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	题名	作者	年代	出处	被引量
1	High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation:Role of endoplasmic-reticulum-stress显示文摘AIM To elucidate how high diet-induced endoplasmic reticulum-stress upregulates thioredoxin interacting protein expression in Müller cells leading to retinal inflammation. METHODS Male C57Bl/J mice were fed either normal diet or 60% high fat diet for 4-8 wk. During the 4 wk study, mice received phenyl-butyric acid(PBA); endoplasmic reticulum-stress inhibitor; for 2 wk. Insulin resistance was assessed by oral glucose tolerance. Effects of palmitate-bovine serum albumin(BSA)(400 μmol/L) were examined in retinal Müller glial cell line and primary Müller cells isolated from wild type and thioredoxin interacting protein knock-out mice. Expression of thioredoxin interacting protein, endoplasmic reticulum-stress markers, mi R-17-5p m RNA, as well as nucleotide-binding oligomerization domain-like receptor protein(NLRP3) and IL1β protein was determined.RESULTS High fat diet for 8 wk induced obesity and insulin resistance evident by increases in body weight and impaired glucose tolerance. By performing quantitative real-time polymerase chain reaction, we found that high fat diet triggered the expression of retinal endoplasmic reticulum-stress markers(P < 0.05). These effects were associated with increased thioredoxin interacting protein and decreased mi R-17-5p expression, whichwere restored by inhibiting endoplasmic reticulumstress with PBA(P < 0.05). In vitro, palmitate-BSA triggered endoplasmic reticulum-stress markers, which was accompanied with reduced mi R-17-5p and induced thioredoxin interacting protein m RNA in retinal Müller glial cell line(P < 0.05). Palmitate upregulated NLRP3 and IL1β expression in primary Müller cells isolated from wild type. However, using primary Müller cells isolated from thioredoxin interacting protein knock-out mice abolished palmitate-mediated increase in NLRP3 and IL1β.CONCLUSION Our work suggests that targeting endoplasmic reticulumstress or thioredoxin interacting protein are potential therapeutic strategies for early intervention of obesityinduced retinal inflammation.	Maha Coucha Islam N Mohamed Sally L Elshaer Osinakachuk Mbata Megan L Bartasis Azza B El-Remessy	2017	World Journal of Diabetes2017，8，2：	8
2	Associations of Location and Perceived Environmental Attributes with Walking in Neighborhoods显示文摘	Humpel N Owen N Leslie E Marshall A L Bauman A E Sallis J F	2004	American Journal of Health Promotion2004，18，3：	1
3	TPH2 in the ventral tegmental area of the male rat brain显示文摘	Carkaci-Salli N Salli U Kuntz-Melcavage K L	2011	Brain Res Bull2011，84，6：	1
4	Emerging breastcancer epidemic:evidence from Africa显示文摘	Sally N A Temidayo O Clement A	2010	Breast Cancer Res2010，12，4：	1
5	Selection for improved growth and wood density in lodgepole pine: effects on radial patterns of wood variation显示文摘	Tongli W Sally N A	2000	Wood Fiber Sci2000，32，4：	1
6	Behavioral epidemiology: a systematic framework to classify phases of research on health promotion and disease prevention 显示文摘	Sallis JF Owen N Fotheringham MJ	2002	Ann Behav Med2002，24，2：	1
7	Choline Acetyltransferase Activity in Vascular Dementia and Stroke显示文摘	Sharp Sally I Francis Paul T Elliott Mark S J Kalaria Rajesh N Bajic Natasha Hortobagyi Tibor Ballard Clive G	2009	Dementia and Geriatric Cognitive Disorders2009，，3：	1
8	Product evalution : air - fluidized beds in an operative seting显示文摘	Sharon A Takiguchi R N Sally A	1992	Nuesing Manage ment1992，23，6：	1
9	Constraint satisfaction problems:algorithm and appli- cations 显示文摘	BRAILSFORD Sally C POTTS Chris N SMITH Barbara M	1999	European Journal of Operational Research1999，119，3：	1
10	Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women 显示文摘	Paul J N Sylvia Pomeroy Sally Kay	1999	Journal of Clinical Endocrinology &Metabolism1999，84，：	1
11	Optical coherence-domain reflectometry: a new optical evaluation technique 显示文摘	Youngquist Rober C Carr Sally Davies D E N	1987	Opt Lett1987，12，3：	1
12	Emerging breast cancer epidemic;evidence from Africa显示文摘	Akarolo-Anthony Sally N Ogundiran Temidayo O Adebamowo Clement A	2010	Breast Cancer Res2010，12，4：	1
13	Determination of clemastine in human plasma by gas chromatography with nitrogen-phosphorus detection 显示文摘	Natalia N D Sally U Y	2000	Journal of Chromatography B2000，744，1：	1
14	Characteristics of a group of adolescents under-going loop electricalexcision procedure(Leep)显示文摘	Sally E Jaquelie N	2003	Elsevier Science Inc2003，16，：	1
15	Im pactof M R Ion treatm entplan and fracture classification of tibial plateau fractures显示文摘	Yacoubian SV N evins R T Sallis JG etal	2003	J OrthopTrauma2003，5，9：	1
16	Product evaluation: Air fluidized beds in an operational setting 显示文摘	Sharon A Taiguchchi R N Sally A	1992	Nursing Management1992，6，：	1
17	Behavioral epidemiology: A systematic framework to classify phases of research on health promotion and disease prevention 显示文摘	Sallis J F Owen N Fotheringham M J	2000	Annals of Behavioral Medicine2000，22，4：	1
18	Serotonin neurons derived from rhesus monkey embryonic stem cells:similarities to CNS serotonin neurons显示文摘	Salli U Reddy AP Salli N	2004	Exp Neurol2004，188，2：	1
19	Advancing science and policy through a coordinated international study of physical activity and built environments:IPEN adult methods显示文摘	Kerr J Sallis JF Owen N	2013	J Phys Act Health2013，10，4：	1
20	Constraint satisfaction problems:Algorithms and applications显示文摘	Sally C Brailsford Chris N Potts Barbara M Smith	1999	European Journal of Operational Research1999，1，19：	1

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