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| 1 | Risk factors of CMV infection in patients after umbilical cord blood transplantation: a multicenter study in China显示文摘Objective:This retrospective study examined risk factors for cytomegalovirus(CMV)infection after umbilical cord blood transplantation(UCBT)and the impact of CMV infection on patient survival.Methods:In all 176 patients,plasma CMV DNA was negative prior to the transplantation,and examined twice a week for 100 d,and then once weekly for additional 300 d.Preemptive antiviral therapy(ganciclovir or foscarnet)was started in patients with>1,000/mL copies of CMV DNA but no full-blown CMV disease,and was discontinued upon two consecutive negative reports of blood CMV DNA test.The survival and risk factors for CMV infection or disease were examined using logistic regression.Results:CMV infection developed in 71%(125/176)of the patients,with a median onset of 32 d.Four patients(2.3%)developed CMV disease.Neither the 5-year overall survival(OS)nor event-free survival(EFS)differed significantly in infected patients vs.those with no infection(59.4%vs.64.8%,P=0.194;53.4%vs.59.1%,P=0.226).A stepwise multivariate analysis indicated an association of CMV infection with age,high-dose glucocorticoids,the number of transplanted CD34+cells,and the number of platelet transfusion,but not with gender,the conditioning regimen,and the day of neutrophil recovery and chronic graft-versushost disease(cGVHD).Conclusions:CMV infection is very common after UCBT,but does not seem to affect long-term survival with preemptive antiviral treatment. | Juan Tong Zimin Sun Huilan Liu Liangquan Geng Changcheng Zheng Baolin Tang Kaidi Song Wen Yao Xin Liu | 2013 | Chinese Journal of Cancer Research2013，25，6： | 8 |
| 2 | Variation and abrupt change of climate in Ili River Basin, Xinjiang显示文摘在这份报纸,在 7 点收集的每月的降水和温度数据从 1961 ~ 2007 在 Ili 河盆驻扎借助于简单回归分析,跑的平均数, db6 小浪功能和 Mann-Kendall 测试被分析。这研究在过去的 50 年以内在 Ili 河盆在不同时间规模期间揭示了气候变化的特征和降水和温度的突然的变化点。结果证明降水从 mid-1980s 增加了直到 2000 并且自从 2000,继续了在更小的大小增加。在学习时期上,降水在夏天和冬季月期间显著地增加了。温度在 1980 年代末极大地增加了,并且继续显示了从 2000 年的一个增加的趋势介绍。温度增加在夏天,秋天和冬季月期间是很重要的。以不同地理,温度增加在在平原和多山的区域的冬季期间是重要的;增加在在 intermontane 盆的秋天期间也是重要的。在 Ili 河盆的气候变化趋势与北方大西洋摆动和高原季风的变化趋势一致。 | SUN Huilan | 2010 | Journal of Geographical Sciences2010，20，5： | 8 |
| 3 | Studies of the Genotoxicity of Glycidyl Methacrylate (GMA)显示文摘The following experiments were conducted to evaluate the genotoxic effects of GMA (glycidyl methacrylale) on mammalian and human cells.(1) Using the absorption spectrum shift method in vitro, we observed that the maximums of calf thymus DNA and GMA were shifted toward longer wavelengths (a change of more than 15nm) and the absorbance decreased after incubation at room temperature for 15min or more.The result indicates that binding of DNA and GMA had occurred.The binding force is strong, not affected by the addition of concentrated sodium chloride solution, and only slightly decreased by the addition of 8 M urea solution.Therefore the bond between DNA and GMA might be covalent.(2) In cell cultures, unscheduled DNA synthesis (UDS) in human and/or rat lymphocyte was induced and DNA semiconserva-tive replication was inhibited by GMA at concentrations of less than 5.2 mM.(3) Sperm abnormality tests and assays of UDS in germ cells of male mice were conducted to study the in vivo genotoxicity of GMA.The results revealed that GMA could damage DNA, increase sperm abnormality frequency, and reduce the number of sperm cells, 1990 Academic Press.Inc. | DAYING XIE, WEI ZHANG, LAIFU CAO, WENQING SUN, ZHONGSHENG LI, QING GAO, YILI WU, HUILAN GAO, HUIFANG YANG, JIM ZUO,~* AND FUDE FANG~* Institute oF Occupational Medicine. Chinese Academy ol Preventive Medicine. Beijing 100050. and *Institute of Basic Medical Sciences, Chinese Academy ol Medical Sciences. Beijing 100730, China | 1990 | Biomedical and Environmental Sciences1990，3，3： | 7 |
| 4 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 5 | Clinical Prediction Models for Hepatitis B Virus-related Acute-on-chronic Liver Failure:A Technical Report显示文摘Background and Aims:It is critical but challenging to predict the prognosis of hepatitis B virus-related acute-on-chronic liver failure(HBV-ACLF).This study systematically summarized and evaluated the quality and performance of available clinical prediction models(CPMs).Methods:A keyword search of articles on HBV-ACLF CPMs published in PubMed from January 1995 to April 2020 was performed.Both the quality and performance of the CPMs were assessed.Results:Fifty-two CPMs were identified,of which 31 were HBV-ACLF specific.The modeling data were mostly derived from retrospective(83.87%)and single-center(96.77%)cohorts,with sample sizes ranging from 46 to 1,202.Three-month mortality was the most common endpoint.The Asian Pacific Association for the Study of the Liver consensus(51.92%)and Chinese Medical Association liver failure guidelines(40.38%)were commonly used for HBV-ACLF diagnosis.Serum bilirubin(67.74%),the international normalized ratio(54.84%),and hepatic encephalopathy(51.61%)were the most frequent variables used in models.Model discrimination was commonly evaluated(88.46%),but model calibration was seldom performed.The model for end-stage liver disease score was the most widely used(84.62%);however,varying performance was reported among the studies.Conclusions:Substantial limitations lie in the quality of HBV-ACLF-specific CPMs.Disease severity of study populations may impact model performance.The clinical utility of CPMs in predicting short-term prognosis of HBV-ACLF remains to be undefined. | Xia Yu Yi Lu Shanshan Sun Huilan Tu Xianbin Xu Kai Gong Junjie Yao Yu Shi Jifang Sheng | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 6 | Resolution of racemic 3-hydroxy-4,5-dimethyl-2(5H)-furanone (sotolon) by packed column supercritical fluid chromatography显示文摘 | XIE Jianchun HAN Huilan SUN Lei | | 0，，： | 1 |
| 7 | A two-step strategy for constructing stable gel polymer electrolyte interfaces for long-life cycle lithium metal batteries显示文摘Due to the high reactivity between the lithium metal and traditional organic liquid electrolyte,the reaction of lithium metal electrode is usually uneven and there are also unexpected side reactions.Therefore,construction of a stable solid electrolyte interface(SEI)is highly essential to improve the performance of lithium metal anode.Herein,a sandwich-like gel polymer electrolyte(GPE)is accurately prepared by in-situ polymerization of Polyacrylonitrile(PAN)nanofiber membrane with trihydroxymethylpropyl trimethylacrylate(TMPTMA)and 1,6-hexanediol diacrylate(HDDA).The resulting GPE with a tightly cross-linked gel skeleton exhibits high ionic conductivity and electrochemical window of 5.6 V versus Li/Li^(+).In particular,the pretreatment of Li metal anode can improve the interfacial wettability,and the synergy of the chemically pretreated Li metal anode surface and the GPE can electrochemically in situ generate SEI with compositionally stable and fluorine-rich inorganic components.Owing to these unique advantages,the interfacial compatibility between the GPE and lithium metal is greatly improved.Meanwhile,the formed SEI can inhibit the formation of lithium dendrites,and decomposition of GPE would be alleviated.The assembled Li-FEC|GPE|LiFePO_(4) full cell shows a high initial discharge capacity of 157.1 mA h g^(-1),and maintains a capacity retention of 92.3%after 100 cycles at 0.2C. | Qiujun Wang Pin Zhang Weiqi Zhu Di Zhang Zhaojin Li Huan Wang Huilan Sun Bo Wang Li-Zhen Fan | 2022 | Journal of Materiomics2022，8，5： | 0 |
| 8 | Synergistically enabling the interface stability of lithium metal batteries with soft ionic gel and garnet-type Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)ceramic filler显示文摘Lithium metal batteries based on solid electrolytes are considered as promising candidates with high energy density and safety.However,the weak solid-solid contact between electrolyte and electrode can easily lead to interface instability and lithium ions discontinuous migration,which seriously reduces the electrochemical performance of the battery.Herein,we construct a soft gel interfacial layer to improve the stability of the solid-solid interface between electrolyte and electrode by means of polyester-based monomers and imidazole-based ionic liquids.Based on this,garnet-type Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO)particles as inorganic ceramic filler were introduced in the layer to obtain composite electrolytes with high ionic conductivity(up to 1.1×10^(-3)S/cm at 25℃).As a result,the assembled lithium symmetric battery of Li|THCE-15%LLZTO|Li suggests excellent cycling stability with 700 h at 0.1 mA/cm^(2)at 50℃,and the lithium metal batteries of LFP|THCE-15%LLZTO|Li delivers high initial discharge capacity of 128.2 mA·h/g with capacity retain of 75.48%after 150 cycles at 2 C.This work paves a new route to build safe and stable lithium metal batteries with synergistic introduction of composite electrolytes between electrolyte and electrode using soft gel interfacial layer and inorganic filler. | Qiujun Wang Weiqi Zhu Ya Su Di Zhang Zhaojin Li Huan Wang Huilan Sun Bo Wang Dan Zhou Li-Zhen Fan | 2023 | Journal of Materiomics2023，9，3： | 0 |
| 9 | Load-forecasting method for IES based on LSTM and dynamic similar days with multi-features显示文摘To fully exploit the rich characteristic variation laws of an integrated energy system(IES)and further improve the short-term load-forecasting accuracy,a load-forecasting method is proposed for an IES based on LSTM and dynamic similar days with multi-features.Feature expansion was performed to construct a comprehensive load day covering the load and meteorological information with coarse and fine time granularity,far and near time periods.The Gaussian mixture model(GMM)was used to divide the scene of the comprehensive load day,and gray correlation analysis was used to match the scene with the coarse time granularity characteristics of the day to be forecasted.Five typical days with the highest correlation with the day to be predicted in the scene were selected to construct a“dynamic similar day”by weighting.The key features of adjacent days and dynamic similar days were used to forecast multi-loads with fine time granularity using LSTM.Comparing the static features as input and the selection method of similar days based on non-extended single features,the effectiveness of the proposed prediction method was verified. | Fan Sun Yaojia Huo Lei Fu Huilan Liu Xi Wang Yiming Ma | 2023 | Global Energy Interconnection2023，6，3： | 0 |
| 10 | Hierarchically designed MoWSe_(2)/WO_(3)/C anode for fast and efficient Na+storage显示文摘Exploring anode materials with high energy and power density is one of the critical milestones in developing sodium-ion batteries/capacitors(SIBs/SICs).Here,the Mo and W-based bimetallic organic framework(Mo-W-MOF)with core-shell structure is first formed by a facile strategy,followed by a selenization and carbonization strategy to finally prepare multileveled Mo WSe_(2)/WO_(3)/C anode materials with core-shell petal like curled nanosheet structure.Between the petal(MoSe_(2))-core(WO_(3))structure,the formation of WSe_(2)flakes by partial selenization on the surface of WO_(3)serves as a heterogeneous connection between MoSe_(2)and WO_(3).The enlarged layer distance(0.677 nm)between MoSe_(2)and WSe_(2)can facilitate the rapid transfer of Na+and electrons.The density functional theory(DFT)calculations verify that the Mo WSe_(2)/WO_(3)/C heterostructure performs excellent metallic properties.Ex-situ X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),and transmission electron microscopy(TEM)confirm the activation process from the initial insertion reaction to the later conversion reaction.Resultantly,when employed as the anode of SIBs,a remarkable capacity of 384.3 mA h g-1after 950 cycles at 10 A g^(-1)is performed.Furthermore,the SICs assembled with commercial activated carbon(AC)as the cathode exhibits a remarkable energy density of 81.86 W h kg^(-1)(at 190 W kg^(-1))and 72.83 W h kg^(-1)(at 3800 W kg^(-1)).The unique structural design and the reaction investigation of the electrode process can provide a reference for the development of transition metal chalcogenides anodes. | Jian Wang Yachuan Shao Fei Yuan Huilan Sun Di Zhang Zhaojin Li S.Ramesh H.J.Woo Bo Wang | 2023 | Journal of Energy Chemistry2023，，5： | 0 |
| 11 | Oleophobic interaction mediated slippery organogels with ameliorated mechanical performance and satisfactory fouling-resistance显示文摘Owing to their inherent semi-solid property and lubricant ability,organogels manifest various unique characteristics and serve as promising candidates for antifouling.However,the poor mechanical properties of organogels often limit their practical applications.Herein,we report a simple and effective method to prepare organogels with reinforced mechanical performance and surface lubricant ability with the synergistic roles played by oleophobic and oleophilic chains.The rigid oleophobic chains have a poor affinity to lubricating solvent,which gives rise to high oleophobic interactions between polymer networks;the soft oleophilic chains possess a high affinity to the low surface energy solvent,which lead to high solvent content to maintain the satisfactory lubricant capacity.The organogel of oleophobic methyl methacrylate(MMA)and oleophilic lauryl methacrylate(LMA)is chosen as a representative example to illustrate this concept.With the optimal composition,the as-prepared organogels offer satisfactory tensile fracture stress,fracture strain,Young’s modulus,toughness,and tearing fracture energy of 480 k Pa,550%,202 k Pa,1.14 MJ m,and 5.14 k J m,respectively,which are far beyond the classical PLMA organogels.Furthermore,the biofouling resistance tests demonstrate 4 to 9-fold reduction of protein and bacteria adhesion on the reinforced organogels surface in comparison to the glass substrate and solvent-free dry organogels.This simple and effective approach to toughen organogels,we hope,can be applied in various fields with different practical functional requirements in the future. | Liangpeng Zeng Hongyuan Cui Huilan Peng Xiaohang Sun Yi Liu Jingliang Huang Xinxing Lin Hui Guo Wei-Hua Li | 2022 | Journal of Materials Science & Technology2022，，26： | 0 |
| 12 | CD19-targeted chimeric antigen receptor-modified T cells induce remission in patients with relapsed acute B lymphoblastic leukemia after umbilical cord blood transplantation显示文摘To the Editor:Umbilical cord blood transplant(UCBT)serves as an alternative option for treating patients with B cell acute lymphoblastic leukemia(ALL),in the absence of a compatible donor.However,disease recurrence presents a difficult challenge.Chimeric antigen receptor(CAR)-T cell therapy is a promising approach for treating patients with relapsed/refractory ALL.Among the intensive investigations of infusion of CAR-T cells after transplant,few focus on patients who were administered CAR-T therapy after they relapsed subsequently to UCBT.Here,we report the response rate,toxicity,and survival of CD19 CAR-T cells administered to 10 children and young adults with relapsed acute B lymphoblastic leukemia(B-ALL)after UCBT.Between April 2018 and September 2019,11 patients with relapsed B-ALL after UCBT were enrolled,including three females and eight males,the median age was 10 years(range 7-22 years)and median weight was 35.0 kg(range 21.0-72.0 kg).Patient 10 was excluded because of unsuccessful cell culture. | Qianwen Xu Hui Xu Lei Xue Min Wang Guiwang Pan Xuhan Zhang Kaidi Song Wen Yao Xiang Wan Juan Tong Huilan Liu Hanying Xu Xin Liu Xiaoyu Zhu Zimin Sun Lin Yang Xingbing Wang | 2022 | Chinese Medical Journal2022，，1： | 0 |
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