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    题名 作者 年代 出处 被引量
1胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 2017中华高血压杂志2017,25,9:2
2Management of button battery stricture in 22-day-old neonate显示文摘RABOEI E H SYED S S MAGHRABi M 2009Eur J Pediatr Surg2009,19,:1
3Is the in vitro antioxidant potential of whole-grain cereals and cereal products well reflected in vivo显示文摘Fardet A Rock E Rémésy C 0,,02:1
4Factors related to regional recurrence in early stage squamous cell carcinoma of the oral tongue 显示文摘An SY Jung E J Lee M 2008Clin Exp Otorhinolaryngol2008,1,3:1
5Outcomes and risks of granulocyte colony - Stimulating factor in patients with coronary artery disease 显示文摘Hill J M Syed M A Arai A E 2005J Am Coil Cardiol2005,46,9:1
6Effects of somatostatin prophylaxis after pylorus-preserving pancreaticoduodenecto- my:increased delayed gastric emptying and reduced plasma motilin显示文摘Shan Y S Sy E D Tsai M L 2005World J Surg2005,29,10:1
7The efficacy of radiographic ana- tomical measurement methods in predicting success after extracor- poreal shockwave lithotripsy for lower pole kidney stones 显示文摘Arpali E Ahinet M Sargin SY 2014Int Braz J Urol2014,40,3:1
8Physical and chemical characteristics of polymer-based spherical activated carbon and its ability to adsorb organics显示文摘KARAKAS SY A AYGUN M GUNES TAHTASAKAL E 2004Carbon2004,42,3:1
9Accumulation of nitrogen and microbial residues during 2000 years of rice paddy and non-paddy soil development in the Yangtze River Delta, China显示文摘Roth PJ Lehndorff E Cao ZH Zhuang SY Bannert A Wissing L Schloter M Kogel-Knabner I Amlung W 2011Global Change Biology2011,17,11:1
10Odour-active components of simulated beef flavour analysed by solid phase microextraction and gas chromatography-mass spectrometry and-olfactometry显示文摘MOON SY CLIFF M A LI-CHAN E C Y 2006J Food Res Int2006,39,:1
11ROLE OF P38 MAPK, AP-1, AND NF-κB IN INTERLEUKIN-1β-INDUCED IL-8 EXPRESSION IN HUMAN VASCULAR SMOOTH MUSCLE CELLS显示文摘Young D Jung Fan Fan David J McConkey Marina E Jean Wenbiao Liu Niels Reinmuth Oliver Stoeltzing Syed A Ahmad Alexander A Parikh Naofumi Mukaida Lee M Ellis 2002Cytokine2002,,4:1
12TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-jun N-terminal kinase in T cells 显示文摘 Rho J Arron J Robinson E Orlinick J Chao M Kalachikov S Cayani E Bartlett FS 3rd Frankel WN Lee SY Choi Y 1997J Biol Chem1997,272,25:1
13Atgl6L1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection 显示文摘Conway KL Kuballa P Song JH Patel KK Castoreno AB Yilmaz OH Jijon HB Zhang M Aldrich LN Villa- blanca El Peloquin JM Goel G Lee IA Mizoguchi E Shi HN Bhan A_K Shaw SY Schreiber SL Virgin HW Shamji AF Stappenbeck TS Reinecker HC Xavier RJ 2013Gastroenterology2013,145,6:1
14Voluntary counseling and testing among post partum women in Botswana 显示文摘Thior I Gabaitiri L Grimes J Shapiro R Lockman S Kim S Kebaabetswe P Garmey E Montano M Peter T Chang SY Marlink R Essex M 2007Patient Educ Couns2007,65,3:1
15Beneficial effects of lamivudine in hepatitis B virus-related decompensated cirrhosis显示文摘Dharmesh Kapoor Rajkumar C Guptan Salma M Wakil Syed N Kazim Rachna Kaul Shri Ram Agarwal Sheikh Raisuddin Seyed E Hasnain Shiv K Sarin 2000Journal of Hepatology2000,,2:1
16Effects of leg penetration on the strength of staple joints in seleted wood and wood-based materials显示文摘Vikram Yadama Bilal M Syed Philip H Steele and Duane E Lyon 1991Forest products journal1991,41,6:1
17Electrochemical study of polyaniline in aqueous and organic medium显示文摘Genies E M Syed A A Tsintavis C 1985Molecular Crystals and Liquid Crystals1985,121,:1
18An in vitro investigation for vaginal bioadhesive properties and swelling states of polymer mixtures显示文摘Baloglu E Ozyazici M Hizarcioglu SY 2003IL Farmaco2003,,58:1
19Terahertz pulsed imaging in vivo:measurements and processing methods显示文摘Parrott E P J Sy S M Y Blu T 0,,10:1
20Biomass recalcitrance: engineering plants and enzymes for biofuels production 显示文摘HIMMEL M E DING SY JOHNSON D K 2007Science2007,315,:1
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