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| 1 | Clinical implications of fatty pancreas:Correlations between fatty pancreas and metabolic syndrome显示文摘AIM:To investigate the clinical implications of lipid deposition in the pancreas(fatty pancreas). METHODS:The subjects of this study were 293 patients who had undergone abdominal computed tomography(CT)and sonography.Fatty pancreas was diagnosed by sonographic findings and subdivided into mild,moderate,and severe fatty pancreas groups comparing to the retroperitoneal fat echogenicity. RESULTS:Fatty pancreas was associated with higher levels for visceral fat,waist circumference,aspartate aminotransferase(AST),alanine aminotransferase (ALT),total cholesterol,triglyceride,high density lipoprotein,free fatty acid,γ-GTP,insulin,and the homeostasis model assessment of insulin resistance (HOMA-IR)than the control group(P<0.05).HOMAIR,visceral fat,triglyceride,and ALT also tended to increase with the degree of fat deposition in the pancreas on sonography.In a multivariate logistic regression analysis,HOMA-IR,visceral fat,and ALT level were independently related to fatty pancreas after adjustment for age,body mass index,and lipid profile.The incidence of metabolic syndrome in the fatty pancreas group was significantly higher than in the control group,and the numbers of metabolic syndrome parameters were significantly higher in the fatty pancreas group(P<0.05).CONCLUSION:Sonographic fatty pancrease showed higher insulin resistance,visceral fat area,triglyceride, and ALT levels than normal pancreases.Fatty pancreas also showed a strong correlation with metabolic syndrome. | Jun Seok Lee Sang Heum Kim Dae Won Jun Jee Hye Han Eun Chul Jang Ji Young Park Byung Kwan Son Seong Hwan Kim Yoon Ju Jo Young Sook Park Yong Soo Kim | 2009 | World Journal of Gastroenterology2009，15，15： | 40 |
| 2 | Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in nonalcoholic fatty liver disease显示文摘AIM To validate the effects of receptor interacting protein kinase-3(RIP3) deletion in non-alcoholic fatty liver disease(NAFLD) and to clarify the mechanism of action.METHODS Wild-type(WT) and RIP3 knockout(KO) mice werefed normal chow and high fat(HF) diets for 12 wk. The body weight was assessed once weekly. After 12 wk, the liver and serum samples were extracted. The liver tissue expression levels of RIP3, microsomal triglyceride transfer protein, protein disulfide isomerase, apolipoprotein-B, X-box binding protein-1, sterol regulatory element-binding protein-1c, fatty acid synthase, cluster of differentiation-36, diglyceride acyltransferase, peroxisome proliferator-activated receptor alpha, tumor necrosis factor-alpha(TNF-α), and interleukin-6 were assessed. Oleic acid treated primary hepatocytes from WT and RIP3 KO mice were stained with Nile red. The expression of inflammatory cytokines, including chemokine(C-X-C motif) ligand(CXCL) 1, CXCL2, and TNF-α, in monocytes was evaluated.RESULTS RIP3 KO HF diet fed mice showed a significant gain in body weight, and liver weight, liver to body weight ratio, and liver triglycerides were increased in HF diet fed RIP3 KO mice compared to HF diet fed WT mice. RIP3 KO primary hepatocytes also had increased intracellular fat droplets compared to WT primary hepatocytes after oleic acid treatment. RIP3 overexpression decreased hepatic fat content. Quantitative real-time polymerase chain reaction analysis showed that the expression of very-low-density lipoproteins secretion markers(microsomal triglyceride transfer protein, protein disulfide isomerase, and apolipoprotein-B) was significantly suppressed in RIP3 KO mice. The overall NAFLD Activity Score was the same between WT and RIP3 KO mice; however, RIP3 KO mice had increased fatty change and decreased lobular inflammation compared to WT mice. Inflammatory signals(CXCL1/2, TNF-α, and interleukin-6) increased after lipopolysaccharide and pancaspase inhibitor(necroptotic condition) treatment in monocytes. Neutrophil chemokines(CXCL1, and CXCL2) were decreased, and TNF-α was increased after RIP3 inhibitor treatment in monocytes.CONCLUSION RIP3 deletion exacerbates steatosis, and partially inhibits inflammation in the HF diet induced NAFLD model. | Waqar Khalid Saeed Dae Won Jun Kiseok Jang Sang Bong Ahn Ju Hee Oh Yeon Ji Chae Jai Sun Lee Hyeon Tae Kang | 2018 | World Journal of Gastroenterology2018，24，48： | 7 |
| 3 | 3-Dimensional liver volume assessment in patients with hepatitis B virus-related liver cirrhosis during long-term oral nucleos(t)ide analogues therapy显示文摘AIM To assess the effect of long-term oral nucleos(t)ide analogues(NUCs) therapy on liver volume change in patients with suppress hepatitis B virus(HBV)-related liver cirrhosis.METHODS We reviewed the data of na?ve patients with HBVrelated liver cirrhosis, who had taken oral NUCs therapy, between 2003 and 2007 at Chonbuk University Hospital. We analyzed two consecutive sets of abdominal computerized tomography scans-one at the time oftreatment initiation and another at the second-year follow-up. Liver volume was calculated by 3-dimensional liver extraction volumetry program.RESULTS A total of 55 patients(34 males) were included. There was 114.3 m L ± 167.8 m L(12.9% ± 17.9%) of increase in liver volume during the two years of NUCs therapy(993.8 m L ± 242.8 m L at baseline vs 1108.1 m L ± 263.3 m L at two-year follow-up, P < 0.001). The ratio of the measured baseline liver volume to the estimated standard liver volume was improved from 70.8% to 78.0%. An increase in liver volume was shown not only in patients with compensated cirrhosis(P = 0.046) but also in those with decompensated cirrhosis(P < 0.001). Significant factors for volume increases were Child-Turcotte-Pugh grade and model for end-stage liver disease score improvement without virological breakthrough. In multiple linear regression analysis, delta albumin and delta alanine aminotransferase levels showed a significant association with the increase in liver volume(P = 0.002 and 0.005, respectively).CONCLUSION Long-term oral NUCs therapy in patients with HBVrelated liver cirrhosis lead to significant increase in liver volume assessed with 3-dimensional liver extraction volumetry program. | Chang Hun Lee In Hee Kim Jin Chang Moon Seung Young Seo Seong Hun Kim Sang Wook Kim Seung Ok Lee Soo Teik Lee Dae Ghon Kim Jae Do Yang Hee Chul Yu | 2017 | World Journal of Gastroenterology2017，23，2： | 6 |
| 4 | Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): short-term outcomes of an open-label randomised controlled trial显示文摘 | Sung-Bum Kang Ji Won Park Seung-Yong Jeong Byung Ho Nam Hyo Seong Choi Duck-Woo Kim Seok-Byung Lim Taek-Gu Lee Dae Yong Kim Jae-Sung Kim Hee Jin Chang Hye-Seung Lee Sun Young Kim Kyung Hae Jung Yong Sang Hong Jee Hyun Kim Dae Kyung Sohn Dae-Hyun Kim Jae H | 2010 | Lancet Oncology2010，，7： | 5 |
| 5 | Efficacy of Pegylated Interferon Monotherapy versus Sequential Therapy of Entecavir and Pegylated Interferon in Hepatitis B e Antigen-Positive Hepatitis B Patients: A Randomized, Multicenter, Phase IIIb Open-Label Study (POTENT Study)显示文摘 | Dae Won Jun Sang Bong Ahn Tae Yeob Kim Joo Hyun Sohn Sang Gyune Kim Se Whan Lee Byung Ho Kim Dong Joon Kim Ja Kyung Kim Hyoung Su Kim Seong Gyu Hwang Won Choong Choi Won Young Tak Heon Ju Lee Ki Tae Yoon Byung Cheol Yun Sung Wook Lee Soon Koo Baik Seung Ha Park Ji Won Park Sol Ji Park Ji Sung Lee | 2018 | Chinese Medical Journal2018，，14： | 5 |
| 6 | The role of vasoepididymostomy for treatment of obstructive azoospermia in the era of in vitro fertilization:a systematic review and meta-analysis显示文摘This study comprises a systematic review and meta-analysis of micmsurgical vasoepididymostomy outcomes in epididymal obstructive azoospermia.A comprehensive literature search was performed using Medline,Embase,and the Cochrane library that included all studies related to microsurgical vasoepididymostomy.Keywords included “vasoepididymostomy,”“epididymovasostomy,”“epididymal obstruction,”and “epididymis obstruction.”Event rate and risk ratio (RR)were estimated.Patency rate and pregnancy rate were investigated.The analysis comprised 1422 articles,including 42 observational studies with 2298 enrolled patients performed from November 1978 to January 2017.The overall mean patency rate was 64.1%(95%confidence interval [CI]:58.5%-69.3%;F=83.0%),and the overall mean pregnancy rate was 31.1%(95%CI:26.9%-35.7%;I^2=73.0%).We performed a meta-analysis comparing the patency rate of bilateral microsurgical vasoepididymostomy and unilateral microsurgical vasoepididymostomy and found an RR of 1.38%(95%CI: 1.21%-1.57%;P <0.00001).A comparison of the site of microsurgical vasoepididymostomy showed that caudal or corpus area was favorable for patency rate (RR =1.17%;95%CI: 1.01%-1.35%;P =0.04).Patients with motile sperm in epididymal fluid exhibited an RR of 1.53%(95%CI:1.11%-2.13%;P =0.01)with respect to patency rate. Microsurgical vasoepididymostomy is an effective treatment for epididymal obstructive azoospermia that can improve male fertility. We find that performing microsurgical vasoepididymostomy bilaterally,anastomosing a larger caudal area,and containing motile sperm in epididymis fluid can potentially achieve a superior patency rate. | Young Eun Yoon Hyung Ho Lee Sung Yul Park Hong Sang Moon Dong Suk Kim Seung-Hun Song Dae Keun Kim | 2019 | Asian Journal of Andrology2019，21，1： | 4 |
| 7 | Multicenter phase Ⅱ trial of modified FOLFIRINOX in gemcitabine-refractory pancreatic cancer显示文摘AIM To evaluate the efficacy and safety of modified FOLFIRINOX as a second-line treatment for gemcitabine(GEM)-refractory unresectable pancreatic cancer(PC).METHODS This study was a prospective, multicenter, one-arm, open-label, phase Ⅱ trial. Patients with unresectable PC, who showed disease progression during GEMbased chemotherapy were enrolled. All patients were administered FOLFIRINOX with reduced irinotecan and oxaliplatin(RIO; irinotecan 120 mg/m^2 and oxaliplatin 60 mg/m^2), which was set according to the phase Ⅰ study of FOLFIRINOX. The objective response rate(ORR), disease control rate(DCR), progressionfree survival(PFS), overall survival(OS), adverse events were evaluated. Additionally, changes in quality of life(QoL) were assessed using a questionnaire on QoL.RESULTS Between August 2015 and May 2016, a total of 48 patients were enrolled. The median follow-up time was 259 d with a median of 8.5 cycles. The ORR and DCR were 18.8% and 62.5%, respectively, including one patient who showed complete remission. The median PFS was 5.8 mo [95% confidence interval(CI): 3.7-7.9] and median OS was 9.0 mo(95%CI: 6.4-11.6). Neutropenia(64.6%) was the most common grade 3-4 adverse event, followed by febrile neutropenia(16.7%). Although 14.6% of patients experienced grade 3 fatigue, most non-hematologic AEs were under grade 2. In the QoL analysis, the global health status score before treatment was not different from the score at the last visit after treatment(45.43 ± 22.88 vs 48.66 ± 24.14, P = 0.548).CONCLUSION FOLFIRINOX with RIO showed acceptable toxicity and promising efficacy for GEM-refractory unresectable PC. However, this treatment requires careful observation of treatment-related hematologic toxicities. | Moon Jae Chung Huapyong Kang Ho Gak Kim Jong Jin Hyun Jun Kyu Lee Kwang Hyuck Lee Myung Hwan Noh Dae Hwan Kang Sang Hyub Lee Seungmin Bang 无 | 2018 | World Journal of Gastrointestinal Oncology2018，10，12： | 3 |
| 8 | Potentiating activity of rhein in targeting of resistance genes in methicillin-resistant Staphylococcus aureus显示文摘Objective: To investigate the synergistic effect between rhein(RHE) and oxacillin against Staphylococcus aureus(MRSA) at the gene level. Method: A minimum inhibitory concentration and checkerboard dilution test were conducted to evaluate antibacterial activity. Reverse transcriptase polymerase chain reaction was conducted to investigate the gene expressions. Results: RHE exhibited a minimum inhibitory concentration of 62.5-250.0 μg/mL against various MRSA strains and the reference strain, respectively. As revealed by the checkerboard assay, a combination of RHE and oxacillin exhibited synergistic or partially synergistic effects against MRSA strains. RHE decreased the expressions of mecA/blaZ in a dose-dependent manner. RHE also decreased the expressions of the regulator genes mecI/blaI and mecR1/blaR1. Conclusions: We suggest that RHE affects the activity of mecR1/blaR1, which is located in the cell membrane of MRSA and results in the suppression of mecA/mecI/mecR1 and blaZ/blaI/blaR1 gene expressions. | Ryong Gong Dae Young Lee Jae Won Lee Doo Jin Choi Geum-Soog Kim Sang Hyuk Lee Young-Seob Lee | 2019 | Asian Pacific Journal of Tropical Medicine2019，12，1： | 2 |
| 9 | Distant skeletal muscle metastasis from intrahepatic cholangiocarcinoma presenting as Budd-Chiari syndrome显示文摘Intrahepatic cholangiocarcinoma is a malignant neoplasm arising from the biliary epithelium, which frequently invades adjacent organs or metastasizes to other visceral organs such as the lungs, bones, adrenals, and brain. However, distant skeletal muscle metastasis of cholangiocarcinoma has never been described before to the best of our knowledge and, furthermore, Budd-Chiari syndrome secondary to intrahepatic cholangiocarcinoma is also extremely rare. Here we present the first case overall of distant muscle metastasis from intrahepatic cholangiocarcinoma presenting as Budd-Chiari syndrome. A 44-year-old man admitted to the hospital with complaints of abdominal distension, edema of both legs, back pain and anorexia of 30 d' duration. Computed tomography and ultrasonography-guided percutaneous muscle biopsy established intrahepatic cholangiocarcinoma with disseminated thrombosis from inferior vena cava to bilateral iliac and femoral veins, and multiple skeletal muscle metastases in bilateral buttock and erector spinal muscle. | Oh Sung Kwon Dae Won Jun Sang Heum Kim Mee Yeon Chung Nam In Kim Moon Hee Song Han Hyo Lee Seung Hwan Kim Yoon Ju Jo Young Sook Park Jong Eun Joo | 2007 | World Journal of Gastroenterology2007，13，22： | 2 |
| 10 | 16S rRNA基因测序技术在肝脓疡细菌鉴定中的作用(英文)显示文摘目的评价16S核糖体RNA(rRNA)基因测序在肝脓疡中细菌鉴定中的应用价值。方法2012年1月—2013年12月间共20例肝脓疡行经皮置管引流的患者,分别行脓液培养,血培养和16S rRNA基因测序。利用454 GS Junior System对脓液基因组DNA行PCR和16S rRNA基因测序。脓液培养,血液培养和16S rRNA基因测序结果进行分别评价。结果脓液和血液培养阳性的患者分别是9例(45%)和4例(20%)。16S rRNA基因测序细菌鉴定率为90%,明显高于传统的培养方法。结论 16S rRNA基因测序方法较传统的培养方法能更准确和有效对肝脓疡进行细菌鉴定。 | 宋伦圭 Yun Gyu Song Sang Gun Shim Kwang Min Kim Dae Soo Kim Sang Haeng Choi Jae Young Song Kon Ho Lee Hyung-Lyun Kang Seung-Chul Baik Woo-Kon Lee Myung Je Cho Kwang Ho Rhee Dong Hae Lee | 2014 | 介入放射学杂志2014，23，10： | 2 |
| 11 | Activation of mitogen-activated protein kinases and AP-1 by polysaccharide isolated from the radix of Platycodon grandiflorum in RAW 264.7 cells显示文摘 | Yeo Dae Yoon Jong Soon Kang Sang Bae Han Song-Kyu Park Hyun Sun Lee Jong Seong Kang Hwan Mook Kim | 2004 | International Immunopharmacology2004，，12： | 2 |
| 12 | Enzyme-amplified SERS immunoassay with Ag-Au bimetallic SERS hot spots显示文摘Surface-enhanced Raman scattering(SERS)enables rapid detection of single molecules with high specificity.However,quantitative and sensitive SERS analysis has been a challenge due to the lack of reliable SERS-active materials.In this study,we developed a quantitative SERS-based immunoassay using enzyme-guided Ag growth on Raman labeling compound(RLC)-immobilized gold nanoparticle(Au NP)-assembled silica NPs(SiO2@Au-RLC@Ag).The enzyme amplified Ag+reduction as well as Ag growth on the RLC-immobilized Au NP-assembled silica NPs(SiO2@Au-RLC),which resulted in a significant increase in SERS signal.In the presence of target antigens such as immunoglobulinG(IgG)or prostate-specific antigen(PSA),Ab1-Antigen-Ab2 immune complex with alkaline phosphatase triggered an enzyme-catalyzed reaction to convert 2-phospho-L-ascorbic acid(2-phospho-L-AA)to ascorbic acid(AA).As produced AA reduced Ag+to Ag,forming an Ag hot spot on the surface of SiO2@Au-RLC,which enhanced the SERS signal of SiO2@Au-RLC@Ag in a solution with a target antigen concentration.The plasmonic immunoassay for IgG detection showed a high linearity of SERS intensity in the range of 0.6 to 9.0 ng/mL with a detection limit(LOD)of 0.09 ng/mL,while an LOD of 0.006 ng/mL was obtained for PSA.The results indicate that the sensitivity of our novel SERS-based immunoassay is higher than that of conventional enzyme-based colorimetric immunoassays. | Xuan-Hung Pham Eunil Hahm Tae Han Kim Hyung-Mo Kim Sang Hun Lee Sang Chul Lee Homan Kang Ho-Young Lee Dae Hong Jeong Hak Soo Choi Bong-Hyun Jun | 2020 | Nano Research2020，13，12： | 2 |
| 13 | Chemical and functional components in different parts of rough rice ( Oryza sativa L.) before and after germination显示文摘 | Hyun Young Kim In Guk Hwang Tae Myoung Kim Koan Sik Woo Dong Sik Park Jae Hyun Kim Dae Joong Kim Junsoo Lee Youn Ri Lee Heon Sang Jeong | 2012 | Food Chemistry2012，，1： | 2 |
| 14 | 18 F-fluorodeoxyglucose positron emission tomography–computed tomography for the evaluation of bone metastasis in patients with gastric cancer显示文摘 | Dae Won Ma Jie-Hyun Kim Tae Joo Jeon Yong Chan Lee Mijin Yun Young Hoon Youn Hyojin Park Sang In Lee | 2013 | Digestive and Liver Disease2013，，： | 2 |
| 15 | Expression of Cancer-Testis Antigens MAGE-A3/6 and NY-ESO-1 in Non-Small-Cell Lung Carcinomas and Their Relationship with Immune Cell Infiltration显示文摘 | Sang Hyun Kim Sangyull Lee Chang Hun Lee Min Ki Lee Young Dae Kim Dong Hoon Shin Kyung Un Choi Jee Yeon Kim Do Youn Park Mee Young Sol | 2009 | Lung2009，，6： | 1 |
| 16 | Preoperative Portal Vein Embolization and Surgical Resection in Patients with Hepatocellular Carcinoma and Small Future Liver Remnant Volume: Comparison with Transarterial Chemoembolization显示文摘 | Dong Dae Seo Han Chu Lee Myoung Kuk Jang Hyun Ju Min Kang Mo Kim Young Suk Lim Young-Hwa Chung Yung Sang Lee Dong Jin Suh Gi-Young Ko Young-Joo Lee Sung-Gyu Lee | 2007 | Annals of Surgical Oncology2007，，12： | 1 |
| 17 | Effects of trimetazidine in patients with acute myocardial infarction: data from the Korean Acute Myocardial Infarction Registry显示文摘 | Jeong Su Kim Chang Hoon Kim Kook Jin Chun June Hong Kim Yong Hyun Park Jun Kim Jin Hee Choi Sang Hyun Lee Eun Jung Kim Dae Gon Yu Eun Young Ahn Myung Ho Jeong | 2013 | Clinical Research in Cardiology2013，，： | 1 |
| 18 | Long non-coding RNA HOTAIR is associated with human cervical cancerprogression显示文摘 | Hee Kim Dae Lee Ga Yim Eun Nam Sunghoon Kim Sang Kim Young Kim | 2015 | International Journal of Oncology2015，，： | 1 |
| 19 | The 5-year functional outcomes after radical prostatectomy: a real-life experience in Korea显示文摘我们关于可勃起的功能和尿克制调查了功能的结果直到在朝鲜的人的一个队跟随激进的前列腺切除术(RP ) 的 5 年。我们回顾地分析了为临床上局部性的前列腺癌症收到了开的 uni- 或双边的神经圆材 RP 并且被跟随在上面的 85 个朝鲜的人的 clinicopathologic 数据为至少 5 年手术后地。从医药记录,病人关于在在 RP 以后的基线和手术后的后续行动的尿、可勃起的功能的地位被估计。在在 RP 以后的 24 和 60 个月,题目大陆(使用的没有垫) 的比例是 89.4% 和 97.6% ,分别地(P = 0.007 ) 。排除题目(n = 24 ) 外科手术前地报导了有严重可勃起的机能障碍或缺乏相关信息,能够不管可勃起的帮助用法有阴道交际的题目的比例在从 RP 的 24 和 60 个月是 47.5% 和 37.7% ,分别地(P = 0.022 ) 。病人在外科的年龄(P = 0.047 ) 并且抢救放射治疗(P = 0.026 ) 被观察是在 multivariate 分析从 RP 在 60 个月有为交际足够的勃起的重要预言者。当病人关于在从 RP 的 2 年的尿克制的手术后的地位通常在 5 年点被维持或改善时,我们的结果显示出那,可勃起的功能被观察到显著地从 2 年衰退了到 5 年后面的 RP。在可勃起的功能追随者 RP 的如此的衰落可能在在在手术后的后续期间收到了抢救治疗的外科或那些相对更老的男人之中是更重要的。 | Sung Kyu Hong Seung Hwan Doo Dae Sung Kim Won Ki Lee Hong Zoo Park Ji Hyun Park Seong Jin Jeong Cheol Yong Yoon Seok-Soo Byun Sang Eun Lee | 2010 | Asian Journal of Andrology2010，12，6： | 1 |
| 20 | Prevalence of Gastroesophageal Reflux Disease Symptoms and Uninvestigated Dyspepsia in Korea: A Population-Based Study显示文摘 | Sun Young Yang Oh Young Lee Young Tae Bak Dae Won Jun Sang Pyo Lee Sung Hee Lee Geun Tae Park Byung Chul Yoon Ho Soon Choi Jun Soo Hahm Min Ho Lee Dong Hoo Lee | 2008 | Digestive Diseases and Sciences2008，，1： | 1 |
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