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| 1 | 桑螵蛸脂类提取物对铜绿假单胞菌的抗菌活性和抗生物膜作用(英文)显示文摘目的:探究桑螵蛸脂类提取物的成分及对铜绿假单胞菌的抗菌和抗生物膜作用。创新点:中国传统中药桑螵蛸一直广泛应用于肾病的治疗,在抗菌领域未见报道,本实验首次证明桑螵蛸脂类提取物对铜绿假单胞菌有明显的抗菌和抗生物膜作用。方法:采用气相色谱-质谱联用技术,测定桑螵蛸脂质提取物的化学成分及其相对比例。采用纸片扩散法和琼脂平板稀释法观察桑螵蛸脂类提取物对铜绿假单胞菌的抑菌效应并测定最小抑制浓度(MIC)。采用结晶紫染色法和扫描电镜(SEM)进行抑制生物被膜的试验。结论:桑螵蛸脂类提取物中含有16种化合物,最丰富的成分分别是倍半萜类化合物、单萜和微量芳香族化合物。桑螵蛸脂类提取物对铜绿假单胞菌的MIC为4 mg/ml,对铜绿假单胞菌生物被膜的抑制作用明显。 | Wen-dong WANG Nan-nan ZHANG Warren CHANDA Min LIU Syed Riaz ud DIN Yun-peng DIAO Lei LIU Jing CAO Xiao-li WANG Xing-yun LI An-hong NING Min HUANG Min-tao ZHONG | 2018 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2018，19，5： | 6 |
| 2 | Inheritance of resistance to race 7 of Cercospora sojina in soybeans and RAPD tagging of the resistance gene显示文摘Frog-eye leaf spot of soybean caused by Cercospora sojina Hara is a kind of worldwide disease. Resistance to race 7 of C. sojina was found to be due to a single dominant gene through analyzing resistant behavior of the cross NEAU91212 (susceptible to race 7)× NEAU9674 (resistant to all races). 3 RAPD markers linked to the resistant gene Rcsc 7 were identified using the BSA method. 2 fragments of OPS03620 and OPS03580 amplified with primer OPS03 co-dominantly segregated in the F2 individuals. The genetic distance between OPS03620 and the resistant gene is 8.7 cM. According to the co-dominant marker, the accuracy of predicting the homozygous and heterozygous resistant F2 individuals were 100% and 97.6%, respectively. | Zou, JJ Dong, W Yang, QK Cao, YP Chen, SY | 1999 | Chinese Science Bulletin1999，44，5： | 3 |
| 3 | Bifunctional catalysts of Co3O4@GCN tubular nanostructured (TNS) hybrids for oxygen and hydrogen evolution reactions显示文摘为氧和氢进化反应(OER/HER ) 的催化剂在精力采购例如切开的水的可更新的绿色的心。尽管不可思议的努力被作了为 OER 和她开发有效催化剂,大挑战在 bifunctional 催化剂的发展尚待。这里,我们报导公司 3 在 graphitic 碳氮化物(GCN ) 的管状的 nanostructures 嵌入并且在低温度通过一个灵巧的、大规模化学方法综合了的 O 4 。在公司 3 O 4 和 GCN 为 OER 和她作为 bifunctional 催化剂导致了优秀性能。混血儿的高表面区域,唯一的管状的 nanostructure,和作文为催化作用使所有氧化还原作用地点容易可得到并且提供了更快的离子、电子的传导。公司 3 O 4@GCN 管状的 nanostructured (TNS ) 混血儿展出了最低过电位(0.12 V ) 和优秀当前的密度(在 OER 的 147 妈 / 厘米 2) ,比基准 IrO 2 和 RuO 2, 并且与在碱的媒介的优异耐久性好。而且,公司 3 O 4@GCN TNS 混血儿在她表明了优秀性能与低得多的发作和过电位,并且稳定的当前的密度。这被期望公司 3 在这研究开发的 O 4@GCN TNS 混血儿将是在大规模水切开和燃料房间的高贵金属催化剂的一种吸引人的选择。 | Muhammad Tahir Nasir Mahmood Xiaoxue Zhang Tariq Mahmood Faheem. K. Butt Imran Aslam M.Tanveer Faryal Idrees Syed Khalid Imran Shakir Yiming Yan Jijun Zou Chuanbao Cao Yanglong Hou | 2015 | Nano Research2015，8，11： | 2 |
| 4 | The Scorpion Venom Peptide Smp76 Inhibits Viral Infection by Regulating Type-Ⅰ Interferon Response显示文摘Dengue virus(DENV) and Zika virus(ZIKV) have spread throughout many countries in the developing world and infect millions of people every year, causing severe harm to human health and the economy. Unfortunately, there are few effective vaccines and therapies available against these viruses. Therefore, the discovery of new antiviral agents is critical.Herein, a scorpion venom peptide(Smp76) characterized from Scorpio maurus palmatus was successfully expressed and purified in Escherichia coli BL21(DE3). The recombinant Smp76(rSmp76) was found to effectively inhibit DENV and ZIKV infections in a dose-dependent manner in both cultured cell lines and primary mouse macrophages. Interestingly,rSmp76 did not inactivate the viral particles directly but suppressed the established viral infection, similar to the effect of interferon(IFN)-b. Mechanistically, rSmp76 was revealed to upregulate the expression of IFN-b by activating interferon regulatory transcription factor 3(IRF3) phosphorylation, enhancing the type-Ⅰ IFN response and inhibiting viral infection.This mechanism is significantly different from traditional virucidal antimicrobial peptides(AMPs). Overall, the scorpion venom peptide Smp76 is a potential new antiviral agent with a unique mechanism involving type-Ⅰ IFN responses,demonstrating that natural AMPs can enhance immunity by functioning as immunomodulators. | Zhenglin Ji Fangfang Li Zhiqiang Xia Xingchen Guo Minjun Gao Fang Sun Yuting Cheng Yingliang Wu Wenxin Li Syed Abid Ali Zhijian Cao | 2018 | Virologica Sinica2018，33，6： | 2 |
| 5 | Hypnotic effect of jujubosides from Semen Ziziphi Spinosae 显示文摘 | Cao JX Zhang QY Cui SY | 2010 | J Ethnopharmacol2010，130，1： | 1 |
| 6 | The burden of headache in China; vali-dation of diagnostic questionnaire for a population - based survey 显示文摘 | Yu SY Cao XT Zhao G | 2011 | J Headache Pain2011，12，2： | 1 |
| 7 | Effectiveness of interventions for hypeen- sion care in the community-a meta-analvsis of controlled studies in China 显示文摘 | LU ZX Cao SY Chai Y | 2012 | BMC Healh Serv Res2012，12，： | 1 |
| 8 | Selenocysteine derivative over-comes TRAIL resistance in melanoma cells : evidence for ROS -dependent synergism and signaling crosstalk 显示文摘 | Cao WQ Li XL Zheng SY | 2014 | Oncotarget2014，5，17： | 1 |
| 9 | A three protein signature and clinical outcome in esophageal squamous cell carcinoma 显示文摘 | Cao HH Zhang SY Shen JH et ai | 2015 | Oncotarget2015，6，： | 1 |
| 10 | Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxOl-dependent expression of key autophagy genes by insulin 显示文摘 | Liu HY Cao SY Hong T | 2009 | J Biol Chem2009，284，31： | 1 |
| 11 | The burden of headache in China: validation of diagnostic questionnaire for a population based survey 显示文摘 | Yu SY Cao XT Zhao G | 2011 | J Headache Pain2011，12，2： | 1 |
| 12 | EDC/NHS erosslinked type U collagen-ehondr- oitin sulfate scaffold: characterization and in vitro evaluation显示文摘 | Cao H Xu SY | 2008 | J Master Sci Mater Med2008，19，2： | 1 |
| 13 | Debonding in RC Beams Shear Strengthened with Complete FRP Wraps 显示文摘 | SY Cao JF Chen JG Teng Z Hao J Chen | 2005 | Journal of Composites for Construction2005，9，5： | 1 |
| 14 | Induction of apoptosis in HepG2 cells by solanine and BCL-2 protein 显示文摘 | Ji YB Cao SY Ji CF | 2008 | J Ethno- pharmacol2008，115，： | 1 |
| 15 | Hypnotic effect of jujubosides from Semen Ziziphi Spinosae 显示文摘 | Cao JX Zhang QY Cui SY Cui XY Zhang J Zhang YH Bai YJ Zhao YY | 2010 | Journal of Ethnopharmacology2010，130，1： | 1 |
| 16 | Tahyna virus infection, a neglected arboviral disease in the Qinghai-Tibet Plateau of China 显示文摘 | Li WJ Cao YX Fu SH Wang JL Li MH Jiang S Wang XE Xing SY Feng LH Wang ZQ Shi Y Zhao SC Wang HY Wang ZY Liang GD | 2014 | Vector Borne Zoonotic Dis2014，14，5： | 1 |
| 17 | Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibi- tion of FoxO1 - dependent expression of key Autophagy genes by insulin显示文摘 | Liu HY Hart J Cao SY | 2009 | J Biol Chem2009，284，31： | 1 |
| 18 | Articular cartilage metabolism in patients with KashineBeck Disease: an endemic osteoarthropathy in China显示文摘 | Cao JL Li SY Sc M | 2007 | Osteo Arthritis Cartilage2007，9，2： | 1 |
| 19 | Accumulation of nitrogen and microbial residues during 2000 years of rice paddy and non-paddy soil development in the Yangtze River Delta, China显示文摘 | Roth PJ Lehndorff E Cao ZH Zhuang SY Bannert A Wissing L Schloter M Kogel-Knabner I Amlung W | 2011 | Global Change Biology2011，17，11： | 1 |
| 20 | Chemical characteristics of wet precipitation at an urban site of Guangzhou,South Chi- na显示文摘 | Cao YZ Wang SY Zhang G | 2009 | Atmospheric Research2009，94，： | 1 |
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