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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Sonodynamic therapy(SDT): a novel strategy for cancer nanotheranostics显示文摘Sonodynamic therapy(SDT) is a promising non-invasive therapeutic modality. Compared to photo-inspired therapy, SDT provides many opportunities and benefits, including deeper tissue penetration, high precision, less side effects, and good patient compliance. Thanks to the facile engineerable nature of nanotechnology, nanoparticles-based sonosensitizers exhibit predominant advantages, such as increased SDT efficacy, binding avidity, and targeting specificity. This review aims to summarize the possible mechanisms of SDT, which can be expected to provide the theoretical basis for SDT development in the future. We also extensively discuss nanoparticle-assisted sonosensitizers to enhance the outcome of SDT. Additionally, we focus on the potential strategy of combinational SDT with other therapeutic modalities and discuss the limitations and challenges of SDT toward clinical applications. | Xueting Pan Hongyu Wang Shunhao Wang Xiao Sun Lingjuan Wang Weiwei Wang Heyun Shen Huiyu Liu | 2018 | Science China(Life Sciences)2018，61，4： | 26 |
| 3 | Two RING-Finger Ubiquitin E3 Ligases Regulate the Degradation of SPX4, An Internal Phosphate Sensor, for Phosphate Homeostasis and Signaling in Rice显示文摘SPX-domain-containing proteins (SPXs) play an important role in inorganic phosphate (Pi) sensing,signaling,and transport in eukaryotes.In plants,SPXs are known to integrate cellular Pi status and negatively regulate the activity of Pi central regulators,the PHOSPATE STARVATION RESPONSE proteins (PHRs).The stability of SPXs,such as SPX4,is reduced under Pi-deficient conditions.However,the mechanisms by which SPXs are degraded remain unclear.In this study,using a yeast-twhybrid screen we iden.tified two RING-finger ubiquitin E3 ligases regulating SPX4 degradation,designated SDEL1 and SDEL2,which were post-transcriptionally induced by Pi starvation.We found that both SDELs were located in the nucleus and cytoplasm,had ubiquitin E3 ligase activity,and directly ubiquitinated the K^213 and K^299 lysine residues in SPX4 to regulate its stability.Furthermore,we found that PHR2,a Pi central regulator in rice,could compete with SDELs by interacting with SPX4 under Pi-sufficient conditions,which protected SPX4 from ubiquitination and degradation.Consistent with the biochemical function of SDEL1 and SDEL2,overexpression of SDEL1 or SDEL2 resulted in Pi overaccumulation and induced Pi-starvation signaling even under Pi-sufficient conditions.Conversely,their loss-of-function mutants displayed decreased Pi accumulation and reduced Pi-starvation signaling.Collectively,our study revealed that SDEL1 and SDEL2 facilitate the degradation of SPX4 to modulate PHR2 activity and regulate Pi homeostasis and Pi signaling in response to external Pi availability in rice. | Wenyuan Ruan Meina Guo Xueqing Wang Zhenhui Guo Zhuang Xu Lei Xu Hongyu Zhao Haiji Sun Chengqi Yan Keke Yi | 2019 | Molecular Plant2019，12，8： | 14 |
| 4 | Mn3O4 nanoparticles@reduced graphene oxide composite:An efficient electrocatalyst for artificial N2 fixation to NH3 at ambient conditions显示文摘Currently,industrial-scale NH3 production almost relies on energy-intensive Haber-Bosch process from atmospheric N2 with large amount of CO2 emission,while low-cost and high-efficient catalysts are demanded for the N2 reduction reaction (NRR).In this study,Mn3O4 nanoparticles@reduced graphene oxide (Mn3O4@rGO) composite is reported as an efficient NRR electrocatalyst with excellent selectivity for NH3 formation.In 0.1 M Na2SO4 solution,such catalyst obtains a NH3 yield of 17.4 μg·h^-1·mg^-1cat.and a Faradaic efficiency of 3.52% at-0.85 V vs.reversible hydrogen electrode.Notably,it also shows high electrochemical stability during electrolysis process.Density functional theory (DFT) calculations also demonstrate that the (112) planes of Mn3O4 possess superior NRR activity. | Hong Huang Feng Gong Yuan Wang Huanbo Wang Xiufeng Wu Wenbo Lu Runbo Zhao Hongyu Chen Xifeng Shi Abdullah M.Asiri Tingshuai Li Qian Liu Xuping Sun | 2019 | Nano Research2019，12，5： | 8 |
| 5 | Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis显示文摘The occurrence of osteoarthritis(OA)is highly associated with the reduced lubrication property of the joint,where a progressive and irreversible damage of the articular cartilage and consecutive inflammatory response dominate the mechanism.In this study,bioinspired by the super-lubrication property of cartilage and catecholamine chemistry of mussel,we successfully developed injectable hydrogel microspheres with enhanced lubrication and controllable drug release for OA treatment.Particularly,the lubricating microspheres(GelMA@DMA-MPC)were fabricated by dip coating a self-adhesive polymer(DMA-MPC,synthesized by free radical copolymerization)on superficial surface of photo-crosslinked methacrylate gelatin hydrogel microspheres(GelMA,prepared via microfluidic technology),and encapsulated with an anti-inflammatory drug of diclofenac sodium(DS)to achieve the dual-functional performance.The tribological test and drug release test showed the enhanced lubrication and sustained drug release of the GelMA@DMA-MPC microspheres.In addition,the functionalized microspheres were intra-articularly injected into the rat knee joint with an OA model,and the biological tests including qRT-PCR,immunofluorescence staining assay,X-ray radiography and histological staining assay all revealed that the biocompatible microspheres provided significant therapeutic effect against the development of OA.In summary,the injectable hydrogel microspheres developed herein greatly improved lubrication and achieved sustained local drug release,therefore representing a facile and promising technique for the treatment of OA. | Ying Han Jielai Yang Weiwei Zhao Haimang Wang Yulong Sun Yuji Chen Jing Luo Lianfu Deng Xiangyang Xu Wenguo Cui Hongyu Zhang | 2021 | Bioactive Materials2021，6，10： | 8 |
| 6 | Hydration-Enhanced Lubricating Electrospun Nanofibrous Membranes Prevent Tissue Adhesion显示文摘Lubrication is the key to efficient function of human tissues and has significant impact on the comfort level.However,the construction of a lubricating nanofibrous membrane has not been reported as yet,especially using a one-step surface modification method.Here,bioinspired by the superlubrication mechanism of articular cartilage,we successfully construct hydration-enhanced lubricating nanofibers via one-step in situ grafting of a copolymer synthesized by dopamine methacrylamide(DMA)and 2-methacryloyloxyethyl phosphorylcholine(MPC)onto electrospun polycaprolactone(PCL)nanofibers.The zwitterionic MPC structure provides the nanofiber surface with hydration lubrication behavior.The coefficient of friction(COF)of the lubricating nanofibrous membrane decreases significantly and is approximately 65%less than that of pure PCL nanofibers,which are easily worn out under friction regardless of hydration.The lubricating nanofibers,however,show favorable wear-resistance performance.Besides,they possess a strong antiadhesion ability of fibroblasts compared with pure PCL nanofibers.The cell density decreases approximately 9-fold,and the cell area decreases approximately 12 times on day 7.Furthermore,the in vivo antitendon adhesion data reveals that the lubricating nanofiber group has a significantly lower adhesion score and a better antitissue adhesion.Altogether,our developed hydration-enhanced lubricating nanofibers show promising applications in the biomedical field such as antiadhesive membranes. | Liang Cheng Yi Wang Guoming Sun Shizhu Wen Lianfu Deng Hongyu Zhang Wenguo Cui | 2020 | Research2020，，1： | 6 |
| 7 | A Method for Detection of Main Metabolites in Aromatic Rice Seeds显示文摘[Objective] A method was developed for the analysis of main metabolites in aromatic rice seeds by gas chromatography-mass spectrometry( GC-MS).[Method]The main metabolites in seeds of 9 different aromatic rice varieties were compared and analyzed with two methods. Method 1: the compound was extracted by the mixture of anhydrous ethanol and methylene chloride( V/V = 1∶ 1) at 60 ℃ for 3 h in water bath; the extract was isolated and detected by gas chromatography-mass spectrometry using HP-5 capillary column with scan monitoring mode. Method 2: the main metabolites in aromatic rice seeds were detected using headspace solid phase micro-extraction and gas chromatography mass spectrometry( GC-MS). [Result]Fifteen types of common metabolites were found in 9 different aromatic rice varieties. Method 1 was more effective than method 2 in detecting the main metabolites in aromatic rice seeds. [Conclusion]This study provides an important reference for clarifying the metabolic pathway of main metabolites in aromatic rice and lays the foundation for further rice breeding. | Bo PENG Dongyan KONG Xiaohua SONG Huilong LI Lulu HE Andong GONG Yanfang SUN Ruihua PANG Lin LIU Jintao LI Qiying ZHOU Yaqin HUANG Bin DUAN Shizhi SONG Hongyu YUAN | 2018 | Agricultural Biotechnology2018，7，1： | 6 |
| 8 | Distinct beneficial effect of Sn on the corrosion resistance of Cr-Mo low alloy steel显示文摘In this work,the beneficial effect of Sn addition on the corrosion resistance mechanism of Cr-Mo low alloy steel was studied.Results demonstrated that Sn improves the corrosion resistance of the steel matrix mainly by influencing the microstructural transformation.Sn addition and the synergistic effect of Sn,Cr,and Mo promote the formation of α-FeOOH,SnO_(2),SnO,Cr(OH)_(3),and molybdates,lead to the improved protection and stability of the rust layer.This synergistic effect also endows the inner rust layer with cation selectivity,preventing the further penetration of Cl-and inhibiting the localized corrosion of steel. | Meihui Sun Xiaojia Yang Cuiwei Du Zhiyong Liu Yong Li Yumin Wu Hongyu San Xiandong Su Xiaogang Li | 2021 | Journal of Materials Science & Technology2021，，22： | 6 |
| 9 | Altered Local Field Potential Relationship Between the Parafascicular Thalamic Nucleus and Dorsal Striatum in Hemiparkinsonian Rats显示文摘The thalamostriatal pathway is implicated in Parkinson's disease(PD); however, PD-related changes in the relationship between oscillatory activity in the centromedian-parafascicular complex(CM/Pf, or the Pf in rodents) and the dorsal striatum(DS) remain unclear.Therefore, we simultaneously recorded local field potentials(LFPs) in both the Pf and DS of hemiparkinsonian and control rats during epochs of rest or treadmill walking. The dopamine-lesioned rats showed increased LFP power in the beta band(12 Hz–35 Hz) in the Pf and DS during both epochs, but decreased LFP power in the delta(0.5 Hz–3 Hz) band in the Pf during rest epochs and in the DS during both epochs, compared to control rats. In addition,exaggerated low gamma(35 Hz–70 Hz) oscillations after dopamine loss were restricted to the Pf regardless of the behavioral state. Furthermore, enhanced synchronization of LFP oscillations was found between the Pf and DS after the dopamine lesion. Significant increases occurred in the mean coherence in both theta(3 Hz–7 Hz) and beta bands,and a significant increase was also noted in the phase coherence in the beta band between the Pf and DS during rest epochs. During the treadmill walking epochs, significant increases were found in both the alpha(7 Hz–12 Hz)and beta bands for two coherence measures. Collectively,dramatic changes in the relative LFP power and coherence in the thalamostriatal pathway may underlie the dysfunction of the basal ganglia-thalamocortical network circuits in PD, contributing to some of the motor and non-motor symptoms of the disease. | Haiyan Zhang Jing Yang Xuenan Wang Xiaomeng Yao Hongyu Han Yunfeng Gao Hongli Chang Tianyu Xiang Shuang Sun Yanan Wang Xiusong Wang Min Wang | 2019 | Neuroscience Bulletin2019，35，2： | 5 |
| 10 | Pain threshold, anxiety and other factors affect intensity of postoperative pain in gastric cancer patients: A prospective cohort study显示文摘Objective: This prospective cohort study explored factors related to postoperative pain in gastric cancer patients.Methods: A total of 236 patients who underwent gastrectomy were enrolled. All patients enrolled in the study completed the Hospital Anxiety and Depression Scale(HADS) questionnaire and Life Orientation Test-Revised(LOT-R) questionnaire on the day before surgery. Heat pain threshold(HPT), cold pain threshold(CPT) and pressure pain threshold(PPT) were measured for all patients one day prior to surgery and demographic details were collected. All patients were connected to a patient-controlled intravenous analgesia(PCIA) pump at the end of the surgery. The occurrence of postoperative pain was used as a dependent variable, and multivariate logistic regression analyses were conducted to screen for factors affecting postoperative pain.Results: In total, 83 patients(35.2%) had postoperative pain. Body mass index(BMI) ≥28 kg/m^(2) [odds ratio(OR): 2.67;95% confidence interval(95% CI): 1.07-6.67], total gastrectomy(OR: 2.64;95% CI: 1.42-4.91),preoperative anxiety score ≥8(OR: 2.37;95% CI: 1.12-5.02), heat pain threshold ≤4.9 s(OR: 2.14;95% CI:1.06-4.32), pressure pain threshold ≤4 g(OR: 2.05;95% CI: 1.05-4.03), and female gender(OR: 1.99;95% CI:1.04-3.83) were risk factors for postoperative pain.Conclusions: Obesity, wide range of gastrectomy, high preoperative anxiety, low HPT and PPT, and female gender are associated with increased risk for postoperative pain. | Hongyu Tan Jin Wei Shuo Li Ling Yu Hongwei Sun Ke Ji Yinkui Wang Changlong Li | 2021 | Chinese Journal of Cancer Research2021，33，3： | 5 |
| 11 | Enhanced Fracture Toughness of Pressureless-sintered SiC Ceramics by Addition of Graphene显示文摘To enhance the fracture toughness of pressureless-sintered Si C ceramic, graphene was introduced as an additive. The effects of graphene contents on the fracture toughness, bending strength, micro-hardness,phase compositions, and microstructure evolutions of the Si C ceramics were investigated in detail by scanning electron microscopy, energy dispersive X-ray spectroscopy, and metallographic microscopy. The fracture toughness, bending strength and micro-hardness increased initially, and then decreased with the graphene content increasing from 0 to 5.0 wt%. The highest fracture toughness of 5.65 MPa m1/2was obtained for sample with 1.0 wt% graphene sintered at 2130 °C for 1 h in Ar, which was about 22.6% higher than that of Si C sample without graphene. In addition, the highest bending strength and microhardness of 434.14 MPa and 29.21 GPa corresponded to the Si C samples with graphene content of 0.5wt% and 2.0 wt%, respectively. | Qisong Li Yujun Zhang Hongyu Gong Haibin Sun Wenjie Li Li Ma Yanshuang Zhang | 2016 | Journal of Materials Science & Technology2016，32，7： | 5 |
| 12 | Chalkiness Characters and Scanning Electron Microscope Observation of Rice Grain Endosperm of Japonica Varieties in Southern Henan显示文摘Chalkiness characters affect not only the grain appearance,milling,eating and cooking qualities but also the grain nutritional quality in rice,thus it is one of the most important traits in rice. It is very important for us to investigate the relation of the chalkiness formation and the development of endosperm structure and starch granule of different rice varieties. Here,we have investigated the chalkiness characters such as chalkiness rate,chalkiness degree and chalkiness area in 15 japonica rice varieties from southern Henan. Furthermore,the endosperm structure and starch granules of rice grain were also observed with scanning electron microscope. The results showed that the 15 japonica varieties have a significantly linear relationship between the chalkiness rate and chalkiness degree. Among the varieties,the biggest difference is the chalkiness rate,the second is the chalkiness area,and the last is the chalkiness degree. Moreover,there is a certain correlation between the distribution of starch granules,the arrangement of endosperm cells and the occurrence of grain chalkiness in the different rice varieties. For the same variety,the starch granules of chalky and non-chalky grains have obvious difference,while the starch granules from the transparent part of chalky rice and non-chalky rice do not have significant difference. The results would provide useful references for the improvement of grain quality in rice. | Bo PENG Yanfang SUN Dongyan KONG Ruihua PANG Xiaohua SONG Huilong LI Jintao LI Qiying ZHOU Qiu HAN Shizhi SONG Hongyu YUAN | 2017 | Asian Agricultural Research2017，9，3： | 5 |
| 13 | Hexagonal boron nitride nanosheet for effective ambient N2 fixation to NH3显示文摘Industrial production of NH3 from N2 and H2 significantly relies on Haber-Bosch process,which suffers from high energy consume and CO2 emission.As a sustainable and environmentally-benign alternative process,electrochemical artificial N2 fixation at ambient conditions,however,is highly required efficient electrocatalysts.In this study,we demonstrate that hexagonal boron nitride nanosheet (h-BNNS) is able to electrochemically catalyze N2 to NH3.In acidic solution,h-BNNS catalyst attains a high NH3 formation rate of 22.4 μg·h-1·mg-1cat.and a high Faradic efficiency of 4.7% at-0.75 V vs.reversible hydrogen electrode,with excellent stability and durability.Density functional theory calculations reveal that unsaturated boron at the edge site can activate inert N2 molecule and significantly reduce the energy barrier for NH3 fonmation. | Ya Zhang Huitong Du Yongjun Ma Lei Ji Haoran Guo Ziqi Tian Hongyu Chen Hong Huang Guanwei Cui Abdullah M. Asiri Fengli Qu Liang Chen Xuping Sun | 2019 | Nano Research2019，12，4： | 5 |
| 14 | Kelly sideband suppression and wavelength tuning of a conventional soliton in a Tm-doped hybrid mode-locked fiber laser with an all-fiber Lyot filter显示文摘We demonstrate a stable conventional soliton in a Tm-doped hybrid mode-locked fiber laser by employing a homemade all-fiber Lyot filter(AFLF) and a single-wall carbon nanotube. The AFLF, designed by sandwiching a piece of polarization-maintained fiber(PMF) with two 45° tilted fiber gratings inscribed by a UV laser in PMF with a phase-mask scanning technique, shows large filter depth of ~9 d B and small insertion loss of ~0.8 dB. By optimizing the free spectral range of the AFLF, the Kelly sidebands of a conventional soliton centered at1966.4 nm can be dramatically suppressed without impairing the main shape of the soliton spectrum. It gives the pulse duration of 1.18 ps and bandwidth of 3.8 nm. By adjusting the temperature of the PMF of the AFLF from 7°C to 60°C, wavelength tunable soliton pulses ranging from 1971.62 nm to 1952.63 nm are also obtained.The generated soliton pulses can be precisely tuned between 1971.62 nm and 1952.63 nm by controlling the temperature of the AFLF. | JIANFENG LI YAZHOU WANG HONGYU LUO YONG LIU ZHIJUN YAN ZHONGYUAN SUN LIN ZHANG | 2019 | Photonics Research2019，7，2： | 5 |
| 15 | Application of Landscape Plants in the Huaxi National Urban Wetland Park显示文摘The current situation of plants in Shilihe Beach of the Huaxi National Urban Wetland Park was investigated and analyzed. The results show that there are about 181 species of landscape plants in this park, of which arbors and shrubs are dominant. Various species of plants grow differently because of different types of artificial maintenance. The overall partition of the wetland park dose not follow the features of a river-type wetland and is not clear. In this park, the planting area of hygrophyte is far less than that of terrestrial plants. As a result, the wetland park is evolving into a public garden. It is suggested that the overall design of the park should be conducted in accordance with site characteristics and resources, and the park should be developed and built reasonably based on the principle that the ecology is a priority. | WANG Jian WANG Xiurong SUN Su TAN Li LIU Hongyu | 2017 | Journal of Landscape Research2017，9，2： | 4 |
| 16 | Distribution and characteristics of telocytes as nurse cells in the architectural organization of engineered heart tissues显示文摘Interstitial Cajal-like cells are a distinct type of interstitial cell with a wide distribution in mammalian organs and tissues,and have been given the name'telocytes'.Recent studies have demonstrated the potential roles of telocytes in heart development,renewal,and repair.However,further research on the functions of telocytes is limited by the complicated in vivo environment.This study was designed to construct engineered heart tissue(EHT)as a three-dimensional model in vitro to better understand the role of telocytes in the architectural organization of the myocardium.EHTs were constructed by seeding neonatal cardiomyocytes in collagen/Matrigel scaffolds followed by culture under persistent static stretch.Telocytes in EHTs were identified by histology,toluidine blue staining,immunofluorescence,and transmission electron microscopy.The results from histology and toluidine blue staining demonstrated widespread putative telocytes with compact toluidine blue-stained nuclei,which were located around cardiomyocytes.Prolongations from the cell bodies showed a characteristic dichotomous branching pattern and formed networks in EHTs.Immunofluorescence revealed positive staining of telocytes for CD34 and vimentin with typical moniliform prolongations.A series of electron microscopy images further showed that typical telocytes embraced the cardiomyocytes with their long prolongations and exhibited a marked appearance of nursing cardiomyocytes during the construction of EHTs.This finding highlights the great importance of telocytes in the architectural organization of EHTs.It also suggests that EHT is an appropriate physical and pathological model system in vitro to study the roles of telocytes during heart development and regeneration. | ZHOU Jin WANG Yan ZHU Ping SUN HongYu MOU YongChao DUAN CuiMi YAO AnNing LV ShuangHong WANG ChangYong | 2014 | Science China(Life Sciences)2014，57，2： | 4 |
| 17 | Bacterial and cyanobacterial diversities determined by T-RFLP analyses in the Jiaozhou Bay显示文摘染色 epifluorescence 显微镜学和 T-RFLP 分析的 DAPI 的方法被用来在在 12 上在调查期间从 12stations 取样在内并且在 Jiaozhou 海湾外面的表面海水和 2004 年 9 月 13 日分析微生物引起的丰富和差异。全部的微生物的 Theabundance 在 10 ~ 的范围是 6 ~ 10 ~ 7 cells/cm~3,类似于那些在在世界上的适度的区域的围住 mostsemi 的海湾。最高微生物引起的密度发生在 Jiaozhou 海湾的东北部分,绕 Loushan 和 Licun 河的嘴,建议并且 theHongdao 水文化耕作区域污染的度和特征,与一起地理并且水文学效果,可以是在 Jiaozhou 海湾影响细菌的丰富和分发的重要决定因素。细菌的社区在内并且在 Jiaozhou 海湾外面能基于 T-RFLP 模式和簇分析被组织进三个班。在海湾嘴和外面的水隧道驻扎,例如 D1, D3, D5, D6 andD7,一起被组织代表在 Jiaozhou 海湾外面与环境交往的在外面细菌的社区。Jiaozhou 海湾,如此的 asA3, A5, B2 和 Y1 的最深处的方面的车站,一起被组织代表居住细菌社区。StationsC1, C3 和 C4 一起被组织并且可以代表在居住社区和外面的社区之间的过渡细菌的集合。然而,为 cyanobacterial 差异的盒子没有如此的一种定义关系,显示 cyanobacteria 对各种条件更灵活、能适应的事实。 | REN Jing DANG Hongyue SONG Linsheng SUN Song AN Liguo | 2006 | Acta Oceanologica Sinica2006，25，4： | 4 |
| 18 | HBB-deficient Macaca fascicularis monkey presents with human β-thalassemia显示文摘Dear Editor,β-Thalassemia is a common severe genetic disease caused by mutations in HBB and affects approximately 1.5% of the global population (Origa, 2017). In southern China, the carrier rate of β-thalassemia is as high as 6.43%, creating a high socio-economic burden (Xiong et al., 2010). In adult humans, there are three types of hemoglobin: HbA1 (~97%), HbA2 (~2%) and HbF (~1%). HbA1 (α2β2) is composed of two a-globin and two β-globi n sub units en coded by HBA and HBB, respectively;HbF (α2β2)is made up of two α-globin subunits and two β-globin sub units en coded by HBG. Mutations in the coding region or regulatory region of HBB are involved in β-thalassemia pathogenesis. Except for some rare dominant mutations, most HBB mutations are recessive (Origa, 2017). Depending on the mutation type, the β-globin level will either be reduced or completely depleted, resulting in α-globin accumulation and precipitation. These α-globin precipitates lead to red blood cell death, resulting in anemia and tissue damage, and even death in thalassemia major patients. Blood transfusions can help slow disease progression but lead to iron overload, ultimately resulting in iron toxicity. Bone marrow transfer is the only cure in the clinic and is available only to a small percentage of patients with human leukocyte antigervmatched donors. Recently, gene therapy and gene editing therapy have shown great promise in curing β-thalassemia (Glaser et al., 2015;Thompson et al., 2018). However, no appropriate animal models are available for evaluating the safety and efficacy of such advanced therapeutic strategies in vivo.β-thalassemia mice are the sole animal model available for research. However, substantial differences have been reported between the types and expressi on patter ns of human and mouse globins (McColl and Vadolas, 2016). Moreover, mice contain no fetal globin gene equivalent, and homozygous mutations of HBB in mouse for early models of β-thalassemia major or Cooley anemia are all embryonic lethal (Huo et al., 2009). Recently, significant phenotype and physiology differences have been reported between SIRT6- null mice and the non-human primate model (Zhang et al., 2018). Thus, an appropriate non-human primate model is needed for human β-thalassemia studies and treatments. | Yan Huang Chenhui Ding Puping Liang Duanduan Li Yu Tang Wei Meng Hongwei Sun Hongyu Lu Yu Chen Xueying Chen Qunshan Huang Jianpei Fang Canquan Zhou Shihua Yang Junjiu Huang | 2019 | Protein & Cell2019，10，7： | 4 |
| 19 | New opportunities and challenges of natural products research:When target identification meets single-cell multiomics显示文摘Natural products, and especially the active ingredients found in traditional Chinese medicine(TCM), have a thousand-year-long history of clinical use and a strong theoretical basis in TCM. As such,traditional remedies provide shortcuts for the development of original new drugs in China, and increasing numbers of natural products are showing great therapeutic potential in various diseases. This paper reviews the molecular mechanisms of action of natural products from different sources used in the treatment of inflammatory diseases and cancer, introduces the methods and newly emerging technologies used to identify and validate the targets of natural active ingredients, enumerates the expansive list of TCM used to treat inflammatory diseases and cancer, and summarizes the patterns of action of emerging technologies such as single-cell multiomics, network pharmacology, and artificial intelligence in the pharmacological studies of natural products to provide insights for the development of innovative natural product-based drugs. Our hope is that we can make use of advances in target identification and singlecell multiomics to obtain a deeper understanding of actions of mechanisms of natural products that will allow innovation and revitalization of TCM and its swift industrialization and internationalization. | Yuyu Zhu Zijun Ouyang Haojie Du Meijing Wang Jiaojiao Wang Haiyan Sun Lingdong Kong Qiang Xu Hongyue Ma Yang Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 3 |
| 20 | Progress of phase-field investigations of γrafting in nickel-base single-crystal superalloys显示文摘With the development of nucleation theory,the calculation of phase diagrams(CALPHAD)method and microscopic elasto-plasticity mechanics,it is possible to apply the phase-field method to simulate the γrafting behavior of nickel-base single-crystal superalloys under the conditions of heat treatment,fatigue and creep testing.Based on the experimental progress in γrafting behavior and in combination with the microstructural simulation of the precipitation and rafting of c0phase,this paper reviews the phase-field investigation of γrafting in nickel–base single-crystal superalloys. | Yan Zhao Hongyu Zhang Hua Wei Qi Zheng Tao Jin Xiaofeng Sun | 2014 | Chinese Science Bulletin2014，59，15： | 3 |
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