,5-TP显示文摘 | Stern R A Kigel J Tomer E | 1995 | JAmer Soc Hort Sci1995,120,1: | 1 |
| 9 | Reduction of irreducible Hawkins Ⅲ talar neck fracture by means of a medial malleolar osteotomy: a report of three cases with a 4-year mean follow-up 显示文摘 | GONZALEZ A STERN R ASSAL M | 2011 | J Orthop Trauma2011,25,5: | 1 |
| 10 | Processing and degradation of chloroplast mRNA 显示文摘 | MONDE R A SCHUSTER G STERN D B | 2000 | Biochimie2000,82,67: | 1 |
| 11 | On the drag and virtual mass coefficients in Biot's equations显示文摘 | Bedford A Costley R D Stern M | 1984 | J Acoust Soc Am1984,76,6: | 1 |
| 12 | Lychee pollination by the Honeybee显示文摘 | STERN R A GAZIT S | 1996 | J Amer Soc Hort Sci1996,120,1: | 1 |
| 13 | General harmonic balance solution of a cracked rotor-bearing-disk system for harmonic and sub-harmonic analysis: analytical and experimental approach 显示文摘 | MOHAMMAD A A-S BUTCHER E A STERN C R | 2010 | International Journal of Engineering Science2010,48,10: | 1 |
| 14 | XPD codon 751 polymorphism,metabolism genes,smoking,and bladder cancer risk显示文摘 | STERN M C JOHNSON L R BELL D A | 2002 | Cancer Epidemiol Biomarkers Prev2002,11,101: | 1 |
| 15 | The extensile approach for the operative treatment of high-energy pilon fractures:surgical technique and softtissue healing显示文摘 | Assal M Ray A Stern R | 2007 | J Orthop Trauma2007,21,3: | 1 |
| 16 | Risk of progression to hypertension in a low-income Mexican population with prehypertension and normal blood pressure 显示文摘 | Jimenez-Corona A Lopez-Ridaura R Stern MP | 2007 | Am J Hypertens2007,20,9: | 1 |
| 17 | Surface plasma oscillations of a degenerate electron gas显示文摘 | Stern E A Ferrell R A | 1960 | Physical Review1960,120,1: | 1 |
| 18 | Reduction of irreducible Hawkins Ⅲ talar neck fracture by means of a medial malleolar osteotomy:a report of three cases with a 4-year mean follow-up显示文摘 | Gonzalez A Stern R Assal M | | 0,,05: | 1 |
| 19 | Epidermal growth factor alters the bax:bcl-2 ratio following massive small bowel resection显示文摘 | Stern L E Falcone R A Huang F | | 0,,: | 1 |
| 20 | Umbilical velocity wave ratios in human pregnancy显示文摘 | Schulman H Fleische r A Stern W | 1984 | Am J Obstet Gynecol1984,148,: | 1 |